Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6603649 | [Erbium 169 synoviortheses and infiltrations of triamcinolone hexacetonide in metatarsopha | 1983 Apr | The authors report their experience in the treatment of metatarsophalangeal arthritis of chronic inflammatory rheumatism by Erbium 169 synoviortheses (112 joints treated) and by infiltrations of triamcinolone hexacetonide (53 joints treated). The steroid appears to have a marked early superiority as it gives 85% good results compared to 61.6% for Erbium 169 after a period of one to three months. However, its results then deteriorate more rapidly and after 6 months, the proportion of good results is greater with the radioactive treatment (64% compared to 46.7%). The authors consider it reasonable to use triamcinolone hexacetonide as the first line treatment as it is easier to manage and less expensive, reserving the radioactive synoviortheses for later with the prospect of more lasting results. | |
| 1086654 | Lymphocytes in rheumatoid and nonrheumatoid synovial fluids. Nonspecificity of high T-cell | 1975 Oct | Lymphocytes were studied in paired peripheral blood and synovial fluid samples from patients with various forms of arthritis, including rheumatoid arthritis (group I) and other polyarthritides of unknown origin (group II), as well as arthritides generally considered not to be immunologically mediated, such as crystal synovitis, traumatic arthritis, osteoarthrosis, and pigmented villonodular synovitis (group III). In all 3 groups the percentages of T lymphocytes were significantly higher in synovial fluids than in the peripheral blood, whereas those of the synovial fluid B lymphocytes were consistently very low and occasionally nil. Absolute numbers of synovial fluid lymphocytes were significantly higher in groups I and II as compared with group III, and in the peripheral blood absolute numbers of lymphocytes in groups I and II were significantly lower than in controls. No correlation was found between absolute numbers of lymphocytes and complement activity in the synovial fluid. The characteristic pattern of high T-cell and very low B-cell percentages in synovial fluids is a general feature of inflammatory exudates and cannot be considered an expression of cell-mediated immunity in itself. | |
| 6574910 | Anti-prostaglandin and anti-inflammatory short-term efficacy of piroxicam in rheumatoid ar | 1983 | The efficacy of anti-inflammatory agents is related to their concentration in the peripheral compartments. In rheumatoid arthritis a drug's affinity for synovial tissue and synovial fluid is a decisive factor in treatment. The short-term efficacy of piroxicam was studied, relating the synovial concentration of prostaglandins and acid phosphatase and LDH to piroxicam synovial and plasma levels. After withdrawal of synovial fluid for pre-treatment measurements, 10 patients received 20 to 30 mg of piroxicam/day for eight days. The drug reached an average level of 3.56 +/- 0.9 micrograms/ml in synovial fluid, and 7.73 +/- 1.6 micrograms/ml in plasma. The acid phosphatase decreased from an initial average level of 29 mu/ml to a final average level of 15.999 mu/ml. The LDH showed an initial average level of 725.3 mu/ml and a final average of 471.2 mu/ml (p less than 0.01). The prostaglandin levels were quantified by two methods: indirectly, by measuring the malonilaldehyde concentration in nMol/ml, which showed an average level decrease of 48.75% in 100% of the cases; and directly, by means of thin layer chromatography and biological assay on rats' gastric fundus, against controls. The disappearance of PGE1 and a significant decrease in PGF2 alpha (100%) were observed. We conclude that piroxicam is an effective drug for the short-term treatment of rheumatoid arthritis. It penetrates rheumatoid synovial fluid, reaching 50% plasma concentrations. It has an anti-prostaglandin action, and could stabilize lysosomal membrane. | |
| 6484556 | [How to treat hyperuricemia?]. | 1984 Sep 15 | Among a normal population, 21.5% of men have a blood level of uric acid above 6.8 mg%. Half of these subjects also present concomitant elevation of at least one other biological parameter. Clinically they differ from normo-uricemic subjects by weight, level of blood pressure and a trend to diabetes. From the recent literature it appears that hyperuricemia by itself does not constitute a risk factor as far as renal and vascular diseases are concerned. However, prevalence of gouty arthritis and urinary stones correlates with the blood uric acid level. Therefore, treatment of asymptomatic hyperuricemia must be avoided, and side effects of the drugs weighed. Acceptable indications for treatment are frequent attacks of urolithiasis or arthritis poorly tolerated by the patients. | |
| 7420164 | Craniocervical abnormalities. A comprehensive surgical approach. | 1980 Oct | Guidelines are proposed for surgical management of symptomatic abnormalities of the craniocervical junction. Experience with 17 recent cases is described. Gas or metrizamide (Amipaque) myelograms with pluridirectional tomograms revealed the etiology and mechanisms of compression of the cervicomedullary junction, as well as its reducibility. Stabilization was the goal in treatment of reducible lesions. Decompression of the cervicomedullary junction was paramount in irreducible cases. Ventral compression was treated in nine patients by transoral transpalatine resection of the odontoid-clivus complex, and all nine improved. A posterior decompression was carried out when bone impingement was present from the dorsal aspect. Fusion was performed in cases in which stability was not achieved by either procedure. | |
| 116482 | Free light chains of immunoglobulins in amyloidosis. | 1979 | Monomeric (M) and dimeric (D) forms of free light chains in serum have been measured by a sensitive radioimmunoassay in eight patients with amyloidosis without monoclonal proteins. Significantly elevated concentrations of D lambda chains were demonstrated in two of four patients with localized amyloidosis. The two patients had a significantly increased D/M ratio of both kappa and lambda chains. One patient had localized amyloidosis and normal concentration of monomeric and dimeric light chains had an abnormal fragment of light chains. A low kappa/lambda ratio was found in patients with localized amyloidosis. Four patients with secondary amyloidosis and renal insufficiency had increased amounts of free light chains. The concentration of light chains and the D/M ratio in this group corresponded to the impairment of renal function. | |
| 226299 | Rheumatoid factor as a cause of positive reactions in tests for Epstein-Barr virus-specifi | 1979 Jun | Sera from twenty-eight patients with rheumatoid arthritis (RA) were titrated in indirect immunofluorescence tests for Epstein–Barr virus (EBV) specific antibodies. All had IgG antibodies to viral capsid antigen (VCA), 64% at titres [unk] 320, and 71% reacted also in tests for VCA-specific IgM antibodies at titres ranging from 20 to 640. The reactions observed in the IgM test were not due to VCA-specific IgM antibodies, however, but rather to rheumatoid factor (RF) usually an IgM antibody to the Fc regions of IgG. The titres recorded in the anti-VCA IgM test correlated significantly with the RF titres and both reactivities were abolished by adsorption onto IgG coated latex particles. In addition, they clearly depended upon the height of the IgG antibody titre to VCA, indicating that the more VCA-specific IgG molecules are present the more likely it is that RF will combine with them in sufficient quantity before or after their attachment to VCA-positive test cells so as to become detectable by the fluorescent antibodies to human IgM. Results comparable in every aspect were obtained with those sera from patients with Hodgkin's disease, nasopharyngeal or cervical carcinomas which reacted in the anti-VCA IgM test. Sera from patients with infectious mononucleosis may also contain RF, but in such cases its removal by adsorption onto IgG-coated latex particles did not generally reduce the VCA-specific IgM antibody titre. Removal of RF from any of the sera studied did not affect the titres of VCA-specific IgG and, where applicable, IgA or heterophil antibody titres. These results re-emphasize the pitfall created by RF noted previously in tests for virus-specific IgM antibodies. | |
| 6785433 | Differences of antigen composition of rheumatoid arthritic (RA) and non-RA derived tissue | 1981 Mar | Antisera produced in a monkey by injections of RA-derived synovial cells grown in tissue culture react preferentially with synovial cells compared to fibroblastic cell strains of other tissues. The antisera also detected differences of the antigenic components of RA and non-RA synovial cells utilizing a number of immunochemical techniques. Following adsorptions with cross-reactive antigen sources the antisera exhibited quantitative differences of reactivity to either RA or non-RA cells by immunofluorescence and complement-mediated cytotoxicity assays. The data were interpreted as indicating that fetal calf serum antigens differentially adhere to RA and non-RA synovial cells, and that antigens in synovial fluid cross-reactive with synovial cell antigens are expressed to a greater degree on RA-derived synovial cells. The results substantiate other reports that synovial cells from RA individuals are different from non-RA cells by a number of growth, metabolic and antigenic characteristics. | |
| 6211315 | Deficient autologous mixed lymphocyte reactions correlate with disease activity in systemi | 1982 Apr | We have examined autologous mixed lymphocyte culture (AMLC) reactions in patients with systemic lupus erythematosus (SLE), classical rheumatoid arthritis (RA), and in normal age and sex matched healthy control individuals. AMLC responses were found to be lower than the median of all controls and patients in 30 of 31 individuals with SLE and RA and in only 2 of 15 healthy controls. In both SLE and RA there was a statistically significant correlation of decreased AMLC reaction with disease activity. On an individual basis, there was no direct correlation between decreased AMLC reactivity, concomitant steroid therapy, or the occurrence of clinical or laboratory parameters of autoimmunity. | |
| 7440721 | Quantitation and characterization of plasma DNA in normals and patients with systemic lupu | 1980 Dec | Using the in vitro DNA labeling technique of nick translation on purified plasma DNA, we have estimated the plasma DNA concentration in three normal individuals to be 266 +/- 57 ng/ml (mean +/- SD). This was not significantly different in three patients with a chronic inflammatory disease (209 +/- 14 ng/ml) or in five patients with steroid-inactivated systemic lupus erythematosus (SLE) (293 +/- 57 ng/ml). In two untreated, newly diagnosed, active SLE patients, however, the plasma DNA concentration was considerably higher (4,024 and 2,437 ng/ml, respectively). Characterization of these in vitro labeled DNA preparations by neutral sucrose-gradient sedimentation analysis showed a sedimentation coefficient of 6-8S, corresponding to a molecular weight of similar to or approximately 0.2-0.45 x 10(6). No difference was observed between normal subjects or patients. In addition, the relative size uniformity of these DNA molecules might suggest some form of specific protection of the DNA from blood DNAases. Further characterization in terms of buoyant density in cesium chloride did not reveal a difference between normal or SLE plasma and the human (HEp-2 cell) DNA used as marker. Taking into account the limitations of the method, no indication of a possible exogenous origin of the DNA circulating in SLE patients could be found. The physiological or pathophysiological role of this plasma DNA remains to be determined. | |
| 6409125 | Neurologic complications induced by gold treatment. | 1983 Jul | Two patients developed a Guillain-Barre-like syndrome and a third suffered neuropathy and myokymia during therapy with sodium aurothiomalate. The cumulative dose at the time of development of neuropathy was different in all 3 cases. Evidence for gold toxicity was suggested by clinical, electromyographic, and histologic findings, as well as the disappearance of symptoms and signs on cessation of gold injections. | |
| 6600614 | Clinical features of patients with antibodies directed against proliferating cell nuclear | 1983 Feb | The clinical and serologic features of 7 patients whose sera contained antibodies directed against proliferating cell nuclear antigen (anti-PCNA) were studied. Five of the patients had systemic lupus erythematosus (SLE), 1 had idiopathic diffuse proliferative glomerulonephritis, and 1 had seronegative arthritis. In a study of various rheumatic diseases, anti-PCNA was found in 2% of SLE sera but was not found in the sera of 100 rheumatoid arthritis patients, 20 mixed connective tissue disease patients, or 50 diffuse scleroderma patients. Patients with anti-PCNA had no history of hemolytic anemia, leukopenia, thrombocytopenia, or pleuro-pericarditis. Evidence that the production of anti-PCNA antibodies is sensitive to corticosteroid therapy is also presented. | |
| 6714820 | [Intra-articular therapy with superoxide dismutase (orgotein) or cortisone in rheumatoid a | 1984 Mar | The use of intra-articular corticosteroid therapy during the acute stage of arthritis is widely accepted. The symmetric involvement in both hands of identical finger joints is the ideal basis for a comparative study of the efficiency of such injections. In a randomized trial corticoid was directly compared with Orgotein, the enzyme "Superoxid-Dismutase" which inactivates oxygen-combinations and thereby interrupts inflammatory reactions. In this way accepted treatment of both sides was possible without the use of a placebo which could be considered as doubtful for ethical reasons. The results were evaluated using the following three reproducible parameters: 1. joint diameter before and after treatment 2. strength of pinch-grip 3. range of motion. Thirty-one patients with ninety-eight affected joints were treated and followed up. Thirty patients showed an improvement upon both treatments. Twenty-six of them reported identical pain relief for the corticoid and Orgotein treated joint on both sides after approximately three injections per finger joint. In four cases pain relief in the Orgotein treated joints was less significant than in the corticoid treated ones. | |
| 6520826 | Modulation of mitogen-dependent lymphocyte stimulation by hyaluronic acid. | 1984 Dec | The stimulation of incorporation of [3H]-thymidine into mononuclear cells (MC) from human body by plant lectins was assessed in the presence of varying concentrations of hyaluronic acid (HA). The simultaneous addition of HA and phytohemagglutinin to MC cultures resulted in a decrease in the incorporation of radioactivity. The magnitude of the decrease was directly related to the concentration of HA added. Kinetic studies, however, indicated that the addition of HA after the initiation of DNA synthesis in the MC cultures also resulted in a decline of the rate of incorporation of radioactivity. The kinetic and analytical data suggest that DNA synthesis by MC in inflammatory arthropathies might be modulated by the HA rich microenvironment of the joint and that this modulation could also occur even if the MC were stimulated before they reached the joint tissues. | |
| 310884 | Patterns of clinical disease associated with antibodies to nuclear ribonucleoprotein. | 1978 Winter | Forty-three patients were studied whose sera were monospecific for nuclear ribonucleoprotein by double immunodiffusion. Thirty-four patients had features typical of systemic lupus erythematosus of which 30 fulfilled the American Rheumatism Association criteria. Clinical features such as rashes, serositis and hematological abnormalities occurred with a frequency expected in SLE. Raynaud's phenomenon occurred in 60%, but other features of mixed connective tissue disease were uncommon. Clinical evidence of renal disease occurred in only four patients. In our experience a good prognosis is related more to the presence of anti-nRNP alone in the serum than to any specific set of clinical findings. | |
| 3901865 | The transoral approach to the base of the brain and upper cervical cord. | 1985 Sep | The transoral surgical approach allows access to structures from the sphenoid sinus rostrally to the fourth cervical vertebral body caudally. It is particularly useful for lesions at the anterior aspect of the craniocervical junction. Relief of the spinal cord compression in rheumatoid atlantoaxial subluxation can be achieved by this route. Removal of extradural and intradural tumours is possible using microsurgical techniques and watertight dural closure with the aid of fibrin glue. | |
| 7457085 | [Myasthenia gravis syndrome following administration of d-penicillamine (author's transl)] | 1980 May | The authors report a case of myasthenia gravis syndrome appearing six months after the start of d-Penicillamine treatment for rheumatoid polyarthritis and disappearing rapidly and definitively after cessation of that treatment. In connection with the case the authors review some forty similar cases in the literature and consider the principal clinical, electrophysiological and immunological aspects. They also discuss the etiopathogenic hypotheses and treatment of this iatrogenic complication. | |
| 6360438 | A serum antibody in patients with rheumatoid arthritis stimulates cathepsin B activity in | 1983 Nov | Mouse peritoneal macrophages were stimulated by sera from patients with active rheumatoid arthritis (RA) to increased intracellular cathepsin B activity. By gel filtration of three RA sera, the stimulatory activity was found in the IgG and to a lesser extent in the IgM containing fraction. The DEAE-cellulose purified IgG preparations of five additional RA patients stimulated intracellular cathepsin B activity significantly above IgG from healthy controls. IgG and IgM antibodies to macrophages were detected in sera from RA patients but not from controls by indirect immunofluorescence (IIF) technique. Pepsin F (ab')2 fragments of IgG from the RA patients also gave clearcut membrane fluorescent staining of the macrophages which demonstrated the antibody nature of the binding. A good correlation between the cathepsin B assay and the IIF was found when serial dilutions of serum were compared. | |
| 3874760 | [Gold-induced fibrosing alveolitis]. | 1985 Jul 26 | Fibrotic alveolitis appeared in a 54-year-old patient undergoing gold therapy. In differential diagnosis, this infrequent side effect of gold therapy is to be distinguished from rheumatoid lung fibrosis. Lymphocyte sub-populations were determined in the broncho-alveolar lavage fluid of the patient. The results obtained support the view that the side effect is due to an immunologically mediated process. | |
| 7286052 | Clinical and methodological studies on intramuscular ketoprofen in postoperative rheumatic | 1981 | Ketoprofen (Kp), given intramuscularly to 15 patients with chronic arthritis on the day after elective joint surgery (13), or during bouts of extreme pain (2), resulted in satisfactory pain relief, and seemed able to replace opiates. A new assay method for plasma Kp, based on gas chromatography/high resolution mass fragmentography is described, which permits determination of Kp even in the presence of probenecid. Kp was rapidly absorbed and peak plasma levels of 10.2 to 18.6 mumol/l were attained within 30 min. Probenecid did not interfere with the elimination of Kp. |