Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 102008 | Clinical and laboratory studies of levamisole in patients with rheumatoid arthritis. | 1978 Jul | Two studies with levamisole in rheumatoid arthritis are reported. In the first study of 30 patients levamisole was superior to placebo in terms of pain relief, reduction in articular tenderness, duration of morning stiffness, erythrocyte sedimentation rate (ESR), and radioisotope uptake in knee and wrist joints. There were no consistent differences in lymphocyte function, immunoglobin or complement concentration, or polymorphonuclear granulocytic function. In the second study forty patients were commenced on treatment with either gold or levamisole. At the end of one year there were significant improvements with both regimens in pain score, joint tenderness and ESR. The patients on levamisole showed significant improvement of duration of morning stiffness, while the patients on gold showed significant improvement of rheumatoid factor titre and left hand grip, but there were no significant differences between the two regimens. | |
| 7042369 | Three trials of indoprofen. | 1981 | Three trials have been used to document various properties of indoprofen. As a simple analgesic, indoprofen (200 mg) was superior to placebo and at least as effective as aspirin (700 mg). As an anti-inflammatory, indoprofen (200 mg four times daily) was superior to both ibuprofen (300 mg four times daily) and placebo. With regular administration, the effect of indoprofen reached a plateau within 24 hours of the start of treatment. Long term administration confirmed the safety of indoprofen and the overall incidence of side effects was similar to that associated with ibuprofen therapy. Equal numbers of patients were withdrawn from the indoprofen and ibuprofen groups but the reasons for withdrawal were different. Patients were withdrawn from the ibuprofen group because of lack of effect and from the indoprofen group because of gastric side effects. | |
| 482671 | [Ketalar pivot anesthesia in cortisone-dependent patients]. | 1979 May | On the basis of results obtained in a series of 6 patients with corticoid-dependency in whom 7 surgical interventions have been carried out the authors present the anesthesia technique on Ketalar pivot according to the following protocol: premedication with Diazepam and atropin; induction of anesthesia with Ketalar (2 mg/kg of body weight) and Pavulon 0,1 mg/kg of body weight); maintenance with Ketalar (1 mg/kg of body weight) at 10-15 minutes, and NO2/O2 4/2 at 1 minute. The cardiovascular stability was satisfactory. No fall in the value of blood pressure was noted. | |
| 268679 | [Synoviorthesis of the knee with osmic acid (OsO4). Results at mid-term]. | 1977 Aug 20 | Synoviorthesis of the knee joint with OsO4 is a simple procedure with few short or long term side effects. The substance used is inexpensive and easy to handle. All studies published so far have confirmed its suitability in the treatment of synovitis of the knee and various other joints. The initial good results deteriorate steadily, primarily in the first year following injection. However, intra-articular administration of OsO4 may be repeated without risk, and achieves as good results as the first synoviorthesis. The less advanced the lesions and the less active clinically and biologically the systemic manifestations, the better the results. Osmic acid does not appear to damage the joint either radiologically or functionally. The effect of OsO4, although probably shorter in duration, is comparable to that of yttrium-90, with the additional advantage that it can be used in young patients. 100 mg (5 ml of 2% solution) can be considered the optimal dose. Synoviorthesis with osmic acid can be performed before going on to surgical synovectomy. Synoviorthesis with osmic acid is ineffective in the treatment of gonarthrosis. | |
| 1205499 | [Mitochondrial antibodies induced by drug administration in patients with and without pseu | 1975 Dec | The pseudo LE syndrome was first described in 1972. It is a severe, sometimes fatal condition, in which high titres of mitochondrial antibodies are a constant feature. In the vast majority of cases detected, Venopyronum in dragée form (containing phenopyrazone, horse-chestnut extract, and cardiac glycosides from various plants), had been taken prior to onset of the clinical symptoms. It is probably commoner, that following intake of the drug mitochondrial antibodies appear without clinical manifestations. In both situations, disposition, dose and duration of treatment are important factors. There is reasonable ground to believe that not just a single component, but rather the combination of various substances in the preparation is responsible for the induction of an autoimmune process. At the present time it appears that an idiopathic form, without drug contact, also exists. | |
| 2931794 | Spontaneous and aggregated IgG induced rheumatoid factor producing cells in rheumatoid art | 1985 | Seropositive rheumatoid arthritis (RA) patients were found to have high numbers of spontaneously occurring cells making rheumatoid factor (RF) reactive with human IgG as measured by a RF plaque forming cell (RF-PFC) assay. There was a significant positive correlation between the number of RF-PFC and both disease activity measured by the sedimentation rate and RF titer measured by the RA latex test. Aggregated IgG and pokeweed mitogen were equally effective stimulators of RF-PFC in cultures of RA peripheral blood mononuclear leukocytes. The rheumatoid ratio of helper (T4): suppressor (T8) T lymphocytes was also significantly increased over the ratio of normal controls, but this ratio did not correlate with the number of RF-PFC. Aggregated IgG or immune complexes may be responsible for stimulating RA RF-PFC in vivo. | |
| 6191909 | The role of the laboratory in rheumatology. Acute-phase proteins. | 1983 Apr | In summary, therefore, the acute-phase protein response is a multiple misnomer. Many of these molecules are associated more closely with chronic than with acute inflammation; only some have been shown to be phasic (indeed, the physiological control of biosynthesis of these molecules is a field wide open to exploration), and some are peptides rather than proteins. Familiarity breeds contempt and perhaps the routine use of the ESR on a purely pragmatic basis has retarded proper detailed consideration of the nature of the molecular events and obscured the need to define their controlling mechanisms. This entire subject deserves closer attention, but attention focused upon the detail of the basic science involved and not simply further extensions of a purely phenomenological nature. | |
| 535290 | Total knee replacement with the Kodama-Yamamoto knee prosthesis. | 1979 Nov | Since 1970, 170 knees have been operated upon using the Kodama-Yamamoto knee prosthesis. Of these 127 had the revised Mark-II prosthesis and of this group 91 cases have been followed for more than a year. Interim results suggest that the total knee score has improved. on the average, from 38 points preoperatively to 74 points after one year. A single early complication involved loosening of the prosthesis in a case of knee infection. Except for this case, no loosening and no radiolucent lines have been observed. Methacrylate bone cement is known to be harmful to bone and soft tissues, and our basic and clinical studies reveal that results improve when the total knee replacement is done without using cement. | |
| 736425 | [Two cases of superficial pemphigus induced by pyritinol (author's transl)]. | 1978 Jun | Pyritinol is presently prescribed in rhumatoid polyarthritis because of its structural analogy to D-penicillamin. Only benign cutaneous side effects had been mentioned up to now. We report two cases of pemphigus occurring during pyritinol therapy given in one case for rhumatoid polyarthritis, in the other case for memory deficiency. Clinical aspect was that of a superficial pemphigus. The histologic picture was in some instances that of a superficial acantholysis, and in other instances, that of an eosinophilic spongiosis. Definite proof of pemphigus was shown by presence of anti-intercellular substance antibodies in the serum and in the skin of both patients. | |
| 3890156 | Antinuclear antibody determination: the present state of diagnostic and clinical relevance | 1985 | Determination of antinuclear antibodies (ANA) will gain in diagnostic significance if a specific type of ANA can be related to a defined clinical disorder. The past decade has brought us quite a lot of papers dedicated to this subject. Yet, with exception of the DNA/anti-DNA system, observed correlations have remained scarce or contradictory. Also, still little is known about the pathogenic role of ANA. Perhaps more recent approaches using biochemical technologies will provide us with highly purified nuclear antigens necessary to study possible correlations at a more sophisticated level. | |
| 6524981 | Human articular cartilage and fibrocartilage: a study with high-angle x-ray diffraction. | 1984 Dec | High-angle x-ray diffraction was applied to the study of four meniscal fibrocartilages and 11 articular cartilages from patients suffering from various articular disorders. In eight samples microcrystals were seen, apatite most frequently, CaHPO4 in two instances, calcium pyrophosphate dihydrate (CPPD) in one. These results confirm the association of various crystals in a single joint, and favour their heterogenous partition on collagen fibres. | |
| 6390022 | Is schizophrenia an autoimmune disease? A review. | 1984 Jul | Autoimmunity has been shown to be the basis of an ever-increasing number of human diseases. Schizophrenia shares a number of genetic features with these autoimmune diseases and therefore could be an autoimmune disease itself. Several lines of evidence suggest that overactivity of dopaminergic pathways in some areas of the brain are involved in schizophrenia, but the apparent absence of an increase in dopamine turnover suggests that this hyperactivity could be mediated by a dopamine agonist rather than by dopamine itself. Schizophrenia is reviewed in the light of precedents from the field of autoimmune diseases in which autoantibodies have been shown to be able to interact with, and sometimes stimulate hormone receptors, thereby causing disease. | |
| 6192736 | An antiglobulin: IgG anti-IgE. Occurrence and specificity. | 1983 Aug | An IgG type of antibody directed against IgE has been studied in serum from healthy and allergic individuals. The technique used is based on a solid phase paper radioimmunoassay in which the discs were sensitized with purified IgE myeloma. After incubation with patient's serum, 125I anti-human IgG was added. The anti-IgE antibodies were partially blocked by endogenous IgE, indicating the presence of IgE-containing immune complexes in the serum. Heating of serum at 56 degrees C disrupted the immune complexes, thereby increasing the detectable levels of IgG anti-IgE. Significantly raised levels of anti-IgE antibodies were found in patients suffering from atopic disorders in comparison with the controls. | |
| 7010258 | Levamisole and immunotherapy: some theoretic and practical considerations and their releva | 1981 | The major features of levamisole immunotherapy are distilled from experiences gained so far. The biochemical effects of levamisole are discussed in view of its effects on T lymphocytes and phagocytes. Potential indications for levamisole treatment are classified after Jerry et al. as immune deficiencies or as immune dysregulation syndromes (such as rheumatoid arthritis and cancer). After a scrutiny of investigations in cancer patients, the conclusion emerges that, in a subsection of patients, mainly those with poor prospects, levamisole improves the prognosis after effective chemotherapy, radiotherapy or surgery when given in time and in an appropriate dosage. | |
| 3970731 | The binding of antihistone antibodies to Crithidia luciliae kinetoplasts is growth cycle-d | 1985 Feb | The Crithidia luciliae immunofluorescence (CLIF) assay is widely used to test for native DNA (nDNA) antibodies in the diagnosis and management of systemic lupus erythematosus. However, sera from patients with drug-induced lupus erythematosus or rheumatoid arthritis, which should not contain nDNA antibodies, occasionally react with the CL kinetoplast. We examined 36 sera from patients with systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, and drug-induced lupus erythematosus, who had positive CLIF tests. All 36 sera were also antinuclear antibody-positive with homogeneous and/or peripheral staining patterns on mouse kidney substrates. After hydrochloric acid extraction of the CL smears to remove histone and other nuclear protein antigens, 14 of the 36 sera no longer produced a positive result on the CLIF test. Ten of these 14 sera again gave a positive CLIF result after the hydrochloric acid-extracted Crithidia substrate had been reconstituted with purified histone. These studies demonstrated that kinetoplast binding was due to antihistone antibodies in at least 10 of 36 initially CLIF-positive sera. Antihistone antibodies were then purified with a histone-affinity column, and these purified antibodies were reactive with CL kinetoplasts. Thus, the CLIF test is not specific for nDNA antibodies. Additional studies using CL from different days of culture indicated that histone antigen expression in the CL kinetoplast was a function of the life cycle of this organism and is most readily detected 2 days after initiation of culture. | |
| 75964 | Lymphocyte stimulation by acetylcholine receptor in polymyositis. | 1978 Mar 9 | Lymphocytes of twenty-seven patients with polymyositis were incubated in vitro with cholinergic receptor rich membranes obtained from the electric organs of Torpedo Marmorata. Lymphocytes of polymyositic patients were slightly stimulated; positive responses were present mainly in patients affected from more than a year. Sensitization against the nicotinic cholinergic receptor may explain the occurrence of the myasthenic syndrome with polymyositis. | |
| 3967411 | Prospective analysis of Sheehan total knee arthroplasty. | 1985 Jan | In a prospective study, the clinical results of 64 Sheehan total knee arthroplasties (TKA) were reviewed in 52 patients, with an average follow-up period of five and one-half years. Like most prosthetic designs in use in 1975, the Sheehan prosthesis did not incorporate patellar resurfacing. The initial clinical success achieved without patello-femoral replacement may become less acceptable with longer follow-up periods. Seventy-four percent of the patients in this study had complete relief of pain or mild discomfort not requiring analgesics. With patellar resurfacing as a secondary procedure in three additional cases, the percent successful results increased to 81%. Five knees (12%) required additional surgery, one because of infection, two because of secondary component failure, and two for loosening. The lack of patellofemoral replacement and prospective failure of both tibial and femoral components, possibly due to high stress-loading in a relatively small surface area, have led to the use of other newer TKA designs. | |
| 6499312 | Arthrodesis after failed knee arthroplasty. A nationwide multicenter investigation of 91 c | 1984 Dec | Ninety-one patients with attempted arthrodesis after failed knee arthroplasty were identified in a prospective nationwide study of knee arthroplasties performed from October 1975 through January 1982 in Sweden. The study included 43 hinged or stabilized, 34 bi- or tricompartment, and 14 unicompartment endoprostheses. Three-fourths of the failures were caused by infections. At follow-up evaluation, two patients had expired from infection and four patients had amputations. Fusion was achieved in only 50% of 108 attempts in 91 knees. Patients with unstable joints had limited function. The fusion rate was relatively high after unicompartment endoprostheses, in cases with sustained rigid fixation, or in cases where infection was brought under control at arthrodesis. Rigid fixation was best achieved with an external double frame or an intramedullary nail. Repeated attempts were worthwhile. Removal of all foreign material, eradication of the infectious lesion, and an arthrodesis performed in a one- or two-stage procedure with insertion of gentamicin beads seemed to be the best way to combat infection. The treatment of prosthetic failures should be referred to centers with special interest in knee arthroplasty. | |
| 6188675 | Symposium on the immunodiagnosis of rheumatic and related diseases, Part II. Rheumatoid fa | 1983 May | Human rheumatoid factors are antibodies of IgG, IgA, or IgM class that show reactions with antigenic determinants present on other immunoglobulin molecules. The most commonly measured rheumatoid factor relates to the 19S IgM type, which reacts by agglutination of latex particles coated with 7S IgG and is often measured in the standard latex fixation test. Approximately 65 to 70 per cent of patients with rheumatoid arthritis show positive serologic tests for rheumatoid factor; however, a number of other chronic disease conditions are also associated with positive rheumatoid factor reactions, including infective endocarditis, sarcoidosis, leprosy, and other hyperglobulinemic conditions. Although extensive serologic and immunochemical studies have identified a number of specific antigenic structural sites on immunoglobulin molecules that react with rheumatoid factors, recent studies have shown that a certain proportion of such antibodies may show cross-reactivity with DNA-histone complexes as well. It is still not entirely clear how rheumatoid factors fit into the pathogenesis of rheumatoid arthritis itself. | |
| 84455 | [Determination of human IgI allotypes by using a set of stable erythrocyte antigenic diagn | 1979 Feb | Technology of preparing a set of stable antigenic diagnostic agents of commercial type for determination of genetic determinants of human IgG and antibodies to them in the human blood sera and in the animal hyperimmune sera was worked out. Antisera against some human IgG allotypes were prepared. The frequency of detection of individual IgG allotypes and antibodies to them in human sera was studied. |