Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6362405 | Pathogenesis of the joint disease of rheumatoid arthritis. | 1983 Dec 30 | The articular inflammation and joint destruction that characterizes rheumatoid arthritis is the result of a complex interaction between cellular elements--that is, inflammatory cells, immunologically competent cells, synovial lining cells--and their soluble byproducts. An understanding of these events must serve as the basis for rational treatment of the disease in the absence of knowledge about the inciting agent. | |
| 6796684 | Effect of auranofin dose regimen change upon cell-associated gold in rheumatoid arthritic | 1981 Sep | We examined whether changes in auranofin dose regimen in rheumatoid arthritis (RA) patients affect cell-associated and/or serum gold levels. In 7 RA patients, a reduction in daily dosage of auranofin from 3 mg bid to 3 mg qd was correlated with a marked reduction (81%-95%) in cell-associated gold, whereas a return to the 3 mg bid dose level resulted in a reinstatement of cell-associated gold. These changes in cell-associated gold were not reflected in alterations of serum gold levels. This apparent lack of change in serum gold level as opposed to cell-associated gold suggests that this phenomenon warrants further investigation. | |
| 950632 | Evaluation of a clinic education program for patients with rheumatoid arthritis. | 1976 Jun | A group education program was developed for clinic patients with rheumatoid arthritis. Teaching methods used included the Arthritis Foundation's handbook, Rheumatoid Arthritis, and a lecture by a rheumatologist. The 20 patients in the study were given a multiple choice test before and after the teaching program to determine their knowledge of arthritis. Results showed group education to be an effective teaching device. It was demonstrated that patients learned from reading the handbook alone, but the combination of reading and lecture was found to be a more effective method. Correlation studies showed that prior to group education, patients had a significant knowledge of their disease which was related to native intelligence, formal education, and socio-economic status, but not to duration of disease or length of clinic attendance. This suggests that future patient education experiments should include a pre-instruction test to document prior knowledge. | |
| 6501797 | Rheumatoid nodulosis in the foot: a variant of rheumatoid disease. | 1984 Sep | Rheumatoid nodulosis is a relatively benign variant of rheumatoid disease. This entity has been previously ignored in the medical literature. Confusion with other diseases that can produce nodules is not infrequent. A discussion of this entity, as well as a case report, will be presented. | |
| 7317114 | Natural cell-mediated cytotoxicity in Sjögren's syndrome and rheumatoid arthritis. | 1981 Nov | Natural cell-mediated cytotoxicity (NCMC) was measured in 7 patients with Sjögren's syndrome without complication of connective tissue disease, 5 patients with Sjögren's syndrome associated with connective tissue disease other than rheumatoid arthritis (RA), 13 patients with Sjögren's associated with RA, and 29 patients with RA without Sjögren's. All 25 patients with Sjögren's syndrome showed a significantly suppressed NCMC. In the patients with RA but without Sjögren's, the NCMC for 21 female patients was rather enhanced when compared with controls, while 8 male patients did not differ from controls. The reduced NCMC in the Sjögren's patients did not seem to correlate with the presence of antilymphocyte antibody. A more accelerated rate of NCMC was demonstrated in the patients with RA who were receiving gold therapy. | |
| 1198080 | Zinc: its relationship to osteoporosis in rheumatoid arthritis. | 1975 | Preliminary studies indicate that plasma zinc concentrations, as estimated by atomic absorption spectrophotometry, are reduced in rheumatoid arthritis. A relationship has also been established between metacarpal index of osteoporosis and plasma zinc concentrations in rheumatoid subjects. | |
| 856134 | Atypical ossicle joint lesions in rheumatoid arthritis with sicca syndrome (Sjögren syndr | 1977 May | Atypical incudomalleal and incudostapedial joint changes were found in a 55-year-old woman with long-standing rheumatoid arthritis and sicca syndrome (Sjögren syndrome). Available audiograms taken at 37 and 42 years of age demonstrated slight bilateral high-frequency loss of hearing. The ossicular joint changes involved dissolution of disk material together with proliferation of synovial-type elements of the disk and articular surfaces, with formation of pannus-like tissue. There was extensive destruction of cartilage, with cellular collagenous tissue extending along the exposed bone surfaces. Despite strong similarities to rheumatoid arthritis, a definite diagnosis cannot be made in the absence of the inflammatory, lymphocyteplasma cell component. | |
| 6847393 | [Formation of collagen fibrils in the synovial membrane in rheumatoid arthritis (electron | 1983 Feb | As demonstrates investigation of the synovial membrane biopsies obtained in patients suffering from rheumatoid arthritis, excessive formation of collagenous fibrillae results from participation, in this process, of activated synoviocytes B, pericytes and fibroblasts capable to intensify secretion and synthesis of tropocollagen. Aggregation of tropocollagen molecules into the collagenous fibrillae occurs in the areas where the inflammation acquires a chronic form where the cellular detritus is accumulated and where immune complexes are deposited. In the places mentioned, together with assembling normal collagenous fibrillae certain pathological fibrillar forms are observed, such as: fibrillae with an increased diameter, fibrillae with a changeable optic density of transversal streakness, those deprived of it, as well as segmentary scrap of fibrillo-formation. It is suggested that disturbance of the tetrary polymerization of the collagenous structures, that occurs at rheumatoid arthritis, prevents the functional-loading rearrangement and reabsorption of excessive fibrillae. Together with phenomena of tropocollagen hypersecretion from activated mesenchymal cells, this results in collagenous hyperfibrillogenesis, in fibrosis of the joints and in their irreversible rigidity. | |
| 4045844 | The measurement of helplessness in rheumatoid arthritis. The development of the arthritis | 1985 Jun | We describe the development of the Arthritis Helplessness Index (AHI), a self-report instrument designed to measure patients' perceptions of loss of control with arthritis. The participants in this research were 219 patients with rheumatoid arthritis (RA) who completed a quantity of mailed materials, including the AHI, functional measures and other psychological scales. Significant evidence of reliability and validity of the AHI was found. Greater helplessness correlated with greater age, lesser education, lower self-esteem, lower internal health locus of control, higher anxiety, and depression, and impairment in performing activities of daily living using a health assessment questionnaire. Over one year, changes in helplessness correlated with changes in difficulty in performing activities of daily living. The AHI appears to be a useful measure for further studies in RA and a valuable clinical tool in monitoring the psychological status of patients with RA. | |
| 6335861 | Antiperinuclear factor in Sjögren's syndrome in the presence or absence of rheumatoid art | 1984 Jan | Serum from 91 patients with Sjögren's syndrome (SS) was examined for antiperinuclear factor (APF). Nine out of 29 patients with SS alone (31.0%) were positive as opposed to 27 out of 40 with SS + rheumatoid arthritis (67.5%) and to 3 out of 22 with SS + other autoimmune disorders (13.6%). A clear relationship was established between APF and agglutinating or non-agglutinating rheumatoid factor. | |
| 425622 | [Long-term results following synovectomy of the knee joint in rheumatoid arthritis (author | 1979 Feb | Late synovectomy of the knee joint in rheumatoid arthritis is considered by many authors as a positive influencing factor with regard to the local development of the disease at that particular site. Since this assumption is based on evaluation criteria which are by no means uniform, it has so far not been possible to compare the individual results achieved by different authors. For this reason, we conducted follow-up examinations of 57 knee joints in 44 patients with rheumatoid arthritis in whom the synovectomy had occurred at least five years ago, using the standardised follow-up scheme devised by Gschwent et al. Most of these cases represented a late synovectomy, as was evident from the duration of the disease and from Steinbrocker's stages. An analysis of the results showed that in our patients, pain and swelling were most impressively improved, in accordance with the reports made by other authors. Less impressive was the improvement of mobility following synovectomy. Despite increasing instability, it was usually possible to improve the ability of the patients to walk, especially in cases where this ability had been severely restricted. X-ray films showed in almost one-half of the cases that the objective finding had deteriorated, whereas in the other half of the patients the status was largely unchanged or even improved. We can sum up these results by stating that, taking into consideration the comparable results published in the literature regarding late synovectomy of the knee joint in rheumatoid arthritis, a positive influence exercised by late synovectomy on the local pathology can be assumed. | |
| 623680 | Radiographic abnormalities of rheumatoid arthritis in patients with diffuse idiopathic ske | 1978 Jan | Radiographic abnormalities of rheumatoid arthritis (RA) in 8 patients with diffuse idiopathic skeletal hyperostosis (DISH) included atypical features: lack of osteoporosis, bone sclerosis and proliferation about erosions, osteophytosis, and bony ankylosis. Atypical clinical features included a high incidence of flexion contractures of elbows, wrists, ankles, or knees. It is not surprising that bone production occurs about involved articulations in patients with RA-DISH, as the latter disorder is characterized by bony proliferation at sites of ligament and tendon attachment to bone in the axial and extraaxial skeleton, perhaps related to stress. | |
| 598117 | Kinesiologic measurements of functional performance before and after geometric total knee | 1977 Jul | Kinesiologic measurements were made in patients with severe arthritis before and after geometric total knee replacements to evaluate the nature, rate and extent of change in their functional ability. Preoperatively, patients with rheumatoid arthritis functioned at lower levels than patients with osteoarthritis. Most patients with rheumatoid arthritis improved steadily after surgery, while progress of those with osteoarthritis was often irregular. The group with rheumatoid arthritis improved more than those with osteoarthritis, but they did not generally reach the functional level attained by the patients with osteoarthritis, and neither group reached the lower limits of normal variability 1 year postoperatively. On the average, both groups gained knee extensions, lost knee flexion, and gained isometric knee flexor muscle strength postoperatively. Every patient with osteoarthritis lost extensor muscle strength 1 year after surgery, while most with rheumatoid arthritis gained. During quiet standing, most patients had straighter knees postoperatively and bore a greater percent of body weight on the operated limb. Patients with rheumatoid arthritis improved more than patients with osteoarthritis in the type and amount of force applied to canes and crutches. Most patients walked faster postoperatively, took longer and more rapid steps, improved the pattern of knee motion used, and had smoother forward, lateral and vertical head motion. | |
| 3906844 | Joint damage in rheumatoid arthritis: radiological assessments and the effects of anti-rhe | 1985 | Joint damage is a major problem in the long-term course of rheumatoid arthritis. It is usually assessed radiologically. In this review the methods of measuring the radiological changes are outlined, and the effects of anti-rheumatic drugs on radiological progression summarised. Two methods of scoring radiographs have become standard techniques; these are the Sharp index and the Larsen index. They both concentrate on cartilage loss and erosive damage in the hands and wrists. Investigations of the effects of drugs upon the radiological progression of rheumatoid arthritis include: indirect studies evaluating the inter-relationships between clinical, laboratory and radiological variables; placebo-controlled studies of slow-acting drugs and similarly controlled studies without a placebo group; open studies evaluating the long-term effects of treatment of slow-acting drugs. Only slow-acting drugs such as gold have been persistently considered to have a possible effect on reducing radiological progression. Unfortunately the therapeutic studies use a wide range of different radiological assessment techniques, and the incomparability is therefore difficult. None of the studies give a good indication that there is a marked reduction in joint damage by slow-acting drugs. On balance studies do suggest minor effects on the process of progression. Instead of debating how strong the evidence of such minor effect really is, it is concluded that rheumatologists should look towards novel therapeutic approaches to induce a major reduction in the rate of damage. | |
| 3157277 | [The disease picture in rheumatoid arthritis as a result of different pathomechanisms]. | 1985 Jan | Even though rheumatoid arthritis is by definition an inflammatory disease, the complex picture of rheumatoid arthritis really owes its development to three completely different pathogenetic mechanisms, namely: Exudative-proliferative processes in the synovial tissue of joints and tendon sheaths and at serous skins; Destruction of articular cartilage and juxta-articular bone by the aggression of non-inflammatory tumor-like cell elements of synovial origin; Primary, non-inflammatory tissue necroses due to infiltration of immune complexes and complement. It is therefore understandable that all therapeutic approaches which have an antiphlogistic character can only influence pain, swelling and morning stiffness, but not the destruction of the joints and the primarily necrotising processes, which can also destroy vital structures in the heart and vessels. | |
| 313550 | The analgesic effect of transcutaneous electrical nerve stimulation (TNS) in patients with | 1979 Jun | Transcutaneous electrical nerve stimulation (TNS) was used on 20 patients with severe wrist pain due to rheumatoid arthritis. Three different stimulation frequencies were used: high 70 Hz stimulation (70 TNS), low frequency 3 Hz stimulation (3 TNS) and brief trains of stimuli with an internal frequency of 70 Hz and with a repetition rate of 3 Hz (3-70 TNS). The analgesic effect was evaluated on the patient's own estimate of pain relief and by means of a loading test in which the length of time the patient could hold a weight before and after TNS was used. The loading test and the patients' own estimate of pain relief corresponded well. After 70 TNS, 18 patients could double their loading time. The corresponding figure for 3-70 TNS was 16 patients and for 3 TNS 5 patients. The average duration of pain relief after cessation of stimulation was 18 h for 70 TNS and 15 h for 3-70 TNS, while those who responded to 3 TNS experienced pain relief for only 4 h on average. | |
| 6338840 | Neutrophil functions and clinical performance after total fasting in patients with rheumat | 1983 Feb | The effects of fasting for 7 days were investigated in 13 patients with rheumatoid arthritis (RA) in comparison with a control regimen in a cross-over trial. The effects of fasting on clinical performance and blood neutrophil functions were studied. During fasting, with a mean weight loss of 5.1 kg, clinical inflammation in the joints and the erythrocyte sedimentation rate (ESR) decreased. During the control period the joints either remained unchanged or deteriorated, and no change was observed in the body weight or the ESR. The locomotion of neutrophils under agarose, induced by a reference serum, decreased during the fasting period (p less than 0.001), but no change in their locomotion was induced by an Escherichia coli bacterial factor. During the control period, however, the locomotion induced by either stimulant was significantly decreased. Generation of migration-stimulating factors from the patients' plasma declined 3 days after the end of fasting (p less than 0.001). The adherence of the neutrophils to nylon fibres was unchanged during both periods. The bactericidal capacity improved during fasting, both in comparison with the initial value (p less than 0.005) and with the values from the control period (p less than 0.001). An association was found between improvement in inflammatory activity of the joints and enhancement of neutrophil bactericidal capacity. Fasting appears to improve the clinical status of patients with RA. This could partly be due to the observed changes in the functions of the neutrophils, since the latter contribute to the inflammatory joint reactions. | |
| 1221497 | Pulmonary involvement in patients with rheumatoid arthritis. | 1975 | Vital capacity (VC) and single-breath diffusing capacity for carbon monoxide of the lungs (Dco) were measured and chest X-ray evaluated in 129 patients with rheumatoid arthritis (RA). 123 of them represented average RA patients, either hospitalized (84 patients, Group I) or outpatient material (39 patients, Group II). The remaining six patients (Group III) represented cases with marked changes in chest X-ray detected in an earlier study. Deviating findings in the 123 cases of Groups I and II were observed as follows: in one the lung function tests or X-ray examinations, 35%; abnormal X-rays, 18%; reduced VC or Dco, 28%; simultaneously low VC and Dco, 7%; and pathological findings in all three tests, 2%. Group III showed extremely low VC and Dco values. Changes in respiratory function involved restrictive impairment and diffusion defects, and the results further implied that restrictive changes develop early, whereas decreased diffusing capacity is associated with more advanced "rheumatoid lung". The disparity abnormal findings in chest X-ray changes and in lung function tests suggests that in examining pulmonary manifestations in patients witu RA, both radiographic methods and pulmonary function tests should be used for relevant evaluation. | |
| 1131287 | The hyperviscosity syndrome in rheumatoid arthritis due to intermediate complexes formed b | 1975 Mar | Three patients with rheumatoid arthritis and abundant circulating intermediate complexes were studied. Two of these patients presented with the hyperviscosity syndrome. All 3 patients had markedly elevated plasma and blood viscosity, and the intermediate complexes were thought to be responsible for the increased viscosity. Studies on the isolated intermediate complexes revealed that they were formed by self-association of IgG-rheumatoid factors. | |
| 3856168 | Pain-mood relationships in patients with rheumatoid arthritis. | 1985 Mar 13 | Pain-mood relationships were investigated in 23 patients with long-standing rheumatoid arthritis over a two-week period. Patients completed form B of the Eysenck personality inventory on entry to the study and visual analogue scales for pain, anxiety and sadness daily throughout the study period. Two pain-mood relationships were identified: a synchronous relationship in which pain and mood scores were positively correlated and an asynchronous relationship in which pain and mood scores were uncorrelated. Furthermore, in all patients reporting high pain and showing synchronous relationships, the pain and mood scores were similar in magnitude, while in all patients reporting high pain and showing asynchronous relationships, the pain and mood scores were dissimilar in magnitude. The latter patients remained calm and happy despite severe pain. All patients reporting low pain showed synchronous and close relationships between pain and mood. Extraversion, neuroticism, age, duration and severity of disease were unrelated to pain severity and the pain-mood relationships recorded. The asynchronous pain-mood relationship was attributed to a coping response to severe pain. Patient education combined with physical, psychological and pharmacological treatments might induce such a response in patients unable to cope with chronic pain. |