Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3987090 | Eosinophil involvement in rheumatoid arthritis as reflected by elevated serum levels of eo | 1985 Mar | Circulating levels of eosinophil cationic protein (ECP), an eosinophil specific granule protein, and numbers of peripheral eosinophils were determined in 42 patients with rheumatoid arthritis. At the time of the investigation the patients were without drug treatment. They had normal blood counts of eosinophils but on average a five-fold increase of the serum ECP values compared with healthy subjects. The intracellular content of ECP in eosinophils isolated from 14 patients was normal. High serum levels of ECP were particularly observed in patients with a disease of rather short duration but with a more aggressive course. Other factors associated with high ECP values were blood eosinophil counts in the upper normal range, high rheumatoid factor titre and increased inflammatory activity as defined by elevated serum haptoglobin and blood platelet counts. No relation was found between serum ECP and circulating immune complexes or serum total IgE. Synovial fluids obtained from 14 patients with rheumatoid arthritis contained very high concentration of ECP; on average nine times higher than those in the circulation of the patients. During corticosteroid but not NSAID therapy serum ECP decreased on average about 50% compared with pre-treatment values. Although eosinophils are not a notable feature of the synovial membrane infiltrate or cellular joint exudate, data obtained indirectly indicates their participation in the inflammatory reaction in RA. | |
| 6425067 | Peripheral blood T lymphocyte subpopulations defined by monoclonal antibodies in rheumatoi | 1983 | The distribution of T lymphocyte subsets was determined in peripheral blood (PB) of two groups of patients with rheumatoid arthritis by using monoclonal antibodies (OKT). In untreated patients the percentage of OKT4+ cells (helper/inducer) was found to be significantly increased as compared to healthy controls. In patients receiving oral gold therapy a similar increase in OKT4+ cells was confirmed; furthermore, these patients showed a significant decrease in OKT8+ cell population (cytotoxic/suppressor) compared to untreated patients and to normal controls. A small numerical superimposition of values of OKT4+ and OKT8+ lymphocytes was observed in untreated but not in treated patients. | |
| 7082113 | Physical and psychosocial function in rheumatoid arthritis. Clinical use of a self-adminis | 1982 May | The treatment of chronic disease is often directed at preservation of function, but most functional measures are crude, and rarely include indicators of psychosocial status. The Sickness Impact Profile (SIP) is a newer "health status" measure designed to comprehensively assess such outcomes. The functional and psychosocial impacts of rheumatoid arthritis and their relation to disease duration were measured by having 79 patients self-administer the SIP. Disease impacts were pervasive, including effects on leisure, social, and sexual activities, as well as physical function. While physical and psychosocial disease impacts were positively correlated, the association diminished with longer duration of disease. The self-administered SIP appears to be practical and useful in clinical settings. Specific results may help to target patient education, increase physician awareness of the distress patients experience, suggest that the need for social rehabilitative services, and help monitor responses to therapy. | |
| 6726714 | Survival and cause of death in rheumatoid arthritis: a 25-year prospective followup. | 1984 Apr | In a 25-year prospective followup of 209 patients with rheumatoid arthritis, median life expectancy was shortened by 7 years in males and by 3 years in females when compared with the general population. The surplus mortality was associated in decreasing order with the disease itself, associated respiratory, urogenital and general infections, and with upper gastrointestinal tract disease, mainly bleeding. | |
| 436534 | Apical fibrobullous disease with rheumatoid arthritis. | 1979 Jun | We describe a patient who developed noninfectious apical fibrobullous disease 12 years after the diagnosis of seropositive, nodular, deforming rheumatoid arthritis. Fibrobullous disease of the pulmonary apices is a rare entity that is usually found in association with ankylosing spondylitis. Its appearance with rheumatoid arthritis has not been reported. Speculative factors which may predispose to apical fibrobullous disease, such as a stiff chest wall, impaired esophageal motiligy, and HL-A antigen B27, were not present in our patient. | |
| 40388 | Rheumatoid arthritis with systemic necrotizing arteritis. | 1979 Sep | An autopsy case of rheumatoid arthritis with active polyarthritis, systemic necrotizing arteritis, pleuritis, pericarditis, rheumatoid nodules in a few organs and a healing gastric ulcer was reported. Histologically, systemic necrotizing arteritis was characterized by vascular changes of the following three types: Granulomatous arteritis with a characteristic arrangement of mesenchymal cells forming a palisade around coagulation necrosis of media and some of them formed a rheumatoid nodule-like lesion in the wall (RA type); Fibrinoid arteritis very similar to the Kussmaul-Maier type periarteritis nodosa (PN type); and chronic arteritis with endarterial proliferation (Ep type). Although it is hard to distinguish arteritis of PN type from the Kussmaul-Maier type periarteritis nodosa, arteritis of RA type with rheumatoid nodule-like lesion in the wall may be interpreted as an extremely developed form of vasculitis in rheumatoid arthritis. | |
| 7430527 | Rheumatoid arthritis masquerading as polymyalgia rheumatica: report of two cases. | 1980 Nov | Polymyalgia rheumatica is a syndrome rather than a specific entity. The cases of two elderly patients are reported. These patients presented with typical polymyalgia rheumatica, but later were shown to have rheumatoid arthritis. Rheumatoid arthritis in the elderly may first masquerade as polymyalgia rheumatica. | |
| 439113 | The development of membranous glomerulonephritis in a patient with rheumatoid arthritis an | 1979 Jan | A case of classical rheumatoid arthritis and Sjögren's syndrome complicated by the development of membranous glomerulopathy is presented. Circulating immune complexes were demonstrated. The possible relationship between glomerulitis and rheumatoid arthritis is discussed and the literature is reviewed. Chrysotherapy was instituted because of persistent synovitis. The patient responded and her proteinuria did not increase. | |
| 6623019 | A comparison between clinical and laboratory tests in rheumatoid arthritis. | 1983 | Five clinical measurements (clinical score, articular index, visual analogue pain score, visual analogue function score, grip strength) were compared with two laboratory tests (the erythrocyte sedimentation rate and serum C-reactive protein concentration) in 68 patients with rheumatoid arthritis (RA). Patients treated with nonsteroid anti-inflammatory drugs showed clinical deterioration when treatment was interrupted, followed by improvement on resumption; there was no change in the laboratory tests. Patients treated with remission-inducing drugs (RIDs) had improved clinical measurements and also reduced erythrocyte sedimentation rate and serum C-reactive protein levels. Treatment with RID's led to similar trends in both clinical and laboratory tests, but correlation coefficients between the tests at intervals rarely attained statistical significance. The different response times for each test and probably also errors inherent in clinical measurements introduced sufficient variability to account for the discrepancy. Of the clinical tests, 'clinical score' appeared the most satisfactory. | |
| 3874814 | Gc (vitamin D binding protein) subtypes in rheumatoid arthritis. | 1985 | Two hundred and six patients with rheumatoid arthritis were examined for their association with the subtypes of Gc (vitamin D binding protein). In patient groups there is 11% excess of individuals with Gc*2 allele compared to the control group, giving a relative risk of 1.55. This risk increases with the humoral status of the individual. A possible physiological basis between the association of vitamin D binding protein and rheumatoid arthritis is discussed. | |
| 6516854 | Methylprednisolone pulse therapy induced fall in natural killer cell activity in rheumatoi | 1984 Oct | Natural killer (NK) cell activity was studied in 8 patients with classic or definite rheumatoid arthritis (RA) by investigating the killing of K 562 cells by peripheral blood lymphocytes before, during, and after intravenous methylprednisolone pulse therapy (MPPT). MPPT produced a considerable fall in NK activity and after 3 months NK activity was less than half that before MPPT. | |
| 6536669 | Plasmapheresis versus lymphoplasmapheresis in rheumatoid arthritis: immunologic comparison | 1984 | Eight patients with Functional Class III, seropositive, erosive rheumatoid arthritis unresponsive to remittive drugs each underwent nine aphereses over 3 weeks. Four had a 40-ml/kg plasma exchange and four others had a 40-ml/kg plasma exchange plus a mean 5.67 X 10(9) lymphocyte depletion. Both groups appeared to improve clinically. T and B cell counts and OK T4 and OK T8 ratios decreased in the lymphoplasmapheresis group. Phytohemagglutinin stimulation decreased in lymphoplasmapheresis and increased in plasmapheresis patients with significant comparisons (p = 0.02). These findings confirm and extend previous work. Plasmapheresis and lymphoplasmapheresis appear to have fundamentally different actions on lymphocyte function. | |
| 7013013 | [Treatment of rheumatoid arthritis with zinc sulfate. Results of a doubl-blind trial]. | 1981 Mar | At the end of a double blind clinical test carried out in 35 patients with classical rheumatoid arthritis, or progressive and with certain diagnosis, it does not appear that zinc sulphate given by mouth at dose of 600 mg/24 hours (divided up into 3 doses) may be a valid basic treatment. In fact, none of the classical clinical criteria (Richtie index, Lee index, etc.) nor laboratory criteria (E.S.R.) show any statistically significant change after 4 and 8 months. The discrepancy between these results and those previously published in discussed. | |
| 7282109 | [Tissue concentrations of non-steroidal anti-inflammatory agents in chronic polyarthritis | 1981 Mar | Non-steroidal antiinflammatory drugs (NSAID) are indispensable for modern treatment of rheumatoid arthritis. Reports on drug concentration in rheumatoid human tissues are still lacking. We now report about steady-state concentrations of Indomethacin and Acemetacin in blood, synovial fluid, synovial membrane, muscle, bone and fat 6h after the last application of Acemetacin resp. Indomethacin. Levels in all tissues, except fat, were found to be significantly higher than in blood. Therefore, a noticeable accumulation of drug occurs in all rheumatoid tissues. | |
| 1253605 | A rheumatoid-like arthritis in calves. | 1976 Jan | Arthritis characterized by lameness. Joint swelling and purulent synovial fluid was seen in a group of dairy replacement heifers. Mycoplasma was cultured from one joint aspirate, but all bacterial cultures were negative. Antiglobulins were demonstrated by double diffusion precipitin tests in the serum and synovial fluid. Due to the clinical and clinical pathological similarities to rheumatoid arthritis in man, the disease was called rheumatoid-like arthritis. The presence of antiglobulin may indicate antibody in the synovial fluid explaining the difficulty in culturing a causative agent. | |
| 749697 | Lateral subluxation of the atlanto-axial joint in rheumatoid arthritis. | 1978 Dec | Involvement of the cervical spine by rheumatoid disease is common, but lateral subluxation at the atlanto-axial level has not been recorded previously. The condition is due to asymmetrical erosion of the lateral atlanto-axial facet joint, and may be complicated by collapse of the lateral mass of the axis. The condition should be suspected in patients with rheumatoid arthritis (RA) who present with occipital, auricular, and/or facial pain. | |
| 4091607 | Realignment stabilization synovectomy in the rheumatoid wrist. A study of twenty-five case | 1985 | The authors studied a series of 25 rheumatoid wrists, stages II and III according to Steinbrocker or Larsen, treated between 1981 and 1983 by realignment-stabilization synovectomy. The mean follow-up period was 2 1/2 years. The different steps of the operation--articular and tenosynovectomy, tendon transfers associated with dorsal ligamentoplasty--have an additive effect in achieving relief of pain, with preservation of the pre-existing mobility and long-term stability in both the frontal and sagittal planes. In other studies, resection of the ulnar head results in a 40 p. cent increment in instability with notably aggravation of ulnar sliding. Preservation of the distal radioulnar articulation according to Sauve-Kapandji's operation constitutes a new approach to rheumatoid arthritis and, in our opinion, appears to be simple and is very efficient in stabilizing the wrist immediately, thus allowing early rehabilitation of these patients. Long-term stability is affirmed by clinical and roentgenologic follow-up. | |
| 199710 | Immunofluorescence studies in a case of rheumatoid neuropathy. | 1977 Sep | Findings in a sural nerve biopsy from a patient with rheumatoid neuropathy are reported. Inflammatory changes in different stages were observed in epineurial arterioles. Arterioles with fibrinoid necrosis contained IgG, IgM, rheumatoid factor and complement. The same substances were found at the inner site of the perineurial sheaths. It is suggested that these proteins leaked out of endoneurial vessels and became trapped in the perineurial sheaths. With anti-herpes simplex virus serum fluorescence was seen in monuclear cells of infiltrated vessel walls. This virus could not be isolated in tissue culture. | |
| 366138 | Levamisole in rheumatoid arthritis--a multivariate analysis of a multicentric study. | 1978 | Statistical analysis of the data from a multicentric study of six months of treatment with levamisole in rheumatoid arthritis involved two steps. In a first step, the differences between observations before and after treatment have been made independent of their initial values. Differences after treatment have been transformed into responses to treatment using a proportionality factor that is related to the initial values before treatment. The second step involved a reduction of the various responses into a single global response by means of a discriminant analysis between two classes. Class membership has been defined by the type of treatment (either placebo or drug) predicted by the investigators at the end of treatment and before breaking of the code of the double-blind study. This method of analysis allows for the combination of multiple clinical observations with a subjective evaluation. Its results can be easily represented graphically and tested for statistical significance. The use of global responses to treatment is illustrated with a comparison of placebo and drug treatments and can be extended to comparisons between investigators or between different dose and time regimens. | |
| 266603 | Coexistence of rheumatoid arthritis and ankylosing spondylitis--report of 10 cases. | 1977 | The distinction between rheumatoid arthritis (RA) and ankylosing spondylitis (AS) has hitherto relied on supporting evidence of characteristic radiological changes in the sacroiliac joints, together with the Rose-Waaler and Latex tests for rheumatoid factor (RF). This distinction has remained incomplete since some 30 per cent of patients with RA may have sacroiliitis, a similar proportion having negative routine tests for RF. The identification of the HLA B27 antigen, present in 90 per cent of cases of AS and six per cent of the normal population, has enabled a number of cases to be recognized in which both diseases appear to co-exist. Ten cases are described in which either RA appears to have developed in patients with AS, or AS in patients with RA. They all fulfil the ARA diagnostic criteria for classical RA, and the criteria for classical AS. The likelihood of these two diseases occurring by chance in an individual might be of the order of 1:50,000 to 1:200,000. |