Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7447218 | Pulse methylprednisolone in rheumatoid arthritis: a double-blind cross-over trial. | 1981 Jan | Ten patients with rheumatoid arthritis unresponsive to conventional therapy participated in a double-blind cross-over trial in which they randomly received either a "pulse" or 1 g of methylprednisolone or placebo, intravenously, once a month for 6 months. Both the drug-first and placebo-first groups had the same mean American Rheumatism Association functional classification, 2.5. During the study patients on methylprednisolone "pulses," compared to placebo, showed significantly better mean tender-joint counts, walking times, and grip strength (p < 0.05). The drug-treated patients also had significantly lower levels of immune complexes (p < 0.01) and IgG (p < 0.01). Effects could still be measured an average of 2.9 +/- 0.4 months after the last dose of methylprednisolone. No significant side effects were noted during the therapy. Despite these findings, "pulse" methylprednisolone did not appear to significantly retard radiologic progression of the arthritis. | |
| 6975825 | Heterogeneity of HLA-DR4 in the rheumatoid arthritis of a Chippewa band. | 1981 Sep | A high frequency of both rheumatoid arthritis (RA) and HLA-DR4 was found in a Chippewa Indian population. Multiple immunogenetic "variants" of HLA-DR4 were demonstrated, each showing a different response in mixed lymphocyte culture which corresponded to a serologic pattern of reactivity to a panel of non-DR4 B cell alloantisera. No DR4-bearing HLA haplotype or DR4 "variant" was common to subjects with RA, all of whom were DR4-positive. The implications are discussed. | |
| 6838025 | Defective serum chemotactic capacity in rheumatoid arthritis. | 1983 Apr | Polymorphonuclear leukocytes (PMN) chemotaxis and serum chemoattractant ability were studied in patients with rheumatoid arthritis (RA) employing the agarose plate technique. No statistically significant differences were observed in random migration of unstimulated cells compared to the controls. Moreover, there were no statistically significant differences between the chemotactic migration of control and patient cells in response to a number of non-treated sera. The chemotactic responsiveness of normal PMN cells to treated rheumatoid serum was significantly less than that observed using treated control serum with Escherichia coli lipopolysaccharide. The possible explanation for this abnormality may be due to the presence of chemotactic inhibitors in some RA serum. No correlation was detected between chemoattractant activity of rheumatoid arthritis serum, circulating immune complexes or rheumatoid factor. There were no statistically significant differences in the adhesiveness of RA-PMNs compared to normal PMNs. | |
| 701344 | Kinematics of the wrist. II. Clinical applications. | 1978 Oct | A reproducible method of measuring carpal height and carpal-ulnar distance and expressing them as ratios of these distances to the length of the third metacarpal, as reported in a previous paper9, was applied to serial roentgenograms of seventeen patients with rheumatoid disease and six patients with Kienböck's disease. These ratios provide an accurate expression of the extent of carpal collapse and of ulnar translation. However, once carpal collapse has occurred, the trajectory of hand motion becomes flattened, and, as a result, the carpal height ratio will vary as the wrist moves from maximum radial to maximum ulnar deviation. These ratios may be of use in predicting a patient's clinical course, but a larger clinical study is necessary before use of the measurements for this purpose can be recommended with assurance. | |
| 50712 | Experimental rheumatoid arthritis-like features induced by prolonged sensitization with fo | 1975 May | Prolonged sensitization with emulsion of an autologous or isologous subcutaneous abscess of Arthus type induced by injection of hen egg-white was performed in 34 rabbits which were divided into (high responder and intermediate responder groups (H- and M-groups) according to individual difference of immune responses. The development of a rheumatoid factor-like substance (RFLS) was demonstrated after 30 experimental days and subsequently observed in 21 out of 33 rabbits. There was no significant difference in the incidence of RFLS between both groups. As to the relation between the development of RFLS and types of focal antigens, the group of the autologous W-substance showed a higher incidence of RFLS than the N-substance. Acute and/or chronic synovitis was demonstrated in 13 of 33 rabbits and inflammatory changes were more intensive and extensive in the later period of experiment. Presence of RFLS in the affected synovial tissues, chiefly in the cytoplasm of plasma cells and mononuclear cells, occasionally in a free state was revealed by immunofluorescent study, and depositions positive for IgG and beta 1C were observed in the wall of blood vessels and fibrinous thrombi in the affected synovial tissues. | |
| 102159 | Rheumatoid arthritis and its variants: analysis of scintiphotographic, radiographic, and c | 1978 Oct | 99mTc pyrophosphate radionuclide scans of the axial and appendicular skeletons in 23 patients with rheumatoid arthritis and 15 patients with systemic arthritic conditions were compared to clinical and radiographic examinations. The nuclear scan was the most sensitive indicator of active disease and correlated extremely well with the other methods. A pattern of abnormal radionuclide activity in rheumatoid arthritis consisting of a symmetric peripheral joint process can be distinguished from that of the rheumatoid variants which tend to have more central skeletal involvement and asymmetric peripheral articular involvement. The nuclear scan is less specific than the radiograph in its ability to distinguish among the clinical entities. However, documentation of scintigraphic activity often antedated radiographic or clinical abnormalities. | |
| 7247263 | A rational regimen for perioperative steroid supplements and a clinical assessment of the | 1981 Jan | Sixty-one patients with rheumatoid arthritis on long-term corticosteroid treatment were managed for 107 orthopaedic procedures using a flexible method of supplementary steroid cover. It was found that the amount actually required was surprisingly small and in 78% of the operations no postoperative supplements were given. There were no consistent factors which would predict a requirement for supplementary steroids in any particular individual. | |
| 7309308 | Rheumatoid vasculitis. | 1981 Oct | Today, we cannot conclude comments on the treatment of immune-complex disease without paying our respects to therapeutic plasmapheresis and leukapheresis. Numerous centers are beginning to examine the value of removing either plasma or lymphocytes from patients with many rheumatic diseases. Efficacy appears to be established in hyperviscosity diseases (Waldenstrom's), myasthenia gravis, Goodpasture's syndrome, RH sensitized pregnant mothers, and thrombotic thrombocytopenic purpura. In active rheumatoid arthritis, it is a useful short-term tool but hardly cost effective. Although it would appear to be an advance from the medieval concept of purging out the "evil humors," pheresis for rheumatoid vasculitis must be considered a limited research tool, which may teach us something about mechanism of action. The mechanical removal of immune complexes by pheresis probably requires additional remittive or immunosuppressive therapy to prevent rebound in immune complex production. Effort now need to be directed to the agents that initiate production of immune complexes. Once the host's antibody system is so stimulated, we often find ourselves trying to close the barn door after the horse is long gone. | |
| 6726721 | A case of rheumatoid nodule formation within the central nervous system and review of the | 1984 Apr | We describe nodule formation within the central nervous system (CNS) in a patient with seropositive rheumatoid arthritis (RA). Review of 13 previous reports of CNS rheumatoid nodule formation suggests that the clinical course is usually one of longstanding seropositive disease. Correlation of neurologic signs and symptoms with anatomic lesions has frequently been tenuous. We conclude that CNS nodules are a rare extraarticular feature of RA which, although often of uncertain clinical significance, should be considered as a possible etiology when neurologic dysfunction occurs in the RA patient. | |
| 92320 | [Modifications in alpha 2 globulins, gamma globulins and in rheumatoid factor during gold | 1978 Dec 15 | A total dose of g 1.071, given as hydrosoluble salts for a 12 month period, showed a significant decrease in serum gamma globulins along with clinical improvement in 17 patients affected with rheumatoid arthritis. A decrease in alpha 2 globulins and in rheumatoid factor titre was observed too, but it was not significant. The data suggest that in rheumatoid arthritis the gold therapy might also be effective on the immunological disease mechanism. | |
| 241596 | Serum sulphydryl levels in rheumatoid patients treated with alclofenac. | 1975 | Serum sulphydryl levels, which are decreased in rheumatoid patients, are increased to near normal during treatment with alclofenac. The biochemical function of the sulphydryl group and its possible pathogenic significance in rheumatoid and other auto-immune diseases are discussed. | |
| 646836 | Ankylosing spondylitis with subsequent development of rheumatoid arthritis, Sjögren's syn | 1978 Apr | Twelve years after the onset of ankylosing spondylitis, a patient developed severe seropositive rheumatoid arthritis with subcutaneous nodules. This was subsequently complicated by Sjögren's syndrome and rheumatoid vasculitis. The literature is reviewed, and the nature of the association between ankylosing spondylitis and rheumatoid arthritis is discussed. | |
| 645749 | Rheumatoid arthritis--a sequel to HBsAg hepatitis. | 1978 May | Reported here is the first case of classic rheumatoid arthritis emerging in the setting of hepatitis B surface antigen (HBsAG)-positive viral hepatitis. Polyfocal arthritis and myalgia, lymphadenopathy and constitutional symptoms were the presenting manifestations of anicteric hepatitis in this 23 year old man. Smooth muscles antibodies, HBsAg and "rheumatoid" factor were demonstrated initially. The hepatocellular disease, biopsy-proved, resolved completely and without recurrence; clinically and serologically. Latex test positivity persisted, increasing in titer, and polyarthritis progressed to fulfull criteria for classic rheumatoid arthritis, with erosions on roentgenogram and characteristic synovial disease. After 60 months of follow-up, the rheumatoid synovitis has continued to progress despite appropriate therapy. The arthritis of viral hepatitis and the significance of rheumatoid factor in association with hepatocellular disease are discussed. | |
| 7064682 | Silastic radial head prosthesis in rheumatoid arthritis. | 1982 Feb | This paper reports our experience of using the Silastic radial head prosthesis in 18 elbow joints affected by rheumatoid arthritis. There was a varying degree of severity of involvement in 15 of the elbows, and in a further 3 cases replacement was carried out at an early stage of the disease. The 3 cases in whom early replacement was carried out had the best results at follow-up and 11 of the remaining 15 were considered to have a satisfactory overall result. The major benefit of operation has been the relief of pain, even in the late cases, whilst preserving stability of the elbow in all but 3 cases. | |
| 6895141 | [Histology of the antiarthritic effect of tribenoside in experimental gonarthrosis]. | 1981 Mar | Animal experiments with chemically induced osteoarthrosis in the knee joint of adult hens have shown that the daily treatment with tribenoside (Glyvenol(R)) using single oral doses of 50 mg/kg or 150 mg/kg, will result in a marked reduction of the intensity and frequency of joint degenerations. This anti-arthrotic effect was quantitatively measured by radiographic and macroscopic methods over a period of 3 months. In the present study we investigated the inhibitory effect of tribenoside on osteoarthrosis by histological techniques. Histological sections of osteoarthrotic articular cartilage of untreated and treated animals were compared and clearly indicated that there were no qualitative differences in alterations of the morphology and histopathology of the tribenoside treated specimen. Only the frequency and intensity of degenerative alterations where markedly reduced in the drug treated animals. Biochemical analysis of joint cartilage demonstrated that tribenoside (150 mg/kg) significantly reduced the loss of proteoglycans in the osteoarthrotic cartilage matrix. Our histological and biochemical findings are in good correlation with the results of our radiographic and macroscopic studies on the effect of tribenoside on experimental osteoarthrosis. The present investigation indicates that tribenoside exerts its antiarthritic effect on the base of its vasotropic properties by stabilization of the capillary system and membrane of the synovial tissue, which provides the transport and exchange of nutritional substrates and metabolites via synovial fluid to or from the articular surface. Our histological findings do not exclude the possibility that tribenoside also has a direct chondroprotective effect. | |
| 104378 | Serum sulfhydryl levels in rheumatoid patients treated with gold thiomalate and penicillam | 1978 | Twenty-six patients with rheumatoid arthritis were treated with sodium aurothiomalate (16 patients) and penicillamine (10 patients) for 9 months. During both treatment periods the content of serum sulfhydryl groups increased and erythrocyte sedimentation rate, rheumatoid factor titre and number of swollen joints decreased. | |
| 6533084 | Clinical response in relation to dose of penicillamine in the treatment of rheumatoid arth | 1984 | Large differences exist in the maintenance doses of penicillamine that clinicians regard as effective and safe in rheumatoid arthritis. From a study of the results of several clinical trials and surveys it is evident that, while some of the differences of regimen result from true individual variation in the response of patients to particular doses, others derive from the variety of criteria of efficacy and toxicity used by different clinicians. No regimen has proved clinically curative or has consistently halted radiographic deterioration. In most surveys regardless of dose at least one-third of the patients stop treatment because of toxicity or inefficacy. Placebo-controlled trials have been of short (less than 1 year) duration and longer term surveys have not included a placebo group so that the therapeutic contribution of penicillamine therapy in the long-term treatment of the generality of rheumatoid patients cannot be estimated accurately. Good control of the disease has been recorded in numbers of patients for five years or more at different doses of penicillamine, most clinicians being prepared to raise or lower doses according to response. Under the prevailing circumstances it may be impossible to complete an adequately controlled long term dose/response study of penicillamine in rheumatoid arthritis. | |
| 7401066 | The coexistence of gout and rheumatoid arthritis: case reports and a review of the literat | 1980 May | We report a case of definite rheumatoid arthritis (RA) by ARA criteria with a high titer rheumatoid factor and coexisting gout as demonstrated by biopsy-proven monosodium urate crystals. Two other cases meeting ARA criteria for RA who probably had gout as their sole disease are described. Criteria for the definition of coexistent RA and gout are proposed. | |
| 4071424 | [Various clinical and instrumental parallels in the condition of the lungs and heart in pa | 1985 | Comparative clinical and instrumental examination of 33 patients with seronegative and 67 patients with seropositive rheumatoid arthritis (RA) has revealed that patients with seropositive RA often manifest the functional and roentgenomorphological signs of lung damage. Pulmonary lesions related pathogenetically to RA were encountered equally often in patients of both groups, whereas those caused by concomitant chronic nonspecific pulmonary diseases were more characteristic of patients with seropositive RA apparently because of a more powerful suppression of immunity. In addition, in spite of the fact that the latter patients did not make any complaints on the part of the heart, they did manifest abnormalities of the phase structure of the cardiac cycle and central hemodynamics. | |
| 6712288 | Lymphoproliferative malignancy in rheumatoid arthritis: a study of 20 cases. | 1984 Apr | A series of 20 patients with definite or classical rheumatoid arthritis who subsequently developed a lymphoproliferative malignancy are described. The mean time between the onset of the 2 diseases was 13.2 years. A wide range of types of non-Hodgkin's lymphoma and Hodgkin's disease were found; there were no unusual histological features in the lymphomas. Although many of the patients had had gold, penicillamine, and other second-line drugs, none of them had received cytotoxic drugs, and there was no evidence that therapy was a cause of their malignancies. The likely cause of the association is a predisposition to both diseases. |