Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6248971 | [Bone scan in the diagnosis of infectious osteoarthritis (author's transl)]. | 1980 May 8 | Bone scan with Technetium 99m is harmless method of evaluation of skeletal lesions. It is safe in pediatrics age group and it can be used in early diagnosis of infectious osteoarthritis. Bone scan differentiate osteomyelitis from cellulitis, and also it may help in diagnosis of subclinical involvement of rheumatoid arthritis, benign and malignant bone tumors, stress fractures and periositis. We report results of bone scan in 30 pediatric patients as follows: osteomyelitis 9 cases, cellulitis 4 cases, infectious arthritis 4 cases, tuberculous osteoarthritis 2 cases, rheumatoid arthritis 2 cases, and other different diseases 9 cases. | |
| 12279913 | New study shows OCs don't reduce rheumatoid arthritis risk. | 1985 Jan | ||
| 25026418 | The management of rheumatoid arthritis. | 1976 Dec | Between two and three per cent of Australians suffer from rheumatoid arthritis, and in addition to the pain and disability experienced by the individual patient there is considerable cost to the community in terms of loss of work, cost of prescriptions and doctor's time. By an appreciation of the natural history of the disease and the potential value and disadvantages of the available treatment methods, these costs may be reduced. | |
| 4059532 | [X-ray diagnostic concept of spondylodiscitis]. | 1985 Jul | The destructive discovertebral lesions of ankylosing spondylitis are discussed. Their evaluation in the literature is compared with the newer histologic and radiologic results. The X-ray findings in rheumatoid arthritis are also presented. Using radiographs from 16 of our own patients suffering from ankylosing spondylitis and 5 with rheumatoid arthritis, we analyze the radiological appearances in question. | |
| 7458147 | Acute cricoarytenoid arthritis: local periarticular steroid injection. | 1980 Nov | Acute cricoarytenoid arthritis is a frequent complication of rheumatoid arthritis and the most frequent otolaryngologic manifestation of the disease. Over 25% of rheumatoid arthritis cases have discomfort from this problem. Other etiologies can produce cricoarytenoid arthritis. Symptoms range from mild discomfort through hoarseness to complete airway obstruction requiring emergency tracheotomy. Chronic cricoarytenoid arthritis may result in joint ankylosis and vocal fold fixation. Single periarticular triamcinolone injections may bring rapid and dramatic relief of the symptomatology of nonankylosed acute cricoarytenoid arthritis for periods of up to one year if other medical management is adequate. Six cases illustrate the problem and the efficacy of this treatment methodology. Findings, pathology and pertinent literature are discussed. Specific criteria for considering this technique are outlined. This form of therapy has not been described previously. | |
| 7375968 | Acute febrile juvenile rheumatoid arthritis in adults: cause of polyarthritis and fever. | 1980 May | Acute febrile juvenile rheumatoid arthritis (JRA) of adult onset is often diagnosed by ruling out other problems. The classification of JRA is primarily based on the distinct type of onset, of which there are usually three: (1) acute febrile or Still's type, (2) polyarticular, and (3) monoarticular pauciarticular arthritis. Fever of unknown cause is frequently the initial symptom. This type of arthritis may be characterized by any or all of the following: unexplained high fever, rash, weight loss, lymphadenopathy, splenomegaly, pericarditis, pleurisy, pneumonitis, abdominal pain, myalgias, arthralgias, arthritis, sore throat, leukocytosis, anemia, circulating immune complexes, liver test abnormalities, and carpal-metacarpal and tarsal-metatarsal fusion. Patients often respond dramatically to anti-inflammatory agents. Corticosteroids, gold salts, penicillamine, and cytotoxic drugs have been effective for certain patients. The prognosis of the disease has been generally favorable. Although symptoms may recur, remission can be prolonged. | |
| 1096832 | Autoantibodies in childhood connective tissue diseases and in normal children. | 1975 Jun | The prevalence of nine serum autoantibodies has been studied in 117 children with various connective tissue disorders and in 134 normal controls. In juvenile rheumatoid arthritis rheumatoid factor was present in 5%, and antinuclear factor in 4%, compared with an incidence of 4% and 0% respectively in controls. In Henoch-Schönlein purpura there was little evidence of associated autoimmune disorder. Gastric parietal cell and thyroid microsomal antibodies were found in 9% and 10% of our control population, but the significance of this is not clear. It is concluded that in children the presence or absence of autoantibodies as diagnostic criteria should be interpreted with the greatest caution. | |
| 6399847 | Collagen autoimmune arthritis. | 1984 | The evidence is now fairly conclusive that collagen-induced arthritis in rodents is mediated by antitype II collagen autoimmunity. Arthritis is probably initiated by binding of antibodies to the surface of intact articular cartilage. Many of the major manifestations of arthritis, including synovial proliferation, pannus formation, marginal erosion of bone, and destruction of cartilage, can be duplicated by injection of isolated antitype II collagen antibodies. It is not known whether delayed hypersensitivity reactions to collagen can provoke similar lesions in the absence of antibody, but circumstantial evidence suggests they do not. Also clear is that not all anticollagen antibodies are capable of inducing arthritis. The minimal requirements for arthritogenic potential are currently under investigation but probably include the ability to bind native autologous type II collagen. Also IgM antibodies alone are either ineffective or are required in relatively higher concentrations than IgG for induction of arthritis. Autoimmunity to collagen is found in many spontaneous and induced rheumatic diseases other than collagen-induced arthritis. There is at present, however, no direct evidence that this autoimmunity actually contributes to the arthritic process. Nevertheless, the human disease most often associated with collagen autoimmunity is rheumatoid arthritis. In many respects the immune reactions detected in humans with rheumatoid arthritis parallel those of arthritis in rodents. That is, responsiveness is under the control of genes within or linked to the major histocompatibility locus. High responders are limited to only a few haplotypes. Cell-mediated reactions are most vigorous in response to denatured collagen and probably have limited specificity for the type of collagen recognized. Antibodies may be separated into at least two groups, one with broad specificity for denatured collagen and a second highly specific for conformation-dependent determinants on native type II collagen. The latter antibodies are of most interest to researchers because they may be like those that induce arthritis in rodents. There is also ample evidence that antibodies are deposited in the joints of rheumatoid arthritis patients, although the specificity of these antibodies is unknown. Generally, collagen-induced arthritis is a model of antibody-initiated autoimmunity arthritis. Specifically, it is a model of type II collagen autoimmune arthritis. In consideration of its extraarticular manifestations, it may justifiably be referred to as type II collagen autoimmune disease.(ABSTRACT TRUNCATED AT 400 WORDS) | |
| 778264 | Detection of antibodies to bacterial cell wall peptidoglycan in human sera. | 1976 Jul | A radioimmunoassay has been developed for the measurement of antibodies to peptidoglycan in human sera including patients with rheumatic fever and juvenile rheumatoid arthritis. The assay is based on the percentage of binding of the hapten 125I-L-Ala-gamma-d-Glu-L-Lys-D-Ala-D-Ala, the major peptide determinant of peptidoglycan. Because of differences in the avidity of the antibodies in different sera, the amount of antibody was expressed as pentapeptide hapten-binding capacity (pentapeptide-HBC in ng/ml of serum). Fourteen out of 105 normal blood donors had a pentapeptide-HBC value greater than or equal to 75 ng/ml serum. Values in healthy children 5 to 18 years of age were less than or equal to 50 ng/ml. Sixty-eight percent of the individuals with rheumatic fever had values greater than or equal to 75 ng/ml, an indication that streptococcal infections can stimulate an immune response to peptidoglycan. Thirty-five percent of the patients with juvenile rheumatoid arthritis had values greater than or equal to 75 ng/ml. Such a finding points to a possible association between bacterial infections and juvenile rheumatoid arthritis. | |
| 4015353 | Parent perceptions of problems experienced by their children in complying with treatments | 1985 Jul | Parents of children with chronic diseases, such as juvenile rheumatoid arthritis (JRA), are responsible for insuring that their children comply with medical regimens. Assessing the perceptions parents have of problems their children experience in complying with treatment would be useful in advising them of how to help their children. In this study, a questionnaire assessing the frequency and type of problems children experienced in complying with treatments of JRA was completed by 37 parents. The parents reported more problems with range of motion exercises and splint wearing than with medications. The most common negative reactions exhibited by the children included complaining, crying, forgetting to do what was prescribed, and noncompliance. Additionally, nearly 50% of the parents relied on their child's report or were vague about how they assessed compliance. Suggestions for advising parents about how they can assess and improve compliance are offered in this report. | |
| 676742 | Natural history of juvenile rheumatoid arthritis. A follow-up study of a case with special | 1978 Jul | A detailed comparison between the clinical and EEG findings is made in a case of a boy with juvenile rheumatoid arthritis (JRA) who died at 15 years, 6.5 years after the beginning of the follow-up period. In the course of the disease, seven EEG recordings were made, showing a progressive diffuse slowing and disorganization with some improvement during short remissions. In relapses, diffuse slowing was associated with grave asymmetries in the EEG which, however, fluctuated and later disappeared without accompanying clinical or neuroradiological abnormalities. An abundancy of different residual findings, however, remained in the EEG after relapses. There were spike-and-wave paroxysms in every record except at the terminal stage. A stepwise slowing and disorganization was also seen in these paroxysms as background activity. The final cause of death was an intraventricular haemorrhage. No cerebral amyloidosis was found at autopsy. In conclusion, it is suggested that JRA is also a brain disease manifested as a cerebral vasculitis. | |
| 433583 | Total hip replacement in juvenile rheumatoid arthritis. Analysis of 59 hips. | 1979 Apr | The results of 59 Charnley low friction arthroplasties in 41 patients with juvenile rheumatoid arthritis are presented. Mean follow-up was 30 months and mean age at operation 30.5 years. At review 90 per cent had an excellent result and 10 per cent a good result as regards pain relief. Mobility was significantly improved in all but two patients. These two patients developed severe ectopic bone formation. With few exceptions, the results remained constant after 6 months. Intraoperative complications were the most common. Careful selection of patients, advance planning of surgery and appreciation of the developmental abnormalities in these hips are essential features in avoiding complications and achieving a good result. | |
| 104619 | Gold nephropathy in juvenile rheumatoid arthritis. | 1979 Jan | A 2-year-old girl was treated with gold salts for juvenile rheumatoid arthritis. Treatment had to be discontinued when persistent proteinuria was detected. As this case report indicates, close monitoring of the urine is mandatory during treatment with gold salts to detect early signs of toxicity: hematuria followed by casts and then proteinuria as therapy is continued. Histologic examination with electron microscopy will help to differentiate the different forms of gold toxicity. When the findings are consistent with gold-induced renal involvement, therapy should be discontinued. The gold nephropathy usually resolves in time, with no permanent renal damage. | |
| 724343 | Chronic salicylate administration in juvenile rheumatoid arthritis: aspirin "hepatitis" an | 1978 Nov | Salicylates provide the backbone of therapy in juvenile rheumatoid arthritis. They are effective in controlling the disease approximately 75% of the time if they are properly used. Salicylate administration is relatively safe if carefully done. Serum salicylate levels should not exceed 30 mg/dl routinely. Patients, physicians, and parents should be alert to early clinical signs of toxicity. Chief hazards of chronic salicylate administration other than salicylism (which should be uniformly preventable) include gastric irritation with questionable relationship to peptic ulcer disease, and rare serious hepatotoxicity, bleeding diatheses, or hypersensitivity reactions. | |
| 6185058 | Serologic studies on the association of rubella virus infection and juvenile rheumatoid ar | 1981 Jun | Rubella haemagglutination-inhibition (HAI) and virus-specific IgM antibody responses were investigated in 26 patients with Juvenile Rheumatoid Arthritis (JRA) and 52 age-and sex-matched controls. 30.8% of patients with JRA showed no serological evidence of a previous infection by rubella virus (RV). In addition, the Geometric Mean Titres (GMT) of rubella HAI antibody among patients with JRA were similar to those found among the control group. Furthermore, rubella-specific IgM responses could not be detected in any of the sera among JRA patients or control children, although they were present in the sera of all 12 (100%) patients with clinical rubella. These data, therefore, fail to suggest serological evidence for the association of RV infection with JRA. | |
| 3970730 | HLA gene frequencies in children and adults with systemic onset juvenile rheumatoid arthri | 1985 Feb | The HLA genetic region was studied in 51 patients with systemic onset juvenile rheumatoid arthritis: 35 with childhood onset and 16 with adult onset (adult Still's disease). HLA genotypes were established by including family members, 261 of whom were also typed in the study. The most marked difference between patients and controls involved the HLA-DR4 gene, which occurred with a frequency of 0.348 in the childhood onset patients and 0.170 in the controls (chi 2 = 8.97, P = 0.0028, adjusted P = 0.017). In contrast, the adult onset patients showed a marginal increase in HLA-DR7, but were similar to controls with respect to HLA-DR4. HLA-Bw35 was increased in children with systemic onset disease, in accordance with earlier findings. The results suggest that patients with systemic onset juvenile rheumatoid arthritis have complex HLA associations which are different in childhood onset and adult onset disease. | |
| 6982335 | Rheumatic diseases in Western Canadian Indian children. | 1982 Jul | For both genetic and environmental reasons the prevalences and characteristics of the rheumatic diseases affecting North American Indian children might be expected to differ from those of similarly affected non-Indian children. We reviewed 34 Western Canadian Indian children with rheumatic disorders. For comparison a group of Caucasian children with chronic arthritis was also evaluated. The prevalence of clinic attendance by Indian children (.059%) was substantially but not significantly more common than attendance by non-Indian children (.034%). When compared to the seronegative spondyloarthropathies (SSA), juvenile rheumatoid arthritis (JRA) was relatively less common in the Indian population (1.2:1) than in the Caucasian children (5.4:1). Of the children with JRA, polyarticular onset type, positive tests for rheumatoid factor and HLA-AW24 were significantly more common in the Indian population (p less than .05). The characteristics of Indian and of non-Indian children with SSA did not differ significantly. Even though an increased prevalence of HLA-B27 may account for the relative increase of SSA in the Indian population, this study indicates that childhood rheumatic diseases other than B27 associated SSA should be recognized as occurring frequently in Indian children. | |
| 6987312 | Quantitative determination of rheumatoid factor by an enzyme-labeled immunoassay. | 1980 | The presence and quantity of rheumatoid factor (RF) in human serum were determined by an indirect enzyme-linked immunoabsorbent assay (ELISA). A human rheumatoid factor control serum, standardized against the WHO reference rheumatoid arthritis serum preparation, was used to derive a standard curve in each assay. The results of unknowns were estimated from the standard curve and reported in International Units (IU) per milliliter (ml). The ELISA assay was compared with the bentonite flocculation test. The overall coefficient of correlation between the two assays was 87%; it was 93.3% for patients with rheumatoid arthritis but only 67.5% for patients with undiagnosed conditions. The error of the ELISA assay (coefficient of variation) was generally less than 10% at both high and low concentrations of rheumatoid factor. The quantitative reproducible nature of the assay allows the detection of small variations of rheumatoid factor level and could be useful in the serial evaluation of patients. | |
| 737000 | The amyloidosis of juvenile rheumatoid arthritis--comparative studies in Polish and Americ | 1978 Jul | Serum SAA concentration was determined by radioimmunoassay in 21 Polish children with amyloidosis secondary to juvenile rheumatoid arthritis (JRA). The results were compared to controls and children with JRA in Polish populations (where amyloidosis is a frequent complication of JRA) as well as to American children with JRA (where amyloidosis in JRA has been observed only sporadically) and American control children. No significant differences of SAA protein levels were found in the amyloidotic Polish children when compared to JRA Polish and American children. However, significantly higher levels of SAA protein were present in amyloidotic Polish children when compared to the control Polish and American group. High serum SAA protein concentration in JRA children did not necessarily correlate with the presence of secondary amyloidosis. Other mechanisms are probably involved in the development of amyloidosis. | |
| 690754 | Diagnostic significance of antibody to native deoxyribonucleic acid in children with juven | 1978 Sep | Sera of children with juvenile rheumatoid arthritis and other connective tissue diseases were tested for antibodies to native DNA by a radiolabeled-binding assay. Normal values were obtained in 130 children with JRA, including 28 with uveitis and 14 with selective IgA deficiency. Normal values were also found in sera from children with dermatomyositis, scleroderma, polyarteritis, ankylosing spondylitis, and a variety of other nonconnective tissue diseases. The only sera with elevated DNA-binding assays were from children with systemic lupus erythematosus. On the basis of these data, increased levels of antibodies to native DNA distinguished patients with active SLE from children with JRA. |