Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6630251 | Total knee arthroplasty in juvenile rheumatoid arthritis. | 1983 Oct | From 1971 to 1981, total knee arthroplasty was performed on forty-eight knees in twenty-eight patients with juvenile rheumatoid arthritis at the Robert Breck Brigham (now Brigham and Women's) Hospital. Seventeen of these patients, with twenty-nine knee-replacement arthroplasties, were followed for from two to eleven years (average, five years) and are the basis for this study. The patients' ages at operation ranged from thirteen to thirty-nine years (average, twenty-three years). Six patients had undergone total hip arthroplasty prior to admission for total knee replacement, and five patients had a total hip replacement performed while they were hospitalized for the knee arthroplasty. Thirteen patients (twenty-one knees) had significant preoperative pain but only three (five knees) had severe discomfort. Four patients were unable to walk, three were household walkers, and ten were limited community walkers. Preoperative deformities of the knees ranged from 20 degrees of varus angulation to 35 degrees of valgus angulation. The average preoperative flexion deformity was 23 degrees and the arc of motion averaged 45 degrees. At follow-up, twenty of the twenty-one knees that had been significantly painful preoperatively were completely relieved of discomfort. The average arc of motion increased by 34 degrees, while in all but one knee the angular deformity had been corrected to zero to 10 degrees of valgus angulation. All but one patient became a limited or full community walker. Complications included one late deep infection and one posterior tibial subluxation. Four knees required subsequent resurfacing of the patella for treatment of pain. We now routinely resurface the patella in all patients with juvenile rheumatoid arthritis who have a total knee replacement. To date no prosthesis has required revision for loosening. Radiolucency of one millimeter or less about the prosthesis was noted at follow-up in eight (30 per cent) of the knees. As custom-made components were required in twelve of the twenty-nine knees, it is obvious that preoperative planning is crucial in the treatment of these patients. Our recent experience has shown that the use of preoperative and postoperative serial casts aids greatly in the correction of severe flexion deformity of the knee. Postoperative manipulation was required for twenty-one of the twenty-nine knees. Skeletal immaturity was not an absolute contraindication to surgery. We think that our results, which showed a marked improvement in both knee function and in quality of life, make the short and long-term risks of knee-implant surgery well worth taking in this patient population. | |
| 6411921 | Blood and serum concentrations of gold after a single dose of auranofin in children with j | 1983 Jun | Three children with juvenile rheumatoid arthritis were given a single oral dose of approximately 0.1 mg/kg of auranofin. Blood concentrations up to 49 ng/ml were detectable at 24 h (earliest sample) and remained detectable for at least 2 weeks (final sample). Disappearance of measurable gold from both the blood and serum appeared to be linear through time. None of the patients experienced significant laboratory abnormalities nor adverse reactions. Gold levels attained in these children were somewhat lower than those seen in adults administered an equivalent dose. | |
| 7161782 | Juvenile rheumatoid arthritis with renal amyloidosis: a 23-year survival. | 1982 Nov | A 14-year-old girl with juvenile rheumatoid arthritis developed severe renal amyloidosis and presented with nephrosis and renal failure. Renal function returned to normal in a year and over 23 years, serial biopsies showed remarkable, biopsy-proven regression of amyloid deposits. Amyloid was not found in skin, gum or rectal biopsies. This case demonstrates an improved prognosis and apparent reversibility. | |
| 868818 | Aspirin-induced hepatotoxicity and its effect on juvenile rheumatoid arthritis. | 1977 Jun | Evidence of hepatic disease was sought in 102 children with juvenile rheumatoid arthritis (JRA) who were treated with aspirin. Serum glutamic oxaloacetic transaminase level was elevated (greater than 39 IU/liter) in 59% of the children. The degree and prevalence of SGOT elevations correlated with aspirin dose and serum salicylate level. Nevertheless, increased SGOT values were frequently present in children receiving moderate aspirin doses and having serum salicylate levels less than 25 mg/100 ml. Elevated SGOT values decreased in proportion to the degree of reduction in aspirin dose. The SGOT values above the 100 IU/liter were statistically associated with reduced sedimentation rates. Concomitant improvement in the clinical manifestations of JRA was noted in some children. | |
| 6299137 | Caprine arthritis-encephalitis: clinicopathologic study. | 1982 Dec | Chronic arthritis caused by caprine arthritis-encephalitis virus was observed after the introduction of new animals into a goat herd. There were high frequency of carpal hygroma and clinical signs of stiffness. The disease was progressive and produced a debilitating lameness among 30% of the affected animals. Laboratory findings were limited to alterations in synovial fluid which showed increased numbers of lymphocytes. Pathologic changes were observed in the joints, bursae, and adjacent tissues. Vascular injury and capillary leakage resulted in exudation into synovial cavities. Fibrin coated the synovial lining and formed (amorphous) long thread-like or broad-based villi. The articular cartilage was eroded. Cartilage erosion and penetration of the articular cartilage by pannus were associated with the presence of subchondral pseudocysts. The morphologic changes in bone and synovial tissues were like those described in human rheumatoid arthritis, except that rheumatoid nodules were not observed. | |
| 333079 | Comparison of tolmetin sodium and aspirin in the treatment of juvenile rheumatoid arthriti | 1977 Nov | The Pediatric Rheumatology Collaborative Study Group was established in 1973 to undertake systematic trials of new drugs in the treatment of juvenile rheumatoid arthritis. The first drug evaluated was tolmetin (1-methyl-5-p-toluoylpyrrole-2 acetic acid), a new nonsteroid anti-inflammatory agent. A four-week open trial with 30 patients and a subsequent 12-week double-blind trial against aspirin with 107 patients were conducted. Tolmetin and aspirin had equal anti-inflammatory and analgesic effects in the treatment of JRA. Elevations of transaminase values attributed to aspirin were not found with tolmetin. Adverse effects accompanying administration of tolmetin did not appear to be of major clinical significance. | |
| 367963 | Treatment of rheumatoid and degenerative diseases with copper complexes: a review with emp | 1977 Sep | This review presents a historical account of the treatment of rheumatoid and other degenerative diseases with copper complexes. Clinical data obtained from 1940 to 1971 are provided for about 1,500 patients with rheumatoid arthritis (acute or chronic), rheumatic fever, ankylosing spondylitis, staphlococcal spondylitis, gonococcal arthritis, chronic gouty arthritis, polyarticular synovitis, coxitis, disseminated spondylitis, arthritis with psoriasis, Reiter's syndrome, lupus erythematosus, sarcoidosis, arthrosis deformans, erythema nodosum, sciatica (with and without lumbar involvement), cervical spine-shoulder syndrome or lumbar spine syndrome. The drugs used in these studies were Dicuprene, Alcuprin, Cuprimyl, and Permalon, a copper-salicylate preparation. A detailed presentation of toxicities associated with the use of these copper complexes is included. | |
| 6190231 | [Antiperinuclear and antikeratin antibodies in liver diseases]. | 1983 Mar 3 | Antiperinuclear factor (APF) was detected in 7 out of 38 patients with autoimmune liver disease (AILD) and in 7 out of 83 patients with non-autoimmune liver disease (NAILD). Anti-keratin antibodies were found in 2 out of 18 patients with AILD and in 3 out of 32 patients with NAILD. Neither APF nor antikeratin antibody was significantly more frequent in AILD than in NAILD. The incidence of APF was shown to be greater (p less than 0.02) in patients with rheumatoid factor (RF) and/or antinuclear antibody. This supports the hypothesis that APF is connected with RF rather than with rheumatoid arthritis, although the presence of APF is evidence towards the diagnosis of rheumatoid arthritis. | |
| 6614276 | The prevalence and incidence of juvenile rheumatoid arthritis in an urban Black population | 1983 Oct | We determined the prevalence and incidence of juvenile rheumatoid arthritis (JRA) in an urban Black population in Baltimore, identifying three cases through review of computerized outpatient encounters and a fourth case by reviewing discharge records at area hospitals. The prevalence of JRA among Blacks, as of December 31, 1980, was estimated as 0.26 per 1,000 (95 per cent confidence interval: 0.07, 0.66), the average annual incidence 6.6 per 100,000 per year (0.8, 23.8) for the years 1979 and 1980. These data suggest that Black race is not associated with significantly increased risk of development of JRA. | |
| 314873 | The association of autoimmune diseases and anti-IgA antibodies in patients with selective | 1979 Jul | The prevalence of antibodies to immunoglobulin A (IgA) was studied in eighty-three subjects with selective IgA deficiency (SIgAD), thirty-three normal individuals, thirty-two children with juvenile rheumatoid arthritis (JRA) and normal or elevated IgA, seventeen children with systemic lupus erythematosus (SLE) and normal or elevated IgA, and thirteen patients with hypogammaglobulinaemia. Anti-IgA antibodies were detected by haemagglutination of human erythrocytes coated with one of two IgA myelomas by the chromic chloride technique. Antibodies to IgA were not found in significant titre in individuals with normal or elevated IgA or in those with hypogammaglobulinaemia. In IgA deficient patients, elevated titres were found in 25--30% of those who were healthy or who had non-rheumatic diseases, 50% of those with rheumatoid arthritis, 77% of those with JRA and 100% of those with SLE. Patients with rheumatic diseases and SIgAD may therefore be particularly at risk of developing anti-IgA-mediated reactions to blood products. | |
| 6308404 | Persistent cytomegalovirus infection--the etiology of Sjogren's syndrome. | 1983 Apr | The persistence of Cytomegalovirus (CMV) with alteration of cell surface expression in certain tissues may initiate the tissue destruction that leads to the clinical manifestations of Sjogren's Syndrome. Salivary gland and lacrimal gland ductal cells are immunologically attacked due to CMV antigenic expression. The destruction of these ducts leads to xerostomia and keratonconjunctivitis sicca, the hallmarks of Sjogren's Syndrome. | |
| 7224690 | Olecranon nodules in a case of Behçet's disease. | 1981 Apr | A 33-year-old male with definite Behçet's disease had rheumatoid-like nodules at his elbows. This finding, we believe, represents another manifestation of vasculitis in Behçet's disease. | |
| 1221495 | Caplan's syndrome - a clinical study of 13 cases. | 1975 | Thirteen cases of Caplan's syndrome were investigated by chest X-ray, rheumatic and immunological tests, heart and lung physiology and pathological-anatomical specimens. No positive correlation was found between exposure time to silica, roentgenolgical findings, degree of rheumatoid factor or physiological findings. In nine of the cases a rapid roentgenological progress took place. Although the combination of lung infiltrations and rheumatic disorders makes an immunological reaction probable, no correlation was found between the degree of rheumatic disorder and roentgenological progress. The hypothesis that silica acts as an adjuvant, which may strengthen an antigen-antibody reaction, was not reflected in rheumatic parameters. The roentgenological examination appeared to be the most sensitive method for following the disease. | |
| 7065923 | [Cytological changes in the parotid gland in Sjögren's syndrome]. | 1982 | A detailed description of the punctate and secretion of the parotid gland in Sjögren's syndrome is presented. In all the stages of the disease 11 out of 12 sick women were found to have lymphocytes of various degrees of maturity, reticular cells, neutrophils and microflora. With the development of pathological changes the cell elements of the secretory and ductal epithelium were less frequently found in the preparations. Occasionally, altered myoepithelial and epithelial cells were observed. | |
| 198870 | [Rheumatic manifestations of Gougerot-Houwers-Sjögren syndrome]. | 1977 Jul | The authors retrospectively survey the concept of the Gougerot-Houwers-5jögren syndrome which links articular disease with the "dry" syndrome (pharyngitis sicca) and then go on to study the rheumatic conditions found in the Gougerot-Houwers-Sjögren syndrome. They point out that the association between the "dry" syndrome and rheumatic appearances varies in frequency according as whether the problem is seen from a rheumatological, dermatological, ophthalmological or stomatological point of view. They establish the frequency of the various rheumatic conditions, stressing the importance of the association with rheumatoid polyarthritis. They study the associated biological and visceral backgrounds, the thyroid, renal, digestive, blood, neural, allergic and immunological conditions and describe the rheumatic appearances of the other collagenoses associated with the "dry" syndrome. They conclude with the current difficulty of restricting the scope of the Gougerot-Houwers-Sjögren syndrome when histological and scintigraphic techniques have broadened it. They would like to see exact criteria adopted to define this syndrome. | |
| 312646 | The immunologic and clinical associations of the split products of C3 in plasma in juvenil | 1979 May | A qualitative counterimmunoelectrophoretic assay for the complement activation products C3c and C3d was used to study plasma from children with juvenile rheumatoid arthritis (JRA) and other rheumatic diseases. Positive tests for C3c,d were found in all patients with active systemic lupus erythematosus (SLE), 7 of 10 patients with active systemic JRA, 16 of 29 with active polyarticular JRA, 7 of 20 with active pauciarticular JRA, and in only 2 of 20 with inactive joint disease. The incidence of positive assays for C3c,d in JRA was increased in the presence of positive latex fixation tests, antinuclear antibody tests, or elevated values for antiglobulins as determined by affinity chromatography, but these associations were not statistically significant. Three joint fluids from children with pauciarticular JRA were negative for C3c,d. These studies show that the subgroups of JRA defined by clinical criteria are heterogeneous by current laboratory parameters and that evidence implicating antigen-antibody complexes in the pathogenesis of JRA is lacking in many patients. | |
| 266604 | HLA and juvenile chronic polyarthritis. | 1977 | HLA antigens were determined in 38 patients with juvenile chronic polyarthritis (JCP) and in 1,000 normal controls. The incidence of the antigen B27 in JCP (55.3 per cent) was higher than in the controls (6.7 per cent). Patients with JCP could be further subdivided into four groups: (1) JCP evolving to ankylosing spondylitis (AS) (N = 3); (2) JCP with sacroiliitis (SI) (N = 18); (3) JCP without SI (N = 10); and (4) juvenile rheumatoid arthritis (JRA) characterized by positive seroloty (N = 7). Groups 1 and 2 had a high incidence of B27 (20/21), as contrasted to groups 3 and 4 (1/17). The sex distribution in groups 1 and 2 was similar to that found in AS in adults, whereas in groups 3 and 4 it was similar to that found in rheumatoid arthritis in adults. It is concluded that if B27 positives develop JCP, they also have a high risk of developing SI and acute uveitis. The authors propose using the term Still's disease for the overall group of children presenting with JCP before the age of 16 years. Subsequent follow-up permits classification into juvenile AS, JCP with SI, JCP without SI, or as JRA. | |
| 24822820 | Functional evaluation of tendon interposition arthroplasty of the trapeziometacarpal joint | 1984 Jun | The carpometacarpal joint of the thumb is a frequent site of pain and disability secondary to arthritis. Surgical treatment for this disease has included arthrodesis, excision, total joint replacement, ligament reconstruction, and tendon or synthetic interposition arthroplasty. The aim of treatment is a functional, pain-free thumb. This study includes 11 patients operated upon utilizing tendon interposition arthroplasty; three patients had bilateral surgery. The primary disease was osteoarthritis in nine patients and rheumatoid arthritis in two. Average followup length postoperatively was 53 months. All patients experienced increased function and alleviation of pain after surgery. Average key pinch measured 8.4 pounds in the osteoarthritic female group. Palmar and radial abduction as well as opposition were full postoperatively. This study shows that tendon arthroplasty provides a painless, well-functioning thumb. Its main advantages over other procedures are the acceptable range of motion obtained, a short postoperative immobilization period, and the ease of its surgical technique. Indexing terms: tendon arthroplasty; osteoarthritis; rheumatoid arthritis; trapeziometacarpal joint. | |
| 3968106 | Late results of synovectomy in juvenile rheumatoid arthritis. | 1985 Jan | We reviewed the records of 251 patients whose cases were diagnosed between 1958 and 1978 at the Children's Hospital Medical Center Special Treatment Center for Juvenile Arthritis. We used a computerized system that included retrieval of data on range of motion, pain, joint swelling, functional capacity, and radiographic changes at each six-month visit over the years that the patient was followed. For the patients who were operated on, the radiographic information was evaluated preoperatively and at the last radiographic follow-up (average, six years after operation). The data bank contained postoperative radiographic information for thirty-two of the joints that had been operated on. We reviewed the late results of forty-one synovectomies in thirty children. The data included range of motion, swelling, and pain before operation, at one and two years after operation, and at an average of 7.1 years of follow-up. There were few if any benefits from the operation with reference to pain or improvement of range of motion, but it did seem to provide permanent relief of the joint swelling. Furthermore, radiographic deterioration seemed to continue in the joints that had been operated on if they already had radiographic changes at the time of operation (late synovectomy). In the joints without radiographic changes at the time of operation (early synovectomy), there seemed to be a continuation of deterioration in those affected by polyarticular disease, while the changes were less pronounced in those affected by pauciarticular disease. We undertook this study with a positive attitude toward synovectomy in the treatment of juvenile rheumatoid arthritis.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1062934 | Case report. The nonspecific rheumatoid subcutaneous nodule: its presence in fibrositis an | 1976 Jan | "Rheumatoid" subcutaneous nodules that were at one time considered diagnostic of rheumatoid arthritis or rheumatic fever have also been found in individuals withoug known disease, in patients with systemic lupus erythematosus, and in other conditions. In this report, subcutaneous nodules were described in one patient with fibrositis and in another scleroderma. Multiple pathogenic mechanisms are probably responsible for development of these nodules. |