Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6947392 | Micrognathia, temporomandibular joint changes and dental occlusion in juvenile rheumatoid | 1981 Aug | Clinical and radiographic examinations of the jaw skeleton of 20 patients aged 15-35 with juvenile rheumatoid arthritis (JRA) and a varying degree of micrognathia were made. Symmetrically underdeveloped mandible and unaffected maxilla were generally found by means of radiographic cephalometry. Overjet (5-15 mm) occurred in 10 patients, incisal protrusion in eight and distal molar relation in 16 (bilaterally in 10). Temporomandibular joint (TMJ) symptoms, mainly pain and morning stiffness, were reported from case histories in 13 patients. Symptoms and signs at the examination were few, except crepitus found in 11 patients, and restricted mouth opening observed in all the patients. In four patients no symptoms had ever been noted. Severe radiographic changes were a characteristic feature in all the patients. Mandibular size (gn-ar distance) was significantly smaller in patients with complete destruction of the mandibular head than in those with partial destruction, indicating a causal relationship between mandibular underdevelopment and arthritis of the TMJ. Flat fossa, anteroposition of remnants of the mandibular head and reduced condylar movement at maximum opening of the mouth were found. Etiologic factors of micrognathia in JRA are discussed, as well as demand and need for treatment. | |
| 322670 | Antiglobulins in juvenile rheumatoid arthritis. | 1977 Mar | With initial hopes of establishing a diagnostic test for juvenile rheumatoid arthritis (JRA), five types of immunoadsorbents were used to search for occult antiglobulins in sera from children. The immunoadsorbents included glutaraldehyde-aggregated globulin, heat- and glutaraldehyde-aggregated globulin, Affi-Gel-bound globulin, Sepharose-bound globulin, and bromozcetyl cellulose-bound globulin. The glutaraldehyde-aggregated immunoadsorbents retained nonspecific protein. The Affi-Gel, Sepharose, and bromoacetyl cellulose absorbents were effective and specific, but the Affi-Gel and bromoacetyl cellulose were impractical for routine use. Separose-bound globulin was selected for use in a survey of 52 patients with JRA and 8 normal children. Materials resembling occult antiglobulins, measured as acid elutable protein, were found in normal children as well as in children with JRA. Only a small proportion of children with JRA had statistically elevated levels of such occult anti-globulin consisted of IgM, IgG, and IgA, and had latex fixation activity in 2 of 5 tested sera from normal children and in 27 of 52 sera from children with JRA. Thus the presence of antiglobulins per se is not diagnostically helpful in distinguishing children with JRA. | |
| 1082363 | The risk of iridocyclitis in juvenile rheumatoid arthritis. | 1976 Jan | A retrospective study comparing 14 patients with juvenile rheumatoid arthritis (JRA) complicated by chronic iridocyclitis (Group I) with an equal number of JRA patients without this complication (Group II) was conducted to determine which factors might aid in the earlier diagnosis of chronic iridocyclitis. Eleven patients in Group I had oligoarticular disease compared to 5 in Group II. Antinuclear antibody was found in 13 patients in Group I compared to only 2 in Group II. Only one of nine patients tested in Group I for the histocompatibility antigen W-27 was positive. The patient with oligoarticular disease and a positive ANA test should be followed closely by the ophthalmologist for the development of chronic iridocyclitis. | |
| 7441661 | Total and free salicylate concentrations in juvenile rheumatoid arthritis. | 1980 Sep | Salicylates are known to be highly protein bound, primarily to albumin. Patients with juvenile rheumatoid arthritis (JRA) are known to have decreased albumin concentrations. Total and free salicylate concentrations were determined for 19 patients with JRA. Although many of these patients were below the normal therapeutic range, the percent of salicylate bound was essentially constant and did not differ significantly regardless of albumin concentrations or total salicylate concentrations. Elevated liver enzymes did not correlate with total or free salicylate concentrations. We conclude that total salicylate concentrations should be used for monitoring aspirin therapy in JRA. Free salicylate concentrations do not appear to be more reliable or feasible. | |
| 6322275 | Self-associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and | 1983 | Self-associating IgG rheumatoid factors isolated from three patients with rheumatoid arthritis activated human monocytes to release prostaglandin E2 as well as a previously described mononuclear cell factor, which stimulates human synovial cells to release additional prostaglandin E2 and collagenase. Thus, the immune complexes composed of self-associating IgG rheumatoid factors can contribute to the processes that destroy cartilage and bone in patients with rheumatoid arthritis. | |
| 6333045 | Radiographic appearance of the sternomanubrial joint in arthritis and related conditions. | 1984 Nov | The sternomanubrial joint (SMJ) was evaluated on the lateral chest radiograph in 177 patients with rheumatic disease and 69 non-rheumatic controls. Abnormalities were categorized as inflammatory changes, proliferative changes, or bone fusion. Patients with rheumatoid arthritis, psoriatic arthritis, or gout were found to have an increased incidence of inflammatory changes. Rheumatoid variants predisposed to early fusion of the SMJ. Patients with diffuse idiopathic skeletal hyperostosis (DISH) exhibited massive and unique hyperostotic changes. | |
| 6733970 | Precipitation of 19S IgM rheumatoid factor-IgG circulating immune complexes in patients wi | 1984 May | Immune complexes (IC) in sera and synovial fluid (SF) from patients with juvenile (rheumatoid) arthritis (JA) were isolated by making use of polyethylene glycol (PEG) to precipitate IC and then using staphylococcal protein A to separate the IC. The isolated IC were compared to IC in sera analysed by sucrose density gradients and measured by the C1q solid phase assay (ClqSPA). Isolated IC from sera of 10 of 16 JA patients demonstrated significant 19S IgM rheumatoid factor (RF) titres in their acid elutes utilizing the haemolytic assay. IgM and IgG were detected by low level radial immunodiffusion in the acid eluate of sera in all 10 patients who had significant RF titres. In isolated IC from SF, three of five JA patients had significant 19S IgM RF titres detected in their acid eluates. By sucrose density gradient analysis of these sera, elevated levels of IC detected by ClqSPA were found in the fractions of greater than or equal to 19S comparable to the previous isolated 19S IgM-IgG complexes. This detection of IC like material containing 19S IgM and IgG by the present method further supports the participation of classic and hidden 19S IgM RF in IC formation in JA patients. | |
| 7234770 | Compliance with salicylate therapy in adolescents with juvenile rheumatoid arthritis. | 1981 May | We compared adolescents' compliance with medical regimens with that of younger children and identified characteristics of noncompliant adolescents. Compliance among 82 patients with juvenile rheumatoid arthritis (JRA) was monitored using serum salicylate levels. Fifty-five percent of adolescents and 55% of children were found to have good compliance. Among adolescent patients with JRA, however, the following factors were associated with salicylate therapy non-compliance: longer duration of disease (more than six years); earlier age at onset (under 9 years); later time of referral to a subspecialist; shorter duration of subspecialty clinic care; and fewer clinic visits. Knowledge of these variables will facilitate development of intervention strategies tailored to meet the age-specific needs of this population with chronic illness. | |
| 305103 | Electrophoretic mobility of lymphocyte populations in juvenile rheumatoid arthritis. | 1977 | Peripheral blood lymphocytes from 16 patients with juvenile rheumatoid arthritis and 27 age-matched healthy controls have been studied, using several lymphocyte markers: electrophoretic mobility (EM), E-rosettes, immunofluorescence, and refringency. Eight patients (mean age, 6 years) were selected with a typical EM pattern--that is, a decrease in the mean EM of T cells and increase in B versus T-cell ratio. The other group of patients (mean age, 11 years) showed no significant difference when compared with their age-matched controls, with the exception of the positive refringence test. These findings suggest an impairment in the maturation of the immune system in childhood, which in turn may be responsible for the increased susceptibility to disease. | |
| 7291954 | Mandibular growth, temporomandibular joint changes and dental occlusion in juvenile rheuma | 1981 | To evaluate the mandibular growth and temporomandibular joint (TMJ) changes in juvenile rheumatoid arthritis, a clinical and radiographic 17-year re-examination of 9 of 19 patients has been carried out. A varying degree of micrognathia (mandibular retrognathia, 'bird face') was observed by means of radiographic cephalometric analysis, at both the base-line and follow-up examination of 6 of the patients. No facial asymmetry was found. Rotation of the mandible in relation to the anterior cranial base during the follow-up period, observed in 5 of the 6 patients, indicated a further disturbance of mandibular growth. In 3 patients with mandibular rotation, a dental occlusion anomaly was observed. The TMJ revealed radiographic changes in 6 patients at the base-line examination and in all patients at the re-examination. Micrognathia and the dental occlusion anomaly were associated with radiographic TMJ changes. | |
| 6979831 | [Seronegative, HLA-B27-positive arthritis (a preliminary report)]. | 1982 | Fifty two patients, 29 males and 23 females, with seronegative polyarthritis, carriers of tissue-compatible antigen HLA--B27 manifested characteristic clinical signs: the disease started at young age--29; it progresses, most frequently, with attacks--acute or subacute as monoarthritis (gonitis) or oligoarthritis, the lower limb joints predominantly involved. The periarticular structures are very often involved in the process--achillitis, styloiditis, talagia and sarcoiliac joints--sarcoiliitis clinically and scintigraphically confirmed. With the family examinations of the patients' relatives the following cases were established: 9 cases with Bechterew's disease, four cases with sacroiliitis, one--with iridocyclitis, two patients with rheumatoid arthritis and 18 healthy carriers of HLA--B27 antigen. The dynamics of the development of typical ankylozing spondylitus was a favourable prognosis and the treatment, most often, covers--nonsteroid anti-inflammatory drugs or low doses of corticosteroids--generally or locally. | |
| 24822607 | Surgical management of the symptomatic cervical spine in rheumatoid arthritis. | 1982 May 1 | Eleven spinal fusions were performed on 10 patients with symptomatic cervical spines secondary to rheumatoid arthritis. A variety of surgical procedures and various types of postoperative immobilization were used. The average patient age at surgery was 43.2 years, with an average followup of 36.9 months. Six of these patients had instability at C1-2, one each at C4-5, C5-6, and C6-7, and one patient had a complete myelographic block without instability at C5-6. Six of the patients presented with neurologic symptoms - all improved; some dramatically. There were no deaths, four transient complications, and no pseudarthroses. Some authors advocate routine, supine, prolonged skull traction postoperatively. We believe that this is not necessary in the uncomplicated rheumatoid spinal fusion, and may be detrimental. Other recommendations for conservative and surgical management are also made. | |
| 3930720 | Slow acting antirheumatic drugs in patients with juvenile rheumatoid arthritis--evaluated | 1985 Jun | Seventy-two consecutive patients with pauciarticular and polyarticular juvenile rheumatoid arthritis (JRA) were randomized into a parallel 50-week open, controlled, comparative trial of hydroxychloroquine (HC), gold sodium thiomalate (GSTM) and D-penicillamine (PEN). Similar improvement of disease activity measurements and reduction of the erythrocyte sedimentation rate were seen in all 3 groups. No HC treated, 3 GSTM treated and 6 PEN treated patients were withdrawn because of adverse reactions. The results of our study indicate that HC is better tolerated than GSTM and especially PEN, but that the drugs are comparable with regard to efficacy in patients with pauciarticular and polyarticular JRA. | |
| 6437413 | Cytotoxic anti-T cell antibodies in children with juvenile rheumatoid arthritis. | 1984 Nov | The object of this investigation was to determine the prevalence of anti-T cell antibodies in 66 children with various connective tissue diseases. Anti-T cell antibodies were found in 43/44 juvenile rheumatoid arthritis (JRA) patients (mean cytotoxicity 15.0%) and in 10/10 children with systemic lupus erythematosus (mean cytotoxicity 20.0%), but in only 1/15 normal controls and in none of 12 children with other arthritides. There was no significant difference in mean percent cytotoxicity among the JRA subclasses. In the JRA patients, the percent cytotoxicity was positively correlated with the erythrocyte sedimentation rate (P = 0.01), but not with the presence or absence of rheumatoid factor, antinuclear antibodies, or immune complexes. The sera of 3 JRA patients repeatedly inhibited the stimulation of normal lymphocytes by mitogens and antigens by 47-99% (measured by the incorporation of 3H-thymidine into DNA) when added to the culture system in the first 24 hours; normal sera did not. Sera from patients with JRA have increased reactivity with mitogen-activated lymphocytes and T cells compared with unstimulated cells as determined by flow cytometry. The expression of the "JRA antigen" requires protein synthesis but not DNA synthesis or cell division. We conclude that the majority of patients with active JRA have cytotoxic anti-T cell antibodies and that in selected patients, these antibodies may play a role in regulation of the immune response. | |
| 103189 | Gold serum levels in children with juvenile rheumatoid arthritis. | 1978 | Serum gold levels were monitored in 66 children with juvenile rheumatoid arthritis, treated with different i.m. dosage schedules of sodium aurothiomalate (Myocrisin, Pharma Rhodia). The ages of the children varied from 1 to 15 years. Gold serum levels in children were related to the dose of Myocrisin calculated per kg of body weight or per square metre of body surface area. The results of our study indicate that in order to achieve a peak serum level at about 500--600 microgram/100 ml (25--30 micromol/l) with weekly injections, the dose of Myocrisin should be about 0.7 mg/kg, or 20 mg/m2. In order to avoid excessively high gold serum concentrations, the maximum single dose should not exceed 27 mg/m2 of body surface area. | |
| 3932059 | [Interferon in chronic polyarthritis. Positive effect in clinical evaluation]. | 1985 Nov 15 | During the last two years, 80 patients with definite chronic rheumatoid arthritis were treated with interferon-gamma. Considerable improvement in the clinical picture occurred in 58, with pain decreasing rapidly and lastingly or even disappearing. Even in largely immobile patients the ability to walk and general mobility were nearly fully restored. The treatment was well tolerated in 74 patients. As the substance is administered subcutaneously it is suitable for out-patient treatment. | |
| 1259792 | Intraarticular activation of the complement system in patients with juvenile rheumatoid ar | 1976 Mar | Analyses of CH50, complement components, properdin factors, and kininogen in synovial fluid of patients with juvenile rheumatoid arthritis revealed evidence of activation of the classic complement pathway in all clinical subgroups. Juveniles with the adult pattern of disease had the greatest incidence of complement abnormalities. Evaluation of individual components by both activity determination and protein measurement showed decreased synovial fluid specific functional activity (activity per microgram protein) to the more marked in synovial fluids with profound depressions of complement activity. These findings provide further evidence that nonfunctional, antigenically intact component protein may remain after complement activation. Radial immunodiffusion measurements of properdin factors and kininogen failed to support their involvement in joint inflammation. Serum complement component measurements by activity but not protein concentration correlated with other parameters or inflammation. Four patients had isolated depressions of serum C2 activity. Immunoglobulin levels, particularly IgA, correlated with some complement measurements and with the sedimentation rate. | |
| 3872364 | HLA-DR and MT associations with the clinical and serologic manifestations of pauciarticula | 1985 Feb | Significant HLA-DR and MT associations were observed with certain clinical and serologic manifestations of pauciarticular onset juvenile rheumatoid arthritis (PO-JRA). An increase in the MTI frequency was found in 56 children with PO-JRA in comparison to 95 normal controls. This association was limited to children with a younger age of onset (less than 6 years) and a persistent pauciarticular course. An increase in HLA-DRW8 and a decrease in DR4 were associated with a younger age of onset and antinuclear antibody (ANA) seropositivity. In addition, an increased frequency of DR5 was seen in ANA positive children. All of these HLA-DR and MT associations were independent of coassociating Ia specificities. | |
| 942498 | Allergy in systemic lupus erythematosus. IgE levels and reaginic phenomenon. | 1976 Jul | Twenty-seven patients with systemic lupus erythematosus (SLE) were investigated for the presence of allergic reactivity, and serum IgE levels were measured by immunoassay. Compared to controls, SLE patients had significant increases of only allergic rhinitis and drug allergy. Despite the usual hyperimmunoglobulinemia in SLE, IgE levels were not elevated (mean: 251 IU). Because recent reports have noted elevated IgE in rheumatoid arthritis, this finding may suggest basic immunologic differences between rheumatoid arthritis and SLE. | |
| 6362682 | [Psoriatic arthritis: considerations on recent studies: serum beta 2 microglobulin and cir | 1983 Sep 30 | The results of two recent studies of our group have been reported. They regard two immunological parameters of psoriatic arthritis: the proportions of T gamma lymphocytes in peripheral blood and the beta 2 microglobulin in the serum. The data obtained in psoriatic arthritis patients have been compared to those found in normal controls and in rheumatoid arthritis patients. T gamma mean values in psoriatic arthritis were significantly lower than those present in healthy subjects and in rheumatoid patients. These last patients showed beta 2 microglobulin mean values significantly higher than those observed in normal controls and in psoriatic arthritis patients. Conversely, the mean of beta 2 microglobulin levels in psoriatic arthritis has been found to be similar to that observed in normal controls, but a superimposition in the range of individual values of these two groups with the concentrations determined in rheumatoid subjects has been found. These results seem to be of interest in relation to the immunopathogenetic mechanism of psoriatic arthritis, but are of little help in the clinical differentiation of the two rheumatological affections considered. |