Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 300101 | A study of specificities of antinuclear antibodies in juvenile rheumatoid arthritis. | 1977 Mar | The sera from 77 children with juvenile rheumatoid arthritis were studied for the presence of antinuclear antibodies, rheumatoid factor, and for antibodies to seven well-characterized nuclear antigens which occur in specific rheumatic diseases of adults. These included: Sm, RNP, DNA, RNA, RAP, SS-A, and SS-B. Forty-nine percent of the sera from patients with JRA contained ANA. The most common pattern was speckled. The frequency of all other positive tests was too low (13%) to make correlations with disease states. However, a small group of girls with polyarticular and late-onset disease had a high incidence of RF or RAP. These two antibodies were not associated with each other as they are in adult RA. | |
| 6830383 | Nonreducible rotational head tilt and atlantoaxial lateral mass collapse. Clinical and roe | 1983 Mar | Nonreducible rotational head tilt resulting from predominantly unilateral collapse of the lateral mass of the atlas (C1) and/or axis (C2) has been characterized in patients with rheumatoid arthritis. An identical phenomenon is reported in five patients with juvenile rheumatoid arthritis (JRA) and in six with ankylosing spondylitis (AS). Most patients had neck pain and crepitus, all had a fixed head tilt deformity, and most also had a rotational deformity. Roentgenographically, all had predominantly unilateral collapse of the lateral masses of C1 and/or C2, and the head always tilted toward the most collapsed side. The patients with JRA had polyarticular disease of long duration and generally mild neck symptoms, with only one requiring neck surgery for pain. The patients with AS tended to have proximal peripheral joint involvement and long-standing disease with more severe neck symptoms; four underwent posterior cervical fusion for intractable pain. None of the 11 patients had demonstrable neurologic deficits. | |
| 671436 | Familial polyarticular osteochondritis dissecans masquerading as juvenile rheumatoid arthr | 1978 Summer | A boy with polyarticular osteochondritis dissecans presented with clinical features of juvenile rheumatoid arthritis. Examination of the synovial fluid of an involved joint demonstrated inflammatory characteristics. Osteochondritis dissecans was present in the patient's mother and brother. Human leukocyte antigens HLA A-2, BW-15 and CW-4 were identified in the affected individuals. | |
| 7123180 | Diagnostic criteria of rheumatoid arthritis in children. Proposed criteria for controlled | 1982 | Several different sets of diagnostic criteria of rheumatoid arthritis in children are in practical use. The criteria most widely applied are discussed here, especially with regard to clinical studies. Reasons are presented for the selection of criteria used in the present controlled clinical studies on rheumatic children in Oslo. Three modifications were made in the North-American criteria: 1) disease onset before 16 years of age; 2) persistent arthritis for more than 3 months; 3) biopsy is preferable in monarticular cases, except in patients with chronic iridocyclitis. | |
| 21283474 | Common foot problems in the arthritic patient. | 1983 Nov | The various arthridities, particularly rheumatoid arthritis and osteoarthritis, are a significant cause of pain in the foot. Symptoms may be due mainly to arthritis, but also may be complicated and even initiated by abnormal biomechanics of the foot. This article discusses the various arthritidities-osteoarthritis, rheumatoid arthritis, gout, psoriatic and non-specific arthritis-and how they affect the foot. By initiating appropriate conservative or surgical treatment in the arthritic disease's early stages, family physicians can prevent serious deformities from developing in the foot. | |
| 3901663 | Acetylsalicylic acid and juvenile rheumatoid Arthritis. Effect of dosage interval on the s | 1985 Sep | A 2-dose regimen and a 3-dose regimen, both with the same daily dose of acetylsalicylic acid, were compared in 8 patients with juvenile rheumatoid arthritis. The regimens were given according to a cross-over design. The serum salicylic acid levels over 24 hours were studied at the end of each treatment period. As expected somewhat greater fluctuations in the salicylic acid levels were observed with the 2-dose than with the 3-dose regimen. However, therapeutically effective serum levels were observed for most of the 24 hour period with both regimens. It is suggested that a 2-dose regimen has advantage with regard to simplicity and compliance. The pharmacokinetic findings indicate that a 2-dose regimen may be useful in patients with juvenile rheumatoid arthritis. | |
| 2415294 | Fever in various rheumatic diseases. | 1985 Sep | In many rheumatic diseases fever may occur. This review presents data about the frequency of fever in rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, crystal induced arthritis, various vasculitides and sarcoidosis. The mechanism by which body temperature rises in these situations is discussed. | |
| 7196576 | Juvenile rheumatoid arthritis. Mode of onset as key to early diagnosis and management. | 1981 Sep | Juvenile rheumatoid arthritis, which affects almost a quarter of a million American children, is diagnosed at the patient's first visit to the physician in only about half of all cases. Early diagnosis rests on recognition of three distinct modes of onset and is important in preventing deformities, blindness, and even death. | |
| 685890 | Erythroid aplasia in juvenile rheumatoid arthritis. | 1978 Aug | A 9-year old girl had clinical manifestations of juvenile rheumatoid arthritis that were further complicated by severe anemia. Subsequent studies showed the anemia to be due to erythroid aplasia. Hematologic remission was induced with prednisone, 60 mg/day. | |
| 12466 | [Juvenile rheumatoid arthritis and related collagen diseases. Clinical aspects (author's t | 1976 Dec | Juvenile rheumatoid arthritis or, more correctly, juvenile chronic polyarthritis with its many clinical manifestations can be separated into the Still-syndrome with acute beginning, high fever and a high percentage of extra-articulalar, i.e. visceral symptoms, and the chronic polyarthritis in the more strict sense with non-visceral symptoms. The subsepsis allergica should be regarded as a subseptic first stage of the Still syndrome. The Still-syndrome implies a systemic disease mainly of the reticulo-endothelial system, with carditis, nephropathy, recurrent erythemas, and a progressing polyarthritis. Later symptoms are amyloidosis, chronic nephritis, myo- and pericarditis, and artheriitis necroticans. Predominanly the involvement of the kidneys is the reasons for the high mortality rate of 13%. Chronic polyarthritis in the strict sense is similar in children and adults, though in children rheumatic factors are rarely detected. The exsudative form of arthritis tends to cause early deterioration. Joint symptoms are distributed asymmetrically and show locally inflammed growth otherwise less common in Still-syndrome. Spondylitis cervicalis rapidly causes ankylosis. Atlanto-axial-arthritis with consequent atlanto-axial dislocation can be the reason for neurological disturbances. Juvenile mono- or oligo-arthritis often turns into polyarthritis; but for joints the prognosis is more favourable. In contrast, rheumatoid iridocyclitis as found in 22% of the cases causes unfavourable complications because symptoms are not noticed in time so that treatment is often too late. Juvenile spondylitis ankylosans begins with a peripheral arthritic stage which is not easily distinguished from chronic polyarthritis. The male sex, mono- or oligoarthritis of the outer extremities, pain in the heel, atlanto-axial-arthritis, iridocyclitis, and a positive HLA of 27 give a diagnostic clue. -- Characteristics of the therapy will be discussed. | |
| 7403511 | Proliferative changes of the hip in juvenile rheumatoid arthritis. | 1980 Aug | A ring of proliferative osteophytes at the junction of the femoral head and neck has been described as a characteristic finding in patients with ankylosing spondylitis. A review of 55 cases of juvenile rheumatoid arthritis, without evidence of sacroiliitis, revealed an identical ridge of osteophytes in 5. | |
| 7194374 | Chlorambucil in the treatment of iridocyclitis in juvenile rheumatoid arthritis. | 1981 Jan | A patient with chronic, progressive, iridocyclitis secondary to pauciarticular juvenile rheumatoid arthritis (JRA) is described. The patient's iridocyclitis was unresponsive to topical, systemic, and subtenon injections of corticosteroids, but did respond to low doses of chlorambucil. The use of immunosuppressives may be indicated in severe, unresponsive iridocyclitis secondary to JRA. | |
| 443214 | Primary ovarian failure, juvenile rheumatoid arthritis, and vitiligo. | 1979 Jun | A female adolescent with primary ovarian failure was found to have circulating autoantibodies to her ovaries. Primary ovarian failure in pediatrics is usually attributed to gonadal dysgenesis. Autoimmune oophoritis is a rare cause and is most often associated with Addison's disease and other autoimmune endocrinopathies. Our patient also had juvenile rheumatoid arthritis and vitiligo. To our knowledge, this case represents the first reported instance of this particular constellation of autoimmune disorders. | |
| 6797606 | Arthritis in Saxon and mediaeval skeletons. | 1981 Dec 19 | Examination of 400 Saxon, Romano-British, and mediaeval skeletons from seven archaeological excavations in the west of England showed an unexpectedly high incidence of osteoarthritis and osteophytosis. Three skeletons had evidence of an erosive peripheral arthritis-one with probable gout, one probable psoriatic arthropathy, and one with possible rheumatoid arthritis. The pattern and types of rheumatic disease, and the resultant disability, were apparently different. An exuberant form of large joint osteoarthritis was common and rheumatoid arthritis and similar diseases rare. | |
| 3159072 | [Functional, social and professional outcome of patients with juvenile chronic arthritis s | 1985 Mar | The authors assessed the outcome of children with juvenile rheumatoid arthritis following an average of 18 years since the onset of the illness. Two-thirds of the patients with the systemic form were asymptomatic. Juvenile rheumatoid arthritis which began with pauciarticular involvement and progressed to polyarticular involvement had the most severe disability, affecting 25% of these patients. Social and professional pursuits were most often satisfactory in spite of numerous problems encountered during the school years. | |
| 849853 | [Pathogenetic concept of experimental mycoplasma arthritis]. | 1977 Feb 17 | Biochemical studies of rats with mycoplasma arthritis revealed new findings in pathogenesis and pathophysiology. Mycoplasma infection which resembles rheumatoid arthritis, leads to an inhibition of the DNA-repair. We were able to proof this enzyme--kinetically and autoradiographically. We also observed for the first time the occurrence of DNA-antibodies in this type of arthritis. It is possible that there is a relation between inhibition of DNA-repair and the occurrence of DNA-antibodies. Thus mycoplasma infection seems to influence DNA-metabolism. There are interesting parallels concerning DNA-antibodies and DNA-repair between experimental mycoplasma arthritis and human systemic lupus erythematosus and rheumatoid arthritis. | |
| 6493840 | Favorable effect of dimethyl sulfoxide on secondary amyloidosis in juvenile rheumatoid art | 1984 | A girl with secondary amyloidosis as a complication of juvenile rheumatoid arthritis was administered dimethyl sulfoxide by topical application to the skin. Her gastrointestinal symptoms and massive proteinuria improved. Decreased left ventricular function and creatinine clearance also improved remarkably. The favorable effect of dimethyl sulfoxide in this single patient deserves further study in a controlled trial. | |
| 1059058 | Temporomandibular ankylosis secondary to rheumatoid arthritis. Report of a case. | 1975 Nov | A case of unilateral bony ankylosis of the temporomandibular joint secondary to rheumatoid arthritis is presented, and the surgical treatment and postoperative regime are suggested. It is believed that, with proper motivation of the patient, an adequate oral opening may be maintained. | |
| 24822986 | Selective hindfoot arthrodesis in rheumatoid arthritis. | 1984 Jan 1 | Rheumatoid arthritis that involves the hindfoot is disabling because it affects the patient's ability to walk. Fifteen patients with ankle pain who demonstrated isolated hindfoot arthritis clinically and radiographically underwent 19 selective hindfoot arthrodeses. At followup averaging 3 ½ years, results were rated good in 16, fair in four, and none were rated poor. Selective hindfoot fusion is effective in relieving pain and restoring the foot to ambulatory status. | |
| 7279462 | Pericarditis and cardiac tamponade in juvenile rheumatoid arthritis. | 1981 Sep | Cardiac tamponade is a rare complication of juvenile rheumatoid arthritis. Three cases seen in the last two years at the Children's Hospital of Philadelphia are reported and compared to four previously reported cases. All three children had systemic-type juvenile rheumatoid arthritis with tachypnea, shortness of breath, and chest pain. Cardiac signs in these children included decreased heart sounds, pericardial friction rub, jugular venous distention, and pulsus paradoxus greater than 12 mm Hg. Roentgenograms of the chest showed cardiomegaly with bilateral pleural effusions. Electrocardiograms showed sinus tachycardia and nonspecific ST-T wave changes. Echocardiograms demonstrated pericardial effusions in all subjects and poor ventricular movements in one child. All three children were treated with short-acting anti-inflammatory drugs and/or prednisone. Pericardiocentesis was performed in two cases. There was no significant morbidity after a mean follow-up of two years. |