Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7432643 | [Celiac disease: association with rheumatoid arthritis and diabetes mellitus. Apropos of a | 1980 Aug 25 | A case of coeliac disease accompanied by serum-negative rheumatoid arthritis and (subsequently) by diabetes mellitus is described. The appearance of a similar clinical and sympatomatological enteric and articular picture in one of the patient's brothers is seen as evidence that the link between the components of the three-fold syndrome is to be found in common genetic factors, with an onset in the form of a cellular and biohumoral immunological disorder. | |
| 897588 | The nitroblue tetrazolium test in juvenile rheumatoid arthritis and the stimulation of gra | 1977 | The spontaneous NBT test was used in 57 children with juvenile rheumatoid arthritis (JRA) and another connective tissue diseases. The patients were grouped according to the various manifestations and divided into different stages of activity. The patients with tendosynovitis and unknown arthralgia showed a negative test. Patients with morbus Wissler without exudative joint manifestations were also NBT-negative, to a large degree. By contrast, all manifestations with joint involvement showed a high per centage of positive results in the NBT test. In a second investigation, the granulocytes of normal persons were stimulated by sera of patients with various manifestations of JRA. The sera of patients with joint manifestations all caused a stimulation of the granulocytes of normal persons, compared with the controls, in which pooled human serum was employed. Stimulation of granulocytes with serum of Wissler patients proved impossible, however. | |
| 879864 | Serum uric acid levels in psoriatic arthritis. | 1977 Jun | Serum uric acid levels were determined in patients with psoriatic arthritis on and off medication, with rheumatoid arthritis on no medication likely to alter serum values, and in patients with uncomplicated psoriasis. Values in males were higher than those in females. A larger prevalence of values above the normal range were seen in males with psoriatic arthritis on uncontrolled medication (13-5%) and in males with rheumatoid arthritis (12%) than in the other groups. The means for both these groups were around the midpoints of the normal range. These findings suggest that hyperuricaemia is not a common characteristic of psoriatic arthritis. | |
| 7120235 | Immune complexes in juvenile rheumatoid arthritis: a comparison of four methods. | 1982 May | Fifty-three children with juvenile rheumatoid arthritis (JRA) were tested for immune complexes (IC) by 4 different methods, Clq solid-phase assay (ClqSPA), 2% polyethylene glycol precipitation assay (PEGPA), Raji cell assay (RCA), and the conglutinin assay (KA). Seventy-nine % of JRA patients demonstrated elevated IC levels by at least 1 method. Fifty-eight % of the JRA patients have elevated levels of IC by ClqSPA, 50% by the RCA, 37% by the KA, but 0% by the PEGPA. Seventy-four % of patients with polyarticular-onset, 88% of pauciarticular-onset, and 80% of systemic-onset JRA showed elevated levels of IC by at least 1 method. In the polyarticular-onset group, both in the rheumatoid factor (RF) positive (100%) and RF negative (64%) patients, and in the systemic-onset group (60%) the most elevated levels were demonstrated by the ClqSPA. The most elevated levels were found in the pauciarticular-onset type (69%) by the RCA. The presence of elevated levels of IC by the KA correlated with the presence of RF (p less than 0.01), hidden RF (p less than 0.05), and antinuclear antibodies (p less than 0.005). Elevated levels of IC detected by the ClqSPA correlated with the presence of RF (p less than 0.01), hidden RF (p less than 0.05), and active disease (p less than 0.01). | |
| 7410470 | Monarticular juvenile rheumatoid arthritis. | 1980 Aug | Seven out of 22 children with monarticular juvenile rheumatoid arthritis (MJRA) developed involvement of other joints between six months and three and a half years from the onset. In the other 15 patients the disease has remained monarticular for between one and 16 years (mean six years). Chronic iridocyclitis was seen in three of the five boys, two with antinuclear antibodies. Children with MJRA and antinuclear antibodies should have periodic ophthalmic assessment. Synovial biopsy was of value primarily in excluding other cases of arthritis, but there was only limited correlation between the histological findings and the subsequent course of the disease. | |
| 24831468 | Plexiform neurofibroma presenting as wrist synovitis: a case report. | 1982 Oct | This is a case report of plexiform neurofibroma of the wrist presenting as a diffuse wrist mass mimicking juvenile rheumatoid arthritis. Although radiologic and clinical findings were consistent with juvenile rheumatoid arthritis, the biopsy diagnosis was plexiform neurofibroma. To our knowledge, a similar case has never been reported. | |
| 3873917 | Hidden 19S IgM rheumatoid factor in adults with juvenile rheumatoid arthritis onset. | 1985 May | Forty-eight adult patients with juvenile rheumatoid arthritis (JRA) (onset before age 16 years) were evaluated at the age of 17 years or more for the presence of hidden 19S IgM rheumatoid factors (RF), i.e., 19S IgM RF that can be detected by the complement-dependent haemolytic assay in the IgM-containing fraction after separation of the serum by acid gel filtration. The average age of the patients was 25.3 years. The mean duration of disease was 16.5 years. Thirty-two of 48 patients (67%) showed the presence of hidden 19S IgM RF in their serum. Disease activity correlated with hidden RF titres in 62% (55/88) of the evaluations. The results indicate that patients with seronegative JRA onset continue to have significant titres of hidden 19S IgM RF in their sera into early adulthood. | |
| 3897537 | Hidden and classical 19S IgM rheumatoid factor in a juvenile rheumatoid arthritis patient. | 1985 Apr | Hidden 19S IgM rheumatoid factors (RF), i.e., 19S IgM RF which can be detected in the IgM containing fraction after acid gel filtration of serum, are found in 59-68% of patients with juvenile rheumatoid arthritis (JRA). Their presence generally correlates with disease activity. We describe a 12 year-old female with a polyarticular onset of JRA who, during her first 15 months of disease, was seronegative but had hidden RF titers of 1:128----1:256. Inhibition studies on her hidden RF showed specificity for HIgG greater than RIgG and equal specificity for the human IgG subclasses (IgG1 = IgG3). In the second and third year of disease, she became seropositive with RF titers varying from 1:40 to 1:320 while her hemolytic titers on her IgM fractions were decreased from 1:128 to 1:32. Inhibition studies now demonstrated a higher avidity for RIgG; and HIgG3 inhibited more than HIgG1. These studies documented for the first time a JRA patient who early in the disease was negative for RF and positive for hidden RF, and who later became seropositive. | |
| 1172374 | Iridocyclitis associated with juvenile rheumatoid arthritis. | 1975 Sep | In a study of 45 patients, those with monarticular and pauciarticular juvenile rheumatoid arthritis, and with antinuclear antibodies, were likely also to have chronic, persistent iridocyclitis. In cases where iridocyclitis was present, topical mydriatics were used to prevent formation of posterior synechiae. Topical corticosteroids were used but discontinued if the uveitis failed to respond. Despite the generally poor prognosis for the vision of these patients, surgery for complicated cataract was often successful. | |
| 24823124 | Evaluation of the pritchard total elbow arthroplasty. | 1982 Jun 1 | Total elbow arthroplasty is a valuable therapeutic modality in incapacitating degenerative joint disease from rheumatoid arthritis. This study is a retrospective analysis of 17 elbow arthroplasties in 13 patients with rheumatoid arthritis using the Pritchard elbow prosthesis. The Pritchard elbow prosthesis has several distinctive design features. This is a semiconstrained prosthesis that has abduction, adduction and rotational capabilities. The prosthesis requires minimal bone resection, providing significant inherent stability. Patient selection for this study has been limited to incapacitating degenerative joint disease from rheumatoid arthritis. The grading system of Pritchard has been adopted to evaluate the results of this study. Greater than 94% of the patients obtained excellent and good results. All of the patients were satisfied with their results. Complications included transient ulnar neuropathy, humerus fracture, and Mark I humeral component fracture. There were no infections and no loosening. The complications reflected technical problems and design limitations of the Mark I prosthesis only. Careful patient selection is the key factor in total elbow arthroplasty. | |
| 7420340 | Shoulder joint rupture in juvenile rheumatoid arthritis producing bicipital masses and a h | 1980 Jul | Multiple episodes of shoulder joint rupture leading to the development of bicipital masses occurred in a 6-yr-old boy with the systemic form of juvenile rheumatoid arthritis. Observations made during the rapid evolution of the masses included early physical findings in the proximal upper arm which suggested a malignancy. An unusual hemorrhagic sign appeared in the cease of the elbow. A sequence of events is postulated to explain the course of development of these masses. | |
| 7465283 | Hidden 19S IgM rheumatoid factor in juvenile rheumatoid arthritis. | 1980 Oct | One-hundred twenty-five serum samples from 82 patients with juvenile rheumatoid arthritis (JRA) were studied for the presence of hidden rheumatoid factor (RF) in an effort to find a better serologic marker to define JRA. Hidden 19S IgM RF was detected by means of a hemolytic assay utilizing the IgM-containing fraction of serum. The IgM fraction was obtained after acid separation of serum on a Sephadex G-200 column. Hidden 19S IgM RF was present in 68% of patients with seronegative JRA with a mean titer of 1:63. The mean titer for the polyarticular JRA group was 1:83, for the pauciarticular JRA group, it was 1:32, and for the systemic type-onset JRA patients, it was 1:32. When disease was active, the mean titer for all JRA patients was 1:108, for the active polyarticular JRA group it was 1:119, for the active pauciarticular JRA, it was 1:97, and for the active systemic JRA patients, it was 1:64. All values were significant at the P less than or equal to 0.001 when compared to disease and normal controls. The hemolytic assay for RF on the IgM-containing fraction of serum thus enhances the serologic capabilities of defining JRA. | |
| 6332502 | Skeletal changes in neuromuscular disorders mimicking juvenile rheumatoid arthritis and he | 1984 Oct | Seven patients with neuromuscular disorders were examined, including one with cerebral palsy, one with Duchenne muscular dystrophy, two with paraplegia, and three with poliomyelitis; all exhibited skeletal changes mimicking those found in juvenile rheumatoid arthritis and hemophilia. These findings included apparent overgrowth of the epiphyses, periarticular osteoporosis, and joint-space narrowing in seven subjects; accentuation of the trabecular pattern in six; gracile bones and soft-tissue wasting in five; tibiotalar slant in two; and premature epiphyseal closure in one. Changes in osseous vascular dynamics and the debilitation or immobilization found both in patients with neuromuscular disorders and those with arthritis may help explain these overlapping findings. While the clinical distinction between the neuromuscular and arthritic disorders is straightforward, the similarity in radiographic appearance has received little attention. If the clinical history is inadequate, this may result in confusion or misinterpretation by the radiologist. In the absence of more specific findings, such as articular erosions or erosions of the femoral intercondylar notch, the differential diagnosis may be mistakenly limited to juvenile rheumatoid arthritis and hemophilia. In such cases, the neuromuscular disorders should also be considered in the differential diagnosis. | |
| 324480 | Antibody levels to enteric bacteria in juvenile rheumatoid arthritis. | 1977 Apr | In order to determine the immunologic status and possible susceptibility to bacterial infection in children with juvenile rheumatoid arthritis (JRA), titer of hemagglutingating antibodies to E coli 055, E coli 086, common antigen, and Shigella polyvalent antigen were measured. Immunoglobulin G was the predominant antibody. IgA antibodies were found in higher titer in children with JRA. No significant differences were found between children with JRA do not have any deficit in antibody production to specific bacterial antigens, and any increased appearance of infection in these children is more probably due to deficiencies in cellular factors. | |
| 1138259 | The "patellar ratio" in hemophilia and juvenile rheumatoid arthritis. | 1975 Jul | The ratio of patellar length to width was analyzed in comparison with subjective examination using radiographs of the affected knees in patients with hemophilia, juvenile rheumatoid arthritis (JRA), and controls to determine the usefulness of this measurement in differentiating the two diseases. A statistically significant difference was found between the proportion of JRA patients, controls, and patients with hemophiliac arthritis involving the knee. It was difficult to distinguish hemophilia from JRA by subjective analysis of the appearance of the knee using standard criteria. The patellar ratio is a more objective criterion which should be helpful in the radiological differentiation of JRA from hemophilia affecting the knee. | |
| 7249018 | Massive calcification of the mitral annulus in a 17-year-old patient with juvenile rheumat | 1981 | Mitral annulus calcification (MAC), while a relatively frequent autopsy finding in older patients, is rare in childhood. Such calcification has generally been regarded as a degenerative change and of no clinical significance. Recent studies have shown that MAC may be associated with hemodynamically significant lesions including mitral insufficiency, arrhythmias, heart block, and, rarely, mitral stenosis. We have studied a case of massive calcification in the mitral annulus in a 17-year-old girl with juvenile rheumatoid arthritis and systemic lupus erythematosis. In this case, the MAC was considered secondary to the rheumatoid disease. MAC in younger patients with no history of rheumatic fever or bacterial endocarditis suggests an associated connective tissue disorder. | |
| 263922 | Corticosteroids in juvenile rheumatoid arthritis. | 1977 Mar | Corticosteroids, although potent suppressors of symptoms and signs of disease, are not effective in curing rheumatoid arthritis in adults or children. Prolonged use of corticosteroids is attended with multiple serious side effects. In JRA, the outlook for most children is good; potentially dangerous drugs should be avoided if at all possible. The indications for corticosteroid usage in JRA might be summarized as: Severe systemic disease unresponsive to salicylates Chronic iridocyclitis unresponsive to topical steroids. Only very rarely for severe arthritis per se; and then with the realization that, although symptoms are being suppressed, the natural history of the disease may not be greatly affected. | |
| 7331861 | Radiographic temporomandibular joint abnormality in adults with micrognathia and juvenile | 1981 | Radiographic findings of the upper and lower jaw bone of 20 adult patients with micrognathia, bird face, and juvenile rheumatoid arthritis are reported. In all patients a symmetrically underdeveloped mandible with the chin posteriorly positioned was found at cephalometry. Arthritic lesion of the temporomandibular joint, mostly symmetric, with limitation of movement and secondary arthrosis, was observed in all patients. Complete absence of the tubercle. Abnormal anterior position of the mandibular head occurred in almost half of the patients. The degree of mandibular growth disturbance seemed to be correlated to the severity of the arthritis, indicating the arthritis to be a causal mechanism of micrognathia. | |
| 1081377 | Rubella antibody levels in juvenile rheumatoid arthritis. | 1975 Aug | Increased rubella antibody titres have been reported in patients with juvenile rheumatoid arthritis (JRA) and it has been suggested that rubella virus may be of importance in the aetiology or pathogenesis of the disease. In the present study, rubella and rubeola antibody titres in 85 patients with JRA were compared to age- and sex-matched controls. 41% of the patients did not have rubella antibody, but the geometric mean titre of those with JRA who had antibody was slightly higher than that of the controls with antibody (58-9 against 42-7; P less than 0-05). The level of rubella antibody titre correlated with serum IgG levels. There was no difference in rubeola antibody titres between patients and controls, and rubeola antibody did not correlate with serum IgG. Fifteen JRA patients developed rubella antibody after rubella vaccine or natural disease. This did not result in unusually high antibody titres and was associated with a mild exacerbation of symptoms in only two patients. This study suggests that the slight increase in rubella antibody in JRA is a nonspecific manifestation of increased immunoglobulins. | |
| 1137612 | Pathogenic implications of age of onset in juvenile rheumatoid arthritis. | 1975 May | An analysis of age of onset in juvenile rheumatoid arthritis was performed in the last 300 children seen in our clinic. There was a peak age of onset in girls at 1 to 3 years. Distribution of age of onset in boys was bimodal with the first peak at 2 years of age and the second at 9 years. There was no accentuation of frequency in either sex in the 10- to 14-year age group. The distribution of age of onset was bimodal in both monarticular and polyarticular onset of disease, but no particular modal age of onset was seen with systemic onset of disease. It is possible that these data reflect that JRA is not a homogenous disease, or that there are age-sex related differences in host susceptibility or pathogenic agents. |