Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 940709 | Needle biopsy of the synovium of children. | 1976 May | While the diagnosis of juvenile rheumatoid arthritis is based on clinical criteria and does not require confirmation by synovial biopsy, biopsy is occasionally desired to exclude other diagnoses. Needle synovial biopsy of the knee may be performed on young children as an office procedure and generally provides adequate tissue for examination. In the author's clinic this procedure has replaced open biopsy of the knee of children. | |
| 6608354 | Autoreactivity to collagen in a murine lupus model. | 1984 Mar | MRL/l mice exhibit many characteristics of human systemic lupus erythematosus including antinuclear antibodies, circulating immune complexes, glomerulonephritis, and death secondary to renal failure. In addition, these mice have elevated levels of rheumatoid factor and spontaneously develop arthritis that has many similarities to human rheumatoid arthritis. Our present studies indicate that, with age, they also develop reactivity to types I and II collagen. The levels of antibodies against native or denatured types I and II collagen in the sera of 4-5-month-old MRL/l mice are significantly higher than those in the sera of age-matched Balb/c or MRL/n mice. The specificity of these antibodies for collagen was demonstrated by a competitive binding assay. The T cells from 1- or 2-month-old MRL/l mice exhibited a significant proliferative response in the presence of type I collagen and a mild or no response to type II collagen. Both antigenic and mitogenic responses decreased with age. The results suggest that the development of autoimmunity to collagen may play an important role in the perpetuation of arthritis, vasculitis, and glomerulonephritis in MRL/l mice. | |
| 901597 | Yersinia-related arthritis in the Pacific Northwest. | 1977 Jul | Serologic evidence of Yersinia enterocolitica infection was sought by agglutination testing in serum samples from several populations, including Haida Indians, Red Cross blood donors, and Caucasian patients with rheumatoid arthritis, ankylosing spondylitis, and Reiter's syndrome. No evidence was found to indicate that yersinial infection was etiologically related to Haida spondylitis or Reiter's syndrome. Four of 28 patients with acute arthritis were diagnosed from serologic evidence as having Yersinia-related arthritis. | |
| 6332582 | Hashimoto's thyroiditis and polyarthritis: a possible subset of seronegative polyarthritis | 1984 Aug | Fifteen patients presenting with inflammatory polyarthritis who had Hashimoto's thyroiditis were investigated. Only 2/15 had frank myxoedema, 8/15 had incipient hypothyroidism (raised levels of thyrotropin or early symptoms of mild hypothyroidism), and 5/15 were euthyroid (thyrotropin levels normal). The presence or absence of rheumatoid factor (RF) distinguished two subgroups with different severity of synovitis. Nine out of 15 (group A) who remained RF negative throughout their follow-up had mild polyarthritis, lacked nodules or erosions on x-ray, and required, in addition to thyroid replacement, non-steroidal anti-inflammatory drugs for control of synovitis. Six out of 15 who remained RF positive (group B) had more severe synovitis, nodules, and erosive x-ray changes, and some required remittive drug treatment to control their disease. HLA-DR2 was present in 67% of group A and 13% of group B patients, while HLA-DR4 was present in 67% of group B and 33% of group A. Group A patients may represent a subset of patients with Hashimoto's thyroiditis and seronegative inflammatory polyarthritis, while group B patients appear to have features suggesting the coexistence of both rheumatoid arthritis and Hashimoto's thyroiditis. | |
| 7409700 | [Drug therapy of juvenile chronic polyarthritis]. | 1980 May 29 | Drug therapy of juvenile rheumatoid arthritis is discussed. Toward and untoward effects of the basic substances gold, D-penicillamine, chloroquine and azathioprine are presented. The symptomatic management is discussed, the critical points of corticosteroids are emphasized. | |
| 7211836 | Granulocytopenia with marked lymphocytosis manifesting Sjogren syndrome. | 1980 | Sjogren syndrome is a multi-system disease leading to diverse organ involvement during its course [1, 2]. Hematologic abnormalities described in Sjogren syndrome include anemia, mild leukopenia [3, 4], eosinophilia, elevated erythrocyte sedimentation rate, hypergammaglobulinemia, mixed cryoglobulinemia, and a variety of autoantibodies [5]. Marked lymphocytosis with granulocytopenia is distinctly unusual and has not been previously reported. We report a case of Sjogren syndrome who presented with constellation of the latter problems without prominent sicca manifestations. | |
| 6569532 | Comprehensive management of juvenile rheumatoid arthritis. | 1984 Dec | Many concerns and difficult challenges are presented by JRA, particularly by the more severe forms of the disease. However, the child, family, school, and multidisciplinary team of health professionals can collaborate to better understand and meet these challenges. Often, in the process, important life lessons are learned and perspectives are gained which ultimately strengthen the child and family. | |
| 3978897 | Sjögren's syndrome and Crohn's disease. | 1985 Jan | Sjögren's syndrome has been associated with many of the disorders in which autoimmunity is considered likely to play a major role in pathogenesis. To date, no such association has been reported with Crohn's disease. A case where this association has been observed is reported here. In the absence of other known primary causes of Sjögren's syndrome, the features of this case are suggestive of a direct relationship between these disorders. | |
| 6393313 | [Mucocutaneous and salivary manifestations of the graft vs host reaction after bone marrow | 1984 | Mucocutaneous reactions to graft versus host disease may be acute (maculopapular rash, scarlatiniform rash, epidermal necrosis), related to T lymphocyte aggression to basal layer cells, or chronic (lichenoid, or even poikilodermic and sclerous lesions) when a complex mechanism is involved. The syndrome sicca is a major manifestation of graft versus host disease of a chronic type, histology showing moderate lymphocyte infiltration and then marked fibrosis. | |
| 6692630 | Total hip and total knee arthroplasty in juvenile rheumatoid arthritis. | 1984 Jan | Total hip arthroplasty (THA) or total knee arthroplasty (TKA) is indicated for patients with juvenile rheumatoid arthritis (JRA) when marked joint destruction is present and pain or deformity compromises function despite optimal medical therapy. Relief of pain, reduction of the deformity, and dramatic improvement in functional status and quality of life can be achieved in most patients. Functional impairment and deformity rather than pain are usually the primary indications for THA or TKA. When there is both hip and knee involvement, hip arthroplasty should probably be done first. Regional anesthetic appears to be the anesthetic of choice. Careful preoperative planning and the availability of custom and minisized components are essential. Small bone size, osteoporosis, and severe soft tissue disease make the surgery technically demanding. Skeletal immaturity may not contraindicate surgery if the patient is otherwise bedridden with progressive deformity. In the hip trochanteric osteotomy is often necessary for adequate exposure, with the possible exception being a patient with juvenile ankylosing spondylitis who is subject to heterotopic bone formation. Although complete capsulectomy and psoas tenotomy may be necessary to relieve a hip flexion contracture, a soft tissue release that produces leg lengthening may lead to nerve palsy. In the hip component loosening has been less common in patients with JRA than in other young patients who have undergone THA, but it is still the most frequent cause of failure. In the knee preoperative and postoperative serial casts can aid in the correction of severe flexion contracture. Secondary patellar pain has been the most common cause of late failure. Patellar resurfacing should probably be performed at the time of the original knee arthroplasty in all patients with JRA. | |
| 6623018 | Persistent and transient IgA deficiency in juvenile rheumatoid arthritis. | 1983 | Twenty-five children with serum IgA levels of less than 0.1 g/l (below the 2.5% confidence limit at 2 years of age) were found among approximately 350 cases of juvenile rheumatoid arthritis (JRA). During follow-up, 10 of them proved to have persistent IgA deficiency, 13 were classified as having transient IgA deficiency, and 2 had consistently low serum IgA. Transient IgA deficiency occurred during treatment, in 9 cases with gold and in 2 with antimalarials. The gold-induced IgA deficiency usually developed abruptly soon after institution of gold therapy, and its duration varied from a few months (4 cases) to several years (3 cases). In 6 cases a low IgA level has returned to normal despite continuing gold therapy. In half the patients with persistent IgA deficiency the course has been mild and oligoarticular, and after a mean duration of 8.8 years only one has active disease. In contrast, in the patients with transient IgA deficiency the disease was characterized by early onset (mean age 3.0 years), a polyarticular course (10/13) and prolonged activity (7/13, mean duration 9.6 years). Coeliac disease was diagnosed in 2 patients, both with persistent IgA deficiency. | |
| 980605 | Serum enzyme abnormalities in juvenile rheumatoid arthritis. | 1976 Nov | Elevated serum transaminases, particularly SGOT, as a result of acetylsalicylic acid (ASA) therapy have been reported in patients with juvenile rheumatoid arthritis (JRA). In order to evaluate the possibilities that these elevated transaminases may result from JRA itself or from concomitant muscle injury, we correlated liver function tests and a specific test for muscle damage, creatine phosphokinase (CPK), with ASA therapy in 37 patients. These JRA patients were evaluated serially; 20 took ASA continuously, 6 took it intermittently, and 11 were on no therapy. Thirty-five healthy children were also studied to establish normal control values for the serum enzyme tests. Mean SGOT and SGPT in the 11 untreated subjects were significantly (P less than.001) higher than normal controls while CPK and alkaline phosphatase (AP) were not elevated. Mean SGOT and SGPT were also significantly (P less than .001) elevated in 20 children receiving ASA continuously; CPK was normal and AP less (P less than .05) than normal. CPK was elevated in 13 patients. Elevation of enzymes was sporadic and there was no correlation with serum salicylate, sex, age, disease duration, type, or activity. We conclude that mild abnormalities of SGOT and SGPT in JRA patients are common, but that they occur sporadically and elevated values appear to be unrelated to ASA therapy. | |
| 759180 | Rheumatoid arthritis and growth retardation in children: treatment with human growth hormo | 1979 Jan 18 | Twenty patients with rheumatoid arthritis or Still's disease associated with growth failure were treated with human growth hormone, 7.5 to 17 U/m2 body surface per week. Five patients did not respond with better growth. In the remainder the mean growth rate increased from 1.9 cm/year (range: 0 to 3.3) to 6.2 cm/year (range: 3.6 to 12) over 5 to 7 months. Twelve patients treated for longer periods increased their mean growth rate from 2.6 cm/year (range: 0.7 to 5.7) to 6.3 cm/year (range: 2.4 to 9.7) and continued to grow during a second year of treatment. Growth velocity decreased in 6 patients when the hGH therapy was discontinued. The causes for this improvement in growth are possibly multifactorial: the growth rate is depressed by the severity of the disease and high-dose glucocorticoid therapy. Increases of growth rate occurred during improvements in the disease, reduction of steroid medication, as a result of therapy with human growth hormone, and because of puberty in some patients. Human growth hormone seemed to improve the underlying condition of four of the patients but had no influence on the disease in the remaining children. | |
| 6838676 | Serotonin content of platelets in inflammatory rheumatic diseases. Correlation with clinic | 1983 Apr | Significantly decreased platelet serotonin contents were measured in rheumatoid arthritis, systemic lupus erythematosus (SLE), progressive systemic sclerosis, and mixed connective tissue disease. An inverse relationship between platelet serotonin levels and clinical disease activity was observed in both rheumatoid arthritis and systemic lupus erythematosus. SLE patients with multiple organ involvement showed the lowest platelet serotonin values. No correlation was observed between platelet serotonin contents and nonsteroidal antiinflammatory drug treatment, presence of circulating platelet reactive IgG, or the amount of circulating immune complexes. The results are interpreted as indicating platelet release occurring in vivo during inflammatory episodes of the rheumatic disorders investigated. | |
| 6628527 | Pharmacokinetics of fenclofenac in children with juvenile rheumatoid arthritis. | 1983 | Twenty eight children (age range 3-17 years) with juvenile rheumatoid arthritis (JRA) received fenclofenac 10-25 mg/kg body weight daily on an open basis. Pharmacokinetic analysis was undertaken on plasma fenclofenac levels measured during the first 3 weeks of treatment. The peak concentration after the first dose was achieved in 2-8 h in non-fasting subjects and was linearly related to dose. The plasma level then decayed biexponentially, as in adults, the initial distribution phase extending to about 12 h after dosing. After treatment for 18 days, blood samples were taken during the 96 h following the last dose of the drug to define the steady state elimination profile. The elimination half-life was 25.4 +/- 7.9 h (n = 17) and did not appear to be dependent on the daily dosage. A therapeutic drug concentration of greater than or equal to 100 micrograms/ml emerged from subjective and objective estimates of the response to treatment and measurement of steady state fenclofenac concentration. Treatment response could be more accurately predicted with the aid of drug concentrations than from dosage alone, although the dose and the steady state drug concentration were positively and linearly correlated (r = 0.61, p less than 0.01). Of 16 children receiving doses in excess of 20 mg/kg/day, 3 experienced dose-related adverse effects, increased serum transaminase activity, vertigo and dyspnoea. | |
| 4436356 | The hand in systemic lupus erythematosus. | 1974 Sep | Hand involvement is common in systemic lupus erythematosus, and is different from that seen in rheumatoid arthritis. Raynaud's phenomenon was present in 50 per cent of our patients and, rather than joint deformity and synovitis, often was the primary cause of disability. Deformities in lupus hands are the result of laxity of the supporting soft-tissue structures about the joint. Articular destruction and ankylosis do not occur unless there is coexistent rheumatoid arthritis. Swanneck deformities without tight intrinsics and hyperextension deformity of the thumb interphalangeal joint are characteristic of this disease in the hand. | |
| 6541701 | Immunologic and inflammatory responses during pregnancy. | 1984 Aug | Rheumatoid arthritis commonly improves markedly during pregnancy, and it has been suggested that this reflects a decrease in immunological or inflammatory effector mechanisms. We elicited a delayed type hypersensitivity (DTH) response to Burro RBC, by injection of primed lymphocytes and antigen into murine footpads. The swelling induced in footpads of pregnant mice was not significantly different from that seen in controls, nor was the response to a non-immunologic inflammatory stimulus, carrageenan, decreased in pregnant mice. On the other hand, a defect in the priming or induction phase of a primary DTH response was impaired in pregnancy, but whether this is relevant to the pregnancy induced remission of rheumatoid arthritis remains to be demonstrated. | |
| 484663 | Localized conjunctival amyloidosis. | 1979 Sep | We treated a patient with localized amyloidosis of the bulbar conjunctiva, which strongly resembled a neoplastic growth. Although the patient suffered from a long-standing, debilitating rheumatoid arthritis, suggesting the possibility of a secondary systemic amyloidosis caused by the chronic effusive process, no specific clinical evidence of systemic amyloidosis was noted. The ocular lesion was, therefore, classified as a primary localized amyloidosis. However, the simple recognition of amyloid in the ocular adnexa should not be considered a complete diagnosis. For such cases in which a prominent underlying systemic disease is present, a thorough medical evaluation and future follow-up should be ensured to rule out the possibility that this represents the initial manifestation of a potentially life-threatening secondary systemic amyloidosis caused by rheumatoid arthritis. | |
| 1027057 | The esophagus in collagen disease. Radiologic findings. | 1976 Jul | A prospective cineradiographic and manometric study of pharyngeal and esophageal dysfunction was performed in 54 patients with rigidly defined scleroderma, polymyositis, systemic lupus erythematosus, and rheumatoid arthritis. Cineradiography was inaccurate in pharyngeal dysfunctions specific for polymyositis. Manometry was an accurate but insensitive test. Manometry was also significantly more accurate than cineradiography in identifying patients with smooth muscle dysfunction (scleroderma). Cineradiographic finding of absent esophageal peristalsis accurately identified patients with scleroderma but it identified only a small percentage (33 percent). Cineradiography finding of diminished esophageal peristalsis was found in scleroderma (23 percent), polymyositis, (30 percent), and SLE (11 percent) and has been reported in rheumatoid arthritis. This finding is a non specific finding suggestive of collagen vascular disease rather than specific for scleroderms. | |
| 22454902 | Indomethacin or amylobarbitone sodium for sleep in rheumatoid arthritis, with some observa | 1974 Apr | 1 A double blind crossover trial in patients with rheumatoid arthritis showed that indomethacin given at night was superior to a hypnotic in providing sleep and relieving morning stiffness. 2 In a second trial, the combination of a hypnotic with indomethacin was not superior to indomethacin alone as judged by patients' preference, but further analysis suggested that the combination improved sleep without affecting morning stiffness. 3 It is argued that the use of a small closed sequential design produced too small a sample in the first trial. In the second trial, the sample was relatively large but the result was inconclusive; measurement of the response in terms of preference alone obscured the effect of treatment on one aspect of the symptomatology studied. |