Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2857948 | Sjögren-like syndrome after drug-induced toxic epidermal necrolysis. | 1985 Mar 16 | 7 of 9 patients recovering from a drug-induced toxic epidermal necrolysis (TEN) which they had had 2 months to 4 years before had xerostomia, or keratoconjunctivitis sicca, or both. 5 patients had symptoms; 2 had severe visual impairment. In 5 cases there was lymphocytic infiltration of small salivary glands; in 2 patients this was identical to that of Sjögren syndrome. None of the patients had antinuclear antibody. TEN may occur during acute graft-versus-host disease (GVHD) and these observations are reminiscent of the sicca syndromes reported during chronic GVHD. They suggest that autoimmune mechanisms may be involved in drug-induced TEN and that Sjögren syndrome may occur as the result of a drug reaction. | |
| 766625 | Familial Sjögren's syndrome with associated primary salivary gland lymphoma. | 1976 Feb | Primary salivary gland lymphoma has been rarely documented in patients with or without Sjögren's syndrome. The association of disseminated lymphoreticular neoplasms with Sjögren's syndrome has been recognized, and the malignancy is usually widespread at the time of diagnosis. Familial occurrence of Sjögren's syndrome is likewise infrequently observed. In the present report we describe a patient with Sjögren's syndrome in whom a primary parotid gland lymphoma subsequently developed. In addition to the propositus, two of four siblings had definite evidence of Sjögren's syndrome and a third had several abnormal studies commonly associated with the disease. This observation suggests that genetic influence alone or in conjunction with other factors may facilitate the development of Sjögren's syndrome. | |
| 7136530 | Tear absorption into the filter-paper strip used in the Schirmer-I-test. A methodological | 1982 Feb | The absorption of tear fluid into the Schirmer-I-filter paper was evaluated by serial measurements in 5 normal volunteers and in 32 patients with Sjögren's syndrome. The length of wetting was correlated to the weight of tear fluid absorbed in the paper strips. A linear relationship was demonstrated. We conclude that the Schirmer-I-test implies reproducible and fairly precise estimation of the tear flow even in cases of small lengths of wetting. The test is reliable, simple and useful for the diagnosis and follow-up of dry eyes, especially in patients with Sjögrens syndrome. | |
| 785388 | [Technetium uptake in the parotid gland. Value of functional parameters in Sjögren's synd | 1976 Jun | Studies of the parotid function were performed on 22 subjects comprising 11 patients with Sjögren's syndrome and 11 normal controls using an Anger camera with digital data processing facility. After injection of 2 mCi of 99mTc-pertechnetate digital scintigrams of the face region were collected and stored onto magnetic tape. 50 minutes after injection the parotid glands were stimulated by administration of Pilocarpin. By subsequent processing of the data uptake curves were obtained for both parotid glands. In allowing for vascular activity three different methods were compared. The most satisfactory method with respect to discriminating the groups under study was using a background region located in the falx cerebri. From the corrected uptake curves a number of parameters were derived and their respective selectivity was investigated by statistical analysis. It is shown that the most suitable parameter characterizing the parotid function is given by the difference of maximum uptake before Pilocarpin stimulation and minimum uptake after stimulation. | |
| 6779137 | [B27-positive diseases. A new concept in rheumatology (author's transl)]. | 1980 Nov 28 | In a large number of rheumatoid factor-negative arthritic conditions there is a number of diseases which are characterized by common clinical manifestations and the genetic property of the presence of B27. The term "B27-positive diseases" is based on a concept arising from intensive nosological studies and provides important suggestions for the study of the pathogenesis of a group of rheumatic diseases in that it emphasizes the significance of a genetic predisposition and makes an infectious etiology probable. | |
| 6602977 | Rheumatic symptoms in primary hyperparathyroidism. | 1983 Apr | In a retrospective survey of 34 patients with primary hyperparathyroidism (HPT), 18 (53%0 complained of musculo-skeletal symptoms during the 12 months before the diagnosis was made and 9 (26%) attended at some time for either a rheumatological or orthopaedic consultation. Myalgia was the most frequently reported symptom which occurred in 41% of patients. Arthralgia, mainly affecting the large joints was present in 11 (32%) patients, 2 of whom had an erosive synovitis mimicking rheumatoid arthritis. Radiological abnormalities were seen in 8 patients. Clinicians should be aware of the variety and frequency of musculo-skeletal symptoms associated with HPT and should consider including serum calcium measurements when investigating rheumatic complaints. | |
| 7338244 | Ruptured Baker's cyst: a radiological diagnosis. | 1981 May | Rupture of a Baker's cyst may mimic thrombophlebitis of the leg clinically. Differentiation of these two entities is important because of therapeutic implications. A history of previous disease involving the knee, especially rheumatoid arthritis, or the finding of joint effusion are suggestive of the diagnosis of ruptured Baker's cyst. This may be confirmed by arthrography. We describe a series of eight patients with the "pseudothrombophlebitis" syndrome. Arthrography showed seven as having a ruptured Baker's cyst, while in one an intact cyst was found. | |
| 6270210 | Immunofluorescent staining of nuclear antigen in lymphoid cells transformed by Herpesvirus | 1981 | An improved fixation method for antigen detection in lymphoblastoid cells is described. Herpesvirus papio nuclear antigen (HUPNA) could be stained in several transformed lymphoid cell lines by anti-complement immunofluorescence (ACIF). Antibody to HUPNA was detected in many human sera containing antibodies to Epstein-Barr virus capsid and nuclear antigen (EBNA). Rheumatoid arthritis sera showed a high incidence of both anti-EBNA and anti-HUPNA antibodies. | |
| 6995270 | Silicone lymphadenopathy: a complication of silicone elastomer finger joint prostheses. | 1980 May | Two cases of lymphadenopathy resulting from a lymph node foreign body reaction to silicone are presented. In each case lymph node biopsy was performed because of the clinical suspicion of neoplastic disease. Histologic study in both cases revealed no evidence of malignant disease, but rather demonstrated multinucleated giant cells in reaction to irregular fragments of refractile foreign material. The foreign substance was consistent in appearance with silicone. In each case a history of long standing rheumatoid arthritis and previous joint replacement with implantation of silicone elastomer prostheses was elicited. | |
| 900719 | Simplified soft contact lens treatment in corneal diseases. | 1977 Jul | The advantages and disadvantages of the newly introduced Plano-T soft contact lens for the treatment of corneal diseases were evaluated. The physical characteristics, base curve, diameter, and thickness account for the fitting advantages which make it a versatile lens. The assumption that one lens fits almost any eye and that it may be used in most instances where a bandage lens is indicated proved correct, except for corneas of extreme measurements as in keratoconus. The results obtained compare very favorably with the results of the more conventional lathe cut lenses for the treatment of corneal diseases. Visual improvement does not seem as dramatic as in the latter, but some of the most common side effects are almost eliminated. Its physical characteristics and actions are reviewed. The corneal diseases for which it has been used are mentioned and the results discussed. | |
| 3983045 | Hypothyroidism presenting as destructive arthropathy of the fingers. | 1985 Feb | A patient presenting with destructive arthropathy of the proximal interphalangeal (PIP) joints of the hands is described. She was initially believed to have rheumatoid arthritis but non-steroidal anti-inflammatory drugs were of no help. The patient was subsequently found to have hypothyroidism and erosive osteoarthritis of the fingers. Joint swelling, pain and stiffness responded dramatically to thyroid hormone substitution. The PIP joint spaces reappeared on the radiographs within 9 months. This case suggest that hypothyroidism may induce destructive arthropathy of the finger joints. As thyroxine replacement may reverse the rheumatic complaints, hypothyroidism should be considered in the differential diagnosis of a destructive arthropathy of unclear aetiology. | |
| 6652392 | Circulating immune complexes in ankylosing spondylitis. | 1983 Nov | Circulating immune complexes were determined in the sera of patients with ankylosing spondylitis using a polyethylene glycol precipitation laser nephelometer technique. Positive results were obtained in 52% of sera from patients with active disease, but only in 20% from those in inactive stages. The immunoglobulin/complement protein ratio differed from that seen in rheumatoid arthritis and in systemic lupus erythematosus, due to the relatively larger amounts of C3 and C4 present in the immune complexes. These findings indicate that circulating immune complexes in ankylosing spondylitis may not be of pathogenetic significance because of their degree of solubilization. | |
| 6970457 | [Mixed connective tissue disease (Sharp syndrome)]. | 1980 Nov 15 | In the Sharp syndrome we have to do with a mixed collagenosis with symptoms of sclerodermia, erythematodes visceralis, dermatomyositis and rheumatoid arthritis. Above all are observed a Raynaud syndrome, polyarthritis and polyarthralgias, swellings of hands and fingers and myositis and myalgia, respectively. For the ascertainment of the diagnosis as independent picture of a disease the immunological profile is decisive. On the basis of three casuistic cases the author adopts a definite attitude to the Sharp syndrome as independent immunopathy. Questions of diagnostics, therapy and prognosis are discussed. | |
| 748911 | [Familial neoplasms and childhood dermatomyositis]. | 1978 May | Familial frequency of malignant neoplasms from 20 children with dermatomyositis was investigated and compared with 225 controls. Eight patients with dermatomyositis (40 per cent) had nine family members with a malignant tumour; this frequency is significantly higher than those found in the controls with juvenile rheumatoid arthritis (P less than 0.01), neoplasms (P less than 0.01), and a variety of diseases (P less than 0.05). This finding and the known association of neoplasm-dermatomyositis might suggest an hereditary predisposing factor, possibly a subtle inmune deficiency, common for tumours and dermatomyositis. | |
| 331886 | Mitochondrial antibodies without antinuclear antibodies in non-hepatic diseases. | 1977 | The term "pseudo-LE syndrome" was previously used to describe an SLE-like disease in which AMA, but not ANA, were found in serum. In an attempt to find patients with this syndrome, we tested 9 358 sera for AMA and ANA. AMA without ANA was found in six patients without liver disease. One of these patients had an SLE-like disease. Two of the others had diseases of the thyroid and one had rheumatoid arthritis--diseases in which AMA have previously been described. One patient had allergic vasculitis and one hypercholesterolaemia; these diseases are not known to be associated with the presence of AMA. | |
| 62903 | Indium-111-labelled leucocytes for localisation of abscesses. | 1976 Nov 13 | Leucocytes from eight patients who were thought to have an abscess were labelled with indium-111 and reintroduced into the circulation. The distribution of radioactivity was followed by whole-body scanning and imaging with a gamma camera. Focal accumulation of radioactivity were observed in the lesion in the three patients with abscesses, in the lungs of a boy with bacterial endocarditis, in the knee of a woman with rheumatoid arthritis, and at the site of intramuscular injections in another patient. The use of radiolabelled cells for the detection of focal pathological processes would seem to be an important addition to conventional diagnostic methods. | |
| 937352 | Pericardial fluid analysis in scleroderma (systemic sclerosis). | 1976 Jun | A patient with scleroderma who presented with pericarditis and effusion is described. Aspirates from this pericardial effusion had the characteristics of an exudate with no evidence of autoantibodies, immune complexes or complement depletion. These findings suggest that the mechanisms operating in the production of pericardial effusion in scleroderma may be different from those found in rheumatoid arthritis and systemic lupus erythematosus. | |
| 3966521 | Penicillamine-induced ocular myasthenia gravis. | 1985 Jan 15 | Two patients with rheumatoid arthritis (two women, 58 and 62 years old) developed reversible penicillamine-induced ocular myasthenia gravis. Both had the HLA-DR1 antigen, unlike most patients with idiopathic myasthenia gravis who show HLA-DR3, suggesting that penicillamine-induced myasthenia gravis and its idiopathic counterpart occur in patients with different genetic backgrounds. In both cases, cessation of drug treatment led to resolution of the symptoms. | |
| 6235859 | Plasmin degradation of cartilage proteoglycan. | 1984 Aug 21 | Employing agarose gel electrophoresis, physiological concentrations of plasmin have been shown to degrade purified proteoglycan monomers and aggregates isolated from bovine articular cartilage. Proteoglycan degradation was (1) proportional to plasmin concentration, (2) dependent on the conversion of plasminogen to plasmin by plasminogen activator, (3) not displayed by plasminogen activator alone, and (4) inhibited by a serine proteinase inhibitor. These results, coupled with other findings, provide further support for a possible role of plasmin/plasminogen activator in cartilage destruction associated with rheumatoid arthritis. | |
| 6607650 | Parasymphyseal insufficiency fractures of the os pubis. | 1984 Mar | Twelve parasymphyseal insufficiency fractures of the os pubis are described in eight osteopenic postmenopausal women, three of whom had rheumatoid arthritis. The fractures involved both right and left pubic bones in three women. Radiographically lesions often appear deceptively destructive and malignant. In six patients, biopsy was performed and showed no tumor. Biopsy can be avoided in an osteopenic woman with recent increased activity, pubic pain, and the characteristic pubic lesion. |