Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6380477 | Odontoid fractures, systemic disease and conservative care. | 1984 Jun | Patients admitted to the Prince Henry Hospital Spinal Unit between January 1982 and January 1983 with a diagnosis of fracture of the odontoid process of the axis were reviewed. There were nine patients representing 20% of all new cervical fractures. The mean age was 64.5 +/- 19.3 years. Alcoholism, brain damage following head injury, osteo-arthritis, cervical spondylosis, rheumatoid arthritis and osteoporosis may be complicating factors in the management of odontoid fractures. A fracture of the odontoid in an elderly patient with a history of minimal trauma suggests osteoporosis. Early mobilization in a custom-moulded orthosis with frequent radiological monitoring prevents the complications of prolonged bed rest. | |
| 7021122 | Piroxicam: a review of its pharmacological properties and therapeutic efficacy. | 1981 Sep | Piroxicam is an N-heterocyclic carboxamide of 1,2 benzothiazine 1,1 dioxide with analgesic and anti-inflammatory activity. It has an extended half-life of about 40 hours and is suitable for once daily administration. Published studies indicate that piroxicam 20mg daily is comparable with aspirin 3 to 6g. indomethacin 75 to 150mg, phenylbutazone 400mg, naproxen 500mg, ibuprofen 1200 to 2400mg and diclofenac 75mg in rheumatoid arthritis. In osteoarthritis, piroxicam 20mg daily is comparable in efficacy with aspirin 2.6 to 3.9g, indomethacin 75mg, naproxen 500mg and fenbufen 600mg but is generally better tolerated than aspirin or indomethacin in patients with arthritic diseases. Piroxicam 20mg was at least as effective as indomethacin 75mg in a study in ankylosing spondylitis. As with other non-steroidal anti-inflammatory drugs gastrointestinal complaints are the most frequently reported side effects and their frequency and severity appears to be dose-related. | |
| 942500 | Clinical studies of antibodies binding polyriboadenylic acid in systemic lupus erythematos | 1976 Jul | Antibodies of polyriboadenylic acid (poly rA) are demonstrated by filter radioimmunoassay in 75% of patients with systemic lupus erythematosus (SLE), in 54% of patients with discoid lupus erythematosus, and in only 0-7% of normal controls and patients with rheumatoid arthritis or Sjögren's syndrome. These antibodies are distinct from antibodies to single- and double-stranded DNA and double-stranded RNA. Poly rA binding is associated with IgM and IgG serum fractions. Because poly rA may have a role in the transcription of mRNA in mammalian cells and viruses, antibodies to poly rA may be important clues to virologic and immunogenetic mechanisms in the pathogenesis of SLE. | |
| 6166721 | Studies on the antigenic determinants in the self-association of IgG rheumatoid factor. | 1981 Jul 1 | The number, location, and other characteristics of the antigenic determinants for self-association of IgG-rheumatoid factors (IgG-RF) were examined using the IgG-RF isolated from the plasma of one patient as a model system. Affinity chromatography was employed for isolation of the IgG-RF. Sedimentation equilibrium ultracentrifugation was used to study the various interactions. The antigenic valence of IgG-RF Fc, normal human Fc, and rabbit Fc fragments was two for the interaction with Fab fragments from IgG-RF, as might be expected from the molecular symmetry of IgG. The antigenic valence of intact normal IgG, however, was only one, indicating that when one of the available antigenic determinants interacted with the Fab fragment of IgG-RF, the other determinant becomes sterically inaccessible. Reduction and alkylation, known to increase the flexibility of the hinge region, did not alter the antigenic valence of IgG for Fab fragments of IgG-RF. The antigenic valence of IgG-RF in self-association could not be experimentally determined but must be two to permit the observed concentration-dependent further polymer formation of IgG-RF dimers. Unique antigenic determinants on the Fc fragments of IgG-RF were sought and not found, thus reaffirming the formation of two antigen-antibody bonds as the basis for dimerization of IgG-RF molecules. The pFc' and Fc' fragments, representing Cgamma3 domains of IgG, failed to show significant interaction with Fab fragments of IgG-RF, indicating that the antigenic determinants were not expressed by the Cgamma3 regions but are located either on Cgamma2 region or require intact Cgamma2 and Cgamma3 regions for expression. These conclusions were corroborated by the antigenic valence of one for the Fc(i) fragment, a new papain-generated intermediate fragment of Fc, composed of two intact Cgamma3 domains and one intact Cgamma2 domain. Normal IgG, because of its valence of one for interaction with IgG-RF, would effectively terminate further polymerization of IgG-RF dimers. This may well in part explain the finding of smaller IgG-RF complexes in the serum than in synovial fluid of patients with rheumatoid arthritis. | |
| 4088101 | Mycoplasma pulmonis arthritis in mice: microbiological and immunological features. | 1985 | Mycoplasma pulmonis m53 was inoculated intraarticularly in the bilateral hind footpads and bilateral knee joints of BALB/c mice. Mycoplasmas were recovered from the affected joints over 20 weeks accompanying acute or subacute inflammation. Intensive deposition of immunoglobulins, a complement (C3) and mycoplasma cell antigens occurred in synovial and adjacent connective tissues. The histopathologically intact kidneys, brain, and lungs showed deposition of IgG and the complement on the endothelial cells of blood vessels. An IgG-rheumatoid factor like substance (RFLS) was detected in the serum of the mice by an enzyme-linked immunoabsorbent assay. Persistence of mycoplasma cells and immune complexes in the articular tissues might cause the prolongation of inflammatory responses in murine mycoplasmal arthritis. | |
| 6247535 | [Angiotensin converting enzyme (ACE) a bloodtest for diagnosis of sarcoidosis (author's tr | 1980 Feb 15 | Serum angiotensin-converting enzyme (ACE) was studied in 50 patients with sarcoidosis (39 active, 11 inactive) as well as in 50 control patients (34 with chronic nonspecific lung disease, 9 with Hodgkin and 7 with rheumatoid arthritis). There was a significant difference of ACE activity between sarcoidosis patients (28.6 +/- 11.4) and controls (14.8 +/- 4), and also between active (32.8 +/- 11) and the inactive (21.9 +/- 5.1) sarcoidosis (p less than 0.001). Coricosteroid treatment seems to lower ACE activity in patients with sarcoidosis without offering a clue for clinical improvement. Increased ACE activity in other granulomatous disorders is being discussed. ACE activity thus proves to be a valuable test especially in differentiating active from inactive sarcoidosis. | |
| 373662 | Acute leukemia and immunosupressive drug use: a review of patients undergoing immunosuppre | 1979 Apr | We have reviewed 61 reported cases of acute leukemia developing in patients who had previously received immunosuppressive agents for non-neoplastic disorders. In three patients the diagnosis of acute leukemia was made less than six months after the first exposure to immunosuppressive drugs and was, therefore, considered coincidental. Among the remaining 58 patients, most diagnoses were of myeloblastic or myelomonocytic leukemia. The underlying diagnoses in most of the 58 patients were rheumatoid arthritis or renal disease or renal transplant. Thirty patients had received alkylating agents exclusively, 10 had received antimetabolites only, while the remaining 18 patients had received multiple therapeutic modalities including antimetabolites, alkylating agents, and/or radiation. Most patients had also received large amounts of corticosteroids. Although we do not have the overall denominator of population at risk, the relatively high proportion of patients who had received alkylating agents before developing acute leukemia doses suggest a causal relationship, and one might, therefore, hesitate before using such drugs in non-life-threatening diseases. | |
| 6186260 | Alizarin red S staining as a screening test to detect calcium compounds in synovial fluid. | 1983 Feb | A simple, rapid screening method using alizarin red S stain and ordinary light microscopy to detect microcrystalline or noncrystalline calcium phosphate salts was used on wet drop preparations of synovial fluids. This proved to be helpful in detecting apatite crystal clumps and small calcium pyrophosphate dihydrate (CPPD) crystals missed by polarized light. The staining was positive in 100% of synovial fluids from patients later proven to have apatite and/or CPPD deposition diseases. Apatite and CPPD crystals were commonly found together in the same fluids. In addition, some synovial fluids from patients with osteoarthritis, renal failure dialysis, rheumatoid arthritis, and gout also exhibited positive staining. The correlation of positive alizarin red S staining with radiologic evidence of osteoarthritis suggests that apatite crystals might be related to articular cartilage degeneration in different rheumatic diseases. | |
| 7043728 | [Diflunisal compared with naproxen in chronic polyarthritis. Double-blind study]. | 1982 Feb 20 | Diflunisal, a new analgesic/anti-inflammatory monosubstance, has been compared with naproxen in a double-blind study in patients with rheumatoid arthritis. In doses of 1 g diflunisal daily and 750 mg naproxen daily both therapies resulted in significant improvements in subjective and objective parameters measured - day and night pain, morning stiffness, Ritchie index, grip strength, and doctor and patient assessment of overall effect. Side effects were uncommon and of little significance in the diflunisal-treated patients, whereas two patients in the naproxen group were dropped from the study because of clinically significant drug-related side effects. It is concluded that diflunisal should be a very useful addition to the therapies currently available. | |
| 117813 | Gold-induced changes in the morphology and functional capabilities of human monocytes. | 1979 Dec | The capacity of gold compounds to induce morphologic changes and alterations in the functional activity of human mononuclear phagocytes (M phi) in vitro was examined. Human peripheral blood mononuclear cells were incubated with gold sodium thiomalate (25 microgram/ml) for 96 hours. As a result, M phi developed electron dense precipitates within phagolysosomes, as well as marked dilatation of these organelles. Gold incubation also altered a number of M phi functions. While viability and adherence were unaffected, the capacity to spread on surfaces was diminished. Pinocytosis of soluble proteins and phagocytosis of opsonized sheep erythrocytes were impaired, but Fc mediated particle binding was not. These data indicate that gold can alter certain functional activities of M phi and support the idea that the major action of gold in rheumatoid arthritis results from its capacity to alter M phi function. | |
| 46754 | Sulfhydryl-dependent thermal aggregation of human gamma globulin: augmentation by hyaluron | 1975 Jan | Hyaluronic acid (4 mg/ml) augmented elevenfold the copper-catalyzed (7 muM) thermal (63 degrees C, 2 hours) aggregation of human gamma globulin (2 mg/ml) in 0.075 M phosphate buffer, pH 7.4. Almost no augmentation of aggregation occurred with hyaluronidase-treated hyaluronate. Hyaluronate-augmented copper-catalyzed thermal aggregation was inhibited by L-histidine, gold thiomalate, N-ethylmaleimide, p-chloromercuribenzoic acid, and ethylenediaminetetraacetic acid. Together with previous reports of a decreased blood histidine concentration in rheumatoid arthritis, these studies provide a possible explanation for the affinity of this disease for joints. | |
| 6131396 | [Immuno-histological findings on Sjögren's syndrome]. | 1983 Feb 11 | Six cases of SS, 12 cases of SS in association with other diseases (AR, LES, MCTD, SSP) and 14 cases of various diseases with no clinical signs of SS (AR, UCTD, LES, MCTD, PM, cutaneous PAN, Scheuermann's disease, ankylosing spondylitis) have been examined. Examination of the patients included general clinical, stomatological and ophthalmological examinations, slit lamp and Schirmer I test, labial biopsy direct immunofluorescence on labial biopsy, indirect immunofluorescence on labial biopsy of a healthy subject scialography and salivary scintiscan. Various seroimmunological tests were also performed--in the hope of identifying LE, ANA, anti-ENA and anti-dsDNA factors. The results of these clinical, immunological, bioptic and instrumental tests were studied with a view to clarifying the diagnostic and nosographic problems of the syndrome. The diagnostic importance of immunological and instrumental tests is emphasized. Labial biopsy in particular also makes it possible to quantify the glandular lesion to some extent as well as providing other histological data regarding any associated disease. Nosographically, it is suggested that SS be definitively included among the connective tissue diseases in recognition of its polymorphism and variety of clinical forms which cover a wide range from definite SS, whether in pure form or associated with other diseases, to "subclinical" SS in systemic diseases. | |
| 148842 | Immune complex glomerulonephritis in sicca syndrome. | 1978 Jun | In three patients with the sicca syndrome (Sjögren's syndrome), who were followed for one to seven years, glomerulonephritis developed. None of these patients fulfilled the diagnostic criteria for systemic lupus erythematosus. All of these patients had circulating immune complexes as detected by the Clq binding assay. Glomerular histology by light and electron microscopy revealed changes compatible with membranoproliferative glomerulonephritis in two of the patients and membranous glomerulonephritis in the third. All patients showed rapid improvement in renal function following moderate doses of corticosteroids. In addition, the treatment decreased the level of circulating immune complexes in two patients who were followed for a sufficient period of time. | |
| 314293 | Antigenic bacterial polysaccharide in rheumatoid synovial effusions. | 1979 Sep | Phenol-water extracted rheumatoid synovial fluids and synovial fluid leukocytes contain an antigen immunologically identical to the Proprionibacterium group bacteria. The antigen was identified by counter-immunoelectrophoresis in 70% of rheumatoid synovial fluid leukocyte pellets and in 60% of rheumatoid synovial fluids. It was also present in 6% of nonrheumatoid fluids and in 22% of nonrheumatoid inflammatory fluid leukocytes. Antigen was not detectable in synovial samples before extraction. Synovial and bacterial antigens were further purified by proteolytic digestion and Sepharose 4B column chromatography. Biochemical and enzymatic studies of bacterial and synovial antigens were similar and consistent with a high molecular weight polysaccharide. Serum antibody to bacterial and synovial antigens was significantly less frequent in rheumatoid sera than in normal controls. The significance of demonstrating a bacterial polysaccharide primarily in rheumatoid synovial effusions is discussed. | |
| 6488886 | The vasculitis of atrophie blanche (livedoid vasculitis) and abdominal aortic pathology. | 1984 Sep | Seven of forty-two patients with livedoid vasculitis whose cases were reviewed at the Mayo Clinic were found to have abdominal aortic disease, in the form of aortic calcification and atherosclerosis or aneurysm. None of these patients had any associated systemic mesenchymal disease (lupus erythematosus, periarteritis nodosa, rheumatoid arthritis, Sjögren's syndrome, or carcinomatous diseases). Three patients received graft replacements for aneurysm or vascular occlusive disease. Removal of the aneurysm in one case was associated with resolution of the livedoid vasculitis. Abdominal aortic changes should be considered in patients with diagnosed livedoid vasculitis. | |
| 6721317 | [Chronic articular manifestations of sarcoidosis. Apropos of 7 cases]. | 1984 | Chronic articular involvement is rare in sarcoidosis (approximately 0,2 p. 100). The authors report seven cases and describe the special features of chronic sarcoid polyarthritis: incidence of synovitis, possibility of destructive forms resembling rheumatoid arthritis, sensibility to steroids, relatively good functional prognosis. The diagnosis is essentially histological; it should be suspected in any chronic polyarthritis of obscure origin and confirmed by synovial biopsy. The physiopathology of sarcoid synovitis has not yet been determined. | |
| 6607346 | Rheumatic diseases in China. | 1983 Nov | Prevalence and clinical manifestations of 5 common rheumatic diseases in China are discussed. Systemic lupus erythematosus appears to be more prevalent in Chinese than in Caucasians with possibly different clinical manifestations, in particular less serositis. Rheumatoid arthritis may be less aggressive and seronegative arthridities are less common. Behçet's and aortitis are frequently seen but not temporal arteritis and polymyalgia rheumatica. | |
| 6967545 | [Aortic regurgitation and aortic stenosis associated with gastrointestinal bleeding. Repor | 1980 Jun 25 | A 67-year-old woman with a double atherosclerotic aortic valvulopathy and rheumatoid arthritis presented recurrent episodes of gastrointestinal bleeding. Selective arteriography of the superior mesenteric artery demonstrated the existence of vascular malformations with extravasation of the contrast. The physiopathology of this lesion is unknown, but its incidence in adulthood suggests a degenerative process. A selective angiogram of the superior mesenteric artery is mandatory in patients with gastrointestinal bleeding and double aortic valvulopathy in order to establish the etiological diagnosis of the hemorrhage. | |
| 837605 | Posterior compartment syndrome resulting from a dissecting popliteal cyst. Case report. | 1977 Jan | Calf swelling, associated with an intra-articular effusion of the knee, should be considered a dissecting popliteal cyst until proven otherwise. The posterior compartment syndrome caused by an increase in pressure within the deep posterior compartment of the leg is usually secondary to trauma. This case history of a dissecting popliteal cyst reports another unusual cause of the posterior compartment syndrome. Popliteal cysts, especially dissecting ones, are typical of connective tissue diseases, and are not limited to rheumatoid arthritis. | |
| 6540403 | Intraluminal clot of the carotid artery detected radiographically. | 1984 Sep | Nine patients had intraluminal filling defects identifiable as clot within the internal carotid artery at angiography. Thrombus was unilateral in eight, bilateral in one. Eight of the 10 clots were attached to atheromatous plaques. Three patients had serious concurrent illness: pancreatic cancer, rheumatoid arthritis with arteritis, and chronic pulmonary disease with polycythemia. In three patients, the clot was related to severe atherosclerosis. In three other patients, all young, the carotid thrombi remained unexplained though two of these patients had coagulation abnormalities. No patient had a new stroke after surgical or anticoagulant treatment. |