Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6842490 | Fatal coccidioidomycosis in collagen vascular diseases. | 1983 Feb | Ten patients who died from coccidioidomycosis in Arizona from 1968 to 1975 had underlying collagen vascular diseases: 4 with rheumatoid arthritis, 4 with systemic lupus erythematosus, and 2 with dermatomyositis. All 10 patients had been treated with corticosteroids; 2 were taking cytotoxic drugs. Collagen vascular diseases and the use of corticosteroids and cytotoxic drugs may be associated with the depression of cell-mediated immunity. The potential for opportunistic coccidioidomycosis should be noted when corticosteroids and cytotoxic drugs are used for treating collagen vascular disease in patients residing in or coming from areas where coccidioidomycosis is endemic. | |
| 6167073 | Fibrositis: misnomer for a common rheumatic disorder. | 1981 May | Fibrositis is a misnomer for a very common form of nonarticular rheumatism. The name implies an inflammatory process in fibroconnective tissue which has never been verified. The symptoms of fibrositis are ill-defined musculoskeletal pain made worse by stress, cold, noise and unaccustomed exercise; there is usually a significant element of depression, nonrestorative sleep, chronic fatigue and early morning stiffness. Results of physical examination are strikingly normal, apart from painful tender spots which are remarkably consistent in location from patient to patient. It is important to realize that fibrositis can complicate diseases such as rheumatoid arthritis and systemic lupus erythematosus, where its prompt recognition is essential in averting inappropriate medication. Drug therapy alone is seldom effective in alleviating symptoms; a carefully planned education program is necessary to readjust both psyche and soma. | |
| 6981182 | The absence of circulating immune complexes in patients with ankylosing spondylitis. | 1981 | Sera from 50 patients with well-defined ankylosing spondylitis were examined for circulating immune complexes using both a Clq binding (fluid phase) assay and a Raji cell assay. No more than five of the patients assessed had circulating immune complexes by either one of these techniques and none were positive in both. This result is in contrast to the high prevalence in sera from unselected patients with rheumatoid arthritis and systemic lupus used as positive controls. | |
| 7211171 | Multiple sclerosis: search for a serologic inhibitor. | 1980 Sep | Complement-fixing (CF) antibrain antibodies are frequently found in serum and CSF in multiple sclerosis (MS). A negative result in the test for these antibodies might depend not only on a lack of antibodies, but also on serologic inhibiting factors. To test this possibility, serum and concentrated CSF samples without demonstrable CF antibrain antibodies were allowed to interact with two standardized positive complement fixation reactions; one for antibrain antibodies and the other a Wasserman reaction. No evidence of inhibiting activity was found in 11 CSF and 15 serum samples from 20 MS patients. On the other hand, inhibiting activity was seen in serum from four of 12 patients with neoplasms and from three of 11 patients with rheumatoid arthritis. | |
| 315113 | Non-HLA lymphocyte cytotoxins in various diseases. | 1979 Jul | Cold non-HLA lymphocyte cytotoxins were found to be principally reactive against B lymphocytes. These antibodies were studied in 1335 patients with a wide range of diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), scleroderma, Hashimoto's disease, asthma, diabetes, lymphoma, psoriasis, leukemia, multiple sclerosis, and also in healthy donors. Antibodies reactive to B lymphocytes in the cold or warm test conditions were not directed against HLA specificities. Since B lymphocytes differ from T lymphocytes principally in that they have surface immunoglobulin, it is postulated that at least one target antigen of cold lymphocyte cytotoxins is not a virus, infectious agent, or a genetically determined structural antigen, but, rather, simply immunoglobulin. | |
| 321160 | The reactivity of the antistriational antibodies associated with thymoma and myasthenia gr | 1977 Jan | Using immunofluorescence forty-nine sera giving striational staining of skeletal and cardiac muscle have been tested on glycerinated myofibrils. By comparing immunofluorescence and phase contrast it has been found that these antibodies are rather heterogeneous but at least three different staining patterns can be identified. Some patterns may be associated with the presence of a thymoma or may be induced by penicillamine treatment of patients with rheumatoid arthritis. Routine screening for antistriational antibodies may lead to the recognition of undiagnosed myasthenia gravis and thymoma. Antistriational autoantibodies may be useful in the further study of the structure and function of the sarcomere. | |
| 170675 | [Hypolipidemias]. | 1975 Sep 27 | Hypolipidemias can be divided in primary, familial and hereditary forms and symptomatic forms which may accompany other diseases. The primary hypolipidemias (abetalipoproteinemia, hypobetalipoproteinemia and analphalipoproteinemia) are very rare. Severe hypolipidemia can be found in some peoples (e.g. the Masai). This article is chiefly devoted to secondary hypolipidemias such as those associated with malabsorption, malnutrition and maldigestion including protein-losing gastroenteropathy, with liver diseases, endocrine diseases (hyperthyroidism, hirsutism) and anemia. Finally, the hypolipidemias secondary to the formation of autoantibodies against HDL and LDL in M-gradient, carcinoma and rheumatoid arthritis are briefly reviewed. | |
| 1116058 | Gastrocolic fistula complicating benign gastric ulcer: case report and review of literatur | 1975 Mar | A review of the literature and report of a case of benign gastrocolic fistula indicate that epigastric pain is the most frequent early symptom. Later, the predominant symptoms are diarrhea, weight loss and feculent vomiting. Patients suffering from rheumatoid arthritis and taking steroids appear to be particularly at risk of developing a gastrocolic fistula. Barium enema is the most reliable method of demonstrating the fistula. Preferred management is a one-stage gastrocolic resection and primary anastomosis. | |
| 388652 | Gold-induced thrombocytopenia responsive to cyclophosphamide. | 1979 Nov | Thrombocytopenia and nephrotic syndrome developed in a 51-year-old patient receiving gold therapy for rheumatoid arthritis. Marrrow findings and platelet infusion studies were consistent with a pattern of increased platelet destruction, known to occur in gold-induced thrombocytopenia. Improvement in the platelet count after therapy with dimercaprol was transient, and although steroids and splenectomy were not effective, a response was achieved with cyclophosphamide. The use of immunosuppressive drugs can be considered in refractory cases of gold-induced thrombocytopenia in which a significant hemorrhagic risk is present. | |
| 37494 | [Autoimmune diseases in the lungs and pleura (author's transl)]. | 1979 Apr | Diseases of autoaggression can be produced if immunotolerance to endogenous tissue is lost. Such diseases become manifest in the pulmonary and pleura regions mainly within the framework of systemic diseases of the connective tissue (collagenoses) and of the vessels (angiitides). Lupus erythematodes disseminatus belongs to the first group which also includes rheumatoid arthritis, sclerodermia, and dermatomyositis, whereas panarteritis nodosa belongs to the second group, which comprises among others arteritis of the arteria pulmonalis, Wegener's granulomatosis, Goodpasture's syndrome and Ceelen's disease. Pleuropulmonary involvement is frequent in these systemic diseases; it is in fact the principal sign in Goodpasture's syndrome and in Ceelen's disease. | |
| 595723 | [Studies on cell-mediated immunity in patients with chronic lymphatic leukemia]. | 1977 Oct 1 | More than 100,000 variables (anamnestic, clinical, serological, radiological and histological individual findings) of 142 patients with rheumatoid arthritis underwent a factor analysis. In the calculatory statistical course by means of information densification we established a few basic variables, called factors. The interpretation of these factors showed apart from logical and pathogenetic connection also relations which gave an impetus for further clinical research. | |
| 974035 | Iron uptake and ferritin synthesis by peripheral blood leucocytes from normal subjects and | 1976 Oct | The ferritin content of monocytes, lymphocytes and polymorphs is reduced in patients with iron deficiency anaemia. In patients with the anaemia of chronic disease a reduced serum iron concentration is associated with an increase in the ferritin content of all peripheral blood leucocytes. Iron uptake by all cell types is related to transferrin saturation. In iron deficiency anaemia lymphocyte iron uptake is greatly increased, possibly relfecting intracellular iron depletion. In patients with active rheumatoid arthritis and carcinomatosis there is no alteration in leucocyte iron uptake or ferritin synthesis. | |
| 1163993 | The potential role of prostaglandins in skeletal and muscular disorders. | 1975 Jul | Musculoskeletal diseases such as rheumatoid arthritis and polymyositis are characterized by chronic inflammation. There is evidence to suggest that prostaglandins participate in the production of the inflammatory response. In several tissues, the production of inflammation has been associated with the release of prostaglandins. The inhibitory effect of some anti-inflammatory agents on prostaglandin synthesis further suggests a prostaglandin role in inflammation. Reduction by prostaglandins of release from cells of mediators of inflammation has been described. Prostaglandin treatment also suppresses acute and chronic inflammation in several experimental models. Thus, prostaglandins may serve to regulate the inflammatory response. | |
| 4618907 | Coeliac disease and autoimmunity. | 1974 Jan | Among fifty-seven patients with proven coeliac disease three also had thyrotoxicosis, two insulin dependant diabetes, three fibrosing alveolitis and one each had vitiligo, rheumatoid arthritis and cryptogenic cirrhosis. Autoantibodies were demonstrated in twelve of thirty-one patients tested, seven of these twelve had one of the above associated conditions. Antireticulin antibodies were found in seven of twenty-three patients tested, and there was a significant association with dietary gluten. These findings appear to support that coeliac disease is associated with disturbed immunity and that a predisposition to autoimmunity may exist. | |
| 3971618 | Supracondylar fracture in a patient with total knee arthroplasty. A case report. | 1985 Mar | A supracondylar fracture occurred in a 48-year-old woman with rheumatoid arthritis and a total knee arthroplasty. The Rush pin technique required minimal surgical exposure and caused little disruption of surrounding soft tissue and blood supply. Soft tissues preserved inherent stability, allowing early range of motion and partial weight-bearing. Follow-up evaluation seven years later demonstrated maintenance of alignment and no loss of range of motion. | |
| 6154292 | Laboratory investigation of systemic lupus erythematosus. | 1980 Apr | Diagnosis of systemic lupus erythematosus (SLE) requires documentation of multisystem involvement and the presence of antinuclear antibodies. In almost all cases of SLE, these autoantibodies are detected at significant titer with a sensitive screening test such as the fluorescent antinuclear antibody test. After other diagnostic possibilities, such as rheumatoid arthritis, have been excluded, several laboratory tests (hematocrit determination, complement tests, anti-native DNA assays) are available to monitor the response to therapy. | |
| 7001493 | Some modern aspects of the mode of action of non-steroidal anti-inflammatory drugs. | 1980 | The modern concepts of the mode of action of non-steroidal anti-inflammatory drugs with reference to the mediators of inflammatory processes are reviewed. It seems likely that prostaglandins (E1 and E2) and the kinin system are closely associated inflammatory mediators which are responsible for maintenance of the signs and symptoms of chronic inflammatory joint disease. It is suggested that the analgesic action of aspirin-like drugs in rheumatoid arthritis is the result not only of blocking production of prostaglandins but also of limiting the increased availability of kinin precursor (kininogen). | |
| 160664 | Liquid paraffin pneumonia--with chemical analysis and electronmicroscopy. | 1979 Jun 29 | Liquid paraffin pneumonia was diagnosed after open lung biopsy in a woman age 73 with a hiatus hernia and rheumatoid arthritis who had been taking liquid paraffin nightly for fifty two years. Histological examination showed a lipid type pneumonia with involvement of alveoli, interstitial tissues and brochioles. Chemical analysis of the lung showed total lipids of 17.7% (w/w), 86% was liquid paraffin which was positively identified by infrared spectroscopy. Transmission electronmicroscopy showed macrophages in the alveoli filled by phagosomes. The alveoli were mainly lined by alveolar type II cells. Scanning electronmicroscopy showed alveoli filled by a mass of vacuoled material. | |
| 662925 | Evaluation of patient education programs. | 1978 Jul | Patient education is a vital component of comprehensive quality care for patients with chronic disease. Rarely is patient instruction evaluated, however, in terms of its effectiveness and efficiency. This article presents a rationale for evaluation of patient education and lists several benefits of evaluation to the clinician. A model for evaluation and evaluation activities is described for both the process of developing a patient education program and evaluating its results. Application of this model and examples of the use of evaluation activities are demonstrated in a "real world" experience. The description of a formal patient education program for rheumatoid arthritis patients in a general hospital setting illustrates the usefulness of evaluation in developing and carrying out effective patient education. | |
| 970769 | Sicca syndrome and total lipodystrophy: a case in a fifteen-year-old female patient. | 1976 Oct | A 15-year-old girl is described with the sicca syndrome of keratoconjunctivitis and xerostomia. There was no associated rheumatoid arthritis or other connective tissue disorder, but total lipodystrophy had been present since the age of 9 years. Marked hyperreactivity of the humoral immune system and suppression of cell-mediated immunity was shown. The association of sicca syndrome with total lipodystrophy has not previously been reported. |