Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6655804 | [Effects of various antibiotics and natural mycotoxins on the hematopoietic stem cells of | 1983 Jul | This experiment was carried out, in order to investigate the effect of antibiotics and natural mycotoxin on the hematopoietic stem cells at the normal and inflammatory condition. Adjuvant-treated rats (Aj-rats) are considered as a model of human rheumatoid arthritis. We measured the CFU-C and CFU-E of bone marrow of normal and Aj-rats which were injected with large (1.0 g/kg X 3) and small doses (0.5 g/kg X 3) of ampicillin (ABPC), cefazolin (CEZ), chloramphenicol (CP) and fusarenon-X (F-X). In Aj-rats the number of CFU-C was 1.5 times higher and CFU-E 60% less than normal. Injection of large doses of ABPC enhanced markedly the numbers of CFU-C in Aj-rats and suppressed slightly CFU-E in normal rats. Large doses of CEZ inclined to increase CFU-C and decreased CFU-E in normal and Aj-rats. Injection of small doses of CP tended to increase CFU-C and to decrease CFU-E, and large doses of CP to suppress both CFU-C and CFU-E levels in normal or Aj-rats. F-X, natural mycotoxin suppressed markedly both CFU-C and CFU-E levels of normal rats, and slightly the CFU-E in Aj-rats. These results suggest that one should pay attention to the fact that some doses of antibiotics or natural mycotoxin might be harmful on the bone marrow hematopoietic stem cells. | |
| 6260121 | "Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, ac | 1981 Mar | Hydroxyapatite crystals in spheroid-shaped masses 1.9-15.6 micrometer in diameter were found in 12 of 13 synovial fluids obtained from the shoulder joints of 4 patients with rotator cuff tears and glenohumeral osteoarthritis. Two of 16 control joint fluids also showed these particles. Collagen types I, II and III were identified in the joint fluid pellets from 3 of the 4 patients, and fibers with typical collagen periodicity were also seen on transmission electronmicroscopy. Collagenase and neutral protease activities were found in fluids from 5 joints in 3 patients, whereas active collagenase was found in only 1 of 10 fluids from rheumatoid arthritis patients and in none of 3 fluids from patients with osteoarthritis. Neutral protease activities were present in several rheumatoid joint fluids. These findings are compatible with the hypothesis of an enzymatic release of hydroxyapatite crystals from the synovium and endocytosis by synovial macrophage-like cells with subsequent crystal-stimulated release of collagenase and neutral protease into the joint fluid, completing a pathogenetic cycle. | |
| 3931797 | Psoriasis: familial predisposition and environmental factors. | 1985 Oct 12 | In a survey for coronary risk factors 14 667 adult men and women answered a questionnaire on lifestyle, diet, and health, including whether they had psoriasis. The overall prevalence of psoriasis was 4.79% in men and 4.85% in women. The data showed an increasing incidence of psoriasis. The association with family history, lifestyle, diet, and health was explored by multiple regression analysis. The occurrence of psoriasis in first degree relatives contributed to more than 90% of the explained variance for both sexes. Of the other variables, only the positive association with rheumatoid arthritis was significant in both sexes. It is concluded that the examined environmental factors have only minor effects on the prevalence of psoriasis. | |
| 4088202 | [Modern trend in artificial joints]. | 1985 Sep | When the bone and joint are destroyed by rheumatoid arthritis, fractures involving joint, bone tumor and osteoarthritis, surgical intervention is indicated to replace affected joint by artificial joint. In 1984, about 27,400 surgeries were done in Japan, including 12,000 endoprosthesis of femoral head and 9,400 total hip replacement. Materials used for artificial joint are stainless alloy, alumina-ceramic, polyethylene and silicon-rubber. Methalcrylate bone cement is frequently used to get anchoring between artificial joint and skeletal tissue, however, it has disadvantage in case of revision. Recently many designs of artificial joint without bone-cement have been developing. It has been elucidated that resistance at friction between ceramic and polyethylene is ten times lessened than metal and polyethylene. Polycentric architecture which is modified from simple ball and socket is known to be that wearing of artificial joint and bone structure is able to be decreased. Durability will be much improved by not only selecting a material but also by devising suitable design. Infection associated with implant should be strictly avoided by using clean operating room and prophylaxis with antibiotics. | |
| 6623452 | Estimating genotype relative risks. | 1983 Aug | When a disease is rare in the general population, genotype relative risks can be estimated from case-control data by adjusting the genotype frequencies in controls to the expected Hardy-Weinberg proportions. The resulting risk estimates are shown to have a smaller variance than those obtained from the observed genotype frequencies, and test statistics are given for adjusted estimates. The tests are shown to have a larger power for detecting genotype association, and heterogeneity in the genotypic relative risks, than those based on the observed frequencies. An application is given to data on rheumatoid arthritis and HLA-DR antigens. | |
| 6849675 | Pyogenic and fungal vertebral osteomyelitis with paralysis. | 1983 Jan | A retrospective review of the cases of sixty-one patients with vertebral osteomyelitis revealed that the associated diseases of diabetes mellitus and rheumatoid arthritis as well as increased age and a more cephalad level of infection predisposed to paralysis. For patients with paralysis and a long-term follow-up, the prognosis for isolated nerve-root deficits is good with or without surgery. For patients with spinal cord compression, the results generally are better with anterior decompression and stabilization than with laminectomy. Early treatment should be directed at prevention of intrinsic spinal-cord damage, which is irreversible. | |
| 7326452 | [The deep arterial system of the wrist]. | 1980 Dec | The deep arterial system of the wrist area is formed by a palmar and dorsal anastomotic network. It arises from the radial, ulnar and interosseus arteries and follows the longitudinal axes: lateral, medial and median. At the level of the radial and ulnar epiphyses the system is essentially periosteal. At the carpal level, the arteries are intra-ligamentous and intra-capsular. The four pedicles of the median axis join the deep palmar arch. All the elements of this system are interconnected. The deep arterial system of the wrist area is separated from the superficial system by a facial layer at the level of the radial and ulnar epiphysis and by the thickness of the capsule and its ligaments at the carpal level. Rheumatoid arthritis invades the wrist following the pattern of the arteries of the deep systems. | |
| 7319432 | Arthrodesis of the first metatarsophalangeal joint. | 1980 Nov | A series of 41 first toe metatarsophalangeal joint arthrodeses performed in 28 patients was subjectively and objectively evaluated by personal interview, physical examination, and follow-up X-rays. The length of the post-operative follow-up ranged from 5 to 58 months, with an average of 35 months. The overall rate of fusion was 95%. Excellent or good results were obtained in 28 procedures, representing 68% of the study of the patients. Utilizing this procedure in the treatment of severe forefoot deformities, secondary to rheumatoid arthritis, demonstrated that 85% of the patients obtained excellent or good results, and, in the treatment of patients with failed bunion surgery, 53% obtained excellent or good results. | |
| 7209350 | [Chronic atrophic polychondritis. Report of three cases, with ultrastructural study by ele | 1980 Oct | The authors report 3 cases of chronic atrophic polychondritis with clinical signs characteristic of the disease. The 3 patients had deafness of perceptive type, very severe in one case. In one case, the relationship between inflammatory rheumatism and rheumatoid arthritis is discussed. The 3 cases include a pathological study under the electron microscope of the cartilage of the ear. Certain ultrastructural peculiarities observed (dense perichondrocyte granules) are compared with the data in the literature. | |
| 7375965 | Hip arthropathy in ochronosis: anatomical and radiological study. | 1980 Apr | Anatomical and radiological studies of four cases of ochronotic arthropathy of the hip were based on the examination of a total of six surgically removed femoral heads. One of these had undergone a surgical biopsy 10 years previously. The impregnation of the articular cartilage by the ochronotic pigment causes it to break into small fragments in the weight-bearing zone. This results in a similar osteoarthrotic remodeling to that commonly attributed to the histologically different "degenerative chondropathy". The labelling of the cartilage in ochronotic arthropathies offers an opportunity for better understanding of the main nonspecific components of osteoarthrotic remodeling. An anatomico-pathological approach explains why their radiological images in the hip may simulate those of rheumatoid arthritis. | |
| 7189217 | Frontometaphyseal dysplasia: autosomal dominant or X-linked? | 1980 Feb | The clinical and radiographic manifestations in a 45-year-old male with frontometaphyseal dysplasia (FMD) are documented and depicted. Deafness and degenerative osteoarthropathy in weight-bearing joints were the main clinical problems. Widespread patchy cranial sclerosis was reminiscent of Paget's disease, while digital deformity resembled rheumatoid arthritis. On the basis of a review and tabulation of published reports, evidence emerges to support the concept of X-linked inheritance. The relationship between FMD and osteodysplasty remains a matter for speculation. | |
| 749703 | Jaccoud's arthropathy. A case report and necropsy study. | 1978 Dec | We present a case of Jaccoud's arthropathy in a 59-year-old woman. She developed painless correctable ulnar deviation at the metacarpophalangeal joints of both hands following 4 attacks of rheumatic fever. Radiology did not show the hook lesions previously described, but we do not consider this sign essential for the diagnosis. There was no clinical evidence of rheumatoid arthritis. We were able to examine 3 complete joints from the left little finger at necropsy. Pathological examination of this kind has been possible only once before. The histological findings were fibrous thickening of the joint capsule, secondary degenerative changes, presumably due to longstanding joint deformity, and no evidence of significant synovial pathology. | |
| 677653 | Delayed onset chloroquine retinopathy: case report. | 1978 Jun | A patient presented with decreased visual acuity and retinal findings compatible with chloroquine retinopathy 5 years after discontinuing regular usage of chloroquine for rheumatoid arthritis. A review of the literature on chloroquine retinopathy is outlined. In addition, the characteristic findings including fluorescein angiography, retinal physiologic studies, and symptoms are reviewed. Chloroquine retinopathy is dose related and essentially irreversible and often progressive once typical findings are noted. To our knowledge very delayed onset of chloroquine retinopathy is a relatively rare phenomenon but the medical and ophthalmic communities must be alerted to the possibly severe complications of this iatrogenic disease entity. | |
| 989096 | Proximal myopathy caused by latrogenic phosphate depletion. | 1976 Sep 20 | Severe proximal myopathy associated with hypophosphatemia developed in three patients with chronic renal failure who had been treated with aluminum hydroxide gel. The syndrome was characterized by severe pain, muscular stiffness, and weakness. The illness was originally misdiagnosed both as uremic myopathy and as an exacerbation of rheumatoid arthritis. In one patient, the correct diagnosis was made when symptomatic relief corresponded to the rise of serum phosphate levels. Discontinuation of antacid therapy was followed by gradual recovery. Oral sodium phosphate brought prompt alleviation of muscular pain and stiffness. | |
| 810391 | Energy intake, disability, disease and skinfold thickness in a long-stay hospital. | 1975 | Body build was assessed by measuring supinator and triceps skinfold thickness of 66 elderly patients in a long-stay hospital. Nursing staff made seven day records of the food intakes for the subjects. These were used to estimate calorie intakes. There was no relationship between energy intake and skinfold thickness. Reduced skinfold thicknesses were more common in subjects with rheumatoid arthritis or a previous fractured neck of femur than in those with cerebro-vascular disease or any other disorder. The findings suggest that the body build of long-stay patients is usually determined by their energy intake prior to admission. The feeding patterns of patients, once they are admitted, have little effect on body build. | |
| 3156707 | Psychological assessment in general orthopaedic practice. | 1985 Apr | The importance of psychologic distress and illness behavior is well recognized in low-back pain but has rarely been studied in other orthopedic conditions. Psychologic and clinical assessment of 100 patients undergoing elective surgery for minor leg conditions or joint replacement for osteoarthritis or rheumatoid arthritis showed surprisingly little psychologic distress or illness behavior, particularly when compared with 235 patients with low-back pain. The most striking finding was that in low-back pain there was a close relation between psychologic disturbance and failed surgery, but the nonspinal patients showed a complete absence of such a relation. This type of psychologic assessment is neither necessary nor helpful in the routine management of most clearly defined, nonspinal, correctly managed orthopedic conditions. | |
| 3844938 | Immunoglobulin degradation and D-penicillamine action. | 1985 Jan 31 | Treatment of human IgG with pancreatic elastase gave a product of higher molecular weight than IgG. Its formation was inhibited by blocking IgG sulfhydryl groups with iodoacetamide. Incubation of the high molecular weight product with either glutathione or D-penicillamine yielded Fab- and Fc-like fragments. Addition of oxidized glutathione to mixtures containing either reduced thiol gave a new product of molecular weight intermediate between the high molecular weight product and Fab- and Fc-like fragments. Oxidized D-penicillamine did not substitute for oxidized glutathione. This new product was formed under conditions that favor protein sulfhydryl-disulfide exchange. The effect of D-penicillamine on its formation was discussed in terms of D-penicillamine's mode of action in rheumatoid arthritis. | |
| 4000329 | Acute interstitial nephritis with bone marrow granulomas and uveitis. | 1985 | A case of interstitial nephritis with bone marrow granulomas and uveitis was presented. A 53-year-old woman was found to be uremic in the course of rheumatoid arthritis. The renal biopsy revealed acute interstitial nephritis with eosinophilic infiltration. She also had bone marrow granulomas and uveitis. These findings were compatible with those of the syndrome described by Dobrin et al. The etiology and the pathogenesis of this syndrome remain unknown. However, the elevation of the erythrocyte sedimentation rate, raised levels of serum immunoglobulins, presence of circulating immune complexes and decreased T-cell population observed in this patient suggest the involvement of immunological disorders. | |
| 3157636 | Red cell enzyme types in rheumatic diseases. | 1985 | We studied the frequencies of red cell enzyme types, AcP, PGM1 and EsD in 213 patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), rheumatic heart disease (RHD), scleroderma (Scl) and psoriatic arthropathy (PsA). The differences in frequency of AcP phenotypes between RA, Scl, and PsA and the Moscow population were significant. In PsA the PGM1 phenotype 1-1 frequency was significantly decreased, while the phenotype 2-1 frequency was significantly increased. | |
| 6863571 | Comparison of serum amyloid A protein and C-reactive protein concentrations in cancer and | 1983 Jul | Serum amyloid A (SAA) concentrations correlate well with C-reactive protein (CRP) concentrations. However, SAA is sometimes raised in disease when CRP is normal. This appears to occur more often in certain diseases such as rheumatoid arthritis, primary biliary cirrhosis and chronic active hepatitis. SAA concentrations did not distinguish between cancer with and without metastases as previously indicated, although mean concentrations were higher in more advanced tumours. Despite the higher sensitivity of SAA over CRP in the inflammatory response, SAA has little advantage over CRP in the assessment of malignant disease. |