Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1001901 | Oral signs of aging and their clinical significance. | 1976 Dec | A look in the patient's mouth can give clues to his overall health. For instance, atrophic glossitis--or breakdown of the tongue's papillary structure--reveals that there may be incomplete absorption of vitamin B complex or some other nutritional deficiency. Tenderness and impaired motion in the jaw can mean any of a number of problems related to other joints of the body. Osteoarthritis is often to blame. Or the disablement may be due to rheumatoid arthritis or to sclerosis of joint surfaces. Atrophy of the alveolar bone, which progresses slowly during normal aging, is speeded up in persons with osteoporosis. Even after all teeth are gone, bone loss continues. It's likely to be excessive and uneven, and the resultant sharp ridges and spicules sometimes cause so much pain and irritation that the patient can't tolerate dentures. | |
| 988926 | Behaviour of leukocyte acid phosphatase in various chronic diseases. | 1976 Apr | Leukocyte acid phosphatases were investigated in 146 patients with different chronic diseases. The method of investigation used was that of Kaplow and Burstone slightly modified by the authors in what regards the pH of the incubation medium. Normal or slightly increased scores were observed in the granulocytic series of patients with chronic myeloid leukemia. In patients with rheumatoid arthritis, chronic hepatitis, lupus erythematosus disseminatus and chronic lymphocytic leukemia a moderate enzymatic activity was generally observed in the lymphocyte and more marked in severe forms of disease. A marked increase of the enzyme activity was observed in patients with myeloma. The possibility of a correlation between the intensity of enzyme activity and immunoglobulin formation is discussed. | |
| 55957 | Humoral and cellular immune response to uveal and joint tissue antigens. | 1976 | The antigens of uveal and joint tissues were investigated in view of the close association between anterior non-granulomatous uveitis and ankylosing spondylitis. Numerous antigenic determinants common to the uvea, the synovail membrane and articular cartilage were demonstrated using soluble and semi-particulate tissue extracts. No circulating auto-anti-uveal or joint tissue antigens could be detected in the sera of patients with anterior non-granulomatous uveitis or ankylosing spondylitis. Cellular hypersensitivity to uvea-retina antigens was present, however, in non-granulomatous uveitis. In ankylosing spondylitis this hypersensitivity was directed against synovial membrane antigens. In rheumatoid arthritis the hypersensitivity was directed against all three tissues (uvea-retina, synovial membrane, articular cartilage). The significance of these findings is discussed. | |
| 1158955 | Bone and joint involvement in primary amyloidosis. | 1975 Jun | Primary amyloidosis is an interesting clinical entity in which amyloid is deposited in various organs, particularly mesodermderived tissues such as heart, skeletal muscle, skin, connective tissue and bone. A case with multiple lytic bone lesions is presented. Comparison to previous similar cases is made with attention being directed to the typical distribution of lesions about large joints with associated soft-tissue prominence and increase in the articular space. The differentiating radiologic features are compared to those of rheumatoid arthritis, hyperparathyroidism, and lytic metastatic lesions, with particular attention being given to the osteolytic lesions of plasmacytomas associated with multiple myeloma. | |
| 6718951 | Increased incidence of recurrent hematuria in ankylosing spondylitis: a possible associati | 1984 | A retrospective analysis of our patients with ankylosing spondylitis revealed a 17.8% incidence of recurrent hematuria. Two of the five patients with recurrent hematuria had previously undergone renal biopsies showing a focal proliferative glomerulonephritis. The only specimen examined by immunofluorescent staining showed the typical changes of IgA nephropathy. A control group of patients with rheumatoid arthritis did not show recurrent hematuria. Recurrent hematuria may be a frequent occurrence in ankylosing spondylitis and may signify the presence of one of the glomerulonephritides such as IgA nephropathy. | |
| 6085818 | Disease susceptibility genes and the Ia system. | 1984 | Certain Ia allotypes such as DR4 show a strong association with particular autoimmune diseases such as rheumatoid arthritis. Despite this strong association, a significant number of individuals with the inappropriate Ia allotype develop the disease. It is proposed that these individuals share an Ia determinant or "epitope" with individuals of the appropriate Ia allotype, and that these epitopes, which are "mobile" and can be transmitted from one Ia haplotype and/or gene locus to another by mechanisms such as gene conversion, form the molecular basis for disease-susceptibility genes. | |
| 6816187 | Comparative evaluation of various methods of detecting antibodies against soluble nuclear | 1982 | Results of anti-ENA antibody employing double diffusion in agar gel, electroimmunoprecipitation (CIE) or passive hemagglutination were compared. The studies were performed on 164 patients including 79 patients with rheumatoid arthritis (RA), 46 patients with systemic lupus erythematosus (SLE), 25 patients with systemic sclerosis (PSS), 13 patients with polymyositis (PM) 5 patients with MCTD and on 30 healthy individuals. The obtained data prompt us to recommend demonstration and identification of anti-ENA antibodies in a screening type CIE assay followed by determination of their titer by hemagglutination test. | |
| 7417709 | Polymorphonuclear motility: measurement by computer-linked image analysis. | 1980 Oct | Most methods of measuring neutrophil motility provide information mainly about the performance of a small proportion of the fastest moving cells. Application of a computer-linked image analysis technique, using the "Quantimet," provides a convenient, automated method of measuring the motility of the whole cell population. This makes it possible to test whether changes in motility represent a homogeneous alteration affecting all cells or a change in the numbers or performance of a subset of cells. In this study the neutrophils from patients with uncomplicated rheumatoid arthritis were found to perform similarly to normals, while cells from patients with Felty's syndrome were markedly slower. This was an overall, homogeneous slowing of the whole cell population, not due to a loss of fast moving cells. | |
| 7396142 | Endotracheal intubation with the fibre-optic bronchoscope. | 1980 Mar | Tracheal intubation with the aid of the fibre-optic bronchoscope was compared to conventional and alternative methods in 41 consecutive patients suffering from advanced rheumatoid arthritis. All patients were scheduled for anterior and/or posterior cervical fusion. It was shown that the use of the fibre-optic bronchoscope significantly diminished the number of complicated intubations and reduced the intubation trauma considerably. The occurrence of postoperative upper airway oedema was significantly related to the extent of the intubation trauma. Tracheal intubation with the fibre-optic bronchoscope is considered useful in adult patients when intubation is expected to be difficult or dangerous and when orthodox intubation is found to be very difficult. | |
| 7428493 | Abnormalities of the cranio-vertebral junction with cervico-medullary compression. A ratio | 1980 | 8 children with cranio-vertebral abnormalities and neurological deficits are reviewed. The specific treatment is dependent on etiology, mechanisms of compression, and whether the bony abnormality can be reduced to its normal position. Irreducible ventral compression of the cervico-medullary junction was relieved by transoral removal of the odontoid-clivus complex in 3 patients. Primary posterior decompression was done in 4 children with dorsal encroachment. A reducible C1-C2 dislocation in 1 child with juvenile rheumatoid arthritis underwent primary posterior fusion. A detailed surgical physiological approach is described. | |
| 315208 | Palindromic rheumatism. II. Failure to detect circulating immune complexes during acute ep | 1979 Aug | Thirty-eight samples of blood and 2 of synovial fluid were obtained from 19 patients suffering from palindromic rheumatism. In 12 cases samples were obtained from the same patient both during and between acute attacks. The presence of immune complexes was sought by a C1q-binding test. Most patients gave negative results: moderately elevated levels were obtained in a few. Broadly the pattern of results showed that individual patients were either positive or negative irrespective of whether they were in an attack or in remission. C3 and C4 measurements showed no significant abnormalities, confirming previous studies. Patients with elevated C1q-binding tests tended to be seropositive. We speculate that these are patients more likely to develop rheumatoid arthritis. | |
| 120934 | Myosin autoantibodies reacting with selective muscle fiber types. | 1979 Jan | Myosin in striated muscle exists in at least two immunologically distinct forms. Human autoantibodies specific for either form show selective muscle fiber reactivity. One group of antibodies reacts with type 2b (white) muscle fibers, the other with type 2a (red) and type 1 (intermediate) fibers. All of these antibodies react with the A band of glycerinated myofibrils. Both groups of antibodies react with cardiac muscle. Muscle-fiber-specific antibodies are detected in approximately 1% of sera submitted for diagnostic screening. Sera from eight patients were studied further. The two patients with antibodies against type 2b (white) muscle myosin had rheumatoid arthritis. The six patients with antibodies against type 2a (red) and type 1 (intermediate) myosin had clinical features which included various autoimmune and infectious disorders. | |
| 591638 | Evaluation of a new test system for rubella haemagglutination inhibiting antibodies. | 1977 Nov | A recently available kit for the determination of rubella haemagglutination inhibiting antibodies (Rubindex, Ortho diagnostics) was was compared with the method used routinely in this laboratory. Rubindex compared favourably in that no significant difference in titre was found in 95.1% of 287 sera tested. Difficulty occurred with some sera from cases of Mycoplasma pneumoniae infection, rheumatoid arthritis, and a small number of normal sera containing human "O" cell agglutinins. This was overcome by treatment of the sera with 2-mercaptoethanol. Rubindex had the advantage that all reagents were provided in kit form and the trypsinised human "O" cells provided had a longer shelf life than chick erythrocytes. | |
| 596146 | Total hip replacement in ankylosing spondylitis. | 1977 | Eighteen total hip replacements were performed in 10 patients with ankylosing spondylitis. The mean observation time was 3.8 years. Seven hips had been operated on before total hip replacement (THR); 6 Were ankylotic before THR. The results as regards pain relief and increased walking distance were good. All hips improved in mobility after THR and this improvement was maintained during the observation time. Six of the 10 patients went back to full-time work. The differences between patients with ankylosing spondylitis and rheumatoid arthritis, as regards indications for and rehabilitation after THR, are discussed. | |
| 787015 | Antiinflammatory drugs and gastrointestinal bleeding: a comparison of aspirin and ibuprofe | 1976 Aug | Gastrointestinal blood loss provoked by short-term and long-term therapy with aspirin and ibuprofen was compared in patients with rheumatoid arthritis. Blood loss was assessed by isotope counting of four-day stool collections after infusion of 51Cr-labeled autologous erythrocytes. After two weeks on drug or after one year on drug, aspirin consistently caused more bleeding than ibuprofen. | |
| 7247974 | Pharmacology of human spontaneous monocyte-mediated cytotoxicity. I. Enhancement by salicy | 1981 Jun | The effect of various antiinflammatory agents on the spontaneous cytotoxicity of human mononuclear cells in vitro was assessed. Acetylsalicylic acid (ASA) and hydrocortisone enhanced spontaneous monocyte-mediated cytotoxicity compared to control values. This enhancement could not be mediated through inhibition of prostaglandin biosynthesis since indomethacin had no effect on cytotoxic function and since the direct addition of PGE2 to the cell cultures did not inhibit the expression of cytotoxicity. Likewise, salicylic acid (SA), which had no effect on prostaglandin biosynthesis, also enhanced monocyte cytotoxicity. Stimulation of monocyte-mediated cytotoxicity resulting in more efficient antigen removal and thus decreasing antigen persistence may be an additional mechanism by which ASA, SA, and hydrocortisone modulate the destructive inflammatory response in rheumatoid arthritis. | |
| 6976616 | Rheumatic disorders in primary care. A study of two primary care centres and a review of p | 1981 | Utilization of care for rheumatic disorders was studied in two primary care units. In both units 12% of visits concerned some form of rheumatic disease. This diagnostic group (chapter XIII of ICD) ranked third after cardiovascular and respiratory diseases. The total number of visits per inhabitant was higher for all diagnoses, as well as for the rheumatic disorders, in the most remote primary care unit. The distribution of rheumatic diagnoses was similar in the two units. Back disorders were most frequent among men, whereas soft tissue rheumatism and back disorders each accounted for one-third of the cases among women. Inflammatory rheumatic diseases and osteo-arthritis played only a minor part. Visits due to rheumatic disorders decreased after retirement age, particularly among men. The findings were representative of primary care in rural areas of Sweden. Only 20% of referrals from primary care to the rheumatology department gave a tentative diagnosis and half of these suggestions were changed after examination. The majority of referred patients without any suggested diagnosis suffered from soft tissue rheumatism or inflammatory rheumatic disorders other than rheumatoid arthritis. | |
| 6968557 | The role of alpha 1 protease inhibitor (alpha 1 antitrypsin) in the regulation of immunolo | 1980 Aug | Twenty-six different alleles have been identified for alpha 1 protease inhibitor (alpha 1 antitrypsin), each designated by a letter of the alphabet. In any individual two alleles codominantly determine the characteristics of alpha 1 protease inhibitor (Pi), including mobility on electrophoresis, serum concentration and acute phase response. Recent evidence has linked some mildly deficient phenotypes of Pi with a variety of chronic immunologic and inflammatory disorders, such as rheumatoid arthritis, juvenile chronic arthritis, systemic lupus erythematosus, ankylosing spondylitis, uveitis, asthma and fibrosing alveolitis, in addition to the well recognised association of severe deficiency with emphysema and chronic liver disease. This disease susceptibility in phenotypes associated with reduced serum levels may be due to alteration in lymphocyte responses, complement activation and leukocyte migration. Pi can also influence the autolytic effects of leukocytic enzymes on tissues and may inhibit some aspects of coagulation and fibrinolysis. Therefore patients with deficient Pi phenotypes are likely to have exaggerated immunologic and inflammatory responses. | |
| 6806318 | Antibodies from patients with connective tissue diseases bind specific subsets of cellular | 1982 Jul | We characterized the RNA-containing antigens precipitated by sera from 260 patients with positive antinuclear antibodies. 49 individuals, most of whom had systemic lupus erythematosus or Sjögren's syndrome, possessed antibodies that precipitated the previously identified RNP, Sm, Ro, and La antigens either singly or in combinations. These antigens, which are located on discrete sets of small nuclear or cytoplasmic RNA-protein particles, exhibited a number of antigenic interrelationships. One patient's serum recognized a new particle containing a small RNA which we have called Th; it also precipitated the Ro complexes. Other patients with systemic lupus erythematosus, hepatitis B virus infection, juvenile rheumatoid arthritis, myositis, and rheumatoid arthritis had antibodies that precipitated specific subsets of ribosomal RNA and transfer RNA. One patient's serum contained a monoclonal immunoglobulin G that precipitated ribosomes. Most of these antibodies identified antigenic determinants constituted at least in part of protein. The specificity of the proteins bound to particular cellular RNA, probably explains the exquisite precision with which antibodies from rheumatic disease patients discriminate among RNA subsets. Such sera should be useful probes for investigating specific roles that different RNA and RNA-protein complexes play in cellular metabolism. | |
| 803182 | Acrylic cement stabilized joint replacements. | 1975 Nov | Surgical management of osteoarthritis, aseptic necrosis and rheumatoid arthritis has been revolutionized by the introduction of acrylic cement-stabilized joint surface replacement. Although single joint surface replacements have been employed extensively for more than half a century, total surface replacement operations with a wear-resistant high-density polyethylene and noncorrosive stainless steel stabilized by acrylic cement were introduced only a little more than 12 years ago. This evolved with Charnley's discovery of the high level of bone tolerance for acrylic cement. Acrylic cement made it possible mechanically to bond artificial joint surfaces to the bone ends and produce an insensitive Charcot-like functioning joint. A barium sulfate additive makes the cement radiopaque for visualizing the bone-cement interface. Barium sulfate additive also lowers the polymerization temperature and opens the polymer for influx of interstitial fluids. Antibiotics have also been added to the cement for prevention and treatment of infection of the surrounding tissues. In aged individuals with cardiovascular disease, the absorption of the acrylic monomer depresses cardiac output and produces hypotension for 2-5 minutes after impaction of acrylic cement into spongy bone. The hypotension has been minimized by cautious fluid replacement and maintenance of adequate blood volume before, during and after the operation. Approximately 30,000 total hip arthroplasties are performed in the United States annually in patients older than 50 years of age with fractured femoral head replacements, bilateral rheumatoid arthritis, old neglected congenital dislocations of the hip or osteonecrosis with and without osteoarthritis. The pain relief is more complete and the functional improvement more predictable than in any other previously recommended surgical operation for the purpose. For this reason, total hip arthroplasty has almost completely supplanted mold-arthroplasty, osteotomy, capsulotomy (hanging hip) and resection of the femoral head. Hemiarthroplasty in the form of femoral head replacement still is the procedure of choice in patients with fractures of the neck of the femur and a normal acetabular articular cartilage, irrespective of age. As a countermeasure against loosening of the prosthesis in patients with osteoporosis and a hollow proximal end of the femur, the stem can be stabilized with acrylic cement. A standard replaceable femoral head for subsequent conversion of femoral head replacement to total hip arthroplasty is an important consideration and presently is under investigation in several medical centers.(ABSTRACT TRUNCATED AT 400 WORDS) |