Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7092606 | [The muscular lesion in myasthenia gravis: study of 17 cases with muscular histochemistry] | 1982 Mar | A study of 17 muscle biopsies from patients with myasthenia gravis was done, using freshfrozen section and histochemistry tecnics. It was found 15 abnormal muscle biopsies. The most common abnormality were small dark angular fibers, excess of lipids droplets outside the muscle membrane, changes in fiber size and type II fiber atrophy. These findings suggested denervation in 11 biopsies, type II fiber atrophy in 7, linfocyte infiltration in 4, fiber necrosis with fagocitosis in 1 and 2 were normal. Was noted a direct correlation between the disease duration and the severity of the histological abnormality. Two patients had tymoma. Congenital myasthenia gravis, rheumatoid arthritis, intersticial hypertrophic neuritis, Hashimoto tireoiditis and concomitance of myasthenic syndrome was found once in different patients. | |
| 7084294 | The development and testing of fenbufen. | 1982 | While looking for new and safer non-steroidal anti-inflammatory drugs (NSAID's) chemists at Lederle Laboratories isolated three compounds, on the basis of animal tests for anti-inflammatory activity, for further screening. Two of these turned out to be metabolites of the third. The parent drug, fenbufen, was found to be inactive in in vitro tests and was thought to be a pro-drug requiring metabolism to produce activity in vivo. This hypothesis has been shown to be correct and further toxicity testing and clinical trials have confirmed the low incidence of gastro-intestinal effects and clinical efficacy of fenbufen in osteo and rheumatoid arthritis. | |
| 7043674 | [The respiratory complications of D-Penicillamine therapy (author's transl)]. | 1982 | The literature is reviewed on patients developing respiratory symptoms while receiving D-Penicillamine, most of whom suffered from rheumatoid arthritis. The manifestations were (in decreasing frequency) bronchiolitis obliterans, interstitial pneumonitis, a Good pasture's like syndrome and bronchospasm. For each complication we discuss diagnostic criteria, the implication of the drug and the pathogenesis. In addition we make suggestions regarding patients on D-Penicillamine and emphasize the need for accurate reporting of adverse pulmonary effects to enlarge the epidemiological picture. | |
| 7303973 | [Kidney involvement in "mixed connective tissue disease" (Sharp syndrome)]. | 1981 Jul | The case in question of the Sharp-syndrome is a mixed collagenosis with symptoms of sclerodermia, Erythematodes visceralis, dermatomyositis and rheumatoid arthritis. Apart from the clinical symptomatology the immunological profile is decisive for the ascertainment of the diagnosis. With the help of 3 descriptions of cases is referred to a frequent participation of the kidneys, particularly histologically and immune-histologically. In contrast to the hitherto existing publications also in missing pathological findings of the urine a renal biopsy should be aspired to, since important therapeutic and prognostic considerations are dependent on this. | |
| 7224687 | Traumatic synovitis in a classical guitarist: a study of joint laxity. | 1981 Apr | A classical guitarist performing for at least 5 hours each day developed a traumatic synovitis at the left wrist joint that was first erroneously considered to be rheumatoid arthritis. Comparison with members of the same guitar class suggested that unusual joint laxity of the fingers and wrist, probably inherited from the patient's father, was of more importance in the aetiology of the synovitis than a wide range of movement acquired by regular practice. Hyperextension of the metacarpophalangeal joint of the left index finger, quantified by the hyperextensometer, was less marked in the guitarists than in 100 normal individuals. This may be attributed to greater muscular control of the fingers. Lateral instability in the loaded joint may be the most important factor in the aetiology of traumatic synovitis. | |
| 6937131 | Effect of gold salts on peripheral blood monocytes and macrophages. | 1981 | Gold salts have a number of actions at a cellular level which theoretically could either independently or in combination result in the suppression of the inflammatory response leading to the characteristic remission seen in patients receiving chrysotherapy for rheumatoid arthritis. Gold salts have a number of effects on peripheral blood monocyte and macrophage invasion of inflammatory sites as suggested by their ability to inhibit macrophage migration in response to known chemotactic factors. Once present within an inflammatory site, the presence of gold ions may inhibit both the ingestion and digestion of particulate matter, as suggested by both the in vivo and in vitro studies on phagocytic activity of macrophages exposed to gold salts. Finally, they may also be responsible for a reduction in antigen processing and their capability to interact with T-lymphocytes in the mediation of cell-mediated immune responses to appropriate antigenic stimuli. | |
| 583017 | [Chromosome studies before and after phenylbutazone infusion therapy]. | 1979 | Studies on chromosomes of lymphocyte cultures of peripheral blood were performed in 15 patients with rheumatoid arthritis (group I: 48-h culture, n = 8; group II; 72-h culture, n = 7) before and after phenylbutazone infusion therapy (600 mg/d for 10 days). The average rate of cells with exchange aberrations of chromosomal type after this therapy (group I: 0.52%; group II: 0.69%) was higher than the control values found before treatment (group I: 0.13%; group II: 0%); X2 test: group I + II: P less than 0.025. The results obtained are discussed. | |
| 273188 | D-penicillamine-induced mucocutaneous lesions with features of pemphigus. | 1978 Mar | Penicillamine (beta1 beta2 dimethylcysteine) is the drug of choice in the therapeutic management of Wilson's disease and cystinuria and has been used in the treatment of some heavy-metal intoxications. Recent studies have shown that it is efficacious in patients with rheumatoid arthritis. Side effects include sensitivity reactions, nephrotoxicity, bone-marrow suppression, hypogeusia, skin lesions, and the formation of autoantibodies. Two cases are described with the features of pemphigus which were attributed to penicillamine therapy. | |
| 576569 | Immunoblastic sarcoma. | 1977 Mar | A systemic, malignant disorder of immunoblasts has been reported to occur as a late transition phase of immunoblastic lymphadenopathy in an older population. With a background of polyclonal gammopathy, drug sensitivity, lupus erythematosus or rheumatoid arthritis, there may develop a progressive "cloning out" of monomorphous immunoblasts to form immunoblastic sarcoma. Recently, a 17-year-old, postpartum girl without these bizarre hypersensitivity phenomena developed a rapidly fatal, systemically malignant process with severe clinical complications. No historical incitent was identified. The pregnancy had been uneventful and birth had produced a thriving, viable infant. This case may represent the youngest patient with primary, malignant immunoblastic disease occurring in the absence of a "hypersensitivity" state. A brief discussion of the clinical situation, management, and autopsy findings, is presented. Basic morphologic criteria for proper differentiation of malignant immunoblastic problems, lymphoma, and Hodgkin's disease are discussed. | |
| 836220 | Juvenile ankylosing spondylitis, its clinical features and HLA-B27. | 1977 Jan 21 | We have experienced six patients of juvenile ankylosing spondylitis. Their chief complaints were polyarthralgia or coxalgia, however, any pain or stiffness in lumbar regions was absent. These clinical features were atypical for those of ankylosing spondylitis, and much more like those of a peripheral arthropathy such as juvenile rheumatoid arthritis. After a long-term follow-up, all the patients showed definite clinical features of ankylosing spondylitis. HLA-B27 was found in 4 out of 6 cases. This frequency is almost equal to that of adult ankylosing spondylitis patients. HLA typing was very important in the early diagnosis. | |
| 1084543 | [Cold lymphocytotoxins in various pathological situations]. | 1975 Dec | Cold lymphocytotoxins have been described extensively in many situations. In the present work, this kind of antibody has been found less frequently than previously in some diseases like infectious mononucleosis, rheumatoïd arthritis, or kidney transplanted patients. These discrepancies may be due to technical considerations. In contrast, cold lymphocytotoxins, in the present work, have been frequently detected in auto-immune hemolytic anemias with cold agglutinins, and in patients having immuno-deficiencies. | |
| 769706 | Phenylbutazone and chromosomal damage. | 1975 Oct | Investigation of 44 paired test and control patients, all suffering from rheumatoid arthritis, following exposure to phenylbutazone (PBZ) and/or oxyphenbutazone (OPB), suggests that there is no significant increase in the level of chromosomal damage in lymphocytes. The control subjects comprised two series, one previously exposed to PBZ and/or OPB, but not for at least 1-5 years, and the other never exposed to PBZ or OPB. No significant difference in the level of chromosome damage was found between patients never exposed, previously exposed, or now receiving PBZ and/or OPB. | |
| 4442013 | Cardiovascular manifestations of ankylosing spondylitis. | 1974 Dec 21 | The incidence of cardiovascular lesions in 97 patients with ankylosing spondylitis (AS) was found to be 14%; 8 patients had isolated aortic insufficiency (AI), 3 had isolated heart block, 2 had combined AI and heart block, and 1 had mitral insufficiency. In comparison with control groups of 81 patients with rheumatoid arthritis and 99 random hospital patients there was no increased incidence of isolated heart block in patients with AS. Clinical and postmortem findings indicated that the cardiovascular lesions of some patients with AS may antedate articular disease and may regress spontaneously. In addition, the unusual occurrence of AI in two patients with psoriatic spondylitis and in one with AS and regional enteritis is documented. | |
| 975758 | The single hot joint. | 1976 Oct | Several points may be stressed. (1)When in doubt, perform joint aspiration and look for crystals of micro-organisms. A joint tap is nearly always indicated. (2)Do not rely on a coincidental elevated serum uric acid level. Question the patient regarding drug therapy and other causes of secondary hyperuricemia. (3)Examine all of the patient, looking for tophi (gout), skin lesions (gonococcal infection, psoriasis), erythema nodosum (allergic reactions, fungal infections), and other clues. (4)Monoarticular rheumatoid arthritis is a rare cause of a single hot joint, but it is much more common that the real rarities (e.g., pigmented willondular synovitis). (5)Anky-losing spondylitis and Reiter's syndrome are common, yet frequently overlooked. (6)Radiologic examination is usually not helpful. (7)Having ruled out infection, crystal synovitis, and hemorrhage, it is sufficient to introduce symptomatic treatment and await the natural development of the joint disease. Follow-up in four to six weeks and simple blood studies often reveal the definitive diagnosis. Most of the time, natural healing processes are effective , and reward the patience of the conservative physician. Blind management must always be avoided. | |
| 6740424 | Amyloidosis at Groote Schuur Hospital, Cape Town. | 1984 Jul 14 | The records of 52 patients with amyloidosis admitted to Groote Schuur Hospital, Cape Town, between January 1969 and August 1982 were analysed. The male: female ratio was 1,3:1 and the mean age was 49,3 years. Forty-eight per cent of the patients had secondary amyloidosis, 21% had primary amyloidosis, 11,5% had localized amyloidosis and 11,5% had amyloidosis associated with multiple myeloma. Tuberculosis, chronic pulmonary sepsis and other chronic infections were present in 88% and rheumatoid arthritis in 16% of the patients with secondary amyloidosis. The commonest features at diagnosis were proteinuria (70%), oedema (52%) and hepatomegaly (39%). The diagnosis of amyloidosis was established by renal, liver and rectal biopsy (either singly or in combination) in 82% of cases. The prevalence of amyloidosis at autopsy was 0,28%. | |
| 6427462 | Circulating thiomalate after administration of disodium aurothiomalate: impurity or active | 1984 Apr | During studies of the metabolism of disodium aurothiomalate in patients with rheumatoid arthritis we have found that its pharmaceutical preparation. Myocrisin, contains 4 to 8% of free thiomalate. To establish whether the free thiomalate previously reported in plasma and urine of patients receiving Myocrisin is a true metabolite or results from this impurity, we prepared aurothiomalate containing 0.1% thiomalate. Intramuscular injection of the purified drug to 2 healthy subjects produced easily detectable levels of thiomalate in both plasma and urine; 7.7 and 9.8% respectively of the doses given were recovered in urine as free thomalate within 4 h. Thus, dissociation of disodium aurothiomalate does occur in vivo, releasing both gold and free thiomalate as potentially active forms. | |
| 6828677 | Arthrography of the traumatized wrist. Correlation with radiography and the carpal instabi | 1983 Mar | Arthrography with fluoroscopic monitoring was used to assess the soft tissues of the wrist in 100 patients who had chronic traumatic pain but did not have rheumatoid arthritis. Findings were correlated with plain radiographs and the carpal instability series. Arthrograms were normal in 26% of cases and demonstrated perforation of the triangular fibrocartilage in 26%, radiocarpal-midcarpal communication in 30%, capsular lesions in 31%, lymphatic opacification in 12%, and tendon sheath filling in 10%. Communication between the radiocarpal and pisiform-triquetral compartments, a normal finding, was seen in 69%. There was a significant association between perforation of the triangular fibrocartilage and both ulna-plus variance and carpal instability. | |
| 7057808 | Lupus myositis. | 1982 Jan | Eleven patients met rigid criteria for having both polymyositis and systemic lupus erythematosus (SLE). The patients differed little in clinical features when compared with patients who had SLE and polymyositis in a previously reported series. The overall mortality rate of 18% and the finding that 56% of survivors were asymptomatic at latest follow-up (average four years) suggest that the prognosis for this subgroup of patients may be more favorable than that for patients with rheumatoid arthritis and scleroderma complicated by polymyositis and may be comparable to the prognosis of the overall group of patients with polymyositis. | |
| 7315797 | Limitations of polyethylene glycol precipitation assays for circulating immune complexes. | 1981 Dec | Polyethylene glycol precipitation assays (PEG-A) have been promoted as technically simple, inexpensive methods for detecting and quantitating circulating immune complexes; however, their specificity and sensitivity have not been clearly defined. Data are presented showing that the percent recovery of IgG in 3.5% PEG increases as the concentration of IgG increases such that hypergammaglobulinemia alone can cause a positive test result. When sera from 25 patients with rheumatoid arthritis were studied, no correlations were found between results obtained by either Raji cell assay, or cryoprecipitation and those obtained by PEG-A. We conclude that 3.5% PEG-A, although appealing because of simplicity, can not be used as a substitute for established, but technically more demanding assays for circulating immune complexes. | |
| 7279174 | Delayed sciatic palsy after total hip replacement: case report. | 1981 Jul | A 33-year-old woman with a 22-year history of juvenile rheumatoid arthritis developed right lower extremity sciatica 32 months after total hip arthroplasty. Physical examination and electromyography localized the abnormality to the sciatic nerve proximal to the midthigh level, involving the branch to the short head of the biceps femoris muscle. At surgical exploration, a sharp spur of methyl methacrylate, used to cement the acetabular prosthesis to the acetabulum, was found to have eroded through the lateral half of the sciatic nerve. The sciatica was relieved by neurolysis. The etiology of sciatic neuropathy after total hip replacement is reviewed. |