Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 576655 | Pseudo-Sjögren syndrome with hyperlipoproteinemia. | 1977 Apr 11 | Eight patients with parotid enlargement were seen because of varying musculoskeletal complaints. All were overweight and hypertensive; six had diabetes mellitus, four had palpable hepatomegaly, and six were 49 years or older. One patient had arthritis type IIB hyperlipoproteinemia. Four patients had varying degrees of fibrositis, and two of these also had osteoarthritis. Of the others, one each had gout, Reiter syndrome, and restless legs syndrome. All had hyperlipoproteinemia type IV or IIB, and none abused alcohol. None of these patients have true Sjögren syndrome. | |
| 6525277 | [Biological screening of immuno-mediated marrow insufficiency by means of the CFU-GM assay | 1984 Nov 30 | We studied in agar growth behaviour of bone marrow granulocyte-macrophage progenitor cells (CFU-GM) in 16 patients with marrow failure in order to discriminate patients with cells inhibiting granulopoiesis both in bone marrow and peripheral blood. Our experimental design was based on: a) agar culture of bone marrow cells before and after treatment with antilymphocyte globulin (AGL); b) agar co-culture of marrow cells with autologous lymphocytes from peripheral blood. ALG treatment of marrow cells determined CFU-GM growth increase in 4 out of 10 patients; in the same patients co-culture with autologous lymphocytes showed a significant inhibition of CFU-GM growth. The growth enhancement induced by ALG treatment "in vitro" associated with growth inhibition in the coculture suggests the existence of a lymphocyte population suppressing the granulopoiesis both in bone marrow and peripheral blood. With this work we propose an experimental model in order to discriminate marrow failure based on cell-mediated suppression of CFU-GM growth in patient susceptible of immunosuppressive therapy with ALG. | |
| 6418871 | Benign lymphoepithelial lesion in a patient with Sjögren's disease and an IgG paraprotein | 1983 Dec | Clinical and laboratory investigations were performed on a patient presenting with xerostomia and swelling of the parotid gland. Lymphoid infiltration of the salivary glands (parotid and labial) and paraproteinaemia were found. Immunoperoxidase studies of labial and parotid glands revealed that local immunoglobulin synthesis was essentially polyclonal although monoclonal staining of Russell bodies within the labial tissue suggested that at least some of the serum paraprotein was being synthesised locally. The implications of these findings are discussed in terms of diagnosis and treatment. | |
| 220715 | [Pernicious anaemia associated with Hashimoto's thyroiditis, Sjögren's syndrome and chond | 1978 Oct 18 | An association of pernicious anaemia. Hashimoto's thyroiditis, Sjögren's syndrome and chondrocalcinosis in a 68 years old women is described. Such an observation, does not seem to have been reported previously; the frequency of the different associations and the specificity of the antibodies observed in each cases are discussed. | |
| 4804458 | Sjögren's syndrome, dysimmunoglobulinaemia and malignant disease. | 1973 May | The occurrence of carcinoma in situ in the stomach and dysimmunoglobulinaemia in a patient who had Sjögren's syndrome is described. This is believed to be the first report of such a case to be found in the literature. Although carcinoma has occasionally been described, in this syndrome its occurrence is probably coincidental and not part of the disease process. There is a greater incidence of lymphoid tumours in Sjögren's syndrome than in the general population. Corticosteroid therapy favourably influenced the immunoglobulin abnormalities and some of the clinical manifestations of the disease. A brief review of the literature concerning Sjögren's syndrome, auto-immunity and malignant disease is included. | |
| 6742917 | Scleroderma, primary biliary cirrhosis, and Sjögren's syndrome after cosmetic breast augm | 1984 Jun | A 52-year-old woman developed scleroderma, primary biliary cirrhosis, and Sjögren's syndrome after cosmetic silicone injections. These conditions may possibly represent 'human adjuvant disease'. | |
| 306226 | Oesophageal variceal bleeding in Felty's syndrome associated with nodular regenerative hyp | 1978 Apr | Four patients with Felty's syndrome developed massive upper gastrointestinal bleeding due to oesophageal varices. The underlying hepatic pathology in all 4 was nodular regenerative hyperplasia. This appears to be a difficult histological diagnosis to make, having been initially reported as normal on percutaneous biopsy or as fibrosis or cirrhosis on wedge biopsy. This series brings the total number of cases reported in the English literature of this association to 12, suggesting a definite symptom complex. The portal hypertension seems to be due to a combination of increased splenic blood flow and postsinusoidal resistance. The clinical importance of this syndrome is that the appropriate therapy for bleeding oesophageal varices appears to be shunt procedure such as a splenorenal shunt with splenectomy, which should be well tolerated. | |
| 4753724 | Treatment of rapidly progressive rheumatoid pneumoconiosis. | 1973 Oct | Davies, D. (1973).British Journal of Industrial Medicine,30, 396-401. Treatment of rapidly progressive rheumatoid pneumoconiosis. Rheumatoid pneumoconiosis is often a fairly benign condition but in some patients it progresses rapidly and causes severe disability. One patient with rheumatoid pneumoconiosis was treated with chloroquine followed by corticosteroids, and another patient was treated with corticosteroids only. Both showed considerable symptomatic and objective improvement with radiographic regression. Treatment has been continued for five and six years respectively but some progression of the disease has again occurred over this time and with a reduced dose of corticosteroids. | |
| 6487929 | Psoriatic arthritis in psoriatic patients. | 1984 Nov | One hundred and eighty patients with psoriasis have been studied in the Neapolitan area to find the prevalence of arthritis in psoriasis. Wright and Moll's criteria for the diagnosis of arthritis were applied. Of 180 psoriatic patients, 62 exhibited arthritis (34.4% of total cases) According to Moll and Wright's five broad clinical forms of arthritis, the following distribution was found: polyarticular in 38.7% of arthritic patients, mono-oligoarticular in 16.1%, distal interphalangeal in 7.5%, deforming or mutilans in 2.3% and spondylitic and/or sacro-iliitic in 20.9%. In 14.5% of arthritic patients an overlap of the spondylitic form and peripheral involvement was also found. Stratification by age of patient populations shows that cutaneous pathology has a homogeneous distribution in the various age decades, while joint symptoms are seen maximally in the sixth decade and are absent in the first two decades. The relationship between the onset of skin lesions and joint pathology demonstrates that skin lesions preceded arthritis in 64.5% of the cases, whilst arthritis antedated psoriasis in only 19.35%. In 16.1% of cases psoriasis and arthritis began almost simultaneously. Nail changes were present in 63% of arthritic patients and in 37% of psoriatic subjects without arthritis. Furthermore, in 88% of arthritic patients in whom arthritis preceded skin lesions, nail changes antedated the onset of clinically apparent psoriasis. Extra-articular features were not found. This absence might be associated with the usual seronegativity for rheumatoid factor in psoriatic arthritis, also confirmed in this survey. | |
| 4037887 | Oesophageal dysfunction in patients with primary Sjögren's syndrome. | 1985 Sep | Oesophageal motility was studied in 22 patients with primary Sjögren's syndrome and 20 normal volunteers. Oesophageal dysfunction was detected in eight of the 22 patients (36.4%) with primary Sjögren's syndrome. No abnormalities were detected in the normal subjects. Individual analysis of the oesophageal motility studies showed different patterns of oesophageal dysfunction; aperistalsis (three patients), triphasic tertiary contractions (two patients), frequent non-peristaltic contractions (two patients), and low contractions (one patient). These oesophageal abnormalities did not correlate with the parotid flow rate, the degree of inflammatory infiltrate of the minor salivary glands, the extraglandular manifestations, or the presence of autoantibodies. | |
| 6301044 | [Late recurrence of Horton's disease with sicca syndrome]. | 1983 Jan 20 | The authors report the case of an eighty-three-year-old woman with giant-cell arteritis who experienced recurrence five years after the withdrawal of corticosteroids which had been given for four consecutive years. This recurrence, demonstrated by arterial biopsy, was accompanied with Sjögren disease proven upon histological examination. With reference to this case-report, the various possible courses of protracted giant-cell arteritis are discussed; relapses occurring more than one year after therapy is discontinued are exceptional. | |
| 7383399 | [Reynolds syndrome associated with Sjögren's syndrome]. | 1980 May 12 | Observation of a case of CREST syndrome associated with autoimmune chronic hepatopathy (so-called Reynolds syndrome) and Sjögren's syndrome brings to the fore the importance of symptomatological superimpositions within the autoimmune diseases. A number of diagnostic and pathogenetic aspects of this rare disease association are discussed. | |
| 7448434 | [Visceral Kaposi sarcoma with angioimmunoblastic lymphadenopathy and latent sicca syndrome | 1980 | A case clinically and morphologically typical angio-immunoblastic lymphadenopathy in a 64-year old man is reported. A sicca syndrome was discovered with histological localization in the labial accessory salivary glands. Death occurred after a course of a few months. The autopsy showed an association of angio-immunoblastic lymphadenopathy lesions of the bone marrow and the lymph node and of typical multivisceral localizations of Kaposi's sarcoma (lymph node, liver, thyroïdd gland) without skin involvement. This association of two diseases characterized by severe dysimmunity with B lymphocytes hyperplasia is discussed, and compared to the others diseases which could be associated with Kaposi's sarcoma. | |
| 6971939 | Modulation of human antibody production in vitro by D-penicillamine and CuSO4: inhibition | 1981 Jan | Pokeweed mitogen (PWM), a T cell dependent, polyclonal B cell activator, stimulates the differentiation of immunoglobulin secreting cells (ISC) from normal human peripheral blood mononuclear cells (PBM). In this in vitro study, PBM failed to generate ISC in response to PWN after brief exposure to penicillamine and CuSO4; preincubation with either penicillamine or CuSO4 alone had no effect. Experiments utilizing purified populations of B and T cells indicated that penicillamine and CuSO4 markedly inhibited helper T cell activity but not B cell function. These observations may explain the effectiveness of penicillamine in rheumatoid arthritis, especially in decreasing rheumatoid factor titers. | |
| 6965861 | Anti-SS-A antibody and other antinuclear antibodies in systemic lupus erythematosus. | 1980 Mar | Randomly selected sera from 88 patients with systemic lupus erythematosus (SLE) were studied for the frequency of antibodies to SS-A, SS-B, RANA, RNP, Sm, Sc-1, and dsDNA. Results were in agreement with previous reports except for an increased incidence of anti-SS-A antibody (33%). Nine of 14 patients with anti-SS-A antibody on whom serial studies were performed had fluctuating titers. Titer changes often correlated with disease activity and dsDNA antibody levels. | |
| 87081 | Dermatological manifestations in psoriatic arthritis: a follow-up study. | 1979 | Of 227 patients with psoriasis and rheumatic complaints, inflammatory arthritis was present in 168 patients, of whom 95 have been followed up for more than 5 years and 28 had been followed up for more than 10 years. In patients with psoriasis and inflammatory arthritis the majority were women, but in the Distal joint group, males predominated. The skin disease usually began on the arms and was restricted in extent, initially. It usually began before the arthritis. A few cases were apparently precipitated by trauma, but more by psychological factors. The course pursued by the skin lesions was generally favourable. The skin lesions were resistant to treatment in 20% of the patients. Puberty, pregnancy and the menopause had little effect on the skin lesions. Nail lesions were present in 80%, a greater frequency than that seen in uncomplicated psoriasis. These nail lesions began at a later age than the skin lesions, and commonly preceded the development of arthritis. There was a family history of psoriasis in 26% of first-degree relatives. A history of polyarthritis was obtained quite frequently, and of psoriatic arthritis in 3% of patients with Distal arthritis, and 2% of the Indistinguishable group. The arthritis was usually mild in degree. Ankylosing spondylitis occurred in 5% and sacro-iliitis in 19%. The sheep cell agglutination test for rheumatoid factor was negative in the majority of patients. It was positive in 16% and a fluctuating positive result was obtained in 10%. | |
| 379847 | [Treatment of auto-immune diseases with special reference to their pulmonary manifestation | 1979 Apr | The treatment of the Goodpasture syndrome, collagenoses (rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis/scleroderma, matosus, progressive systemic sclerosis/scleroderma, dermatomyositis/polymyositis), necrotizing angiitis (periarteritis nodosa, Wegener's granulomatosis) and idiopathic pulmonary fibrosis is reviewed. Their pathogenesis and morbid anatomy is outlined. The uncommunness of these disorders and their pulmonary manifestations is emphasized. The most frequently employed therapeutic agent are the corticosteroids together with acetylsalicylic acid and indomethacin. The effectiveness of immuno-suppressive and cytostatic drugs (azothioprine, cyclophosphamide, chlorambucil) and of D-penicillamine in the treatment of the different disorders is described. Standard programmes for treating any of these diseases have not yet emerged; the long-term results tend do be unsatisfactory. Co-operation with other specialists (nephrologists, rheumatologists, dermatologists) is often necessary in the treatment of these disorders. | |
| 3158801 | A general strategy for the use of allogeneic lymphocyte infusions in the treatment of diso | 1985 Mar | Allogeneic lymphocytes can exert very potent non-specific immunomodulatory effects both in vitro and in vivo. Repeated infusions of allogeneic suppressor or helper populations may find use in the treatment of diseases characterized by impaired suppressor function (such as many autoimmune diseases) or impaired helper function (such as AIDS), respectively. Nutritional adjuvants for use with allogeneic suppressor therapy may include essential fatty acids, zinc, selenium, and vitamin E; the latter two nutrients as well as vitamin C and beta carotene may have value as adjuvants for allogeneic helper therapy. In a small preliminary trial, long-lasting normalization of rheumatoid factor titers and clinical symptoms has been achieved in 5 of 7 cases of chronic rheumatoid arthritis treated with allogeneic lymphocyte infusions, selenium, and vitamin E. These results indicate that allogeneic lymphocyte infusions accompanied by antioxidant support can promote the induction of new appropriate suppressor activity in the host. This phenomenon of allogeneic suppressor induction may be more clinically important than direct allosuppression of host B cells under the conditions of this study, and may find application in the treatment of a number of autoimmune disorders. | |
| 7281913 | [Experiences with the total endoprosthesis of the knee joint to Blauth (author's transl)]. | 1981 Feb | Following a brief review of the differential indication for total prosthesis of the knee joint, the article reports on 136 implantations of the hinged prosthesis according to Blauth. In 94% of the cases the results were good and very good (n = 66) within an average follow-up examination period of 2 years. One of the main features of the success of the treatment is the relief from pain achieved with this prosthesis provided it functions well. Differentation of the treatment results according to the basic underlying disease (rheumatoid arthritis; pangonarthrosis) shows that good results were achieved particularly in relatively young rheumatic patients thanks to their co-operative capacity during the follow-up treatment period. The following relevant complications were seen among the 136 implantations: one early infection, three late infections, two deaths due to cardiovascular general complications, and one fatal case of sepsis as a result of a late infection. The rate of the aseptic loosenings was 1.5% only, and hence favourably low, as was evident from the follow-up examinations of the implanted knee joints. Lateralisation of the patella, which occurred in one-half of the cases, is attributed by us to an intraoperative weakening of the medial patella ligament (which acts as an auxiliary extension apparatus). We intend to counteract this in future via an additional lateral capsular discision. The follow-up study presented here confirms the efficiency of the Blauth model, as well as the generally valid indication criteria for total implantation of the knee joint. | |
| 7224294 | Efficacy of immunoserodiagnostic procedures in the recognition of canine immunologic disea | 1980 Oct | Six immunologic tests were conducted on a large population of dogs with a variety of diseases. The test results were analyzed retrospectively and correlated to the clinical and final pathologic diagnoses. The results indicated that rheumatoid factor and the direct antiglobulin (Coombs) test were both sensitive and specific for the diagnoses of canine rheumatoid arthritis and autoimmune hemolytic anemia. The antinuclear antibody test was useful in supporting the diagnosis of systemic lupus erythematosus (SLE) only when both antibody titer and the staining pattern were taken into consideration. The lupus erythematosus cell test was specific but not sensitive when used to confirm a diagnosis of canine SLE. Cellulose acetate serum electrophoresis and immunoelectrophoretic techniques were each useful in supporting the diagnosis of multiple myeloma. Epizootiologic data collected in this study indicated that dogs with primary immunologic disease had a poor prognosis. A female predisposition was observed in cases of canine autoimmune hemolytic anemia and SLE. Ovariectomy seemed to prevent the development of canine SLE. |