Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4087275 | Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis. | 1985 Oct | Breast enlargement is an unusual complication of D-penicillamine therapy for rheumatoid arthritis. We observed breast enlargement and hyperprolactinemia in a woman receiving D-penicillamine for systemic sclerosis. Treatment with danazol was associated with a reduction in both the breast size and the prolactin level. | |
| 4019594 | Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on | 1985 Feb | When plated on the surface of collagen gel substrata, all types of fibroblasts rapidly begin to migrate down into the three-dimensional collagen matrix. We have previously demonstrated that normal (adult and foreskin), foetal and transformed fibroblasts may be distinguished from each other by virtue of their differential migratory response to changes in cell density. The effects of cell density on fibroblast migration into the gel may be expressed by a single numerical value, the 'cell density migration index' (CDMI). We now present evidence that ostensibly normal skin fibroblasts obtained from the majority of patients we examined with carcinoma of the breast, malignant melanoma, familial polyposis coli, retinoblastoma and Wilms' tumours display aberrant CDMI values falling within the foetal range. Skin fibroblasts obtained from the majority of patients examined with genetic or chronic diseases (e.g. rheumatoid arthritis, Duchenne muscular dystrophy) displayed CDMI values falling within the normal range. | |
| 6605682 | Comparative study of gastrointestinal microbleeding caused by aspirin, fenbufen, and place | 1983 Oct 31 | Fifty volunteers, randomly divided into five groups, received placebo, fenbufen, or aspirin at dosages used in treating osteoarthritis and rheumatoid arthritis (fenbufen, 600 or 900 mg daily; aspirin, 3.6 g daily) for 28 days. Following radioactive chromium labeling of red cells in each subject, stool specimens were collected weekly for determination of blood loss by radioisotope procedure. Statistical analyses demonstrated no significant differences in gastrointestinal microbleeding between subjects who received fenbufen (600 or 900 mg daily) and those who received placebo. Conversely, there were significant (p less than 0.01) differences in microbleeding between subjects given aspirin and those given either dosage of fenbufen or placebo. | |
| 7419829 | The role of cryoglobulins and immune complexes in vasculitis. | 1980 Oct | Immune complexes play a major role in a variety of diseases such as lupus and rheumatoid arthritis. Cryoglobulins, especially those of the mixed type, represent a type of immune complex that is particularly easy to isolate, and hence lend themselves readily to the identification of the responsible precipitating agents. This report presents the clinical, laboratory, and pathologic features of 40 patients with mixed cryoglobulinemia and offers some speculation based on currently available evidence on the role of cryoglobulins in pathogenesis. | |
| 6969066 | Failure to find C1q-binding material and anti-IgG antibodies in ankylosing spondylitis. | 1980 Oct | C1q-binding immune complexes (C1C), anti-IgG antibodies (anti-IgG Ab), and complement levels were investigated in the serum of 37 patients with ankylosing spondylitis (AS). In all these studies the mean levels observed in patients with AS were similar to those in 31 normal subjects. Moreover, no significative difference in either CIC or anti-IgG Ab levels was observed when the patients were classified in different clinical forms according to the localisation (peripheral and central) or to the gravity (mild and severe) of the AS. In a parallel study increased CIC and anti-IgG Ab levels were found in most of the 81 patients with seropositive or seronegative rheumatoid arthritis. | |
| 517464 | Pericardial-fluid complement: normal values. | 1979 Dec | Reports of low pericardial-fluid complement levels in systemic lupus erythematosus and rheumatoid arthritis have been difficult to interpret, as few data are available to describe complement concentrations in patients without pericardial disease. The authors therefore determined normal values under standardized conditions of collection, storage, and assay. The normal ranges for pericardial-fluid C3, C4, and total hemolytic complement were 35-127 mg/dl, 6.3-23 mg/dl, and 1.9-9.1 CH50 units, respectively. Storage at -20 C resulted in a 50% reduction in values. Hence, storage at -70 C is recommended. As the level of pericardial-fluid total hemolytic complement is normally low, caution is needed in interpreting its apparent reduction in various immunologic diseases. | |
| 456771 | Circulating Clq binding complexes in inflammatory bowel diseases. | 1979 | To determine whether circulating immune complexes are present in the sera of patients with inflammatory bowel disease (IBD), a 125I-Clq binding assay was performed. Of the 55 IBD serum samples tested, the 24 ulcerative colitis samples demonstrated significant binding (33.1 +/- 8.3%, p = 0.02), whereas the 31 Crohn's samples bound essentially normal amounts (29.2 +/- 7.4%). A positive control group consisting of 27 patients with rheumatoid arthritis was also studied. Sera from 4 patients wiht IBD and colonic cancer when tested, bound 40.2 +/- 8.0% of the available 125I-Clq, while 10 patients with previous colectomies and ileostomies gave results similar to those of 15 healthy controls and 11 patients with irritable colon. | |
| 659554 | Quantitative gas-liquid chromatographic method for the determination of indomethacin in bi | 1978 Jun 1 | A sensitive and specific gas chromatographic method for the analysis of indomethacin has been developed. After extraction of the drug from blood or urine with ethylene dichrloride a derivative is formed with pentafluorobenzyl bromide. 5-Fluoro-indomethacin is used as an internal standard. The overall recovery of indomethacin is 85.1 +/- 2.3% and the method can detect 10 ng indomethacin in a 1 ml plasma or urine sample. No interference in the method is seen with some commonly used drugs. The method has been used to measure plasma indomethacin concentrations in 20 patients with rheumatoid arthritis, being treated with 25 mg indomethacin three times daily. The plasma concentration ranged from 168-596 ng/ml. | |
| 73956 | Is primary biliary cirrhosis an immune complex disease? | 1977 Dec 17 | Large immune complexes are present in the circulation of patients with primary biliary cirrhosis and result in the activation of complement by the classical pathway. Such large complexes are capable of producing tissue damage. The granulomatous lesions surrounding the small bile-ducts within the liver of patients with primary biliary cirrhosis and the vasculitis, rheumatoid arthritis, and associated lesions are all compatible with immune complex injury. It is postulated that such large complexes could be formed in the vicinity of the bile-ducts by an antigen absorbed from the bile or biliary epithelium. Complexes reaching the systemic circulation might be responsible for the associated extra-hepatic diseases. | |
| 970290 | Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs | 1976 Sep | A delayed hypersensitivity response was induced in the rat paw using pertussis vaccine. Oedema was measured after the challenging injection. D-penicillamine and levamisole enhanced the response, while indomethacin suppressed it. This model is useful to distinguish the effects of anti-inflammatory drugs from those like D-Penicillamine which have a specific activity in rheumatoid arthritis. | |
| 7278 | [Metabolic degradation of cartilage by leucocyte enzymes under the influence of antirheuma | 1976 Feb | Lately the importance and participation of leucocytes in rheumatoid arthritis have been discussed. In order to study catabolic reactions in connective tissue we investigated the autolytic liberation of mucopolysaccharides in cartilage alone and in the presence of leucocyte enzymes. Factors of optimal experimental conditions, such as pH and constituents of incubation medium, incubation time and the number of leucocytes, were determined. In further experiments we studied the influence of antirheumatic drugs, such as sodium salicylate, phenylbutazone, pentosanpoly-sulfate and gold thiopolypeptide, on cartilage degradation. In our experiments only phenylbutazone and pentosanpoly-sulfate exerted an inhibitory effect on leucocyte-stimulated degradation of cartilage. The relevance of this finding for the therapeutic use of these drugs is evaluated. | |
| 809985 | Para-articular ossifications after primary prosthetic replacement ad modum Austin T. Moore | 1975 Sep | This study concerns the frequency of para-articular ossifications after primary prosthetic replacement ad modum Austin T. Moore in the treatment of unstable fractures of the femoral neck. In 121 patients who were X-rayed after surgery ossifications were found in 45 per cent of the cases. Patients that preoperatively had severe coxarthritis or rheumatoid arthritis are excluded. Two thirds of the bone formations described were very small and without clinical importance. About 20 per cent of the ossifications were of a considerable size, but no clinical consequences could be demonstrated. About 12 per cent of the ossifications--6 per cent of all the patients in this study--were large, and only in this group could a compromised hip function be found. It seems as the process of ossification is limited to the first 3 postoperative months. There is a good correlation between the communications regarding ectopic bone formation after total hip replacement and the frequency found in this study. | |
| 1226868 | [The significance of immunologic phenomenons in pulmonary diseases of children (author's t | 1975 Jan | Under special conditions the lung develops reactions of hypersensitivity, e.g. by the contact with antigens consisting of foreign proteins, organic dusts or different pathogen organisms. It must be distinguished between uncomplicated allergic and autoimmune diseases. The exact separation is difficult, because transitions from one state to the other are possible. The autoimmunisation is a very complicated phenomenon, where endogensou cells are effective as auto-antigens and induce the development of auto-antibodies. From the pathological-anatomical point of view thate are no typical structural changes in the lung, which define a disease as a special autoimmune disease. But the prevalence of round cells in inflamed tissue, the appearance of granuloma with epithelial cells point to immunological phenomenons. Examples for allergic diseases are: "Asthma bronchiale, pigeon-breeder disease, mite-allergy, farmer's lung, drug-induced allergy", and for autoimmune diseases: "Lupus erythematosus, rheumatoid arthritis, polyarteritis nodosa, idiopathic pulmonary hemosiderosis, idiopathic pulmonary fibrosis." The drug-therapy consists of corticoids and immune-suppressive drugs. | |
| 1111483 | Flecked retina. Appearance secondary to oxalate crystals from methoxyflurane anesthesia. | 1975 Jan | Calcium oxalate crystals were demonstrated in the retinal pigment epithelium (RPE) of a 66-year old white man with changes in the fundus oculi consistent with the flecked retina ayndrome. The patient had a history of rheumatoid arthritis, mild hypertension, and mild renal insufficiency presumed due to his hypertension. He underwent prolonged abdominal surgery under methoxyflurane anesthesia, following which he developed acute irreversible renal failure. Calcium oxalate crystals were demonstrated postoperatively in a kidney biopsy specimen. He subsequently was maintained on renal dialysis with decreasing renal function. Several weeks before his death fundus examination revealed a picture suggestive of a flecked retina syndrome. At autopsy, widespread oxalosis was found including crystals in the RPE and in some areas in the neural retina and cillary epithelium. | |
| 1111277 | The CLUE test. A multiparameter coagulation and fibrinolysis screening test using the plat | 1975 Jan | Optical density measurements of plasma clot formation and lysis were recorded using a platelet aggregometer and strip chart recorder. It was discovered that, by adding standard solutions of ellagic acid-activated partial thromboplastin, urokinase, and CaCl2, and monitoring the reaction via the recorder, characteristic curves would be generated by normal human plasma. The curve segments were labeled Tc (clotting time), which correlated with the activated partial thromboplastin time, Fc (maximum optical density change), which paralleled fibrinogen concentration, and Tl (lysis time), which corresponded generally to plasminogen levels. Deviations from normal curve segments, observed in disseminated intravascular coagulation, hypo- and hyperfibrinogenemia, factor VIII deficiency, severe hepatocellular disease, juvenile rheumatoid arthritis, and neonates (normally low in plasminogen), indicated abnormalities which were substantiated by standard procedures. This new test, given the acronym "CLUE" for clotting and lysis, urokinase enzyme activated, appears to be sensitive, inexpensive and easily performed on a sample of 0.2 ml. of plasma in only 15 minutes. | |
| 3912505 | Diagnostic and predictive value of the lupus band test in undifferentiated connective tiss | 1985 Dec | The value of the lupus band test (LBT) in predicting outcome of patients with undifferentiated connective tissue disease (CTD) was studied. Thirty-three patients with undifferentiated CTD who had LBT between 1977 and 1982 underwent repeat clinical and serological assessments and LBT at 13 to 59 months followup. Six patients (18%) developed SLE, and 2 (6%) developed rheumatoid arthritis during the followup period. No single, combination, number, or intensity of proteins at the dermal-epidermal junction (DEJ) or epidermal nuclear staining (ENS) could be used to predict which undifferentiated CTD patients would develop SLE at followup. Findings on LBT were not significantly different in patients with undifferentiated CTD versus SLE. | |
| 3930612 | The production of small IgG aggregates by glutaraldehyde cross-linking. | 1985 Oct 10 | Reaction conditions have been determined for the production of soluble IgG polymers in the size range 10 S to 30 S by covalent cross-linking with glutaraldehyde. This size range is comparable with that of the immune complexes which are frequently found in the circulation of patients with certain autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. The yield of IgG aggregates in this size range is far greater than has been reported for cross-linking by other bifunctional reagents or for aggregation by heating. Glutaraldehyde cross-linked IgG polymers are stable and biologically reactive. They can also be labelled with fluorescein and freeze-dried with minimal loss of integrity or reactivity. | |
| 6391403 | Insulin autoimmunity as a cause of hypoglycemia. | 1984 Dec | "Autoimmune" hypoglycemia is a syndrome consisting of fasting hypoglycemia, hyperinsulinemia, and insulin-binding antibodies in a patient who has never been exposed to exogenous insulin. The stimulus for insulin-antibody formation and the mechanism of the hypoglycemia in this condition remain unknown. Three patients with this rare syndrome had severe hypoglycemia of limited duration. Two had received a drug containing a sulfhydryl group (methimazole and penicillamine) as treatment for an autoimmune disorder (Graves' disease and rheumatoid arthritis, respectively). A third patient who underwent surgery for a suspected insulinoma was found to have pancreatic beta cell hyperplasia. Drugs containing a sulfhydryl group may have a role in the etiology of the syndrome. Additionally, our findings suggest a relationship between circulating insulin antibodies and beta cell hyperplasia. | |
| 6707531 | [Capillaroscopy and Raynaud's phenomenon]. | 1984 | Nailfold capillary microscopy is a simple and noninvasive screening test for the etiological diagnosis of Raynaud's phenomenon: --dilating capillary dystrophia, with its large capillary loops (megacapillaries), it is a very specific sign of connective tissue disorders, especially systemic sclerosis; --meshed or branched-tree shaped capillaries are neocapillaries, the meaning of which is very often a dermal vasculitis (S. L. E., rheumatoid arthritis, paraneoplastic Raynaud's phenomenon, or even chilblains); --when numerous abnormal capillary loops and hemorrhages are seen without any special pattern, the diagnosis of idiopathic Raynaud's disease is very unlikely and an extensive biological investigation is needed; --nailfold capillaries look like normal in idiopathic Raynaud's disease and, in this case, only a sharp physical examination and a few biological tests are required. Conjunctival angioscopy is a useful complementary test in some cases when nailfold capillaroscopy is unreliable. Capillary video microscopy is an interesting method for further investigations about the physiopathology of Raynaud's phenomenon. | |
| 6419385 | HLA-DB3: population distribution and family studies of a new HLA-D antigen associated with | 1983 Nov | On the basis of studies with 6 HTCs in four different families the new cluster DB3 identified in the 8th Workshop can be considered an established specificity of the HLA-D series. In 112 healthy Caucasoids resident in South East England the frequency of this antigen was 2.6% similar to the frequency found in 142 Caucasoid patients with rheumatoid arthritis. The frequency in 54 unrelated Chinese individuals from Shanghai and of 120 Nigerians was 7.5% and 3%, respectively. All Caucasoid individuals who were DB3 were also DR4 whereas no such association was found in the two other population groups. |