Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 232945 | A new function for ceruloplasmin as an acute-phase reactant in inflammation: a scavenger o | 1979 | In summary, purified human ceruloplasmin inhibits several reactions mediated by superoxide anion in a fashion consistent with an ability to scavenge this free radical. It must be pointed out, however, that on a weight basis, the superoxide-scavenging activity of ceruloplasmin is substantially less than that of purified human erythrocyte superoxide dismutase. Nevertheless, since superoxide dismutase is almost exclusively an intracellular enzyme, ceruloplasmin probably represents the major circulating scavenger of superoxide anion radicals. The level of superoxide dismutase in human plasma has been reported to be 0.7 microgram/ml. It is not clear, however, how this was measured. We have found that concentrations of plasma exceeding 10% (v/v) interfere significantly with the assays routinely employed for detecting superoxide-scavenging activity. Consequently, we have not yet been able to quantify the superoxide-scavenging activity of either ceruloplasmin or superoxide dismutase in whole human plasma. Thus, we can only speculate that under conditions where levels of ceruloplasmin are markedly elevated, as during pregnancy, during acute infections, or in association with inflammatory diseases (such as rheumatoid arthritis), this acute-phase reactant may play a major role as a circulating scavenger of oxygen-derived free radicals. | |
| 3876265 | Serum protein polymorphisms in patients with primary Sjögren's syndrome. | 1985 | The distribution of 4 serum proteins, the protease inhibitor alpha-1-antitrypsin, haptoglobin, transferrin and group-specific component or vitamin D-binding protein, were examined in 26 patients with primary Sjögren's syndrome and 208 healthy donor controls. No significant associations were found between any of the 4 systems and susceptibility to primary Sjögren's syndrome. | |
| 47019 | Chronic pancreatitis, sclerosing cholangitis, and sicca complex in two siblings. | 1975 Mar 8 | A new syndrome of chronic pancreatitis, sclerosing cholangitis, sicca complex, and other features was found in a brother and sister. Leucocyte-migration inhibition in the presence of a bile antigen in both patients suggested that immune mechanisms may be involved. | |
| 6462781 | Focal prostatic granulomas rheumatoid like--probably iatrogenic in origin. | 1984 Apr | Small focal rheumatoid nodule-like granulomas have been noted in the prostatic chips from 11 repeat transurethral resections (TUR) in 10 patients. The lesions are situated in the prostatic stroma and are characterized by a central zone of fibrinoid necrosis, a peripheral palisade of fibroblasts and histiocytes and variable numbers of lymphocytes and giant cells. These granulomas are only noted in prostatic tissue from repeat TURs, are not evident in the original TUR tissue and probably have an iatrogenic basis. As yet, they appear to be of no clinical significance, but the entity is not well recognized, and the surgical pathologist should guard against over-interpretation of the lesions. | |
| 6681127 | Serum C-reactive protein in primary Sjögren's syndrome. | 1983 Jan | Only 11 out of 50 patients with primary Sjögren's syndrome were found to have minimal or moderate increases of C-reactive protein (CRP) levels. Patients with elevated CRP levels did not differ clinically from those with normal CRP levels. Thus, primary Sjögren's syndrome is one of the inflammatory disorders characterized by a relatively low CRP response. | |
| 7038859 | Xerostomia in Sjögren's syndrome treated with Sali-Synt. A double-blind cross-over trial. | 1982 | In a double-blind cross-over trial, a new synthetic saliva Sali-Synt was compared with placebo for the treatment of xerostomia in Sjögren's syndrome. Sali-Synt may soothe the pain in the mouth and reduces sleep disturbances better than placebo, but no statistically significant differences were found. Seven patients of 12 preferred Sali-Synt to placebo in helping xerostomia. | |
| 463173 | [The clinical picture of "circumscribed granuloma diseases"]. | 1979 Jun 1 | Characteristic findings, differential diagnosis and clinical course of the so-called "circumscript granulomas" (Granuloma anulare, necrobiosis lipoidica, Miescher's granulomatosis, disciformis, necrobiosis maculosa, granuloma multiforme, actinic granuloma, granuloma faciale and lethal midline granuloma etc.) are represented in a condensed clinical survey. | |
| 6638957 | Polymorphous meningitis with atypical mononuclear cells in Sjögren's syndrome. | 1983 Oct | Central nervous system complications in Sjögren's syndrome have been reported sporadically for years. We examined the nature and frequency of central nervous system abnormalities in 11 patients with clinically documented Sjögren's syndrome on whom postmortem examination was performed. In 9, characteristic mixed (polymorphous) inflammatory infiltrates containing large atypical mononuclear cells were observed in the leptomeninges, choroid plexus, or both; only 5 of the 9 neurological symptoms, however. Among patients with central nervous system lesions, 3 had definite vasculocentric inflammation and 1 had a necrotizing vasculitis with extensive subarachnoid hemorrhage. Four patients had evidence of chronic subarachnoid microhemorrhage associated with polymorphous meningitis. Atypical mononuclear cells in a polymorphous inflammatory exudate were observed in antemortem cerebrospinal fluid cytological specimens from 2 of the patients. The findings suggest that central nervous system involvement in Sjögren's syndrome is common and that neurological symptoms are related to polymorphous meningitis and vasculitis. Detection of atypical mononuclear cells in cerebrospinal fluid specimens may be of diagnostic value. | |
| 7035538 | [Pseudo-lymphomas of the ocular adnexa: their relations to Sjögren's syndrome (author's t | 1981 | Studies over the last fifteen years, of histological, immunological and hematological parameters has, led to the description of a non-malignant lymphoproliferation: a pseudo-lymphoma which is in the middle of the spectrum between glandular localisation of Sjögren's syndrome and frank neoplasia. This type of proliferation has been also observed in the conjunctiva, without antecedents of Sjögren syndrome. Histologically and immunologically, it is dysimmunitary process which has the potential to regress with appropriate immunosuppressive therapy, or to progress to malignant lymphoma. | |
| 81519 | Serum beta-2-microglobulin in Sjögren's syndrome. | 1978 | The serum concentration of beta-2-microglobulin was determined with a radioimmunoassay in 52 patients with keratoconjunctivitis sicca, 29 of whom had Sjögren's syndrone. Eleven (38%) of the patients with Sjögren's syndrome had high serum values. These cases had a higher mean age and a higher frequency of the complete triad of Sjögren's and of antinuclear antibodies than had the lower value cases. The sicca components per se did not seem to influence the serum concentration of beta-2-microglobulin. Most of the few complications occurred in patients with high values. | |
| 4841836 | Studies on control of granulopoiesis in man. I. Relationship of leukocyte colony-stimulati | 1974 Jul 20 | We examined the relationship of leukocyte colony-stimulating activity (CSA) in vitro to neutrophil count in vivo. Using a standard two-layer system, cultures of 10(6) leukocytes were assayed for their ability to stimulate colony formation by human bone marrow colony-forming cells. The total leukocyte CSA per ml (TLCSA) of blood varied directly with the blood neutrophil count in a group of patients with a wide range in blood neutrophil count, and in two patients recovering from neutropenia in whom serial observations were made. In the latter two patients the rise in TLCSA did not antedate the rise in blood neutrophil count, suggesting that blood leukocyte colony-stimulating factor (CSF) per se probably has little biologic significance. However, release into the circulation of cells which generate CSF could be an important way of controlling the amount of CSF acting within the marrow. In one patient the CSA of dialyzed serum increased after the rise in TLCSA, while undialyzed serum contained no CSA. | |
| 7103531 | Dermatomyositis and dermatitis herpetiformis. | 1982 Aug | Primary hypothyroidism, dermatomyositis, dermatitis herpetiformis (DH), and Sjögren's syndrome developed sequentially, over a 20-year period, in a 67-year-old woman. The principal manifestations of her illness were periodic and simultaneous exacerbations of dermatomyositis and DH. Her histocompatability antigens were A1,B8, a haplotype associated with autoimmune diseases. We suggest that this unusual disease complex has a genetic basis. | |
| 7192987 | Effect of long-term treatment with circulating thymic factor on murine lupus. | 1980 Dec | Mice from three different strains (NZB, B/W, and Swan) which spontaneously develop a lupus-like disease and show a premature decline of their secretion of the circulating thymic factor, Facteur Thymique Sérique (FTS), were treated repeatedly with FTS and followed for the evolution of their autoimmune disease. The autoimmune sialoadenoitis (Sjögren's syndrome) appearing in NZB and B/W mice, evaluated here by a scintigraphic method, was completely prevented or even cured by FTS treatment. The increase in anti-erythrocyte autoantibody production was transiently delayed in aged NZB mice. Conversely, antiDNA antibody production either remained unaffected or was accelerated (in B/W mice) by FTS treatment. These results demonstrate that the restoration of the failing thymic secretion does influence autoantibody production, in a manner depending primarily on the autoantigen eliciting the autoimmune response. However, caution is urged in the application of this approach to human lupus without further studies. | |
| 518370 | [Autoimmune diseases of the salivary glands]. | 1979 | The structural and functional features of the salivary glands and their function associated with the immunocompetent system are described. The disturbance of such association, in the author's opinion, is conducive to the development of a peculiar tumour pathology (adenolymphomas) and autoimmune processes (Sjögren syndrome autoimmune parotitis). Based on the data from the literature two forms of this disease are distinguished: (1) a distinct nosological form developing as a result of various exo- and endogenous injuries, and (2) manifestations of other diseases, as a rule, of the autoimmune genesis accompanied by the secondary involvement of the salivary glands. The morphological picture in both forms is identical. It is suggested that in systemic involvement of the salivary, lacrimal and other glands and some autoimmune disease the term "Sjögren syndrome" be used, and the distinct disease be termed "autoimmune parotitis". | |
| 7056095 | Panconductional defect in mixed connective tissue disease: association with Sjogren's synd | 1982 Feb | A patient in whom mixed connective tissue disease in association of Sjögren's syndrome had previously been diagnosed, experienced a syncopal attack. Electrocardiographic monitoring revealed periods of profound sinus bradycardia, sinus arrest with slow junctional escape rhythm, and first degree atrioventricular block during several episodes of dizziness. Complete right bundle branch block was a constant finding in this patient. Sinoatrial conduction time and sinus node recovery time were prolonged. Coronary heart disease was excluded by normal coronary arteriographic findings. This patient represents a rare case of cardiac involvement in mixed connective tissue disease. | |
| 4045849 | Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of Sj | 1985 Jun | Fibronectin, a high molecular weight plasma protein, was applied locally to 12 patients with keratoconjunctivitis sicca of Sjögren's syndrome refractory to conventional treatment. All patients had ophthalmologically proved keratoconjunctivitis sicca of unknown etiology and were suffering from severe eye symptoms. Fibronectin was purified from autologous plasma and administered to the patients as tear drops 3 times a day. All patients responded to the therapy with fewer subjective symptoms and decreased fluorescein staining. All but 3 responded to the therapy as judged by rose bengal test. No adverse effects were encountered. We conclude that local application of fibronectin may benefit patients with keratoconjunctivitis sicca of Sjögren's syndrome. | |
| 6134486 | [Gougerot-Sjögren syndrome, periarteritis nodosa, non-Hodgkin's lymphoplasmocytic lymphom | 1983 | A Sjögren syndrome was confirmed histologically in a 19 year old woman. Four years later, periarteritis nodosa (PAN) with characteristic vascular lesions on muscle biopsy occurred simultaneously with lymphatic hyperplasia comprising splenomegaly and polyadenopathy. The PAN was cured with corticosteroids and cyclophosphamide and the lymphadenopathy regressed. Several months after treatment was stopped the lymphadenopathy recurred which histologically resembled a malignant non-hodgkin lymphoplasmocytoma secreting an IgM kappa monoclonal immunonoglobulin. During the PAN and the establishment of the lymphoproliferative syndrome a severe C4 deficit was detected which disappeared after chemotherapy. | |
| 553260 | Sicca complex and cholangiostatic jaundice in two members of a family probably caused by t | 1979 Oct | An entire family (father, mother, and three daughters) were given thiabendazole because one of the children had acquired pinworm infestation. The mother and one daughter (non-infected) developed a sicca complex (keratoconjunctivitis sicca and xerostomia) accompanied by cholangiostatic jaundice. Sjögren's syndrome is an autoimmune disease and presents many immune mechanism aberrancies. An association between autoimmune liver disease and sicca complex has been reported. Labeled mitochondrial antibodies bound to the parotid duct have been noted in patients with autoimmune cholangiostatic jaundice and such antibodies may be similar to the antibody against salivary duct found in Sjögren's syndrome. It is suggested that in these two patients, thiabendazole may have acted as a hapten and by binding to the body protein induced the production of autoantibodies which may have acted against the biliary epithelium, the salivary duct epithelium, and the lacrimal gland ducts. | |
| 3874985 | B cell malignant lymphoma in a patient with progressive systemic sclerosis and Sjögren's | 1985 May | We report a patient with progressive systemic sclerosis (PSS) and Sjogren's syndrome (SS) who developed B cell malignant lymphoma 11 and 10 years after the onset of signs of PSS and SS, respectively. As her lymphoma developed, autoantibodies such as rheumatoid factor and antinuclear antibody disappeared from the serum, the lupus erythematosus test yielded negative results and her immunoglobulin levels declined. A good response to chemotherapy was obtained but she died of acute interstitial pneumonitis. Postmortem examination revealed marked diffuse interstitial fibrosis of the lungs. | |
| 6256864 | [Adult Still's disease with constrictive pericarditis, Sjögren's syndrome and varied leuc | 1980 Jun 18 | Adult Still's disease is a newly described disorder that is of interest not only for the rheumatologist but also for the internist since fever or extra-articular symptoms can reveal this disorder, which appears to be identical to the Wissler-Fanconi's syndrome. We report a new case characterized by the occurrence of a constrictive pericarditis with clinical features of protracted fever, by the late appearance of a Sjögren's syndrome and by peculiar blood abnormalities: hyperleucocytosis up to 80 000 after splenectomy, transient Felty's syndrome, blood monocytosis and bone marrow mastocytosis. |