Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6587966 | Lacrimal gland accumulation of 67Ga-citrate in patients with Sjögren's syndrome. | 1984 | The extent of 67Ga accumulation in the two lacrimal glands in patients with keratoconjunctivitis sicca (KCS) of Sjögren's syndrome was studied. Of the two main groups one consisted of 69 subjects without ophthalmic complaints (control group), the other consisted of 26 patients with KCS of Sjögren's syndrome. Of the 26 patients with KCS, 7 had been diagnosed as probable KCS (probable sub-group) and the other 19 had been diagnosed definite KCS (definite sub-group). About 3 mCi (111 MBq) 67Ga-citrate was injected IV into each subject and this was followed by scintigraphy at 24, 48, and 72 h after the injection of 67Ga. A positive finding in the lacrimal gland was noted in 64 of 69 subjects (92.7%) in the control group and in 7 of 7 patients (100%) with probable KCS. Three of 19 patients with definite KCS (15.7%) showed positive findings under scintigraphy. When the scintigraphic finding in the lacrimal gland is not positive in patients with suspected KCS of Sjögren's syndrome, they can then be diagnosed with little risk as definite KCS cases. Shirmer's test was performed on subjects in the probable and definite groups. There was statistical significance between the positive and equivocal or negative scintigraphic finding and Schirmer's values. These results suggest a correlation between gallium accumulation in the lacrimal gland and the tear production. | |
| 7206552 | [Sjögren's reticular pigmentary dystrophy (author's transl)]. | 1980 Dec | An examination of two families with reticular pigmentary dystrophy of the retina is reported, and typical findings are reviewed. Visual actuity, visual fields, dark adaptation and color vision were normal; the photopic ERG was normal or subnormal, while the scotopic ERG was normal. Only the EOG findings were pathologic in all of the subjects examined. A description of the various forms of reticular dystrophy and of its differential diagnosis is followed by a discussion concerning the classification of all varieties of this disease as patterned dystrophies of the pigment epithelium. | |
| 7401742 | [Absence of antiDNA antibodies in the cryoglobulins of a case with sicca syndrome (author' | 1980 Jul 15 | Cryoglobulins are serum immunoglobulins (immunocomplexes) that precipitate in the cold and redissolve on warming. Cryoglobulins from patients with several diseases showed the presence of antiDNA antibodies when previously underwent incubation in acid buffer. The possibility that antiDNA antibodies might constitute the immunocomplexes found in patients with systemic lupus erythematosus and with other connective tissue diseases is suggested. Negative findings in relation to the presence of antiDNA antibodies in cryoglobulins of a case with sicca syndrome are reported. | |
| 380383 | Study of filamentary keratitis by replica technique. | 1979 Jul 2 | Histopathological study of filamentary keratitis was done by using replica technique in five patients. The filaments are produced by sliding of the epithelial cells around small areas of focal degeneration of the superfical epithelium. In comparison to the filaments in other conditions, the filaments in KCS are smaller and thicker and do not show the torsional segment. The filaments contain degenerated epithelial cells and alcian blue-PAS positive mucoid material. Making a corneal replica may result in healing of filamentary keratitis. | |
| 3983668 | Congenital complete heart block with maternal primary Sjögren's syndrome. | 1985 Apr | We have described a case of congenital complete heart block associated with maternal primary Sjögren's syndrome. This diagnosis should also be considered when evaluating mothers of children with congenital heart block, especially when no connective tissue disease is otherwise clinically apparent. The potential significance of antibodies to SSA in this association remains to be determined. | |
| 6385607 | Mucosolvan in the treatment of patients with primary Sjögren's syndrome. Results from a d | 1984 Aug | Thirty-six patients with primary Sjögren's syndrome were randomized to Mucosolvan (60 mg X 2 daily) or placebo, in a double-blind cross-over study. Each period of treatment was 3 weeks with 1 week wash-out in between. None of the objective ophthalmological tests (Schirmer-1-test, break-up time, van Bijsterveld score, cornea sensitivity, appearance of nuclear chromatin in conjunctival epithelial cells, tear lysozyme) improved during the investigation period. | |
| 7396792 | Computerized tomography with simultaneous sialography in evaluating parotid tumors. | 1980 Aug | In an effort to improve on the amount of preoperative information obtainable, computerized tomography was combined with contrast sialography in the evaluation of parotid masses. Experience to date is limited to 17 patients, but this combination of techniques seems to demonstrate clearly the margins of the tumor, whether or not there is extraparotid extension, whether the mass is medial or lateral to the facial nerve, and whether or not the mass will hamper access to the main trunk of the facial nerve. | |
| 7364988 | Lamellar ichthyosis, dwarfism, mental retardation, and hair shaft abnormalities. A link be | 1980 Apr | There is an expanding list of syndromes that combine ichthyosis with neuroectodermal and mesodermal defects. We present the case of a young woman with the following features: lamellar ichthyosis, dwarfism, mental retardation, nail and dental abnormalities, unusual facies, poor sexual maturation, punctate cataracts, and hair shaft abnormalities. There were no neurologic or auditory defects. Hair examination revealed pili torti, trichoschisis, bright and dark bands with polarizing microscopy, and a low hair sulfur content. The patient did not have aminoaciduria or immunoglobulin abnormalities. We believe that this case is a link between the ichthyosis-associated syndromes and the group of syndromes that have in common abnormal hair with clean transverse fractures (trichoschisis) and low sulfur content. A more complete examination of the hair in other patients with ichthyosis and associated abnormalities will probably reveal more patients with this new syndrome. | |
| 7424202 | Necrotizing lesions in Sjögren's syndrome. II. An electron microscopic study. | 1980 Mar | Further evidences about necrotizing lesions in Sjögren's syndrome are presented. Electron microscopic studies disclosed acinar replacement by a mucus-containing lake surrounded by remnant myoepithelial cells. Interepithelial lymphocytes infiltrate the acinar walls in adjacent areas and macrophages bearing mucoid material within cytopasmic vacuoles were found in the interstitium. The significance of these findings in the natural history of Sjögren's syndrome is discussed. | |
| 637648 | Sjögren's syndrome with pseudolymphoma 13 years after Hodgkin's disease. | 1978 Apr | A patient who had Hodgkin's disease at age 11 that was cured by radiation therapy, had nonspecific adenopathy at age 20. When he was 24 years old, the symptoms of Sjögren's syndrome developed, and this diagnosis was confirmed by biopsy of the lip. The patient subsequently had dyspnea and a diffuse pulmonary infiltrate which, at open lung biopsy, was diagnosed as pseudolymphoma and has responded to cytotoxic chemotherapy. This is the first reported case of Sjögren's syndrome and pseudolymphoma following the cure of a malignant lymphoma. The interrelationship between lymphoid malignancies, autoimmune diseases, and pseudolymphoma is herein discussed. | |
| 359712 | Detection of antisalivary duct antibody from Sjögren's syndrome by an autoradiographic me | 1978 | A new technique to detect anti-salivary duct antibody (ASDA) has been developed by using autoradiographic, rather than immunofluorescent methods. The antibody activity detected by autoradiography is probably classic ASDA. Both techniques may be consecutively performed on the same tissue section without attenuation of either. Some of the potential advantages of the radiolabelling of ASDA are pointed out, and a few preliminary experiments using the labelled antibody as a marker are presented. | |
| 70545 | [Cellular immunity in Sjögren's syndrom (author's transl)]. | 1977 May | The authors made cellular immunological investigations with lacrymal and salivary gland antigens on 11 Sjögren's syndrome patients. The changes following the immuno-suppressive treatment were observed by the blasttransformation of the lymphocytes and by the inhibition of the leuckocyte migration. | |
| 3888458 | Complement C4 allotype association with and serum C4 concentration in an autoimmune diseas | 1985 Apr | Serum C4 concentrations and C4 allotypes were determined wherever possible on eight dogs with an autoimmune disorder characterized by antinuclear antibody (ANA) positivity, pyrexia, and seronegative arthritis. Three of the six dogs tested serially showed hypocomplementemia at disease onset with return to normal concentrations with clinical remission following steroid therapy. All five dogs C4 allotyped were phenotypically identical. The phenotype (C4-4) was significantly increased in the diseased dogs. Thus C4 allotype may provide a marker for susceptibility to development of an autoimmune disorder in the dog. Serum C4 concentrations may help in disease diagnosis and monitoring the effectiveness of therapy. | |
| 6816931 | Human lymphocyte antigens characterizing psoriatic arthritis and its subtypes. | 1982 Sep | We performed human lymphocyte alloantigen determinations in patients with psoriatic arthritis (PsPA) who were clinically classified into arthritic subtypes and disease severity. The total PsPA group demonstrated elevations of HLA-BW38, CW6, DR4 when compared with controls (p less than 0.001). Severe arthritics have increased DR4 frequency when compared with less severe arthritics (p less than 0.02). Those with mild disease have increased A3, B7 frequency which was absent in patients with moderate or severe arthritis. Rheumatoid-like PsPA patients have increased DR4, B40 frequencies; those with spondylitis, B27, CW1. PsPA is associated with many genes in the major histocompatibility complex. Distinct groups of patients with PsPA as determined by type and severity are identifiable by the presence of specific human lymphocyte antigens. | |
| 24822711 | The noiles hinge knee prosthesis with axial rotation. | 1979 Nov 1 | The Noiles total knee prosthesis is a constrained knee which provides free axial rotation of the tibia. Because it does not have a fixed coupling between the femur and the tibia, the prosthesis greatly reduces the transmission of torsional forces to the prosthesis-cement-bone interface. The possibility of prosthetic loosening, sometimes caused by forces generated during full flexion in a conventional hinge prosthesis, is significantly reduced. This knee replacement is indicated in severe rheumatoid and degenerative arthritis of the knee joint, severe instability or failure of a previous prosthesis. The prosthesis provides sturdy mechanical support with high load carrying capability, low friction and low wear. Forty arthritis patients with at least 18 months follow up will be discussed. The average preoperative knee evaluation was 30 points on the knee scale, and the average postoperative knee evaluation was 90 points on the knee scale. Surgical technique, advantages and complications will also be discussed. | |
| 6627812 | Incidence of acute rheumatic fever. A suburban community hospital experience during the 19 | 1983 Dec | The incidence of acute rheumatic fever has declined remarkably in the past three decades, but the disease has not been eradicated, as some physicians believe. This study documents the diagnosis of the disease in 23 middle-class children from Fairfax County, Virginia, during the 11-year-period from 1970 through 1980. This county has one of the highest median family incomes in the United States. The annual age-adjusted incidence rate of initial attacks of acute rheumatic fever per 100,000 Fairfax County children declined from 3.0 in 1970 to 0.5 in 1980. In six of the 23 children, carditis accompanied by monarticular arthritis or arthralgia was present. Another seven children had carditis plus polyarthritis. Two patients had Sydenham's chorea. None of the children had erythema marginatum or rheumatoid nodules. In two children, symptoms of acute rheumatic fever developed two weeks after they finished a 10-day course of penicillin for Group A streptococcal pharyngitis. The remaining 21 children had not been considered ill enough to be brought to medical care prior to development of symptoms of acute rheumatic fever. | |
| 6099694 | Pharmacological and biochemical activities of tenoxicam (Ro 12-0068), a new non-steroidal | 1984 Dec | Tenoxicam, a new non-steroidal anti-inflammatory drug has been compared with piroxicam and indomethacin in a range of pharmacological and biochemical inflammation test systems. In a chronic (17-day) adjuvant arthritis in the rat, tenoxicam and piroxicam were equally effective in reducing several indices of inflammation and were less ulcerogenic and better tolerated than indomethacin. The oxicams reduced the oedematous and cellular components of a carrageenan pleurisy at 4 hours while at 24 hours they increased exudate volume and selectively inhibited the accumulation of mononuclear cells. These agents also reduced the inflammatory component of a delayed hypersensitivity response to methylated bovine serum albumin in the mouse. The oxicams were about 100-fold less active than indomethacin as inhibitors of prostaglandin synthetase but all three compounds reduced about equally the release of prostaglandin E2 from phagocytosing rat PMN and interleukin 1-stimulated human rheumatoid synovial cells. The compounds had no effect on the release of superoxide anion, lysosomal enzymes or collagenase from cultured cells, neither did they inhibit isolated collagenase. Only indomethacin stabilized albumin against heat denaturation. | |
| 444417 | Liposome-incorporated corticosteroids: I. The interaction of liposomal cortisol palmitate | 1979 Apr | Cortisol palmitate-containing liposomes were stable in rheumatoid synovial fluid at 37 degrees. Two hours after the intra-articular injection of such liposomes into experimentally arthritic rabbits relatively high proportions of the steroid and lecithin components were recovered from the synovialis. The level of cortisol in the tissue at this time was inversely related to the chronicity of the inflammation. It was found also that the degree and duration of the anti-inflammatory activity of the liposomes was greatest in the initial acute phases of the inflammation. | |
| 6378107 | An immunohistological study of secondary Sjögren's syndrome. | 1984 Jun | The labial biopsies from 13 patients with secondary Sjögren's syndrome (SS) and four disease controls were examined with a panel of monoclonal antibodies to human leucocyte antigens. Large numbers of T cells were found in most of the biopsies. In seven SS patients the T helper/inducer subset was found to be predominant. Antibody to HLA class I antigens consistently stained leucocytes, but other cell types stained more variably. Although the staining with antibody to HLA class II antigen was often weak, approximately as many cells stained with this antibody as with an antileucocyte antibody, implying that the T cells were activated. Anti-IgD revealed membrane staining of a corona of IgD-positive cells in structures resembling germinal centres. Isolated cells throughout the sections also showed strong cytoplasmic staining with anti-IgD. These results suggest a role for T-cell-dependent local antibody synthesis in the pathogenesis of the disease. | |
| 6882489 | Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms. | 1983 Aug | Natural killing (NK) by peripheral blood mononuclear cells (PBMC) against K562 cells was examined in 27 patients with Sjögren's syndrome and 17 normal controls. NK activity in the patients was significantly reduced compared with normal controls (34.6 +/- 3.4% versus 52.2 +/- 3.4%, P less than 0.001). Patients with secondary Sjögren's had lower cytotoxicity compared with those who had primary Sjögren's (28.5 +/- 5.5% versus 37.3 +/- 4.2%, P less than 0.01). The proportion of PBMC with characteristics of NK cells was not decreased in the patients. NK by normal PBMC was diminished both in the presence of sera from patients with reduced NK and when the effector cells were pretreated with the sera. Pretreatment of target K562 cells did not alter NK activity. Suppression of NK by sera from patients did not correlate with levels of immune complexes or with antilymphocyte antibodies. Some patients had adherent cells which inhibited NK function. Addition of either indomethacin or catalase partially restored NK activity in such patients, indicating that both prostaglandins and hydrogen peroxide play a role in suppression. These data suggest that multiple mechanisms are involved in the defective NK activity seen in patients with Sjögren's syndrome. The reduction of NK activity in Sjögren's syndrome may contribute to the increased incidence of lymphoid malignancy. |