Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2983595 | Primary Sjögren's syndrome after infectious mononucleosis. | 1985 Apr | A healthy young woman developed primary Sjögren's syndrome after protracted infectious mononucleosis. The diagnosis of primary Sjögren's syndrome was supported by histologic evidence of sialadenitis in labial salivary glands, rheumatoid factor, hypergammaglobulinemia, the HLA-B8 phenotype, and a high titer antibody to the anti-La (SS-B) nucleoprotein that co-precipitated the small ribonucleic acids encoded by Epstein-Barr virus, EBER 1 and EBER 2, as well as "host" RNA. There was strong humoral immunity to the Epstein-Barr nuclear and capsid antigens, but weak T-lymphocyte-mediated cytotoxicity to Epstein-Barr-transformed lymphoblasts, anergy to antigens used to elicit delayed-type hypersensitivity, and a low T-helper/T-suppressor cell ratio. The series of events initiated by infectious mononucleosis was attributed to a genetic defect in the immune response. Association of viral RNA with the La nucleoprotein resulted in a break in immunologic tolerance via a T-cell bypass effect with induction of anti-La (SS-B) by polyclonally activated B lymphocytes leading to autoimmune sialadenitis. | |
| 463909 | Vasculitis and Sjögren's syndrome with IgA-IgG cryoglobulinemia terminating in immunoblas | 1979 Jul | Generalized lymphadenopathy and other manifestations of Sjögren's syndrome developed in a 68 year old woman with a long history of systemic vasculitis and arthralgia. An unusual immunologic feature was hypogammaglobulinemia and immunoglobulin A (IgA) monoclonal immunoglobulinemia with mixed IgA-IgG cryoglobulin. At autopsy, the histopathologic findings were compatible with immunoblastic sarcoma. The monoclonal IgA protein, found in serum, pleural and pericardial fluids, showed rheumatoid factor activity. Immunocytes from the immunoblastic sarcoma were found to be the source of the monoclonal IgA protein. | |
| 182887 | Polymorphonuclear leukocyte inclusions and impaired bacterial killing in patients with Fel | 1976 Aug | Humoral factors, phagocytosis, bactericidal capability, and ultrastructural morphology of blood polymorphonuclear leukocytes were investigated in 10 patients with Felty's syndrome. Five patients had suffered significant bacterial infections in the past two years while five other patients had not had bacterial infections. The patients with infections had higher concentrations of serum cryoglobulins, and their neutrophils contained immunoglobulin inclusions as seen by immunofluorescent and electron microscopy. Additionally, leukocytes from these patients showed decreased ability to kill Staphylococcus aureus and a minor defect in phagocytosis. There was a generalized subcellular disorganization of these inclusion containing neutrophils and a slower than normal release of lysosomes. Several of the above abnormalities may contribute to an increased susceptibility to bacterial infections in patients with Felty's syndrome. | |
| 1172885 | Malignancy and the benign lymphoepithelial lesion. | 1975 Feb | The benign lymphoepithelial lesion of salivary glands is now considered the histological hallmark of a variety of clinical and pathological disorders affecting salivary tissues. Malignancy arising in the lesion is uncommon, but may take origin in either the epithelial or lymphoreticular components. Lymphomas and pseudolymphomas associated with salivary gland lymphoepithelial lesions have been predominately extra-salivary and strongly correlated with Sjögren's syndrome. Epithelial malignancy has not been associated with autoimmunity and with few exceptions has been of the anaplastic type. This report presents two patients with intra-salivary lymphomas arising in a benign lymphoepithelial lesion of salivary glands and a patient with anaplastic carcinoma arising in the epithelial islands of the lesion. The fourth patient manifested pseudolymphomatous lymphoreticular hyperplasia in lung and submandibular gland and illustrates the possible multiple organ involvement that may occur in patients with benign lymphoepithelial lesion, even without clinical evidence of concommitant autoimmune disorders. | |
| 6532180 | The usability of the MRL/1 mouse strain in detection of anti-rheumatic drugs. | 1984 Dec | D-Penicillamine (5 mg/kg), prednisolone (0.5 mg/kg), tolfenamic acid and thiabendazole (10 mg/kg) were chronically administered to male and female mice of MRL/1 strain. The treatment was started either at 4 weeks of age (prophylactic dosing) or at 12 weeks of age (therapeutic dosing) and continued until the termination at 24 weeks of age. In male mice all the drugs caused a significant retardation in IgM-RF formation with one of the dosing regimes. D-Penicillamine and prednisolone also had an inhibitory effect on lymph node enlargement. In female mice, however, only thiabendazole retarded the RF activity significantly. None of the drugs had any marked effect on anti-ssDNA antibody formation, and none of the treatments affected the development of renal disease or modified the survival of these mice. | |
| 6159678 | Laboratory findings in patients with psoriasis, with special reference to immunological pa | 1980 | Twenty-five male and 25 female consecutive patients hospitalized because of psoriasis were examined. The clinical and radiographical findings are presented in detail elsewhere. Increased serum IgA, C3, C4, and C3PA concentrations were found in patients both with and without arthropathy and/or sacro-iliitis. Increased IgG concentrations were found in patients without arthropathy, and of C1 inhibitor concentrations in patients with arthropathy and/or sacro-iliitis. IgG and IgA concentrations were lower in patients with arthropathy than in those without, the difference being most significant in patients with arthropathy of large joints. An association was found between increased C4 concentration and sacro-iliitis, increased CRP concentration and sacro-iliitis and increased C3 concentration and phalangeal joint arthropathy. C4 and CRP concentrations were not associated. A close association between CRP and SAA was observed. Our results indicate that psoriatic arthropathy is not a single uniform joint disease, but represents different forms of arthropathy. | |
| 7416815 | Survey of synovial fluid cryoprecipitates. | 1980 Jun | Synovial fluid cryoproteins from various inflammatory and noninflammatory arthritides were examined for the presence of immunoglobulin, fibrinogen, antiglobulin activity, and third component of complement and correlated with the synovial fluid leucocyte count. The majority of rheumatoid synovial fluid cryoproteins contained either IgG-IgM complexes or IgG alone. Contrary to previous reports, many synovial fluid cryoproteins from psoriasis, Reiter's syndrome, nonspecific acute polyarthritis, gout, and gonococcal arthritis also contained IgG and occasionally IgG-IgM complexes. Noninflammatory synovial fluids were less likely to contain any immunoglobulin. The highest concentration of cryoprotein was found in Reiter's syndrome. There was a significant (P < 0.05) correlation between the presence of immunoglobulin and the concentration of the synovial fluid cryoprotein with the synovial fluid leucocyte count. Since synovial fluid cryoproteins containing immunoglobulin are present in the synovial fluids of many diverse rheumatic diseases not postulated to be immune complex mediated, they may be a nonspecific phenomenon related to the degree of inflammation. | |
| 3874034 | Detection and quantitation of circulating immune complexes in arterial blood of patients w | 1985 Aug | We developed antigen-nonspecific enzyme-linked immunoassays (ELISA) to quantitate IgG-C3- and IgM-C3-containing circulating immune complexes (CIC) in venous and arterial blood from rheumatic disease patients. Standards were diethylaminoethyl (DEAE)-purified, heat-aggregated IgG incubated with fresh human serum (for IgG-C3 CIC) and IgM rheumatoid factor-rich serum incubated with reduced, alkylated IgG and then with fresh human serum (for IgM-IgG-C3 CIC). Venous serum and plasma IgG-C3 and IgM-C3 CIC correlated closely (P less than 0.01). Rheumatoid arthritis (RA) and systemic lupus erythematous (SLE) patients had elevated levels of venous IgM-C3 CIC (P less than 0.0001) but not IgG-C3 CIC; patients with vasculitis, inflammatory rheumatic diseases, or noninflammatory rheumatic diseases had mean values similar to normal individuals. Venous IgG-C3 and IgM-C3 CIC did not correlate. Paired venous and arterial samples from 16 rheumatic disease patients averaged comparable amounts of IgG-C3 and IgM-C3 CIC, respectively; venous and arterial IgM-C3 CIC levels in patients significantly exceeded normals (P less than 0.05). Venous and arterial IgG-C3 CIC levels correlated closely (P less than 0.01) as did venous and arterial IgM-C3 levels (P less than 0.05). Thus, arterial CIC offered no advantage over venous determinations for rheumatic disease patients. IgM-C3 CIC were elevated in patients with RA and SLE when IgG-C3 CIC were not. Ig isotype-specific CIC quantitation may be useful for certain rheumatic diseases. | |
| 3905247 | Skin contact with gold and gold alloys. | 1985 Aug | 3 types of reaction to gold merit discussion. First, there is the effect known as black dermographism, in which stroking with certain metals immediately produces well-defined black lines on the skin. Some gold alloys are amongst such metals. The evidence indicates that the effect is the result of impregnation of the skin with black metallic particles generated by mechanical abrasion of the metal by contaminants of the skin. There is no positive and unequivocal evidence of the ability of metals to mark uncontaminated skin so rapidly that it is possible to write upon it. Secondly there are the 2 related phenomena of the wear of gold jewelry, and the susceptibility to certain individuals to blackening of the skin where it is in contact with such jewelry. The occurrence of smudge, as it is often called, is not very common, but is brought to the attention of most jewelers from time to time. In extreme cases it may make it embarrassing for the person concerned to wear metallic jewelry. It would appear as if gold smudge also results mainly from mechanical abrasion of jewelry, though this may be aided and/or supplemented in some instances by corrosion of gold or gold alloy induced by certain components of the sweat. Finally, there is the question of true allergic responses to contact of the skin with gold and its alloys. Judging from the very few cases which have been recorded, such responses are extremely rare. Some recent observations on the reactions of metallic gold with amino acids and of reaction to contact of the skin with gold on the part of rheumatoid arthritis patients undergoing gold therapy, are, however, relevant in this connection. | |
| 4001042 | Polymyalgia rheumatica and giant cell arteritis. The dilemma of therapy. | 1985 Jun | Polymyalgia rheumatica, next to rheumatoid arthritis the most common inflammatory rheumatic disorder of the elderly, is a nonspecific clinical syndrome involving pain in the shoulder and pelvic girdles. Giant cell arteritis appears to localize in elastin-containing arteries and can cause similar myalgias. A relationship exists between the two diseases, as evidenced by their frequent coexistence in the same patient. The symptoms of polymyalgia rheumatica respond to low-dose corticosteroid therapy, while giant cell arteritis requires higher doses to prevent blindness due to involvement of the temporal artery. The key decision in therapy, therefore, concerns the dose and duration of use of steroid for polymyalgic symptoms. In this decision, prevention of the catastrophic complications of giant cell arteritis and avoidance of needless side effects of high-dose steroid therapy in the elderly are competing considerations. | |
| 6145354 | Malignancy in primary biliary cirrhosis. High incidence of breast cancer in affected women | 1984 Jun | Primary biliary cirrhosis is characterized by abnormalities in both cellular and humoral immunity. It is associated with presumably autoimmune diseases such as Sjögren's syndrome, rheumatoid arthritis, and scleroderma. Sjögren's syndrome and scleroderma have been noted to have an increased frequency of malignancy. Of 208 patients with primary biliary cirrhosis, followed for one month to 15.9 years, extrahepatic malignancies developed in 11, six of whom were women with breast cancer, and one with hepatocellular carcinoma. The incidence of breast cancer was 4.4 times (p less than 0.01) the incidence expected from the rate prevailing in the same age range in a comparable normal population. The incidence of cancer in sites other than the breast and of primary hepatocellular tumor was not significantly increased. | |
| 15226966 | Surgical considerations in aortitis. Part III: Syphilitic and other forms of aortitis. | 1983 Dec | The majority of cases involving clinically significant aortitis result from Takayasu's disease, syphilis, and mycotic aneurysms, although aortitis may occur as a part of the clinical manifestation in other diseases of known and unknown etiology. Syphilitic aortitis can be treated successfully if an accurate diagnosis is made early and if appropriate antibiotic therapy is instituted. Untreated or treated inadequately, late cardiovascular complications can occur, namely, aortic aneurysm, aortic valvular insufficiency and coronary osteal stenosis. Surgical treatment should be considered when any of these late complications become manifest. Aortitis can occur with rheumatic fever and, occasionally, in rheumatoid arthritis. Giant-cell arteritis is a disease that can affect large, medium or small arteries, and usually occurs in patients over 50 years of age, chiefly women. The entire aorta may be affected. It is the only form of aortitis commonly associated with dissecting aneurysm of the aorta. Corticosteroids are effective in treating the active form of the disease and can usually prevent the development of later severe complications. Surgery is indicated when a dissecting aneurysm develops. | |
| 6652914 | Immunoradiometric assay for human complement component C9 utilising monoclonal antibodies. | 1983 Oct 31 | A two-site immunoradiometric assay for human C9 has been developed. The assay utilised two non-competing monoclonal antibodies to C9 in a single incubation assay protocol. The detection limit of the assay was 0.1 ng (1.4 X 10(-15) moles) in a sample volume of 100 microliters. Using this assay the C9 concentration in normal human plasma was 60.2 +/- 14.9 mg/l (mean +/- 1 standard deviation, 8.5 X 10(-10) mol/l. Significantly elevated levels were found in the plasma of patients with rheumatoid arthritis (90.4 +/- 19.9 mg/l, mean +/- 1 SD). Measurements of C9 in cerebrospinal fluid and synovial fluid were also performed. The low levels of C9 in cerebrospinal fluid (less than 1 mg/l), undetectable by previously available assay methods, were easily measurable with this highly sensitive assay. | |
| 6854024 | A standardized method for quantitating the complement-mediated immune complex solubilizing | 1983 May 13 | A standardized radioassay for measuring the complement-mediated immune complex solubilizing capacity (CMSC) and the initial kinetics of the solubilization (IKS) reaction is described. The total complement (C)-mediated solubilizing capacity was determined after incubation of diluted serum and 125I-BSA-anti-BSA. Percentage C-mediated solubilization (CMS) was measured after centrifugation by determining the distribution of radioactivity. The dependency of CMSC upon factors such as serum dilution and buffer system used, amount of IC added to serum, serum storage conditions and centrifugation conditions was investigated in order to optimize the assay. The CVt of the standardized assay was 0.10-0.17 depending upon the CMSC level measured. Treatment which inactivates C factors (heating), interferes with C activation (EDTA) or activates and consumes C components (zymosan) markedly reduces the CMSC. Preliminary investigation of pathological sera showed that both IKS and CMSC were clearly reduced in SLE sera. By contrast, rheumatoid arthritis sera exhibited normal IKS and only marginal reduction in CMSC. | |
| 6980377 | Molecular weight of circulating immune complexes in patients with glomerulonephritis. | 1982 | The Clq-binding test was used to detect circulating immune complexes in 86 patients with glomerulonephritis at the time of renal biopsy. By gel filtration of the sera it was possible to estimate the molecular weight in 24 of these patients. The molecular weight of circulating immune complexes varied from 150,000 to above 1.2 X 10(6) and was not related to the type of glomerulonephritis as defined by light microscopy, renal function, proteinuria, hematuria or antecedent infections. In 8 patients with rheumatoid arthritis and in 5 patients with secondary syphilis and no evidence or renal disease, only circulating immune complexes with a molecular weight below 1.2 X 10(6) were detected. 7 patients with glomerulonephritis had electron-dense deposits in glomeruli on electron microscopy, but the molecular weight of circulating immune complexes was not related to the site of the deposits on either side of the basement membrane. | |
| 6797777 | Does long-term low-dose corticosteroid therapy cause hypertension? | 1981 Dec | 1. One hundred and ninety-five patients undergoing low-dose prednisone or prednisolone therapy were investigated. Blood pressure, weight, serum urea, sodium and potassium were recorded before therapy and again after at least 1 year of therapy. 2. The rise in both mean systolic and mean diastolic blood pressure was paralleled by an increase in the prevalence of arbitrarily defined hypertension. 3. There was no relationship between change of blood pressure and either dose of corticosteroid or duration of therapy. Blood pressure before therapy was the main determinant of the change in blood pressure. 4. Mean serum sodium levels rose slightly but serum potassium levels did not change during the follow-up period. There was no significant weight gain. 5. These results indicate that treatment of asthma and rheumatoid arthritis with prednisolone or prednisolone in low dose does not cause hypertension or biochemical features suggestive of mineralocorticoid excess. | |
| 7001171 | Genetic factors predisposing to chronic lymphocytic leukemia and to autoimmune disease. | 1980 Sep | Among 320 relatives of 28 patients with chronic lymphocytic leukemia (CLL), 4 had CLL, 1 had lymphosarcoma, and 2 other adults had leukemia of unknown type. Autoimmune disease including hyperthyroidism, pernicious anemia, rheumatoid arthritis and systemic lupus erythematosus affected 18 relatives. HLA typing of members of two families demonstrated that within each family the patient with CLL shared a common haplotype with relatives with autoimmune disease, but the haplotype was different in the two kindreds. In contrast, CLL was encountered in only 1 and autoimmune disease in 4 of 396 relatives of a group of 28 control patients. These data together with information from earlier reports support the hypothesis that genetic factors distrubing the regulation of the immune system may predispose both to lymphoid neoplasms and to autoimmune disease. The concept is supported by an array of experimental studies in animals. | |
| 477066 | GUEPAR knee arthroplasty results and late complications. | 1979 May | One hundred eight GUEPAR knee arthroplasties have been studied with a follow-up of one year on 41; 2 years on 22 and 3 years on 45 knees. Overall results were 17% excellent, 44% good, 10% fair and 29% poor. Excellent results were comparatively fewer in rheumatoid arthritis. There was a deterioration in the quality of results of arthroplasty with longer follow-up. The incidence of deep infection was 11%. There was a significant correlation between early wound drainage and deep infection. More than half of the infected knees have not required intervenition as yet. One knee was revised and 3 had attempted arthrodesis with one successful fusion. Two patients died with septicemia. Axle migration occurred in 8 knees and femoral stem breakage in 2 knees. Loosening was found in 27% of the knees with progressive reduction in quality of the arthroplasty. Incomplete cementing predisposed to loosening. Patellar symptoms were present in 28% of the knees. Patellar subluxation and dislocation occurred in 49% of the knees. More than half of these were symptomatic. With normal patellofemoral alignment, pain was more common in the osteoarthritic knee. Use of a patellar implant with GUEPAR knee prostesis should be restricted to severely disabled patients with major fixed deformities. Mechanical failure can be minimized by proper positioning of the implant, correct alignment of the extensor mechanism and adequate cement around the entire stem. | |
| 684157 | Dermatitis herpetiformis--a skin manifestation of a generalized disturbance in immunity. | 1978 Apr | Detailed investigations on 42 patients with dermatitis herpetiformis (DH) are presented, emphasis being placed on the presence of other disorders having a prominent immunopathogenic basis. These patients and 42 age and sex matched controls were submitted to an extensive clinical and investigative search for the presence of disorders with an immunological basis including the atopic disorders. The findings provided further evidence supporting the association of dermatitis herpetiformis with thyroid disease and pernicious anaemia. A statistically increased incidence of Raynaud's phenomenon and atopy was found in the patients with dermatitis herpetiformis compared to the control group. In addition, of the patients with dermatitis herpetiformis, two had rheumatoid arthritis, two had ulcerative colitis, one had systemic lupus erythematosus and four had splenomegaly. The possible basis for these associations is discussed and it is suggested that dermatitis herpetiformis may be part of a wider spectrum of disease. Genetic linkage and the formation of immune complexes following exposure to a dietary antigen may both be responsible for the disorders associated with DH. | |
| 320644 | Metabolic disturbances of the lymphoid cells and their significance for clinical pathology | 1977 Jan | The presentation and discussion of the metabolic disturbances of lymphoid cells is preceded by some brief data on their nomenclature, philogeny, morphology and methodology (some regarding T and B lymphocytes). The most noteworthy results of cytochemical investigations are those concerning cellular biochemical components such as DNA, RNA, glycogen and lipids. Emphasis is layed on the results of optic and electronic cytoautoradiographic investigations. The cytoenzymologic explorations have shown the necessity of determining the activity of certain enzymes such as acid phosphatases, beta-glucuronidase, aryl-sulphatase, succin-dehydrogenase (SDH), lactic and malate dehydrogenases (LDH and MDH), glucose-6-phosphate-dehydrogenase (G-6-PD), DNA- and RNA-polymerases, certain proteases, dihydrofolate-reductase, a.o. The author insists on the value of the data obtained by the above mentioned investigations for the diagnosis, prognosis and therapy of acute and chronic leukemias, various lymphomas, Waldenström's macroglobulinemia, rheumatoid arthritis, chronic hepatitis, systemic lupus erythematosus, myasthenia gravis, a.o. |