Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2397624 | Dead Sea bath salts for the treatment of rheumatoid arthritis. | 1990 Jul | Thirty patients with classical or definite rheumatoid arthritis were randomly divided into two groups of fifteen patients each of similar age, sex, duration and severity of disease, and medical treatment. All patients were treated once a day with bath salts heated to 35 degrees C for twenty minutes. Group I received Dead Sea bath salts and Group II, the control group, received sodium chloride (NaCl). The study was double-blind and of two weeks' duration. All patients were evaluated by one rheumatologist both before treatment, and two weeks later at the end of the treatment period. Follow-up evaluations were made one and three months after conclusion of the treatments. The clinical parameters evaluated included duration of morning stiffness, fifteen meter walk time, hand-grip strength, activities of daily living, circumference of proximal interphalangeal joints, number of active joints, Ritchie index and the patient's own assessment of disease activity. The laboratory parameters evaluated included erythrocyte sedimentation rate and serum levels of amyloid A, rheumatoid factor, sodium, potassium, calcium and magnesium. A statistically significant improvement (p less than 0.01 or p less than 0.05) was observed in Group I only, in most of the clinical parameters assessed. Maximal therapeutic effect was obtained at the end of the treatment and lasted up to one month. | |
| 3293127 | [Apical pulmonary fibrosis and rheumatoid polyarthritis]. | 1988 | The authors report a case of apical pulmonary fibrosis associated with rheumatoid arthritis. The pulmonary lesions were clearly different from the classical features of pleuro-pulmonary disease in rheumatoid arthritis. They were identical to those described in ankylosing spondylitis. A review of the literature reveals recent report on ten similar cases. The authors discuss a possible relationship with bronchiolitis obliterans. | |
| 2724254 | Rheumatoid pancarditis in a patient with well controlled rheumatoid arthritis. | 1989 Mar | Significant rheumatoid cardiac disease usually occurs in the presence of active extraarticular disease, high titer rheumatoid factor, and systemic vasculitis. We report a patient who died of severe, widespread intracardiac rheumatoid disease, with none of these hallmarks present. The inflammatory infiltrate was centered on the collagenous skeleton of the heart; such a predilection has not been previously reported. | |
| 2665798 | Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogeneti | 1989 Jul | The type II collagen (CII) induced arthritis animal model (CIA) provides opportunities to study the nature of autoimmune reactions leading to arthritis and may be used as a model for rheumatoid arthritis (RA). Thus, in similarity with RA, the CIA model, when induced with autologous CII, shows a chronic and progressive disease course. The susceptibility to both RA and CIA are correlated to the expression of certain MHC class II allotype genes. In both diseases are autoantibodies to CII and rheumatoid factors produced. Immunohistopathology of affected joints show in both diseases a dominance of activated macrophages/fibroblasts with a significant infiltration of activated T cells and an infiltration of granulocytes. We do here suggest that both RA and CIA are dependent on a synergy between delayed type hypersensitivity and immune complex mediated inflammatory mechanisms and that CIA provides opportunities for studies of immunospecific reactions leading to arthritis. | |
| 3024592 | Human parvovirus infection in early rheumatoid and inflammatory arthritis. | 1986 Oct | Evidence of recent infection with human parvovirus B19 (HPV) was found in two patients with early rheumatoid arthritis (RA) and in four patients with acute inflammatory arthritis (IA). Both of the patients with RA but only one of the four patients with IA carried RA associated haplotypes. No evidence of persistent infection with HPV was found, but evidence of past infection with HPV was significantly more common in patients with RA than in controls. The results confirm the arthritogenic potential of HPV and are consistent with the hypothesis that rheumatoid arthritis may develop in a genetically predisposed patient after an arthritogenic insult such as an HPV infection. | |
| 2009649 | Current principles of rehabilitation for patients with rheumatoid arthritis. | 1991 Apr | Rehabilitation is rooted in the comfort and palliation that sufferers of rheumatic symptoms have sought from physical modalities throughout history. In recent decades, several of these empiricisms have been tested scientifically. Furthermore, function has joined comfort as a desirable and measurable outcome. This article highlights some of the more substantive information as it relates to rheumatoid arthritis. It is clear that such information facilitates more effective and efficient programs of intervention. It is equally clear that the therapeutic perspective of rehabilitation for rheumatoid arthritis is more appropriately applied throughout the course of the disease in an ongoing program of habilitation than held in reserve as a form of salvage. | |
| 3300834 | Combined D-penicillamine and chloroquine treatment of rheumatoid arthritis--a comparative | 1987 Aug | Seventy-two patients with relatively early but progressive rheumatoid arthritis were treated with chloroquine sulphate, D-penicillamine or a combination of both drugs over 1 year. Chloroquine resulted in significantly fewer side-effects but combined treatment appeared to increase the risks of toxicity. Significant clinical improvements were seen with each regimen and these were indistinguishable between treatments. However, chloroquine had less impact on haemoglobin, ESR, rheumatoid factor levels and C-reactive protein than the other treatments. Furthermore, radiological deterioration was most frequent amongst those given chloroquine alone. Combination treatment with D-penicillamine and chloroquine thus offered no advantages. Chloroquine caused fewer side-effects than both D-penicillamine and combination treatment but appeared to have a less pronounced effect on the disease process as measured by laboratory and radiological indices. | |
| 3720203 | Measurement of stiffness in the metacarpophalangeal joint: the effects of physiotherapy. | 1986 May | Five common modes of physiotherapy were applied to a group of normal subjects and to a group of patients with rheumatoid arthritis. The metacarpophalangeal joint stiffness was measured before therapy and immediately afterwards and the results compared. The only statistically significant result was that short-wave diathermy and ultrasound both reduced the amount of energy dissipated in the joints of the patients. No significant changes occurred in the normal group. | |
| 3823777 | [Comparative study of rheumatoid polyarthritis with and without the Gougerot-Sjögren synd | 1986 Dec | Clinical, biological and evolutive profiles of rheumatoid polyarthritis (RP) associated or not with a Gougerot-Sjögren syndrome (GSS) were compared in two series of 27 patients matched according sex and age, and recruited among 158 patients examined during a period of 36 months. The GSS was defined by the presence, in addition to RP, of xerophthalmia (Schirmer and Rose Bengal tests were positive) and/or salivary glands disorders (histological abnormalities at stages III or IV of Chisholm classification). The evolution of RP and the importance of articular or extra-articular involvement of the disease are identical in both groups. Biologically, the prevalence of agglutinating rheumatoid factors, antinuclear antibodies and specific organ antibodies, is not different from one group to the other. Only the serum levels of gammaglobulins and circulating immune complexes are higher in the presence of a GSS. Finally, it was not necessary to resort more often to steroid therapy and/or immunosuppressors for RP with GSS than for isolated RP. In summary, in the same age group and same sex, RP associated to a GSS do not appear to have a fundamentally different profile, contrary to what might have been suggested by previous studies. | |
| 2353152 | Raised C-reactive protein response in rheumatoid arthritis patients with secondary Sjögre | 1990 | The levels of serum C-reactive protein (CRP) were found to be significantly higher in the presence than in the absence of secondary Sjögren's syndrome in patients with rheumatoid arthritis, while the values of erythrocyte sedimentation rate and serum fibrinogen were not significantly different. The levels of CRP were found to be normal in 22 out of 24 patients with primary Sjögren's syndrome. | |
| 3566819 | Airways disease in rheumatoid arthritis patients. One element of a general exocrine dysfun | 1987 Mar | Airflow limitation is a frequent finding in patients with rheumatic diseases. We have previously suggested that it is associated with autoimmune exocrinopathy in Sjögren's syndrome. To compare clinical features of patients with and without airways dysfunction and to further test the hypothesis of a link between airways disease and exocrinopathy, we prospectively studied 2 groups of 15 lifetime nonsmoker female patients with seropositive rheumatoid arthritis (RA). The 2 groups were similar in their clinical and immunologic features, but differed in terms of airways function. Salivary, lacrimal, and sweat gland dysfunction were significantly more prevalent or severe in the group with airways disease. Antinuclear antibodies were also more prominent in the patients with airways disease, but antibodies against RNP, SS-A, SS-B, and double-stranded DNA were not present in these patients. HLA-DR4 was found in 80% of the RA patients with airways disease and in 57% of those without airways disease. HLA-B8 and DR3 were equivalently distributed in both groups. This prospective study further documents the existence of small airways disease in RA and supports the view that autoimmune exocrinopathy predisposes to its expression. | |
| 1909156 | Animal models of rheumatoid arthritis. | 1991 Jun | Experimental animal models of arthritis, including type II collagen-induced arthritis, proteoglycan-induced arthritis, adjuvant arthritis, pristane-induced arthritis, and streptococcal cell wall-induced arthritis have contributed to recent advances in the understanding of the immunopathology of arthritis. The dissection of the T-cell populations regulating the autoimmune response is currently the most active area of investigation. Research into the mechanism underlying the association of specific class II major histocompatibility complex antigens with arthritis has focused attention on the interaction of particular V beta T-cell subsets with antigens presented in context of permissive major histocompatibility complex antigens. Several models indicate that both the structure of the major histocompatibility complex antigen and the T-cell receptor may be critical in the development of autoimmunity, while the MIs antigen system appears to regulate the availability of T cells with self-reactivity specificities. Studies on the role of heat-shock proteins in experimental arthritis have prompted research into the role of gamma/delta T cells in joint disease, while the availability of recombinant cytokines has permitted the direct analysis of soluble factors. In addition to providing basic insights into autoimmune disease, animal models continue to provide the means to test novel experimental approaches to the treatment of rheumatoid arthritis. | |
| 2080397 | [Anti-radical enzymes, oxygenated free radicals and lipoperoxydation in rheumatoid polyart | 1990 Dec | Three aspects of the action of oxygenated free radicals were studied in 10 controls and 20 patients with rheumatoid arthritis, 11 not treated and 9 treated with D-penicillamine. Free radical production was evaluated in whole blood, malondialdehyde was measured in plasma, the concentration of antiradicular enzymes (copper and manganese superoxide dismutase, catalase and glutathion peroxydase) in hemolysate, platelets and plasma and copper superoxide dismutase activity in a chloroform erythrocyte extract. Only patients treated with D-penicillamine showed a significant decrease in the concentration of platelet anti-radicular enzymes and plasma manganese superoxide dismutase. The involvement of oxygenated free radicals in the pathophysiology of rheumatoid arthritis and in the mechanism of action of D-penicillamine in this pathology is discussed. | |
| 3393674 | Seronegative and seropositive rheumatoid arthritis: radiographic differences. | 1988 Aug | Patients with seronegative and patients with seropositive rheumatoid arthritis (RA) have clinical, genetic, and immunologic differences. This study was undertaken to determine whether the two populations differ radiologically. Seventeen patients with seronegative RA were closely matched with seropositive control subjects. Radiographs of the hands and wrists were studied blindly, and disease severity was quantified with use of a modification of the Beaver Creek grading sheet. The following distinguishing features were also evaluated: osteosclerosis, new bone formation, carpal predominance, ankylosis (fusion), symmetry, and classical erosions. Seropositive patients had more severe disease, with larger and more numerous erosions, while the seronegative group had more osteosclerosis, carpal predominance, fusion, and new bone formation. Symmetry was equal in both groups. Although there were definite quantitative and qualitative differences between the two populations, radiologists should be cautious in using these criteria because of the great deal of overlap between the two groups. | |
| 2110252 | Prospective two-year followup of recombinant interferon-gamma in rheumatoid arthritis. | 1990 Mar | Seventy patients with rheumatoid arthritis (RA) completing a 12-week multicenter double blind trial comparing recombinant human interferon-gamma (r-IFN-gamma) with placebo were enrolled in a longterm prospective protocol evaluating r-IFN-gamma in RA. Forty (57%) patients after 1 year and 26 (37%) patients after 2 years continued the drug with sustained clinical benefit. Over 2 years, r-IFN-gamma was discontinued in 44 patients (lack of efficacy--25, withdrawn consent--7, noncompliant--4, suspected adverse drug reactions--2, concurrent illness--6). Two years of treatment with r-IFN-gamma were well tolerated with sustained clinical benefit in some patients with few significant adverse drug reactions. | |
| 2490853 | Urinary excretion of the hydroxypyridinium cross links of collagen in patients with rheuma | 1989 Aug | Values for urinary hydroxypyridinium cross links of collagen measured by high performance liquid chromatography in a group of 19 seropositive patients with rheumatoid arthritis (RA) were compared with 19 controls matched for age and sex. The amounts of pyridinoline, expressed relative to creatinine, were significantly higher in the RA group, but there was no significant increase in a bone specific analogue, deoxypyridinoline. There were significant positive correlations between pyridinoline excretion and both C reactive protein and erythrocyte sedimentation rate, whereas there was an inverse relation with grip strength. The data indicated that pyridinoline concentrations in urine are strongly associated with disease activity in patients with RA. | |
| 3729575 | Rheumatoid factor in rheumatoid arthritis associated renal disease and in lupus nephritis. | 1986 Jun | To test the hypothesis that rheumatoid factor (RF) protects against (immune complex mediated) renal disease, patients with rheumatoid arthritis (RA; 48 with nephropathy of various types, 35 without renal disease) and systemic lupus erythematosus (SLE; 35 with and 17 without nephritis) were evaluated for the presence and titre of RF. There was no correlation between RF and nephropathy in RA, whereas in SLE RFs were almost exclusively seen in patients without nephropathy. This result supports the above hypothesis for lupus nephropathy but not for RA associated renal disease, and it may be explained by a more pronounced role for immune complexes in SLE and interference of RFs with the complexes. | |
| 3764734 | [Histocompatibility antigens in psoriatic and seronegative rheumatoid arthritis]. | 1986 | Antigens of A and B loci of the histocompatibility system were investigated in 173 patients: 35 with psoriatic arthritis, 38 with seronegative rheumatoid arthritis, 80 with seropositive rheumatoid arthritis and 20 with uncomplicated psoriasis. The results of typification showed that B13 antigen was common in every other patient with uncomplicated psoriasis or psoriatic arthritis, and in the patients with seronegative rheumatoid arthritis it was much more common than in the patients with seropositive rheumatoid arthritis or in the population. Proceeding from the authors' and literature data it was assumed that as a matter of fact, part of the patients (about 15%) with seronegative rheumatoid arthritis had rheumatoid-like psoriatic arthritis without skin manifestations. | |
| 3784899 | Rheumatoid vasculitis: survival and associated risk factors. | 1986 Nov | We describe the clinical and laboratory characteristics of 52 patients with rheumatoid vasculitis whose condition was diagnosed at a tertiary care center between 1974 and 1981, and we report their survival and the factors that were associated with decreased survival. The patients with rheumatoid vasculitis had decreased survival in comparison with an age-, sex-, and region-matched general population. Their survival was also decreased in comparison to that of an incidence cohort of community patients with rheumatoid arthritis. In the latter cohort, decreased survival was confined to those patients with classic but not definite rheumatoid arthritis. After partial correction for referral bias, we found no difference in survival between the cohort with rheumatoid vasculitis and the cohort with classic rheumatoid arthritis. We found that the age at diagnosis of rheumatoid vasculitis, the therapeutic decisions before and at diagnosis, and the referral distance were the best predictors of survival. Abnormal urinary sediment and hypergammaglobulinemia also predicted poor survival, but because of a lack of specificity in a small number of clinically abnormal values, we urge a cautious interpretation of their importance. | |
| 2067812 | [Calcification of the meniscus]. | 1991 Jan | Degenerative-dystrophic changes in resected damaged menisci are noted with frequency, their calcification is a rare event. The authors in their orthopedic practice observed three patients with meniscus calcification. There is given a communication of one observation. The authors believe that meniscus calcification is an indication for its removal. |