Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1941811 | Oligosaccharides: an optional extra or of relevance to disease mechanisms in rheumatology? | 1991 Aug | I have discussed how oligosaccharides may be important to receptor ligand binding and how in some instances abnormalities can be detected in disease. Manipulating these structures offers the potential for developing novel therapeutic strategies, but perhaps more work is needed to define how subtle variations in these structures occur in normal physiology and how this relates to the pathophysiological mechanisms in disease. | |
| 3337928 | What are the 'best' measurements for monitoring patients during short-term second-line the | 1988 Feb | Seventy-one patients with active rheumatoid arthritis were treated with one of five second-line agents and monitored for 24 weeks using seven clinical and seven laboratory measurements. Statistical tests were used to determine which measures changed fastest, which changed most and which most closely reflected changes in the others. The results consistently showed that articular index and summated change score were the 'best' clinical measures while ESR and plasma viscosity were the 'best' laboratory measures. Traditional measures such as grip strength and joint size fared badly and cannot be recommended. Clinical variables improved slightly more rapidly than laboratory measures, but the latter showed the greater change. | |
| 3763227 | [Rheumatism league: self-help organizations]. | 1986 Aug | Chronic illnesses should be combated totally by social medicine. This fact was not recognized until the first half of this century, and it was not until after the Second World War that steps were taken towards realizing this goal. The following are examples of the visible progress that has been made to date: professional organizations for rheumatologists; intensification of research; founding of clinics, spas, and therapy centers; active social medicine leagues; support for patient self-help organizations. All of those involved in combating rheumatism must work together. | |
| 3763216 | [The idea of team work as the basis of integrated therapy of polyarthritis]. | 1986 Aug | As a generalized immunological disease without known etiology, rheumatoid arthritis cannot be treated either entirely medically or entirely surgically. Integrated treatment must include medication, surgery, and physiotherapy. When arthritis is in the beginning stages, the rheumatologist takes care of the basic treatment. With further advancement of the disease, however, reconstructive surgery plays a leading role. The rheumatic patient offers physiotherapeutic, social, reeducational, occupational, prosthetic, and psychological challenges. Treatment is therefore carried out with the best results when done by a specialized team in specialized hospitals. | |
| 2728794 | Fine needle aspiration cytologic findings and differential diagnosis of solitary pseudorhe | 1989 May | The cytologic findings in fine needle aspirates of two solitary pseudorheumatoid nodules are presented. The main characteristic of the smears was a necrotic granular and filamentous background accompanied by a granulomatous inflammatory infiltrate. The differential diagnosis is analyzed. The results in these cases indicate that the diagnosis of a solitary pseudorheumatoid nodule may be made by fine needle aspiration cytology after a critical evaluation of the cytologic and clinical data and with the help of special stains and microbial culture. | |
| 3206156 | [Benign acute edematous polyarthritis in the elderly. Apropos of 4 cases]. | 1988 Nov | Four retrospective cases of acute, benign, edematous polyarthritis are reported in elderly patients. These cases have in common a sudden onset of distal edema of the 4 extremities, which is severe, associated with primary or secondary joint pain and an inflammatory syndrome. A picture of symmetrical polyarthritis similar to rheumatoid polyarthritis develops secondarily. This polyarthritis is sero-negative. In less than 2 years, it spontaneously evolves into a complete cure without any clinical or radiological sequelae. This picture appears to be a specific entity in the elderly, different from rheumatoid polyarthritis. Ten identical cases have been reported by McCarty under the name of RS3PE syndrome. The onset with edema, sero-negativity and the spontaneous cure are the main characteristics. The nosology of this disease among "polyarthritis of the elderly", is discussed here. | |
| 3439368 | [Patient education in chronic polyarthritis. 2. Organizational and curriculum concept of p | 1987 Nov | In our outpatient rheumatology unit, nearly all patients with rheumatoid arthritis (n = 412, responder rate 89%) were asked for their concepts of patient information and what they thought the aims of a patient education program should be. The patients preferred information about biomedical and practical aspects of their disease more than talking about psychosocial problems. In the same way, from a patient education program they wanted cognitive knowledge and practical help for the daily coping with the disease more than psychological help. Considering the results of the interviews, we developed an educational program for outpatients with rheumatoid arthritis. Its organization and curriculum reflect didactic and methodical aspects of patient information in a chronic rheumatic disease. | |
| 3518277 | [Status of arthrosonography in rheumatologic diagnosis: examination technic, findings and | 1986 Jan | Between July 1984 and October 1985 the elbow joints of 135 patients were examined by arthrosonography. Of these 97 patients suffered from rheumatoid arthritis, 4 from psoriatic arthritis, 2 from suspected ankylosing spondylitis, 1 from gout, and 27 patients were found to be normal. The equipment used was a Kretz sector scanner Combison 320 and a Siemens Sonoline SL linear scanner. The examination was divided into three parts: longitudinal and transversal scans of the fossa olecrani, the fossa coronoidea and fossa radii. We found, that inflammation of the elbow joint has to be evaluated separately for each part of the joint. The more intense the inflammation, the more certain diagnosis becomes. Bursitis and rheumatoid nodules could be separated sonographically. Also synovialitic complications such as of the bone and the development of synovial cysts could easily be recognized. These arthrosonographical findings are a valuable help in the diagnostics of rheumatic diseases. Their interpretation, however, requires the input of all clinical data. | |
| 2639738 | [TMJ examination in patients with underlying rheumatic diseases]. | 1989 Nov | Within this scope of a diagnostic study 50 patients with underlying rheumatic disease and temporomandibular joint symptoms were examined in the rheumatological and oral-maxillofacial surgery specialty. About half of the patients with inflammatory rheumatic disease showed a primary temporomandibular arthritis, about half of which had radiological findings of advanced stage of arthrosis deformans. Therapeutical particularities of the treatments of primary temporomandibular arthritis are shown. | |
| 3763215 | [New knowledge and clinical trends in the diagnosis and therapy of inflammatory rheumatism | 1986 Aug | Progress in the diagnosis of forms of inflammatory rheumatism represent not only a semantic problem reflected by the changes in and differentiation of rheumatological nosology. The line of demarcation between reactive forms of arthritis and chronic, destructive processes--the chronic polyarthritis (RA) model--is decisively important from a therapeutic point of view. Knowledge regarding rheumatoid joint destruction is not only the prerequisite for an understanding of radiological morphology, the loss of form and function but also forms the bridge to rheumatic orthopedics. This connection between internal rheumatology and orthopedic rheumatology--the "Rheumatism center" model--represents the recent types of progress made in the long-term treatment of chronic joint disease. Corresponding models and hypotheses are presented with regard to an effective therapy structure for rheumatic diseases. | |
| 2080681 | [Facets of control of rheumatic diseases in East Germany]. | 1990 Sep | Guidelines for treating rheumatic diseases in the GDR are formulated based on the sociomedical and economic impact of class XIII (International Classification of Diseases, Injuries and Causes of Death (ICD) of WHO, 9th revision: 1975); these consider trends in temporary incapacity of employees and their utilization of hospital services, as well as statistics of disability pensions. The presentation of the organized cure and care programs, with special emphasis on rheumatology practitioners is followed by a discussion of issues in graduate, postgraduate, and continuing rheumatological education. Finally, a cursory review is given of the priorities and tasks of rheumatology research in the GDR. | |
| 3763226 | [Social and psychological consequences of inflammatory joint diseases]. | 1986 Aug | The treatment of rheumatic disease should take into consideration the changing roles in life and be planned according to the patient's social and psychological situation. Education of the arthritic patient is important for adequate coping with the problems of the disease. | |
| 2823331 | [Follow-up study in chronic polyarthritis as represented in roentgen image]. | 1987 Sep | Thirty-one patients with chronic polyarthritis under medical treatment had x-rays of their hands performed at the beginning of the illness and after seven years, on average. The findings were compared with clinical and biochemical data. Despite treatment, there was marked progression in the periarticular destructive changes, although the clinical features had improved. The extent of periarticular destruction was significantly greater amongst seropositive than amongst seronegative patients, both at the beginning and the end of the study, but there was no significant difference in the rate at which this progressed. It was not possible to demonstrate a statistically significant correlation between the radiological appearance of the joints and the clinical and laboratory findings. | |
| 1923577 | Collaborative practice: a coordinated approach to patient care. | 1991 Sep | Mr. Michael is a patient who was cared for at our institution when surgery for a severe rheumatoid neck deformity was planned for him. This article demonstrates how preplanning, collaborative practice, and communication among the health care team members successfully facilitated a positive outcome for this patient. | |
| 2009680 | Advances in imaging of rheumatoid arthritis. | 1991 Apr | Several new imaging modalities have been found useful in clinical evaluation of patients with rheumatoid arthritis (RA). Magnetic resonance (MR) imaging has proven to be an excellent noninvasive method to evaluate the spine, shoulder, hip, and knees; its use for the evaluation of smaller joints is still being investigated. In patients with RA, MR imaging has been used to evaluate cervical spine instability, rotator cuff tear, osteonecrosis, and osteomyelitis. Patients with RA may have advanced osteoporosis, predisposing to insufficiency fractures. This includes fractures associated with increased activity after hip or knee arthroplasty. Newer methods for measuring the degree of osteoporosis include single photon absorptiometry, dual photon absorptiometry, quantitative computed tomography (CT), and dual-energy projection radiography. It has not yet been determined which of these methods will be most widely used in the future, but quantitative CT and dual-energy projection radiography currently show the most promise. Ultrasonography provides an excellent noninvasive method for the diagnosis of popliteal cysts, and color Doppler sonography can differentiate cyst and popliteal aneurysm. As compared to radiography or conventional CT, high-resolution CT provides an improved method to detect the early changes of RA in the lung parenchyma. | |
| 2292653 | Postoperative pressure under the rheumatic feet. | 1990 Nov | The authors examined ten seropositive rheumatoid arthritis patients with an EMED gait analysis system in a mean four years after foot surgery and compared that with ten normal subjects who formed a control group. The maximum pressure in the toe regions was almost the same as in the control group. The rheumatoid arthritis group had significantly increased maximum pressure in the first metatarsal and tarsal region. | |
| 2917234 | Rheumatoid arthritis and motor neurone disease--an association? | 1989 Feb | Three patients with rheumatoid arthritis and motor neurone disease are presented. The neurological syndrome supervened after 2, 19 and 23 years of polyarthritis and led to death within 4 years. The diagnosis of motor neurone disease was confirmed at post mortem in one case. Common immunological mechanisms may account for this previously unreported association. | |
| 3136966 | A clinical and biochemical assessment of etidronate disodium in patients with active rheum | 1988 Mar | Diphosphonates reduce the rate of bone turnover. They have additional pharmacological properties improving adjuvant arthritis in rats and lowering ESR in this condition. We have evaluated etidronate disodium, a diphosphonate commonly prescribed in the United Kingdom for Paget's disease in patients with rheumatoid arthritis. Apart from an early improvement in articular index, perhaps reflecting anti-inflammatory activity, no significant change occurred in clinical variables or in laboratory indices of 'secondline' action at a dose of 5 mg/kg/day. | |
| 2921941 | Rheumatoid aortitis: a rarely recognized but clinically significant entity. | 1989 Mar | Aortitis as a feature of rheumatoid arthritis is considered rare. We have, however, identified 10 patients with aortitis from among 188 consecutive autopsy cases of rheumatoid arthritis. There were 5 men and 5 women with a mean duration of rheumatoid arthritis of 9.6 years. Nine were rheumatoid factor positive and had associated nodules. In addition to standard treatment regimens, 9 patients received corticosteroids. Although involvement of the thoracic aorta was most common, involvement of both the thoracic and abdominal aorta was present in 4 cases. Two patients had aneurysmal dilatation of the thoracic aorta and 1 of the abdominal aorta. Microscopic features of aortitis included necrosis of medial smooth muscle and elastica, with an inflammatory infiltrate comprising primarily lymphocytes and plasma cells. A panmural aortitis was seen in 3 cases. Rheumatoid granulomas were noted in the aortic wall in 5. The diagnosis of aortitis was not made until autopsy in any case. Aortitis was hemodynamically significant in 3 patients. Two had congestive heart failure secondary to thoracic aortitis and aortic valvulitis, and 1 had rupture of an abdominal aortic aneurysm at a site involved by aortitis. Seven patients had rheumatoid vasculitis with a mean of 10 organs involved. Six of these died of complications directly related to vasculitis, including 4 patients with coronary arteritis and associated myocardial infarction. Aortitis can be a feature of severe rheumatoid arthritis and is often associated with rheumatoid vasculitis. Hemodynamic compromise does occur and may be fatal. | |
| 2869859 | Rheumatoid arthritis: etiopathogenetic considerations. | 1986 Mar | Although the etiology of rheumatoid arthritis remains unknown, evidence accumulated in the past several years seems to suggest that pathogenetic mechanisms are multifactorial. Genetic predisposition, perhaps mediated by the HLA system, may render an individual susceptible to the action of an undefined microbial agent, most likely a virus, resulting in the triggering of an inflammatory reaction that, if unchecked, will lead to the development of synovitis and eventually to tissue destruction. It is quite possible that similar pathogenetic events play a role in some of the extra-articular manifestations of the disease, including Felty's and Sjögren's syndromes, and vasculitis. Further understanding of the mechanisms involved should improve our understanding of the disease process and may result in new therapeutic approaches. |