Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3220627 | The shock-absorbing effect of soles and insoles. | 1988 | The capacity of heel inserts of different plastic and rubber materials to attenuate heel-strike forces was analysed. The heel-strike response was recorded by accelerometers fastened on to the skin. Thirteen rheumatoid patients with a knee arthroplasty and five healthy controls were tested. Inlay material of 6 mm thickness did not significantly reduce the tibial deceleration produced by heel-strike. However, shoes with heels of polyurethane plastic of 20 mm thickness significantly lowered the amplitude of the tibial response compared with rubber-heeled shoes. The possible implications of this for patients with degenerative joint diseases or with joint implants is discussed. | |
| 3952471 | Dendritic cells from human rheumatoid synovial inflammatory tissue and peripheral blood as | 1986 Mar | Dendritic cells (DC) were purified from the peripheral blood (PB) of normal individuals and from the synovial fluid (SF) and synovial tissue (ST) of patients with rheumatoid arthritis. These cells are strongly HLA-DR positive and lack B-cell, T-cell, and monocyte markers as well as Birbeck granules. The DC were compared with monocytes and non-T cells from PB for their ability to act as accessory cells for T-cell responses to concanavalin A (Con A) and phytohaemagglutinin (PHA). DC from PB, SF and ST were much more efficient accessory cells for the mitogenic responses than autologous monocytes from PB. The mean PHA responses in cpm obtained with DC from the various compartments were 4-20 times greater than the responses obtained with monocytes from PB. The Con A responses obtained when the various DC populations were used as accessory cells were 3-13 times greater than those obtained with monocytes from PB. The mitogenic responses seen with monocytes were very low. The non-T cells, which comprise a mixture of cells obtained after removal of T cells, also gave low T-cell responses to PHA and Con A compared with DC as accessory cells. | |
| 3704106 | Small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs for rhe | 1986 Jan | Evidence is presented for a non-specific ulcerative process in the small bowel of patients with rheumatoid arthritis. All three cases presented with lower gastrointestinal bleeding; on withdrawal of non-steroidal anti-inflammatory drugs no further bleeding occurred. Non-steroidal anti-inflammatory drugs may lead to small bowel ulceration in inhibiting mucosal glycoprotein synthesis and increasing intestinal permeability. | |
| 3793385 | Expression of muscarinic cholinergic receptors on lymphocytes during rheumatoid arthritis. | 1986 | The level of muscarinic receptors on lymphocytes from rheumatoid arthritis (RA) patients in comparison with healthy individuals was determined by the binding studies of a specific muscarinic ligand [3H]-QNB in the presence of the competitive antagonist atropine. The response to phytohaemagglutinin and the influence of acetylcholine on this process in patients' lymphocytes was also studied. We have found direct correlation among PHA stimulation indices, the level of muscarinic receptors, and the influence of acetylcholine on PHA stimulation indices. Differences in these parameters occurring in systemic forms of RA as compared to other RA patients are also described and their possible mechanism discussed. The influence of cholinergic stimulation on the reactivity of lymphocytes after PHA in different forms of RA could depend on the number of muscarinic receptors present on the lymphocyte surface, as well as on the activity of soluble factors, which could modulate the functional state of the receptors. | |
| 1983194 | DNA variants of alpha-1-antitrypsin in rheumatoid arthritis with and without pulmonary com | 1990 Nov | Restriction fragment length polymorphisms (RFLPs) of alpha-1-antitrypsin were studied in 99 subjects with rheumatoid arthritis alone, 21 subjects with rheumatoid arthritis and pulmonary fibrosis, 26 subjects with rheumatoid arthritis and bronchiectasis, and 86 controls. No associations with either rheumatoid arthritis itself or with the associated pulmonary disorders were noted in this U.K. Caucasoid population. | |
| 3398755 | [Tele-gamma irradiation of subdiaphragmatic lymph nodes in rheumatoid arthritis]. | 1988 Jul | The authors described methods of gamma-beam therapy of the retroperitoneal lymph nodes in patients with rheumatoid arthritis and therapeutic results. The para-aortal and ilioinguinal lymph nodes were irradiated in 20 patients at a dose of 20 Gy during 2 weeks. Half of the patients demonstrated improved general status with a decrease of disease activity and normalization of the articular syndrome. | |
| 2660098 | [Rheumatoid arthritis in theory and practice. What do we expect from immunology?]. | 1989 | A short review is provided on the present state of knowledge concerning immunopathogenesis of rheumatoid arthritis (RA) and the implications of this knowledge for eventual future development of therapy. It is concluded that potential points for interference have been identified on the molecular level with increasing knowledge mainly on molecular aspects on T-cell activation, and that methods for interference can be schematically divided in "specific" and "unspecific". The greatest challenge for the future resides in development of "specific" therapies, and the prospects for the success of such an approach is discussed on the basis of our current knowledge on the structure of transplantation antigens which provide increased. | |
| 3705774 | [Rheumatoid arthritis, progressive systemic sclerosis without skin involvement and mixed c | 1986 Jan | We report on four members of a family with rheumatic diseases. Rheumatoid arthritis of an extremely severe and mutilating type developed in a 17-year-old boy (Patient 1). The disease showed some characteristics of juvenile chronic arthritis. 20 years later his sister (Patient 2) was affected by progressive systemic sclerosis (PSS) with arthritis, Raynaud's phenomenon, aperistalsis of the esophagus and pulmonary fibrosis, however without skin involvement. After 2 years rheumatoid arthritis developed in the mother of the family (Patient 3) and another 2 years later the second son (Patient 4) was affected by mixed connective tissue disease (MCTD) with arthritis, Raynaud's phenomenon, aperistalsis of the esophagus and a high titer of antibody to extractable nuclear antigen (ENA). Rheumatoid factor was found in Patient 1, 2 and 3. All members of the family expressed HLA-DR3 in association with HLA-B8. Earlier reports in the medical literature of the familial occurrence of rheumatoid arthritis, progressive systemic sclerosis, systemic lupus erythematosus and other collagen diseases, e.g. mixed connective tissue disease, are reviewed, with a discussion of the possible etiologic mechanisms. | |
| 3600221 | [Renography and dynamic scintigraphy of the kidneys in rheumatoid arthritis]. | 1987 Jun | The diagnostic potentialities of dynamic scintigraphy of the kidneys in the detection of renal disturbances were studied in 42 patients with rheumatoid arthritis. Dynamic scintigraphy was performed for 20 min. starting from i.v. injection of 370 MBq of 113mIn-DTPA. The results of radionuclide renography and dynamic scintigraphy were compared by the time of half-life of 131I-hippuran and 113mIn-DTPA, respectively. The results were also verified with clinico-laboratory findings. Significant correlation between indices of the period of half-life of 131I-hippuran and 113In-DTPA (r = 0.81) was revealed. An analysis of the results has shown that dynamic scintigraphy permits the detection of disturbances of renal function more frequently than renography (p less than 0.01) and clinico-laboratory methods of investigation (p less than 0.02). | |
| 2103766 | [HLA antigens in patients with rheumatoid arthritis, their relatives, and spouses]. | 1990 Mar | The results of the comparison between phenotypic frequency of HLA antigen classes I and II in patients afflicted with rheumatoid arthritis (RA) and their relatives (study carried out in the east of Andalusian), showed a significant increase of HLA A24, B51, B44, CW1 ans CW5 class I antigen in the group of relatives. We found a statistically significant DR4 antigen class II increase in both, patients and relative groups. The marriage parther of patients with RA did not have variations in class I or II HLA antigens compared to the control group. We concluded that RA is probably related to the following antigens: A24, B51, B44, CW1, CW5 and DR4. | |
| 3607375 | Enhanced chemotaxis of monocytes in rheumatoid arthritis. | 1987 Aug | The migration responsiveness to zymosan-activated serum of monocytes isolated from the blood of 19 rheumatoid arthritis (RA) patients and 19 healthy subjects was measured. The chemotaxis of RA monocytes, but not their random migration or chemokinesis, was significantly greater than that of monocytes from normal healthy subjects. To investigate whether this effect were due to soluble factors present in RA blood, the migration of monocytes from healthy subjects was assessed in the presence of sera from 28 RA patients and 21 healthy subjects. The inability of RA sera to modify the migration of normal monocytes implies that the enhanced chemotaxis of RA monocytes is attributable to the inherent property of these cells and not due to the activity of serum modifying factors. | |
| 2059539 | Results of elbow synovectomy in rheumatoid arthritis. | 1991 | Synovectomy of the elbow was performed on 54 patients (70 elbows) with rheumatoid arthritis. The mean follow-up time was 7.5 years (range 1.5-22 years). Clinical evaluation showed marked relief of pain in 28 elbows (40%). In 27 cases (38.5%) the pain was moderate but still less than preoperatively. Severe pain was recorded in 15 cases (21.5%) at the time of check up. As to postoperative range of movement, the mean flexion are was 114.5 degrees and the mean rotation are 134.5 degrees. Latitudinal instability was recorded up to 5 degrees in 33 (47%) elbows, up to 10 degrees in 20 (28.5%), up to 15 degrees in 6 (8.5%), and more than 15 degrees in 11 (16%). The mean carrying angle was 10 degrees in valgus. Measurement of strength in flexion and extension showed a reduction of approximately 50% compared to age-matched healthy controls. Reoperations were performed in 10 elbows (14%); the interval between the primary synovectomy and second operation in these cases averaged 8 years. | |
| 3261029 | Complement (C3) metabolism in rheumatoid arthritis in relation to the disease course. | 1988 | Metabolic turnover studies of the third component of complement, C3, were performed in 23 patients with rheumatoid arthritis (RA) to get a direct insight in the dynamics of complement synthesis and catabolism. Results of these turnover studies were related to the serum level of the total amount of C3 as well as to that of the activation product C3d. A hypercatabolism of C3 was observed in 12 of the 23 patients studied. Six of these 12 patients showed signs of extra-articular RA; only one patient with extra-articular manifestations had a normal catabolism of C3. Decreased serum levels of C3 were not found in any of the patients with a hypercatabolism of C3, indicating that the accelerated turnover was compensated by an increased synthesis. In RA patients levels of the activation product C3d could not correlate with the turnover of C3. However, in selected RA patients without signs of nodules or extra-articular manifestations, they could. Thus, our results indicate that serum levels of C3 and C3d do not reflect C3 metabolism in RA patients. Furthermore, the existence of extra-articular manifestations is accompanied by a more pronounced activation of the complement system. | |
| 2768320 | Inflammatory cell changes in haversian canals. A possible cause of osteoporosis in rheumat | 1989 Aug | We studied the morphology of the haversian canals in the osteopenic cortical bone of the medial femoral neck from patients with rheumatoid arthritis and compared the findings with those in patients with osteoarthritis and with uncomplicated coxa valga. In the rheumatoid bone, the diameters of the canals were larger and many more contained osteoclasts. Fewer haversian canals showed only lining cells than in the osteoarthritic or coxa valga patients. In bone from rheumatoid patients, especially in canals with osteoclasts, small blood vessels were frequently lined by tall endothelial cells with an infiltration of mononuclear cells. These morphological differences are discussed with reference to the possible mechanisms of loss of cortical bone in rheumatoid arthritis and other conditions. | |
| 2965554 | Association of HLA-B35 with mucocutaneous lesions in Israeli patients with rheumatoid arth | 1988 Mar | Seventy-four Israeli patients with rheumatoid arthritis (RA) were studied for possible association between HLA antigens and adverse reactions to gold treatment (aurothioglucose). HLA-B35 was significantly increased in patients who developed gold induced mucocutaneous lesions. These results are in accord with earlier reports, despite the different genetic background of the Israeli RA population and the different type of gold compound used. | |
| 2758772 | Outcome in patients hospitalised for psoriatic arthritis. | 1989 Jun | Forty patients hospitalised for treatment of psoriatic arthritis (PsA) were followed for a mean of 8.0 years. At the end of this time none had died and only 8% were in functional class IV. 90% received second-line therapy. There was a high incidence of skin rashes on gold but hydroxychloroquine was well tolerated. Patients with psoriatic arthritis had a better outcome than patients with rheumatoid arthritis treated with the same regime. | |
| 1715157 | Hepatic methotrexate content and progression of hepatic fibrosis: preliminary findings. | 1991 Jul | Liver tissue from 16 patients with rheumatoid arthritis was studied. The patients had received low dose methotrexate weekly for a minimum of 12 months between two liver biopsies. The progression of pericellular fibrosis was measured by computerised image analysis. Extracts of these liver biopsy specimens were pooled into five samples according to the progression of hepatic fibrosis and analysed by high performance liquid chromatography. The concentrations of methotrexate, 2,4 diamino-N(10)-methylpteroic acid, and methotrexate polyglutamate were markedly increased in the samples obtained from the three patients who recorded the greatest increase in fibrosis. These preliminary data suggest that progression of hepatic fibrosis is related to the retention of methotrexate and metabolites in the liver. | |
| 3402526 | Transsynovial kinetics of piroxicam in patients with rheumatoid arthritis. | 1988 | Twenty-four patients suffering from rheumatoid arthritis, who required articular puncture, participated in this open label study. Following a washout period of 7 days piroxicam 20 mg was administered once daily for 7 days. The average drug concentration in a dose interval in plasma fluctuated between 4.45 micrograms/ml and 8.02 micrograms/ml, and in synovial fluid it ranged between 4.16 micrograms/ml and 5.55 micrograms/ml. Piroxicam was eliminated from plasma with a half-life of 41.7 h and 43.2 h from synovial fluid as calculated from measured and interpolated data from all patients. Despite the short treatment period, clinical improvement could clearly be demonstrated. | |
| 2968782 | Immunohistology of rheumatoid nodules and rheumatoid synovium. | 1988 May | The immunohistological features of rheumatoid nodules and rheumatoid synovium were examined using monoclonal and polyclonal antibodies raised against macrophages, HLA-DR, leucocyte common antigen, and immunoglobulin components. The palisading cells surrounding the necrotic centre of the rheumatoid nodule were shown to be HLA-DR positive leucocytes, mostly histiocytes. The inflammatory infiltrate associated with rheumatoid nodules showed many immunohistochemical similarities to that of rheumatoid synovium, including a preponderance of IgG positive plasma cells, and a similar number and microanatomical pattern of distribution of HLA-DR positive cells. The significance of these findings for the cellular immunopathology and aetiology of the rheumatoid lesion is discussed. | |
| 3707216 | Assessment of inflammation in the rheumatoid knee joint: correlation between clinical, rad | 1986 Apr | Standard clinical methods of assessing joint inflammation are being supplemented increasingly by radioisotopic and thermographic studies. However, the correlation between these different methods has not been firmly established. In the quantification of synovitis by infrared thermography we have shown that the heat distribution index (HDI) based on thermal pattern is more reliable and is less affected by diurnal variations in joint temperature than the commonly used thermographic index, which is based on average skin temperature values. In 20 patients with rheumatoid arthritis whose knees were being treated with intra-articular steroid we obtained 184 serial paired observations over a period of 24 weeks for clinical assessment, HDI, and 99mTc pertechnetate uptake. We found significant correlations (p less than 0.001) between the three methods of assessment (except for pain and HDI (p = 0.116)). |