Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1690541 | The relationship between CD5-expressing B lymphocytes and serologic abnormalities in rheum | 1990 Mar | The influence of genetic factors on the expression of CD5+ B lymphocytes and their relationship to a broad spectrum of autoantibodies was investigated in a study of 12 patients with rheumatoid arthritis (RA) and 52 of their healthy first-degree relatives. The proportion of CD5+ B cells was significantly higher in RA patients (mean +/- SEM 23.9 +/- 2.7%) compared with that in their relatives (18.3 +/- 1.1%, P less than 0.05) and compared with that in a group of healthy control subjects (16.1 +/- 1.8%; P less than 0.05). Much more striking, however, were the high levels of CD5+ B cells found in the patients and their relatives in 5 of the families studied. Increases in total immunoglobulin levels and autoantibody levels were frequently observed in RA patients (approximately 20-40%) and their relatives (approximately 10-20%). Furthermore, a statistically significant correlation (P less than 0.01) between IgM rheumatoid factor and the percentage of B lymphocytes expressing CD5 was observed. | |
| 2595336 | Early arthritides: nosography, nosology, and diagnostic criteria. | 1989 | Follow-up studies of patients with early arthritides are sparse and they are usually restricted to certain diagnostic groups. Therefore 141 unselected patients suffering from arthritis since no more than 12 months were entered into a prospective study. The largest group (n = 57, 40%) consisted of patients with definite rheumatoid arthritis. Forty individuals (28%) were judged to have undifferentiated arthritis since they could not be classified according to established diagnostic criteria initially. After 9 +/- 3 months mean follow-up only 21 of 45 patients (47%) fulfilling criteria for definite rheumatoid arthritis at the onset of the study remained in this category, 9 (20%) still suffered from arthritis but they met less than 5 ARA criteria, and 15 (33%) went into remission. Among 50 patients with undifferentiated arthritis or spondylarthropathy an even smaller proportion of 16 individuals (32%) still had arthritis, which could not be classified, whereas 34 (68%) showed no signs of persisting peripheral arthritis. Thus, criteria diagnoses are inadequate for the selection of the patients at the onset of the disease since they are frequently false positive and they omit other arthritides important for differentiation. Further disadvantages of criteria diagnoses are evident: they imply a large spectrum of manifestations of the disease, they overlap with other entities, they do not provide sufficient information regarding the prognosis and adequate treatment. To improve the prognostic value of a nosological classification a concept of descriptive diagnoses is discussed. | |
| 2229968 | Results of dorsal wrist synovectomies in the rheumatoid hand. | 1990 Sep | Seventy-eight patients with rheumatoid arthritis had 102 dorsal wrist tenosynovectomies, intraarticular synovectomies, and Darrach resection from 1962 to 1982. Follow-up after surgery averaged 11 years, with a range from 3 to 20 years. Pain was diminished in all but 17 wrists and motion decreased an average of 13 degrees. Synovitis recurred in 16 wrists and x-ray evidence of progressive intraarticular destruction was seen in 45 wrists. Revision surgery was necessary in 28 wrists. | |
| 3944158 | Long-term results of synovectomy in rheumatoid patients. | 1986 Feb | Seventy-eight knees in fifty-five rheumatoid patients were evaluated clinically and radiographically at an average of 14.1 years (range, ten to twenty-three years) after synovectomy. The functional result was excellent in seventeen, satisfactory in thirty-one, unsatisfactory in eighteen, and poor in twelve knees. Pain and recurrent effusions were significantly reduced after synovectomy, but the range of motion of the knee remained unchanged. Radiographs demonstrated progressive changes of degenerative joint disease but apparent arrest of inflammatory disease changes in about 67 per cent of the knees. We believe that synovectomy of the knee is a good treatment alternative for selected patients with early stage-I rheumatoid arthritis that has proved resistant to standard medical therapy. | |
| 2380221 | Insertion of a prosthetic hip into a total hip allograft. Case report. | 1990 Jul | We describe a patient in whom a total hip replacement had failed and who subsequently fractured her proximal femur. The prosthetic hip and the surrounding bone were excised and replaced by a matched pair of allograft components. She obtained seven years of pain free hip function before the graft showed radiographic signs of failure; it was then replaced by a new prosthetic hip. | |
| 3524480 | Gastrin, gastric acid secretion, and gastric microflora in patients with rheumatoid arthri | 1986 Jun | The relation between the basal and stimulated gastric acid secretion, plasma gastrin, and the gastric microflora was examined in 45 patients with rheumatoid arthritis. Sixteen patients (36%) had basal achlorhydria, and of these, 10 (22%) had achlorhydria or hypochlorhydria after stimulation with pentagastrin. The peak acid output and acidity showed inverse correlation with the disease duration but were not associated with age or with the degree of physical disability. Hypergastrinaemia was found in nine patients (20%), of whom 6 (13%) had significant titres of parietal cell antibody. The acidity of the peak acid output showed negative correlation with plasma gastrin. It was confirmed that the gastric secretory state is a determinant of plasma gastrin levels and in addition influences the growth of micro-organisms in the gastric lumen. The type of microflora in the non-acid stomach was similar to that found in the saliva. A subgroup of eight females was identified who showed low gastric acid secretion rates, positive bacterial cultures, and atlantoaxial subluxation. Gastrin- and insulin-like immunoreactivities were found in joint fluid. The concentrations reflected their plasma levels, suggesting that the peptides are not released at the inflammatory site, but rather that they reach synovial fluid from circulating blood. | |
| 3437426 | Retropharyngeal hematoma as a new cause of acute upper airway obstruction in rheumatoid ar | 1987 Dec | A patient with severe rheumatoid arthritis (RA) receiving chronic anticoagulation therapy developed acute life threatening airway obstruction. The source of obstruction was a retropharyngeal hematoma compressing the upper airway rather than acute laryngeal dysfunction from the patient's RA. Our case illustrates a new cause of acute stridor and airway obstruction in RA. Publications on upper airway obstruction in RA and airway obstruction secondary to retropharyngeal hematoma are discussed. | |
| 1875668 | [The renin-angiotensin-aldosterone system and arterial hypertension in patients with rheum | 1991 Feb | Renin-angiotensin-aldosterone++ system was investigated in 60 patients suffering from rheumatoid arthritis. Forty-four of them (group 1) had arterial hypertension (144 +/- 4/94 +/- 2 mm Hg), sixteen were free of hypertension (120 +/- 3/80 +/- 1 mm Hg). Twenty-nine control subjects comparable by AH standing and demographic parameters had essential hypertension stage IB-IIA by A. L. Myasnikov classification (141 +/- 3/89 +/- 1 mm Hg). A tendency to renin suppression was dominating in 72% of group 1 patients (plasma renin activity less than 1.0 ng/ml/h). In this group there appeared high concentrations of A II (14.2 +/- 3.1 pg/ml) and plasma aldosterone++ (238 +/- 94 ng/ml). Rheumatoid vasculitis manifested in 86% of patients. Control subjects exhibited plasma renin activity greater than 3.0 ng/ml/hin 48%, average A II concentration was similar to that of group 1 (12.4 +/- 2.7 ng/ml/h, p greater than 0.05), plasma aldosterone++ level was significantly lower (176 +/- 29 ng/ml, p less than 0.05). Correlations were established between A II concentration and ESR (r = 0.39, p less than 0.05), A II and rheumatoid factor titers (r = 0.40, p less than 0.05). These indicate that immunopathological reactions are responsible for shifts in renin-angiotensin-aldosteron system in hypertensive rheumatoid arthritis subjects. | |
| 2745482 | Patellar replacement in bilateral total knee arthroplasty. A study of patients who had rhe | 1989 Jul | Thirty-five patients who had rheumatoid arthritis of both knees, but no gross deformity of the patella, had bilateral total knee arthroplasty. In each patient, one knee had a patellar replacement and the other did not. All of the patients were followed for a minimum of two years. The results were the same in both knees in terms of relief of pain and improvement in function, arc of motion, and muscle power. Although no complications that were related to patellar replacement developed in these patients, routine replacement of patellae that have little or no deformity does not seem advisable. | |
| 2871887 | A prospective five-year comparison of treatment which included penicillamine with that exc | 1986 May | Seventy-three patients with early, active rheumatoid arthritis (RA) were randomly allocated either to a group that received penicillamine or to a control group from which penicillamine was barred, any other second-line drug being permitted. Most (87%) of the controls received chrysotherapy at some stage. Clinical, serological and radiographic progress was observed for at least 5 years. Outcome after 5 years for the 27 remaining in the penicillamine group was compared with that for the 23 surviving controls. Both groups had improved clinically but deteriorated radiographically, with much individual variation. A subset of patients, mostly seronegative, who were radiographically normal at the outset remained so, regardless of treatment. Penicillamine was as effective as the control group treatments in relieving synovitis and as ineffective in arresting radiographic deterioration. | |
| 2269165 | [Video arthroscopy in diagnosis and treatment of TMJ disorders]. | 1990 Jul | Video arthroscopy using the double puncture method was applied in 32 patients with disc dislocations, disc perforations, rheumatoid arthritis and varying joint disorders of unidentified etiology. In disc dislocation cases the alterations observed in the superior joint cavity correlated well with the preoperative diagnosis, whereas minor and lateral disc perforations escaped detection by arthroscopy, possibly due to technical problems. Based on a critical assessment of this method, arthroscopic operative techniques are being developed for disc dislocations and hypermobility disorders, possibly even for chronic arthritis and related conditions. | |
| 2794706 | Stabilisation of the wrist in rheumatoid disease. | 1989 Aug | Internal splintage was undertaken of fifteen wrists for pain and instability, using an intramedullary Rush nail. The patients were examined at an average of thirty-three months after operation. Spontaneous fusion in a useful position had occurred in all but one. The operation is simple and external immobilisation is unnecessary. | |
| 1957937 | Psychiatric status of patients with primary fibromyalgia, patients with rheumatoid arthrit | 1991 Dec | OBJECTIVE: The major purpose of this study was to compare the frequency of the occurrence of DSM-III diagnoses in patients with primary fibromyalgia syndrome, patients with rheumatoid arthritis, and subjects without pain. METHOD: Thirty-five patients with primary fibromyalgia, 33 patients with rheumatoid arthritis, and 31 nonpatients without pain were blindly assessed for psychiatric diagnoses with the Psychiatric Diagnostic Interview. RESULTS: Data from this interview revealed no group differences in terms of lifetime history of any psychiatric disorders, including major depression, somatization disorder, or anxiety-based disorders. Analysis of the auxiliary symptoms of depression on the Psychiatric Diagnostic Interview revealed that the patients with fibromyalgia did not report a higher frequency of vegetative signs of depression. However, analysis of the somatization scale revealed an interaction between medical and psychiatric diagnoses: patients with primary fibromyalgia syndrome and a psychiatric history endorsed significantly more somatic symptoms than did patients with rheumatoid arthritis or subjects without pain, and fibromyalgia patients without a psychiatric history were no more likely to endorse somatic symptoms than were arthritis patients or subjects without pain. CONCLUSIONS: The Psychiatric Diagnostic Interview data failed to discriminate in any major way between primary fibromyalgia syndrome (a disorder with no known organic etiology) and rheumatoid arthritis (a disorder with a known organic etiology). Therefore, these data do not support a psychopathology model as a primary explanation of the symptoms of primary fibromyalgia syndrome. | |
| 1887428 | [The function of the effector cells of inflammation in rheumatoid arthritis]. | 1991 | As many as 105 patients with rheumatoid arthritis were examined for function of tissue and circulating neutrophils. The effect of serum factors on the nature of inflammation and synovial fluid was estimated both in the joint and in the focus of aseptic inflammation. The defense mechanisms of regulating inflammation, different trends in the effects of serum and synovial fluid on cell migration and oxygen metabolism were revealed, relations between the phenomena under study and the disease activity and local inflammation were defined. | |
| 2747991 | [Rheumatoid arthritis with cervical localization. Description of a case with neurological | 1989 Jun | A case of a patient with rheumatoid arthritis with a cranio-cervical junction involvement is presented. Medullary compression was present and was partially invalidating. Radiological and CT scan signs are explained and their relationship with a clinical symptomatology is discussed. The importance of radiological monitoring is emphasised in order to avoid dangerous neurological complications. | |
| 2896003 | Molecular polymorphism of various HLA-D subregions and rheumatoid arthritis. | 1988 Jan | In Caucasian populations, rheumatoid arthritis (RA) is generally associated with serologic HLA-DR4 specificity. In order to refine this correlation in the HLA-D region, we used six different probes pertaining to this locus: DR beta, DQ beta, DQ alpha, DO beta, DP beta and DP alpha. In this step, pooled RA and control DNA were hybridized with DR beta and DQ beta probes after digestion with 12 different endonucleases. Some bands appeared specific in the RA pool. In fact, with genomic DNA from 13 unrelated typed RA patients and 12 matched or partially matched control cells, these bands were revealed to be related to DR4 and/or DR1, with DR beta and DQ beta probes hybridizing BamHI, EcoRV, PvuII and StuI digests. With other probes, no differences could be related to RA disease. The polymorphism detected by these probes was suggestive of a gradient of decreasing complexity from DR beta to DO beta through DQ beta and DP beta, which could reflect discrete functions of each subregion. | |
| 1891575 | Psychodynamic, time-limited group therapy in rheumatic disease--a controlled study with sp | 1991 | Forty-six female patients with rheumatoid arthritis or primary Sjögren's syndrome participated in a prospective, controlled study of psychodynamic, time-limited group therapy. The paper concentrates on the qualitative outcome evaluated according to the patients' perceptions of what was appreciated as being most helpful in the group. Yalom's 'curative factors Q-sort' served as parameter of effect. Special attention will be given to the prevalence of alexithymia in rheumatic patients, and to the possibilities of ameliorating alexithymic features through group therapy. | |
| 2768297 | Surgical implications of varus deformity of the knee with obliquity of joint surfaces. | 1989 Aug | Some arthritic knees with varus deformity show excessive valgus angulation of the femoral joint surface with proximal tibia vara. This causes a downward and medial inclination of the articular surfaces in the coronal plane. The patients we studied had a medial shift of the standing load-bearing axis, and arthritic changes mainly in the medial compartment. Some also had lateral tibial subluxation with twisting of the distal femur and proximal tibia in opposite directions. We assessed the articular geometry by precise radiographic analysis, and compared the results with those in normal volunteers and a group of osteoarthritic patients. The prevalence of this type of deformity in our osteoarthritic patients was 11.5%; its recognition allows the use of specific operative correction that may include double osteotomy or the precise orientation of prosthetic components. | |
| 3947414 | Lymphoid irradiation in intractable rheumatoid arthritis. A double-blind, randomized study | 1986 Jan | Twenty patients with intractable rheumatoid arthritis were treated with 750-rad or 2,000-rad lymphoid irradiation in a randomized double-blind comparative study. Over a 12-month followup period, there was a significant improvement in 4 of 7 and 6 of 7 standard parameters of disease activity following treatment with 750 rads and 2,000 rads, respectively. Transient, short-term toxicity was less frequent with the lower dose. In both groups, there was a sustained peripheral blood lymphopenia, a selective depletion of T helper (Leu-3a+) lymphocytes, and reduced in vitro mitogen responses. These changes did not occur, however, in synovial fluid. These results suggest that 750-rad lymphoid irradiation is as effective as, but less toxic than, that with 2,000 rads in the management of patients with intractable rheumatoid arthritis. | |
| 2727549 | Activity of rheumatoid arthritis and levels of collagen antibodies: a prospective study. | 1989 | Thirty-seven patients with classical or definite rheumatoid arthritis (RA) were studied prospectively over a period of 12 months to assess whether there was a relationship between disease activity and raised levels of antibodies to native or denatured type II collagen. Nineteen patients had inactive RA according to ARA criteria for disease remission and 18 had active RA throughout the study. At the beginning of the study the levels of collagen antibodies were comparable in each group. After 1 year, antibodies to denatured type II collagen in patients with inactive RA had declined to significantly lower levels whereas in patients with active RA the levels of antibodies fluctuated during the period of study and were not significantly different at the end. There was no relationship between levels of antibodies to type II collagen and any specific index of disease activity, severity of X-ray changes in the hands and feet, or progression over 1 year in X-ray changes. The finding of a decline in levels of antibodies to denatured type II collagen in inactive RA suggests that the anticollagen response is an integral component of the rheumatoid process and could have a primary or secondary role in pathogenesis. |