Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2661580 | The distal radioulnar joint in rheumatoid arthritis. | 1989 May | Rheumatoid arthritis commonly affects the distal radioulnar joint (DRUJ). This can result in pain, instability, or tendon rupture. The goals of surgical reconstruction of the DRUJ are to relieve pain, stabilize the joint, and prevent tendon rupture. We review many of the previously described procedures and report our experience with distal ulna excision and soft tissue reconstruction with a distally based slip of extensor carpi ulnaris tendon. | |
| 3743089 | Pulmonary hypertension in a patient with diffuse fibrosing alveolitis due to rheumatoid ar | 1986 | A 43-year-old patient with a two-year history of rheumatoid arthritis developed diffuse pulmonary fibrosis with increased lung elasticity. Pulmonary artery catheterization revealed pulmonary hypertension at rest. Treatment with steroids and immunosuppressive drugs prevented progression of the disease. | |
| 2785297 | Co-segregation of HLA and rheumatoid arthritis in multicase families. | 1989 Jan | Inheritance of parental HLA haplotypes was examined in the offspring of 95 multicase rheumatoid arthritis (RA) families. Overall, in these families there was no evidence of preferential transmission of one parental haplotype, although this might have been expected given the loading of these families with RA cases. However, there was a difference in inheritance when the affected and non-affected offspring were compared. A co-segregation analysis showed that the inheritance of parental HLA haplotypes was different between the affected and the unaffected offspring. Unlike a previous report, no difference was demonstrated in this study between the offspring of affected and non-affected parents. Similarly, the affected offspring of HLA DR4 heterozygote parents were more likely to inherit HLA DR4 than the non-affected offspring. It is concluded first that linkage studies of RA using the affected sib-pair method are not invalidated, which would have been the case in the presence of preferential transmission of HLA to all offspring. Secondly, HLA and specifically HLA-DR4 does co-segregate with RA, and, finally, parental RA status, independent of DR4, has little influence in explaining the genetic susceptibility to RA. | |
| 2901304 | How reliable is ESR as a measure of disease activity in rheumatoid arthritis treated with | 1988 Jun | Forty-two patients with active rheumatoid arthritis treated with hydroxychloroquine sulphate (400 mg day-1) for six months have been compared with patients treated with D-penicillamine (n = 14), aurothiomalate (n = 13), sulphasalazine (n = 15) and chloroquine (n = 17) to compare the changes in articular index, plasma viscosity and ESR. Results indicate that while articular index and plasma viscosity show significant improvement for all treatments, the ESR fails to improve during hydroxychloroquine therapy. | |
| 2057710 | [Decrease of the functional affinity of rheumatoid factors under the effect of tiopronin]. | 1991 Apr | Sixteen rheumatoid arthritis patients were serologically examined, before and after a 2-month treatment with tiopronine (TP). The titer of agglutinating rheumatoid factor (RF) as well as the level of non-agglutinating RF were significantly reduced in serum and synovial fluid (SF). The functional affinity of the remaining RF was attenuated in serum (p less than 0.01) and SF (p less than 0.05). Conversely, the proportion of asialylated IgG was enhanced in serum (p less than 0.05) and SF (p less than 0.05). These findings would suggest that TP might restore the efficacity of sialyl transferase at the B lymphocyte level. | |
| 3502559 | HLA antigen associations with radiological changes in the hands, feet, and cervical spines | 1986 Jun | Clinical, laboratory, and genetic features measured at the onset of rheumatoid arthritis in 100 patients were compared with the severity of radiological changes in the hands and feet and in the cervical spines at a mean of 7.7 years. HLA-Dw4 was associated with more severe (p = 0.009) and HLA-Dw2 with less severe (p = 0.02)radiological changes in the hands and feet but the single strongest correlation with the severity of peripheral erosions was rheumatoid factor (p = less than 0.0001). Although none of the standard clinical or laboratory parameters correlated with severity of cervical spine changes, the presence of HLA-Dw2 and/or HLA B7 cross-reactive group were associated with more severe radiological changes in the cervical spine (p less than 0.02). Discriminant analysis selected certain standard laboratory parameters which in combination provided the most powerful prognostic index of radiological outcome in the hands and feet which was correct in 82 per cent. The addition of HLA data did not improve this figure. Conversely, the combination of the presence of HLA-Dw2, B27, and older age of onset of disease was found to be the most powerful predictor of the development of cervical spine changes and successfully predicted this complication of RA in 73 per cent. | |
| 1662820 | Infectious etiology of rheumatoid arthritis. | 1991 Nov | The infectious etiology of rheumatoid arthritis has been a long-standing hypothesis and in recent years is being examined with greater sophistication and scientific rigor. Synovitis may result indirectly from infection by the deposition of circulating immune complexes, by molecular mimicry, by in situ antigen deposition, or by arthritogenic toxins. Of candidate pathogens, recent interest has focused on mycobacterial HSP, EBV, and parvovirus B19. There is circumstantial evidence to support a link between each of these microorganisms and RA but presently all fall short of definitive proof of causality. It is anticipated that clearer answers may be forthcoming on this perplexing and intriguing question with the application of molecular biologic techniques to the study of synovial tissues. | |
| 1692419 | Disease-modifying anti-rheumatic drug therapy. An expensive therapy despite inexpensive dr | 1990 | In a study of the costs for drug therapy, 81 patients with rheumatoid arthritis taking parenteral gold, penicillamine or chloroquine were included. The patients were assessed for costs, directly and indirectly caused by the therapy, during a 12-week period. The three therapy groups were comparable in terms of number of patients, sex, age and duration of disease. There were substantial differences in costs for therapy between the three disease-modifying anti-rheumatic drugs. Treatment with parenteral gold gave the highest cost, 2.2 times that of chloroquine and 1.4 times the cost of penicillamine. The cost for the antirheumatic drug constituted a minor part of the total cost (4.4-15.4%). The need for patient visits for treatment and safety controls was a major factor in the overall cost. | |
| 3263759 | Variability of methotrexate pharmacokinetics and pharmacodynamics. | 1988 | It is apparent that MTX is a useful agent in the treatment of rheumatoid arthritis resistant to first and second line therapies. However, despite its long term use in this disease, considerable uncertainty exists about the basic pharmacokinetics of low dose oral MTX and therefore about its pharmacodynamics. It is probable that when MTX is re-examined with the help of modern analytical technology in a rheumatoid setting that pharmacological insights to the variability in dose-response relationships for efficacy and certain toxicities may emerge. There is still considerable uncertainty of the hepatotoxic potential of MTX. Further investigation of the accumulation of active polyglutamated MTX in liver may throw light on the likelihood of promoting iatrogen disease and perhaps the contribution of oral administration to this problem. Finally, examination of dose-response relationship utilising accurate pharmacokinetics may help to establish guidelines for the safe and effective usage of MTX in rheumatoid arthritis. | |
| 3103807 | Increased intestinal permeability in patients with rheumatoid arthritis: a side-effect of | 1987 Apr | Intestinal permeability in controls and in patients with active rheumatoid arthritis was assessed by measuring the radioactivity in 24-h urine collections after oral administration of 51Cr-EDTA. Intestinal permeability in the patients was found to be significantly increased in comparison to controls. Of the patients, 6/7 (86%) not taking any prescribed nonsteroidal anti-inflammatory drug (NSAID) at the time of study had normal results, whereas 23/29 patients (79%) taking prescribed NSAIDs displayed increased intestinal permeability. It has not been determined beyond doubt whether this finding is due to disease process or therapy with oral NSAIDs. | |
| 3791719 | Serum IgA and gold toxicity in rheumatoid arthritis: lack of predicting value. | 1986 Oct | The previously reported predictive value of serum IgA for gold toxicity was investigated by measuring such immunoglobulins in 114 patients affected with rheumatoid arthritis and treated with gold salts over a period of 36 months. Side effects were observed in 41 cases (35.9%) (toxic group), mostly within the first year of treatment. Basal levels of IgA were normal in all but 2 patients who maintained low levels throughout the follow-up but did not show any toxic effects. Before therapy and during gold salt administration no difference in serum IgA was noted between the toxic and the non-toxic group. After 6 months of therapy a significant decrease (p less than 0.05) in serum IgA (although never below normal limits) was detected in the toxic group as compared to both the basal values of the same group and the values of the non-toxic group at the same control. Moreover, we did not find any difference in serum IgA between toxic patients with and without mucocutaneous reactions. In our experience the monitoring of serum IgA is not useful in predicting gold toxicity. | |
| 2042980 | Correlation of histopathological features of pannus with patterns of damage in different j | 1991 May | The cartilage-pannus junction has been studied in multiple sections from 23 rheumatoid joints. Changes suggesting a metaplastic reaction of the articular cartilage, termed transitional fibroblastic zone, were commonly found in hips and knees, but were rarely present in metatarsophalangeal joints, in which an invasive pannus with cartilage degradation in close association with inflammatory cells was seen. Thus when multiple sections from rheumatoid joints were examined a transitional fibroblastic zone was found in 1/15 (7%) sections from metatarsophalangeal joints compared with 29/57 (51%) and 15/48 (31%) sections from knee and hip joints respectively. In contrast, an invasive pannus occurred in 11/15 (73%) sections from metatarsophalangeal joints compared with 22/57 (39%) sections from knees and 19/48 (40%) sections from hips. These findings led to the suggestion that this pathological variation between different joints may explain the predominance of erosive change in small joints as compared with joint space narrowing with secondary osteoarthritis found in large joints in rheumatoid arthritis. Inappropriate comparisons between different joints may in part explain the variation in findings of previous histopathological studies. | |
| 2015160 | The pharmacokinetics of the enantiomers of flurbiprofen in patients with rheumatoid arthri | 1991 Jan | Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios were small. The average values (+/- s.d.) of oral plasma clearance, volume of distribution and elimination half-life for R(-)-flurbiprofen were 0.075 (+/- 0.066) l min-1, 12.47 (+/- 5.79) l and 138 (+/- 61) min, respectively. The average values (+/- s.d.) of oral plasma clearance, volume of distribution and elimination half-life for S(+)-flurbiprofen were 0.057 (+/- 0.035) l min-1, 12.81 (+/- 4.43) l and 155 (+/- 49) min, respectively. S(+)/R(-) ratios (+/- s.d.) rose from 1.06 (+/- 0.12) to 1.75 (+/- 0.61) at the end of the 12 h interval in plasma and from 1.18 (+/- 0.13) to 1.47 (+/- 0.24) over the measured time course in synovial fluid. Increases in S(+)/R(-) ratios may be clinically important as they demonstrate accumulation of the pharmacologically active species. | |
| 2892878 | Thyroid stimulating antibodies in rheumatoid arthritis: an in vitro phenomenon. | 1987 Oct | The purpose of the study was to evaluate the frequency of thyroid stimulating immunoglobulins and their possible effect in vivo in patients with rheumatoid arthritis. Thyroid stimulating antibodies (TSAb) were present in 17 (68%) of 25 patients with rheumatoid arthritis, whereas only 2 (8%) had thyrotropin binding inhibiting immunoglobulins (TBII). The groups with and without TSAb were comparable with regard to sex, age, anti-inflammatory drugs, serum thyroglobulin levels, antithyroglobulin and antimicrosomal antibodies, rheumatoid factor, as well as to the serum levels of thyroxine and 3, 5, 3'-triiodothyronine. A possible stimulating effect of TSAb in vivo was evaluated by an ultrasensitive immunoradiometric assay for TSH. Both groups had normal serum TSH levels, and no significant difference was found between the two groups suggesting that the demonstration of TSAb in vitro is not always associated with a stimulation of the thyroid gland in vivo. | |
| 2336551 | Radiographic measurements of occipito-atlanto-axial dislocation in rheumatoid arthritis. | 1990 | Atlanto-axial dislocation is frequently found in patients with rheumatoid arthritis. Vertical atlanto-axial dislocation with invagination of the dens into the foramen magnum may result in most serious myelopathy. Decompression, removal of the dens and atlanto-axial fixation have given fair results in such cases. It is our aim, however, to prevent myelopathy in our rheumatoid patients. The prerequisite for that is routine, radiographic examination of the cervical spine and prophylactic atlanto-axial fixation. For these routine controls we need a radiographic measuring method which can be used even in cases of greater destruction. Our radiographic measuring method is compared with other methods and seems to be more appropriate and also gives information about the forward or backward tilting of the atlas. In a group of non-rheumatoid patients we have measured normal figures for this method. | |
| 3182890 | Palmar shelf arthroplasty. A follow-up note. | 1988 Oct | Palmar shelf arthroplasty was described by Albright and Chase as a successful, so-called conservative surgical alternative for the treatment of subluxation of a wrist that is affected by advanced rheumatoid arthritis. Subsequent to their report, seven wrists in six patients who had been treated with a palmar shelf arthroplasty by Albright and Chase or by their trainees were studied, after an average follow-up of nine years. All of the patients had long-term relief of pain and improved motion of the wrist, and all were satisfied with the result of the procedure. All but one patient had increased function. | |
| 3219782 | Antibodies to histones in rheumatoid arthritis. | 1988 | Using a newly developed enzyme-linked immunosorbent assay, antibodies to histones (H1, H2A, H2B, H3 and H4) were found in 32 out of 40 rheumatoid arthritis patients with antinuclear antibodies at a titer greater than or equal to 100 as measured by indirect immunofluorescence. The anti-H2A reactivity was higher in patients with secondary Sjögren's syndrome than in those without, but the highest antihistone reactivity and the most heterogeneous patterns were observed in patients who were receiving D-penicillamine. | |
| 2746586 | Synovial fluid acidosis correlates with radiological joint destruction in rheumatoid arthr | 1989 Apr | Metabolic variables in samples of synovial fluid (SF) from 33 rheumatoid arthritis (RA) knees were analyzed. These variables were correlated with radiological destruction and SF proteoglycan concentrations. SF acidosis correlated with radiological involvement (rs = 0.62, p less than 0.002), but not with proteoglycan concentrations. A weak correlation was found between SF acidosis and granulocyte concentrations (rs = 0.37, 0.02 less than p less than 0.05). Metabolic variables covaried as expected. Samples from right and left knees from the same patients correlated regarding cellular and metabolic variables. Our results indicate insufficient nutritional supply in RA joints with increasing radiological involvement. | |
| 3498276 | [ Serum osteocalcin in chronic polyarthritis in stage III]. | 1987 May | Osteocalcin, a major noncollagenous protein component of bone matrix which reflects the level of new bone formation, was measured in serum by radioimmunoassay, in 45 patients with rheumatoid arthritis (RA) (Steinbrocker stage III) and in 45 age- and sex-matched healthy subjects. According to the literature, serum osteocalcin concentrations were slightly decreased in the RA group but this was not statistically significant. Only RA patients on corticosteroid therapy had statistically significant decreased osteocalcin levels, compared with normal controls. No correlation was determined in the RA patients between serum osteocalcin levels and levels of C-reactive protein, erythrocyte sedimentation rate, circulating immune complexes (Clq binding assay) and rheumatoid factors of the IgA, IgG or IgM class. | |
| 2728409 | [Persistence of viruses in rheumatoid arthritis]. | 1989 Jan | Humoral and cell-mediated immune response to antigens of hepatitis B (HBsAg and HBeAg), delta-virus, rubella, and measles viruses was studied. Detection in a number of patients with rheumatoid arthritis of HBsAg and HBeAg in blood sera permits a conclusion that productive virus infection is formed in such patients. At the same time in patients with rheumatoid arthritis areactivity of immunocytes to HBsAg and HBeAg was found while marked sensitization of lymphocytes to rubella virus antigens was demonstrated. The patients with rheumatoid arthritis, however, do not develop mere long-term carrier state of hepatitis B virus but form primary chronic hepatitis as a consequence of virus infection. This is indicated by an increase in the level of alanine aminotransferase (1.6 +/- 0.8 mmol/l) and detection of antibody to delta-virus in such patients (28.6%). |