Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2363254 | [The use of immobilized granulated G-actin with magnetic properties in patients and experi | 1990 Mar | G-actin was isolated from human myocardium, purified by means of repeated polymerization-depolymerization and immobilized in polyacrylamide gel by the procedure of "emulsion granulation". The granules acquired magnetic properties after addition of iron protoxide hydrophilic particles into the polymerizating mixture. Immobilized G-actin in granules with magnetic properties was used for production of specific antisera, for isolation of pure antibodies by means of an immunosorption procedure, for estimation of specific antibodies in blood sera of patients with rheumatism, of healthy persons and of experimental animals using immunofluorescent, immunoenzymatic and radioimmune procedures. | |
| 2138721 | [Cutaneous side effects induced by D-penicillamine in the treatment of rheumatoid arthriti | 1990 Mar | After considering the cutaneous side effects of D-penicillamine in rheumatoid arthritis management, a few cases of cutaneous adverse reaction observed in 5 (13%) of 38 patients, who received the drugs, are described. Two patients had an early rash; one showed a late rash; one had a late rash with symptoms of initial pemphigus and drug-induced LES (presence of antinuclear and anti-dsDNA antibodies). Finally, one patient showed a drug-induced pemphigus with high titre of reticular anti-skin antibodies. All these manifestations required definitive discontinuance of the drug. | |
| 3659381 | Carpal alterations in adult-onset Still disease, juvenile chronic arthritis, and adult-ons | 1987 Nov | A specific pattern of pericapitate involvement of the wrist has been described in the rheumatologic literature as characteristic of adult-onset Still disease (AOSD), a relatively rare disorder that is often diagnosed by exclusion after extensive and frequently invasive tests. To evaluate the potential diagnostic value of carpal radiography in suspected cases of AOSD, a retrospective blinded analysis of 48 patients (16 each with AOSD, juvenile chronic arthritis, and adult-onset rheumatoid arthritis) was performed. Pericapitate articular alterations without radiocarpal involvement were found to be distinctly unusual among patients with rheumatoid arthritis but frequent in the setting of AOSD. In juvenile chronic arthritis severe pericapitate involvement also occurs frequently but is more likely to be associated with interosseous fusion and severe pancompartmental disease. | |
| 1980561 | Immunohistochemical demonstration of collagenase and tissue inhibitor of metalloproteinase | 1990 | Degradation of fibrillar collagens is a central process in joint destruction in rheumatoid arthritis. Collagenase responsible for the collagenolysis has been immunolocalized on the extracellular matrix components at the cartilage/pannus junction in the rheumatoid joint, but very little is known about cellular source of the proteinase. In this paper monospecific antibodies against collagenase and tissue inhibitor of metalloproteinases (TIMP) were applied to rheumatoid and normal synovium to identify cells synthesizing and secreting the enzyme and its inhibitor. By treating the specimens with the monovalent ionophore, monensin, both collagenase and TIMP could be immunolocalized in hyperplastic synovial lining cells in rheumatoid synovium, but not in the cells of normal synovium. Dual immunolocalization studies demonstrated that the majority of the lining cells (approximately 64%) produce both collagenase and TIMP, while approximately 3% of the cells were positive only for collagenase, and 11% only for TIMP. Neither collagenase nor TIMP was immunolocalized on the extracellular matrix components in the synovia examined. These data suggest that synovial lining cells in rheumatoid arthritis secrete both collagenase and TIMP into the joint cavity. The role of collagenase in joint destruction in rheumatoid arthritis is discussed with reference to the regulation of the activity by TIMP. | |
| 2402988 | Elbow arthroplasty in rheumatoid arthritis. Function after 1-2 years in 20 cases. | 1990 Aug | The function of the hand and arm was studied after total elbow arthroplasty in a consecutive series of 18 rheumatoid patients with a total of 20 primary arthroplasties and one revision. Extensive clinical evaluation with locomotion score and Sollerman's hand function test was undertaken preoperatively and at 6 months postoperatively. The mean flexion range increased 25 degrees and extension lag decreased 5 degrees. Pain relief was achieved in all the cases, and 16 of 20 primary operated on elbows became fully painfree. Hand function score (max. 80) improved from 52 to 64, upper extremity score (max. 100) from 57 to 68 and subjective score (max. 100) from 46 to 58. Complications were 2 cases of ulnar nerve paresthesia and 1 epicondylar fissure. | |
| 1812554 | [The psychological personality characteristics of patients with rheumatoid arthritis]. | 1991 Jul | A psychological examination of 135 patients with rheumatoid arthritis (RA) (Bechterew Institute questionnaire) was made. Harmonious, neurasthenic, hypochondriac, paranoiac, apathetic and anxious attitudes to the disease were most frequent. Psychological features of personality in patients with RA do not depend on the sex, degree of activity, course, stage and the disease duration. The psychological characteristics of the patients allow one to make a differentiated approach to psychotherapy and prescription of psychotropic drugs. | |
| 2075397 | [Comparison of radiologic lesions of rheumatoid polyarthritis in function of the presence | 1990 Oct | The authors compared, with the help of five radiological indices bearing on part (hand and wrists) or the all the articulations of the limbs concerned by rheumatoid arthritis (RA), a group of 45 RA with rheumatoid factor IgA (RF IgA) with a group of 45 RA without RF IgA by matching them according to age, sex and duration of evolution. They did not find any significant difference between the two groups for any of the indices. Although they are more often associated with agglutinant RF IgM, the RA with RF IgA are not more severe on the radiological level than the RA without FR IgA. | |
| 1767344 | [Measurement of quality of life in rheumatoid arthritis]. | 1991 Oct | This study was designed to explore the health status or quality of life (QOL) in 366 patients with rheumatoid arthritis in Japan. Physical, social, and emotional functions of the patients, namely the QOL, were measured by the modified health assessment questionnaire, the quality of well-being score, and the face scale, respectively. These functions were also evaluated by the new methods using visual analogue scales. The longer the duration of rheumatoid arthritis, the worse the QOL measures in these patients. A similar result was observed in the relationship between the stage classification of progression of rheumatoid arthritis and the QOL measures. In contrast, the traditional medical process measures, such as Lansbury activity index, sedimentation rate, and serum CRP concentration did not correlate with the duration of the disease. We conclude that the QOL measures in this study are useful for evaluation of the functional status and well-being of patients with rheumatoid arthritis. However, the clinical usefulness of these measures for evaluation of effectiveness and/or side effects of anti-rheumatic drugs still remains unknown. | |
| 11188593 | Hand splinting in rheumatoid arthritis. A perspective on current knowledge and directions | 1991 Jun | A theoretical rationale for the use of hand splints in rheumatoid arthritis and selected literature relevant to the efficacy of splints in the acutely inflamed or chronic rheumatoid joint are briefly reviewed. The purposes of this review are to provide a broad perspective on nonsurgical hand splinting and to suggest some directions for future research based on this perspective. | |
| 2259841 | Complement-mediated inhibition of immune precipitation in rheumatoid vasculitis. | 1990 | Complement-mediated inhibition of immune precipitation (CMIP) was measured in patients with rheumatoid arthritis (RA), rheumatoid vasculitis (RA VASC), patients with skin vasculitis not associated with a systemic connective tissue disease and normal healthy controls. CMIP was impaired in 100% (14/14) of the RA vasculitic patients, 60% (12/20) of the RA patients and 22% (2/9) of the dermovasculitic patients. The degree of impairment of CMIP was significantly greater in the RA vasculitic patients compared to the non-vasculitic patients. This difference was due to the significantly lower complement levels and the presence of higher concentrations of an inhibitor of CMIP in the RA vasculitic sera. The levels of this inhibitory activity correlated significantly with IgM rheumatoid factor concentration. Serial studies in three patients with RA vasculitis treated with corticosteroids and immunosuppressive drugs showed significant clinical improvement in two patients, which was associated with improvement in CMIP, reduction in circulating immune complex levels and reduction in IgM rheumatoid factor concentrations. | |
| 2460213 | Do mast cells intervene in the vasoproliferative process of the rheumatoid synovitis? | 1988 Jul | On the basis of these evidences: a) the role played by heparin in the promotion of angiogenetic processes; b) the isolation of an angiogenetic factor in the synovial fluid from patients with rheumatoid arthritis; c) the significant increase of mast cells in the synovial membrane of the same patients, we suggest the possibility that the vasoproliferative processes in the course of rheumatoid arthritis may be mediated by heparin contained in the secretory granules of mast cells and released during the inflammatory process in response to numerous and heterogeneous stimuli. | |
| 2652936 | [Coexistence of polymyalgia rheumatica/temporal arteritis and chronic polyarthritis]. | 1989 Jan | Prompted by one of our own case studies, which we report here, we reviewed the literature for coincidence of rheumatoid arteritis (RA) with polymyalgia rheumatica (PMR) and temporal arteritis (TA), respectively. The indicative feature of this uncommon condition was found in 13 cases, whereas in 70 other cases reported, the diagnosis of combined RA and PMR/TA was probable. Diagnostic criteria for determining combined RA and PMR/TA will be discussed, as well as the clinical important feature of senile RA. | |
| 3267314 | Reduction of rheumatoid periodontoid pannus following posterior occipito-cervical fusion v | 1988 | Nine patients (four females and five males) with chronic rheumatoid arthritis (RA) and atlanto-axial (AA) instability subjected to occipito-cervical fusion were evaluated clinically and radiologically. All of them had soft tissue formation (pannus) around the odontoid peg. The age ranged from 50 to 79 years (mean: 66). The duration of the RA disease was 3-48 years (mean: 18.5). All patients were seropositive. Both conventional radiography and magnetic resonance imaging (MR) were performed pre- and postoperatively. All fusions except one were stable. One patient was re-fused after 2 months because of wire break. With regard to pain all patients had improved and eight were pain free. Six patients who experienced signs of myelopathy prior to the fusion had improved at follow up. MR revealed reduction of pannus in all nine cases. This was obvious in one patient within 6 weeks postoperatively. The MR findings of a reduction or even disappearance of pannus following posterior fusion should decrease the need for transoral surgery. | |
| 3619610 | Robinson Bashall Functional Assessment for arthritis patients: reliability and validity. | 1987 Aug | The Robinson Bashall Functional Assessment (RBFA) for arthritis patients has four scales: self-care, ambulation, transportation, and activity tolerance. Criticism has been directed at the Assessment because it is relatively time consuming and requires a trained professional to conduct it. Tests of reliability revealed that the internal consistency of the total Assessment was moderate, interrater reliability was high, and test-retest reliability ranged from moderate to high. Analysis of scale validity (content, clinical, concurrent, and discriminant validity) showed content validity to be low to moderate. Therapists found the scales more useful in identifying patient problems than in assessing improvement in function over time. There were low positive correlations between dressing, undressing, and ambulation scores and ROM scores on admission. Correlations between the American Rheumatism Association Functional Classification and scales of the RBFA were significant, while the Assessment as a whole and all four scales discriminated significantly between the functional abilities of patients on admission and discharge. | |
| 1954701 | Chronic hepatitis during rheumatoid arthritis. | 1991 Sep | Chronic hepatitis is infrequently reported in the course of RA (1.9%). We report 6 cases with such an association. The six patients were all female (mean age: 59.5 years) with typical RA (ACR criteria), and sicca syndrome in 5 cases. Chronic hepatitis always developed after the onset of RA (delay: 1 to 47 years). Laboratory findings revealed a mild increase of transaminases. Alkaline phosphatase were increased in 3 cases. Liver insufficiency was present in 4 cases and polyclonal hypergammaglobulinemia in 6 cases. Rheumatoid factors were detected in 5 cases; antinuclear antibodies and anti-smooth muscle antibodies were also detected in 5 cases. Histological examination of liver biopsy disclosed active chronic hepatitis in 5 cases (with cirrhosis in 3 cases) and persistent chronic hepatitis in 1 case. Steroid therapy was administered in 4 cases of active chronic hepatitis with clinical and biological improvement (18 months to 6 years follow-up). One patient died of gastric bleeding. | |
| 3950028 | Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. | 1986 Jan | Four patients with rheumatoid arthritis developed a similar type of lymphoreticular tumour. The morphology and immunocytochemical findings suggested that this was a form of malignant histiocytosis: there may be an important correlation between this tumour and rheumatoid arthritis. | |
| 3281605 | Analysis of clinical judgment helps to improve agreement in the assessment of rheumatoid a | 1988 Feb | Experienced rheumatologists differ widely in their assessments of rheumatoid arthritis even after extensive efforts to improve agreement by discussion and consensus. The use of computer feedback to provide an analysis of clinicians' judgment policies in a highly structured investigation has been shown to improve agreement, but this may not apply in normal clinical practice. Here the successful convergence of clinical agreements by three rheumatologists using computer assisted feedback over several months in a National Health Service outpatient department is reported. In the three months without feedback their pooled agreement for assessing the severity of rheumatoid arthritis was r2 = 0.62. During the three months in which feedback was provided agreement rose to r2 = 0.92. The principal component of all three judgment policies at the end of the feedback period was 'articular index'. | |
| 3422015 | Accelerated nodulosis and vasculitis during methotrexate therapy for rheumatoid arthritis. | 1988 Sep | Three women with classic rheumatoid arthritis, who were receiving weekly doses of methotrexate (MTX), developed accelerated subcutaneous nodulosis, despite good response to the drug. In 2 of the patients, the onset of nodulosis occurred within 3 months and 5 months, respectively, after starting MTX; in the third patient, it was observed only after 4 years of MTX therapy. In all 3 patients, the onset was unusually abrupt, with extensive distribution and remarkable nodule size. Additional manifestations of cutaneous vasculitis in 2 of the patients and Raynaud's phenomenon in the third appeared concomitantly with the nodulosis. Physicians prescribing MTX therapy for patients with rheumatoid arthritis should be aware of these potential complications. | |
| 2920049 | Demonstration of a cross-reactive idiotype (IdRQ) in rheumatoid factors from patients with | 1989 Feb | A human monoclonal IgM kappa paraprotein with rheumatoid factor (RF) activity was used to elicit antiidiotypic antibodies in rabbits. The antiidiotypic antiserum thus obtained reacted with samples from 40% of 72 rheumatoid arthritis patients, but not with any of the samples from 22 aged control subjects having serum RF. Our findings suggest that, despite the similarities between RF from rheumatoid arthritis patients and that from healthy individuals, the expression of V region genes may be different in healthy subjects and those with the disease. | |
| 1848880 | Correction of ulnar drift during silastic metacarpo-phalangeal joint arthroplasty. | 1991 Feb | In previous published accounts of silastic replacement arthroplasty of the M.P. joint of the finger in rheumatoid disease, dynamic splintage has been used for up to six months after operation to ensure correction of ulnar drift. We have investigated two methods of surgical correction in a prospective trial in consecutive patients. No dynamic splintage was used. Both resulted in correction of ulnar drift from an average of 34 degrees (maximum 92 degrees) to 8 degrees (maximum 32 degrees) in 86 fingers. The two methods both corrected ulnar drift well, but crossed intrinsic transfer gave a better range of active movement and is recommended as an alternative to dynamic splintage. |