Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2377868 | [Immunoglobulin therapy of rheumatoid arthritis]. | 1990 Jan | The authors studied the effect of the Soviet-made immunoglobulin drug intended for intramuscular administration on the clinico-immunological indices of 15 patients with rheumatoid arthritis (RA). The drug was administered in a dose of 1500-1800 mg for 7 days running of each month. The control group included 15 patients with RA who received the drug in extremely low doses in accordance with the same pattern. Significant positive changes in the majority of the clinico-laboratory indices were noted in the main group. Individual assessment of the drug efficacy allowed one to note improvement in 8 patients (out of 14) in one month, in 7 (out of 12) in 3 months, in 4 (out of 7) in 6 months. One patient exhibited considerable improvement of her state and one developed fever due to which the treatment was discontinued. The results of the therapy correlated with deexpression of Ia-antigens under the effect of the drug on the peripheral blood lymphocytes. | |
| 3262665 | Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and | 1988 Oct 15 | An ELISA was used to measure soluble IL-2R (sIL-2R) in the sera and synovial fluids of patients with rheumatic diseases. Patients with rheumatoid arthritis had raised levels of sIL-2R both in their sera and in their synovial fluid compared to patients with osteoarthritis and age-matched healthy controls. Mononuclear cells from the synovial fluid of rheumatoid arthritis patients were found to produce spontaneously high levels of sIL-2R which eluted at approximately m.w. 40,000 on gel filtration. In contrast, autologous peripheral blood cells only produced comparable levels upon stimulation with mitogenic lectin. Sequential studies indicated that serum sIL-2R levels were highly correlated with disease activity, indicating that measurement of sIL-2R may be a useful clinical marker in the future. Within the joint, synovial fluid sIL-2R levels correlated significantly with immunoreactive IL-1 beta levels, providing evidence for a role of IL-1 in immune activation in the synovium. In synovial fluids, sIL-2R level also correlated with functional inhibition of IL-2-driven responses in vitro. Furthermore, sIL-2R immunoreactivity in synovial fluid eluted at m.w. 100,000 coeluting with IL-2-inhibitory activity and consistent with a role for sIL-2R in down-regulation of IL-2 responses. The abnormal m.w. may be accounted for by complex formation in the synovial fluid. Given the ability of sIL-2R to bind IL-2, the presence of sIL-2R within the joint may contribute to the well documented "IL-2 defect" seen in rheumatoid arthritis. | |
| 3044411 | Ultrasonography of the hand in rheumatoid arthritis. | 1988 Jul | High resolution ultrasonography of the hand and wrist was performed on 20 patients with definite or probable rheumatoid arthritis (ARA standard criteria) in its early stage. In all the patients, swelling of the soft tissues of the fingers corresponded to an enlargement of the joint capsule containing a hypoechoic exudate. The rheumatoid nodules appeared as fluid-filled rounded cavities with sharp borders. Rheumatoid tenosynovitis was observed in 18/20 patients. This corresponded to oval or spindle-shaped cavities with a hypoechoic (10/18 cases) or anechoic content (8/18 cases) and with the tendon ribbon inside. Rupture of a tendon was diagnosed in 8/20 cases and it was always confirmed at surgery. Tenosynovitis of the flexor carpi ulnaris at the wrist level was observed in 10/20 patients. Ultrasonography is proposed as an effective first-line approach and as a periodical follow-up survey in early stage rheumatoid arthritis, in combination with standard radiography. | |
| 2939238 | Serum beta-endorphin in primary fibromyalgia syndrome: a controlled study. | 1986 Feb | Serum beta-endorphin was assayed without knowledge of study subject category in 44 consecutive patients with primary fibromyalgia syndrome, 3 patients with rheumatoid arthritis (RA), and 30 normal controls, all females. Mean serum beta-endorphin levels were 81 +/- 28 pg/ml in patients with fibromyalgia, whereas those in normal controls and patients with RA were 73 +/- 17 pg/mg and 73 +/- 18 pg/ml, respectively. These differences were not statistically significant. Serum beta-endorphin levels did not correlate with relevant clinical variables in either fibromyalgia or RA groups. | |
| 1941815 | Serum osteocalcin levels in rheumatoid arthritis: a marker for accelerated bone turnover i | 1991 Aug | Levels of serum osteocalcin (OC) are increased in diseases with high bone turnover. We determined OC levels in (1) 15 patients with definite rheumatoid arthritis (RA) in early stages according to Steinbrocker's functional class FC I-II, (2) 40 patients at advanced stages (FC III-IV) and (3) 17 patients with late RA (onset at age of 65 or more). Sixty-two healthy volunteers, divided into 3 subgroups corresponding to the patients, and 19 patients with primary fibromyalgia syndrome (FMS) served as controls. All patients were included in a short term as well as a longitudinal study over one year. Mean OC levels were significantly elevated in patients with late onset RA compared with healthy controls (p = 0.037), while the OC values in early RA FC I-II and advanced RA FC III-IV did not differ significantly from the corresponding control group and the patients with FMS. The late RA group showed a positive correlation between OC and the erythrocyte sedimentation rate (ESR) (r = 0.641, p = 0.007) with a significant decrease of OC (p less than 0.01) as well as ESR (p = 0.047) over one year. We conclude increased OC levels correlate with disease activity in older patients with active RA, suggesting impaired bone turnover. This finding supports the picture of heterogeneity in RA with more late onset patients displaying "high bone turnover." | |
| 2609058 | [Dynamics of granulocyte proteins after lymphocytapheresis in patients with rheumatoid art | 1989 Jul | The authors studied concentrations of granulocytic proteins, lactoferrin, leukocytic thermostable alpha-glycoprotein in the blood plasma of patients with rheumatoid arthritis. High concentrations of the above proteins were observed in RA patients. | |
| 1946911 | [Stress and behavior in coping with illness by patients with chronic polyarthritis]. | 1991 Sep | 39 female patients with chronic rheumatoid arthritis and 17 healthy women were assessed for their stress-coping mechanisms. As compared to healthy controls, the coping behavior of patients with rheumatoid arthritis is characterized by a significantly higher degree of playing down the stressful situation through comparison with others, by more substitutive gratification, by more attempts at controlling their reaction, but fewer attempts at controlling the situation. Moreover, patients with rheumatoid arthritis show less self-accusation, but also less guilt-defence. These coping mechanisms are most probably acquired already during the second year after the onset of illness and do not change significantly thereafter. | |
| 3402850 | Foot pressure studies in the assessment of forefoot arthroplasty in the rheumatoid foot. | 1988 Jun | To assess the results of forefoot arthroplasty, dynamic and static foot pressure studies have been made of the rheumatoid foot in both a prospective study group of 60 feet and in a retrospective study group of 18 feet. Significant reductions of pressure in the forefoot were found. Problems associated with the first and fifth metatarsals were considered. | |
| 2399957 | Rheumatoid arthritis "in the buff": erosive arthritis in defleshed bones. | 1990 Aug | Examination of isolated bones from patients with unequivocal rheumatoid arthritis provides only a glimpse of the disease but has been the only "gold standard" for recognition of osseous lesions as compatible with the diagnosis of rheumatoid arthritis. Documentation of skeletal pathologic changes in confidently diagnosed individuals has been a major missing link in the transition from clinical to skeletal analysis. Availability of appropriate skeletal material from two patients with long-standing, well-documented rheumatoid arthritis provided the opportunity for acquiring such information. The osseous appearance, skeletal distribution, and distinguishing features of rheumatoid arthritis "in the buff" were delineated in two contemporary patients and in a skeletal population of 2,906 individuals. The preconceived notion of anticipated severity of disease has hereby been tested and found wanting. Severe lesions are not recognizable or distinguishable from artifact in relatively fragile rheumatoid arthritis-affected bones, whether freshly prepared or remotely sampled. Characterization of the nature and epidemiology of osseous alterations in two contemporary skeletal populations permitted the development of a standard for recognition of the disease in skeletal populations. | |
| 3632068 | Acute non-infectious arthritis of the hip in patients with rheumatoid arthritis. | 1987 Jun | Five patients with rheumatoid arthritis and no previous hip joint disease developed an acute disabling arthritis in one hip joint. Roentgenograms were negative and synovial fluid from the hip joint was inflammatory, but no crystals were seen and cultures were negative. Four of the five patients responded rapidly to intra-articular corticosteroids, and none of the five has had further hip joint symptoms during a mean follow up period of two years. | |
| 2348422 | Pathology of femoral heads in patients with rheumatoid disease. | 1990 Apr | In a study of 107 femoral heads removed surgically from 91 patients with generalized rheumatoid arthritis (RA), 96 showed rheumatoid stigmata; in 24 of these, fractures were a dominant feature. Of the 11 heads without rheumatoid stigmata, 5 had changes indistinguishable from osteoarthritis (OA), 5 had intracapital fractures and 1 had massive necrosis. The nature of eburnation was analyzed. Attention was drawn to fractures involving all the pillars supporting the subchondral plate and named "the dome shear fracture." The high incidence of fractures (29 of 107) was attributed to steroid therapy. The controls used were femoral heads from 400 patients with OA, 10 with ankylosing spondylitis and 10 treated with steroids for reasons other than RA. In most instances, a clear distinction could be made between RA and OA in the femoral head. | |
| 3814972 | A reappraisal of synovectomy and radial-head excision in rheumatoid arthritis. | 1987 Feb | A review of the literature reveals that radial-head excision for rheumatoid destruction of the elbow is a worthwhile operation, producing complete pain relief in many and substantial improvement in approximately 75%. Recurrence of symptoms eventually occurs in 50% patients. | |
| 2378172 | Alkaline phosphatase activity in the serum of patients with rheumatoid arthritis. | 1990 May | Alkaline phosphatase (ALP) activity was determined in the serum of 145 patients with rheumatoid arthritis (RA) and of 56 patients with osteoarthritis (OA). The mean ALP concentration was 226.9 U/L in RA and 168.7 U/L in OA (p less than 0.001). The prevalence of hyperphosphatasemia was 28% in RA vs 7.1% in OA (p less than 0.01). ALP concentrations significantly correlated with the erythrocyte sedimentation rate (p less than 0.05). Eighteen out of 46 (39%) rheumatoid patients in whom ALP isoenzymes determination was performed showed a predominant liver fraction and 10 (22%) a predominant bone fraction. In women, both ALP and its bone isoenzyme correlated with the number of joints involved by RA. During the followup, major changes of the type of predominant ALP isoenzyme were observed. | |
| 3166655 | Cytological assessment of knee effusions. | 1988 | Effusion fluid from 80 knee joints was obtained from patients prior to arthroscopy and arthroscopic surgery and submitted to independent physicochemical analysis and cytological examination. The majority of the effusions were secondary to osteoarthrosis and traumatic mechanical derangement. These two conditions gave nonspecific findings on physicochemical analysis and cytology, and the cytologist diagnosed on 13% of these correctly. Cytological examination of fluid from rheumatoid knees revealed ragocytes in just over half the cases, and on this basis, the cytologist was able to correctly diagnose rheumatoid arthritis. Contrary to other reports, we conclude that physicochemical analysis and cytological examination of joint fluid is of little value in the assessment of knees presenting to the orthopaedic surgeon. | |
| 1787497 | Humanized monoclonal antibody treatment in rheumatoid arthritis. | 1991 Nov | A 41-year-old woman with active, seropositive erosive rheumatoid arthritis was treated with the humanized monoclonal antibody Campath 1H. She had not responded or developed side effects to myocrisin, sulfasalazine and penicillamine, and had not responded to inpatient bedrest and physiotherapy. There was a rapid clinical improvement within 24 hours of infusion, which was maintained for about 12-14 weeks after the infusion. The lymphocyte count was suppressed for 7 months after treatment. There were no significant side effects during or after treatment. No anti-Campath 1H response was detected. This preliminary study suggests humanized monoclonal antibody therapy may be of value in the treatment of rheumatoid arthritis. | |
| 3259005 | The aminoterminal-type-III procollagen peptide and proteoglycans in serum and synovial flu | 1988 | The concentrations of aminoterminal-type-III procollagen (procollagen N-) peptide, and of proteoglycans were measured in knee-joint synovial fluid and serum from patients with rheumatoid arthritis or reactive arthritis. All synovial fluids contained large amounts of intact propeptide. The synovial fluid: serum propeptide ratios were high, suggesting local propeptide liberation. A correlation was demonstrated between the propeptide concentration in synovial fluid and in serum. In rheumatoid arthritis, the propeptide concentration in synovial fluid was related to local inflammatory activity, and the serum concentration was correlated with the presence of nonspecific markers of inflammation. The presence of smaller propeptide fragments in synovial fluid indicated that some degradation occurred locally. The local metabolic changes were most prominent in patients with joint erosions. Patients with nonerosive rheumatoid arthritis and reactive arthritis had similar synovial fluid propeptide concentrations. The proteoglycan content of synovial fluid was inversely related to the degree of joint destruction, and was highest in patients with reactive arthritis. No correlation was observed between the concentrations of propeptide and proteoglycan in synovial fluid. Intraarticular glucocorticoid injection reduced the levels of propeptide and proteoglycan in synovial fluid. | |
| 2092954 | [Juvenile ankylosing spondylitis (JAS) and juvenile rheumatoid arthritis (JRA)]. | 1990 Dec | The diagnosis of JAS in 19 of the 24 patients with oligo-articular and the polyarticular subtypes of JRA established primarily was reexamined. Coexistence of JAS and rheumatoid arthritis was found in 4 of the 19 patients with JAS. Of the 19 patients with JAS, 18 were male and 1 was female. The mean age of onset of the disease was 12.6 years (ranging from 8 to 16). Peripheral arthritis was the first symptom in all the 19 patients, predominantly in the joints of knee, hip and ankle. 69% of the 13 patients with hip involvement developed deformity. Twelve patients had lumbosacral pain. Arthritis occurred in 7 of the 19. There was X-ray evidence of sacroilitis in all the JAS patients. In 3 of the 19 patients' families, all the family members had ankylosing spondylitis. Laboratory investigations confirmed the presence of HLA-B27 and absence of RF and ANA in these 19 patients. The study shows that early findings of JAS are not easy to distinguish from those of JRA and that the diagnosis of JAS should be considered for a boy of teenage with chronic arthritis. | |
| 3766129 | Meningioma with multiple rheumatoid nodules. A case report. | 1986 | A case of a left tentorial meningioma in a 42-year-old man with a 12-year history of widespread manifestations of active rheumatoid arthritis, is reported. The patient had numerous subcutaneous rheumatoid nodules involving among other areas, the nuchal scalp. The surgically removed meningioma contained many classical rheumatoid nodules with gradual transitions seen from tumor cells to the pallisading peripheral cell layer of the nodules. Although intracranial rheumatoid nodules of the dura mater, leptomeninges, and of the choroid plexus have been described earlier, this appears to be the first reported case of rheumatoid nodules found within the substance of a meningioma. The participation of the tumor cells in the formation of rheumatoid nodules attests to the potential of neoplastic meningothelial cells to behave as mesenchymal elements under certain circumstances. | |
| 3518440 | Is atherosclerosis a complication of long-term corticosteroid treatment? | 1986 May | In clinical practice, arteriosclerotic heart disease has not been recognized as a complication of long-term corticosteroid treatment. Yet, an increasing body of evidence suggests that prolonged corticosteroid therapy accelerates the development of atherosclerosis. An important element in this process may be the fact that corticosteroids induce or exacerbate several known coronary risk factors, including hypertension, hypercholesterolemia, hypertriglyceridemia, and impairment of glucose tolerance. One group of patients that is often exposed to long-term corticosteroid treatment is that with rheumatoid arthritis. These patients have an increased mortality, with cardiovascular disease appearing to be a major contributor to this decreased survival. The weight of evidence relates the development of atherosclerosis to corticosteroid use. However, no long-term epidemiologic or morphologic studies have been performed to elucidate this issue. Until these are accomplished, prolonged therapy with this medication, particularly in younger persons, should be avoided whenever possible. | |
| 3950052 | Ibuprofen kinetics in plasma and synovial fluid of arthritic patients. | 1986 Jan | After administration of a single dose and at steady state, ibuprofen concentrations were measured simultaneously in plasma and synovial fluid obtained from eight patients with rheumatoid arthritis. By seven hours after a dose at steady state, the mean synovial fluid: plasma ibuprofen concentration ratios were constant, and the synovial fluid levels were, on average, greater than those in plasma. The extent to which ibuprofen was bound to protein was somewhat greater in plasma than in synovial fluid. As a result, the mean synovial fluid:plasma free concentration ratio for seven-hour and later specimens was greater than that based on total concentrations. The degree of accumulation of ibuprofen in each fluid was minimal, consistent with its short half-life. |