Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2310230 | Listeria monocytogenes infection in a prosthetic knee joint in rheumatoid arthritis. | 1990 Jan | The prosthetic knee joint of a 64 year old woman with severe rheumatoid arthritis was found to be infected with Listeria monocytogenes. After treatment with intravenous antibiotics, symptoms gradually resolved. She subsequently received prolonged treatment with oral co-trimoxazole and 18 months later remained well. | |
| 3096626 | Effects of aurothioglucose and auranofin on radiographic progression in rheumatoid arthrit | 1986 Sep | Radiographic films of 40 patients participating in a single centre patient blind study of auranofin versus aurothioglucose were evaluated in a random order by one reader. The two treatment groups were comparable with respect to number of erosions and total radiographic score at the start of the study. Only in the auranofin-treated patients was a statistically significant increase in the mean number of new erosions (p less than 0.001 at 6 months and p less than 0.01 at 12 months treatment, paired t-test) as well as in the total radiographic score (p less than 0.01 at 6 and 12 months treatment, paired t-test) observed. Results of this study confirm that parenteral gold compounds do retard radiographic progression of joint destruction in the treatment of rheumatoid arthritis. The effects on radiographic progression shown in this study are in agreement with other reports which, based on clinical and biochemical parameters, have shown that auranofin is somewhat less effective than the injectible gold salts. | |
| 3798045 | Similar survival rates for rheumatoid and non-rheumatoid cancer patients. | 1986 | The survival rate for cancer patients with rheumatoid arthritis was compared with that for non-rheumatoid cancer patients. This was accomplished by linking two nationwide Finnish data registers, the Social Insurance Institution's Population Register and the Finnish Cancer Registry. For 2012 of the 2062 rheumatoid patients with cancer diagnosed after the diagnosis of rheumatoid arthritis, the Cancer Registry was successfully searched for a non-rheumatoid of diagnosis of control patient who matched with respect to sex, age, year of diagnosis of cancer and location of the tumour (and also, for leukaemia, with respect to cell type). The 5-year relative survival rate for male rheumatoid patients was 21.2% and, for the control cancer patients, 25.4%. In females, the corresponding rates were 38.2% for the rheumatoid patients and 41.2% for the control patients (p less than 0.05). At some sites, particularly with leukaemia, the rates for the rheumatoid patients were lower than those for the control patients. The difference, however, only reached a 5% significance level for colorectal cancer in males. Rheumatoid arthritis and its treatment do not seem to have any appreciable effect on the survival of cancer patients. | |
| 3628763 | Cervical spine involvement in rheumatoid arthritis: MR imaging. | 1987 Oct | Magnetic resonance (MR) imaging of the cervical spine was employed in 18 patients with rheumatoid arthritis and suspected cervical involvement. Fifteen patients had symptoms referable to the cervical spine, and seven had neurologic deficits. In three patients who were asymptomatic with regard to the neck, MR imaging was performed because of abnormal cervical radiographs. Cervical radiographs were available for all patients; bone erosion was evident in 14, subluxation in 17, and no abnormalities in one. MR imaging demonstrated indentation or abnormal signal in the caudal brain stem and/or cervical spinal cord in ten patients, including the seven with related neurologic deficits; discrete indentation or distortion of the dura without visible morphologic effect on the underlying neuraxis was observed in five other patients. In all patients with neurologic symptoms, cord or brain-stem abnormalities were seen on MR images. MR imaging therefore appears to provide valuable information regarding the status of the spinal cord and dura in patients with rheumatoid arthritis. | |
| 2144538 | Penicillamine-induced ocular myasthenia gravis in rheumatoid arthritis. | 1990 Sep | We report a case of a 47-year-old woman with rheumatoid arthritis who developed ocular myasthenia gravis during penicillamine treatment. Her serum contained elevated titers of acetylcholine receptor antibodies, and her symptoms resolved 8 weeks after discontinuation of penicillamine. We review the clinical and laboratory features of this syndrome of penicillamine-induced myasthenia gravis and discuss its pathophysiology and treatment. | |
| 3814971 | Rheumatoid arthritis with vertical atlanto-axial subluxation complicated by hydrocephalus. | 1987 Feb | The present report describes a patient with rheumatoid arthritis and vertical atlanto-axial subluxation who developed hydrocephalus with high intraventricular pressure and neuropsychiatric abnormalities. The vertical atlanto-axial subluxation and hydrocephalus were visualized by magnetic resonance imaging, which clearly demonstrated the basilar impression by the dens and ventricular enlargement. The patient recovered completely after ventriculo-cardial drainage. | |
| 2145318 | Distribution of CD45RA and CD45RO T-lymphocyte subsets in rheumatoid arthritis synovial ti | 1990 Jul | We have characterized the lymphocytes in the synovium of patients with rheumatoid arthritis (RA) by immunohistochemistry using monoclonal antibodies directed against B lymphocytes, T lymphocytes, and antibodies directed against CD45RA and CD45RO, which define T-cell subsets. Both CD45RA+ and CD45RO+ T lymphocytes were detected in the perivascular regions. CD45RA+ lymphocytes were present primarily in perivascular areas of moderate to large lymphocytic infiltration. Some synovial perivascular lymphocytic aggregates were organized into focal areas of CD45RA+ B lymphocytes surrounded by CD45RO+ T lymphocytes. In areas of diffuse lymphocytic infiltration, the T lymphocytes were CD45RO+. These data suggest that both CD45RO+ and CD45RA+ T lymphocytes enter the RA synovial tissue via the synovial vasculature and that, once in the tissue, the CD45RA+ T lymphocytes may undergo activation/maturation and acquire the CD45RO phenotype. | |
| 2319516 | Intravenous pulsed steroids in rheumatoid arthritis: a comparative dose study. | 1990 Feb | This prospective, double blind study was undertaken to test the efficacy of intravenous "minipulse" (100 mg) methylprednisolone (MP) therapy versus standard pulse (1000 mg) MP therapy in rheumatoid arthritis (RA). Thirty-six patients with RA synovitis flares were randomized to receive either 100 or 1000 mg MP IV QD x 3 doses. These 2 universally comparable groups exhibited no statistically significant differences in their striking prompt and sustained clinical improvement. These data suggest that minipulse MP is as efficacious as conventional pulse MP in the treatment of RA flares. | |
| 2197997 | Immunoglobulin V genes expression and mRNA sequencing in rheumatoid arthritis. | 1990 Jun | Antibodies to exogenous antigen and to self antigen--that is, autoantibodies, are both encoded by the combining of V, D, and J genetic elements in the heavy chain, and V and J in the light chain immunoglobulins. The mechanism which generates autoantibodies does not seem to differ from that which generates the immune response to foreign antigen, and analysis of DNA from normal and autoimmune strains of mice appears similar with no appreciable defects in the immunoglobulin germline genes. Although there is restricted use of particular gene families in murine antibodies to exogenous antigen, the preferential use of particular V genes in murine autoantibodies remains controversial. Until recently, because of the obvious limitations on human experimentation, there was little information about the genetics of the human autoimmune response. Recent developments in molecular cloning techniques, however, some of which are discussed here, have shown that the germline arrangement of the human immunoglobulin variable genes differs from that found in the mouse. Furthermore, there is increasing evidence that human autoantibodies make restricted use of the V gene repertoire, and this indicates that the human autoimmune response is less polymorphic than the murine autoimmune response. | |
| 2962982 | Disablement and the social context of daily activity. | 1987 | This paper presents a discussion of current approaches to assessment of disablement in the light of findings from a study of people with rheumatoid arthritis. It begins with a critical evaluation of the assumptions underlying assessment of activities of daily living and notes recent attempts to broaden these to incorporate some understanding of social roles. Material from an in-depth study of people with rheumatoid arthritis is then used to illustrate the dynamics of social role relationships and their reciprocal relationship to disablement. Particular attention is given to gender differences in role responsibilities and the way in which these affect the expectations that are placed upon people with chronic illness. | |
| 2688848 | Inflammatory disorders of the vertebral column: seronegative spondyloarthropathies, adult- | 1989 Dec | A variety of inflammatory disorders may involve the spine and sacroiliac joint. Of these, the seronegative spondyloarthropathies (consisting principally of ankylosing spondylitis, psoriasis, Reiter's syndrome, and certain intestinal diseases), adult-onset rheumatoid arthritis, and juvenile chronic arthritis are particularly important. The imaging abnormalities accompanying these disorders, supplemented with some clinical and pathologic data, are the subject of this review. | |
| 3773579 | Weights for scoring the quality of well-being instrument among rheumatoid arthritics. A co | 1986 Nov | The importance of measuring health outcomes such as functional status and quality of life has increased with the greater emphasis on efficiency and on judgements of clinical effectiveness of therapies for patients with chronic disease. One measure of health status, the quality of well-being (QWB), has received significant attention as a health policy model because it quantifies health on a scale ranging from "zero" (death) to "one" (optimal health). The scale is based on weights (values) that were derived by having several thousand individuals in the general population rate scenarios in which a patient is described in terms of mobility, physical activity, social activity, and major symptom or problem. The present study was undertaken to determine if a disease-specific population composed of patients with moderate and moderately severe rheumatoid arthritis who were participating in a national multicenter trial of a new oral therapeutic agent, would rank scenarios similarly to the general population sample. In this study, close agreement was found between the weights obtained from the general population sample and the weights obtained from the sample of rheumatoid arthritic patients (R = 0.937). The investigators believe that the study supports the use of the original general population weights and suggest that the index may be used for populations with a specific condition as well as for general populations. | |
| 2739537 | [Clinical and epidemiologic study on the correlation of chronic rheumatoid arthritis in ad | 1989 Jan | A clinical investigation was performed on a sample of 91 randomly selected rheumatic (R.A.) patients, 70 females and 21 males (mean age 52.6), and in a control group of 41 not R. A. subjects, in order to identify the prevalence of signs and symptoms of temporo-mandibular joint (t.m.j.) dysfunction. The collected data were used to calculate the Helkimo Anamnestic and Clinical Indices. Signs of dysfunction were found in almost all the subjects (except three) and their frequency was significantly higher in women than in men (p less than 0.01). The most common clinical findings were: crepitus from t.m.j. (not significant), impaired mandibular mobility (p less than 0.001), tenderness to palpation of the masticatory muscles, and macroglossia (p less than 0.01). Radiographic examination was also performed in 51 patients, showing in many cases signs of inflammatory arthritis as well as of overimposed degenerative arthritis. The survey showed a significant incidence of structural and functional involvement of t.m.j. in R.A. | |
| 3718554 | Impact of specific therapy upon rheumatoid arthritis. | 1986 May | We performed a prospective, parallel, descriptive study of 737 consecutive new uses for 11 drugs prescribed for patients with definite or classic rheumatoid arthritis. The patients were from 5 geographically dispersed sites. Researchers used validated outcome assessment instruments to measure endpoints of disability, pain, patient global assessment, medication costs, laboratory costs, and number of physician visits. Patients were studied by strict prospective protocol at 6-month intervals for 3 years. Controls included parallel results with other drugs, and before and after values for the individual patient. Beneficial effects were observed with the "disease-modifying" drugs: intramuscular gold, penicillamine, and methotrexate. Of these, gold had the most apparent effect. An average of 9 months of gold therapy resulted in highly significant reductions in disability (P less than 0.005), pain (P less than 0.001), and patient global assessment (P less than 0.005). However, patients receiving gold and methotrexate had nearly twice as many visits to physicians. In addition, drug costs increased strikingly with gold, and laboratory costs tripled. Relatively minor differences among nonsteroidal antiinflammatory agents were difficult to interpret. The outcome assessment techniques used in the study are sensitive measures, which confirm the results of experimental studies and extend observations to new outcomes, including cost and disability. | |
| 3954931 | Plasma and synovial fluid kinetics of flurbiprofen in rheumatoid arthritis. | 1986 Feb | Clinical assessment, plasma and synovial fluid kinetics were studied in 29 rheumatoid patients receiving 100 mg flurbiprofen twice daily. Clinical assessment and pharmacokinetic measurements varied widely within the group of patients. The average values for plasma clearance, volume of distribution and elimination halflife of flurbiprofen were 0.65 +/- 0.24 ml min-1 kg-1, 0.160 +/- 0.093 l kg-1 and 3.1 +/- 1.7 h, respectively. Synovial fluid drug concentrations peaked later and were lower than corresponding plasma concentrations: 5.2 h and 4.4 mg l-1 as against 1.49 h and 12.5 mg l-1, respectively. At 48 h after an oral dose of flurbiprofen, all the drug had been cleared from the synovial fluid. Synovial fluid drug concentrations were not related to synovial fluid albumin concentration or pH. There was a weak relationship between synovial fluid drug concentration and the thermographic measurements of disease activity. The fractions of flurbiprofen not bound to protein in synovial fluid and plasma were not significantly different. A simple model is proposed to account for the plasma and synovial fluid pharmacokinetics. | |
| 3382451 | Repeat radiation synovectomy with dysprosium 165-ferric hydroxide macroaggregates in rheum | 1988 Jun | Because of failure to fully respond to an initial intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates, 17 patients with seropositive rheumatoid arthritis underwent repeat radiation synovectomy using this agent. Of the 13 patients who were evaluated 1 year later, 54% (7 knees) had good results, 31% (4 knees) had fair results, and 15% (2 knees) had poor results. The initial lack of significant benefit from radiation synovectomy did not appear to preclude a favorable response to a second injection. | |
| 3349848 | Pulmonary hypertension in a patient with rheumatoid arthritis. | 1988 Apr | A 53-year-old woman who had suffered from severe rheumatoid arthritis developed pulmonary hypertension. Her small arteries in the lung showed plexogenic arteriopathy with fibrous intimal hyperplasia. There was also vasculitis of the small arteries in other organs and mural thrombosis in the pulmonary stem and abdominal aorta. The plexogenic arteriopathy which was responsible for pulmonary hypertension appears to be the result of vasculitis in association with rheumatoid arthritis. | |
| 3739540 | Spontaneous peritonitis and rheumatoid arthritis--a case report. | 1986 Apr | An unusual case in which an adult patient with rheumatoid arthritis developed a fulminant spontaneous gram-positive bacterial peritonitis and underwent emergency laparotomy for this condition is presented. Spontaneous peritonitis in adult patients was previously seen only in patients with liver disease, nephrotic syndrome or systemic lupus erythematosus. | |
| 2941476 | Long-term follow-up of metacarpal phalangeal arthroplasty with silicone Dacron prostheses. | 1986 Jul | Sixteen patients who had eighty-nine metacarpal phalangeal arthroplasties with silicone Dacron prostheses (Niebauer type), were followed for an average of 11 1/2 years. Evaluation for palmar subluxation, ulnar drift, range of motion (ROM), pain relief, and stability showed it was satisfactory for relief of pain and correction of ulnar drift but it was eventually poor for range of motion and stability. If the arthritis was not controlled, the function of the hand decreased progressively, in spite of prosthetic replacements of the joints. | |
| 2278144 | [Clinical trial of the treatment of rheumatoid arthritis with TFX (thymus factor X)]. | 1990 Sep 1 | The results of rheumatoid arthritis treatment with the preparation TFX (extract of calf thymus) are reported. The drug was given to 11 patients with intense inflammatory process treated previously in typical fashion without evident improvement and in whom immunological studies demonstrated disturbances of cell-mediated and humoral response. The duration of treatment and observation was 6 months. In 9 patients clinical improvement was achieved. We observed no correlation between clinical improvement and immunological indices besides statistically significant changes of skin tests. The results (assessment of health state, laboratory investigations) encourage to TFX use in the treatment of rheumatoid arthritis. |