Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1684921 | Effects of antirheumatic treatment on gastric secretory function and salivary flow in pati | 1991 Nov | Many patients with rheumatoid arthritis have impaired gastric acid secretion and dysfunction of the lacrimal and salivary glands, conditions which have been proposed to be due to glandular atrophy. The hypothesis that the rheumatoid inflammation by itself has a depressive effect on these secretory functions was tested on 20 patients with active rheumatoid arthritis who underwent 16 weeks of sulphasalazine therapy. The patients responded well to the treatment, with reduction of joint indices and acute phase reactants. The resting and stimulated whole salivary secretion rate increased in 9/10 and 8/10 patients, respectively. The maximal gastric acid output increased in those patients who had a moderate reduction in acid output prior to treatment. When estimated by s-pepsinogen I, the gastric secretory capacity increased in all patients but one. In a group of auranofin treated patients, s-pepsinogen I rose only in those who responded to treatment with reduced disease activity. These results support the idea that the impaired secretory functions are at least partially reversible and probably also partly inflammatory mediated. | |
| 3031003 | Neutrophil collagenase in rheumatoid interstitial lung disease. | 1987 Feb | Ten patients with rheumatoid arthritis were evaluated by bronchoalveolar lavage. Five patients (group I) had interstitial lung disease by physiological and radiographic criteria, whereas five (group II) had no evidence of lung disease. Lavage fluid from four of the five group I patients contained an active collagenase which by inhibitory profile and substrate specificity appeared to be of neutrophil origin. None of the group II patients demonstrated lavage fluid collagenase. Treatment of lavage fluid with trypsin failed to uncover latent collagenase activity in either group, suggesting that the collagenase is present entirely in an active form. These findings parallel those observed in idiopathic pulmonary fibrosis and suggest a potential pathogenetic role for collagenase in rheumatoid interstitial lung disease. | |
| 2383081 | Delayed rupture of the spleen in rheumatoid arthritis. | 1990 Jul | When tripping and falling patients with rheumatoid arthritis may adopt the 'fetal tuck' position to protect their painful deformed hands. There is then a risk of splenic injury by the left elbow, which may not be immediately apparent. | |
| 3632070 | Pneumococcal septic arthritis in rheumatoid arthritis. | 1987 Jun | Septic arthritis is associated with a definite morbidity which may be related to a delay in diagnosis and hence treatment. The cases of three patients with rheumatoid arthritis and chronic chest disease where the joint sepsis was not the predominant feature are presented. The responsible organism was Streptococcus pneumoniae which had spread after recent chest infections. Minimal joint symptoms or general malaise in association with an unexplained rise in erythrocyte sedimentation rate in these circumstances warrant a search for joint sepsis. | |
| 2678390 | [Controlled blind study of the effectiveness of hemosorption in rheumatoid arthritis]. | 1989 Apr | Nine patients with classic rheumatoid arthritis underwent first placebo-hemosorption and then hemosorption. According to the arthrogram there was no significant difference between the action of these two procedures during the first three days. Both procedures evoked activation of the complement system and changed the balance of immunoregulatory subpopulations of lymphocytes. Short-term stimulation of phagocytosis and a decrease in the level of circulating immune complexes coinciding with it in time were specific for hemosorption. | |
| 3432983 | [Induction of flare-ups of chronic progressive polyarthritis in mice after injection of ty | 1987 Dec | Immunization by heterologous type II collagen induces in mice a sudden onset of subacute polyarthritis. In order to form a model of auto-immune pathology, we immunized DBA/1 mice with homologous type II collagen extracted from mice xiphoid process; the induced disease corresponds to a progressive chronic polyarthritis with bouts interspersed with remissions, and predominates especially in males. Type II anti-collagen auto-antibodies are found in the serum, with no correlation between the level of mice type II anti-collagen immunoglobulins G and the clinical manifestations of the disease. The histological study demonstrates signs of hyperplastic villous synovitis, with a discrete and infrequent infiltration with mononuclear cells. The model that is obtained is similar to rheumatoid polyarthritis, but also to spondylo-arthropathies. | |
| 1778681 | Life events and irrational attitudes in patients with rheumatoid arthritis: relations to p | 1991 | Previous research on the effects of life events on maladaptation suggest they should be related to disease impacts in rheumatoid arthritis (RA). From the concept of Rational-Emotive-Therapy the hypothesis was derived that irrational attitudes-in a similar way-are associated with disease related impairment. Subjects were 128 patients with definite RA from a specialized treatment center. When disease activity was controlled, positive change was associated with less disability, negative change was related to general symptoms. Relations between life events and three pain measures could not be established. Irrational attitudes shared significant common variance with three pain-measures (attributes, recent intensity, avoidance), with physical abilities, and with general health condition. The results were discussed with respect to literature and to clinical practice. | |
| 2324446 | Metacarpal-phalangeal joint arthroplasty of the rheumatoid thumb. | 1990 Mar | Fifty patients with rheumatoid arthritis had 59 Swanson implants of the metacarpal-phalangeal joint of the thumb. Eleven patients (15 implants) have since died and only 1 patient (1 implant) has been lost to follow-up leaving 43 implants available for study. The most common preoperative deformity was a boutonniere deformity with a flexible interphalangeal joint. All thumbs had less pain after operation. The average range of active motion is 25 degrees, with a flexion arc from 15 to 40 degrees. There is an average key pinch strength of 4 pounds (range, 0.5 to 10). Improvement in activities of daily living were noted in 40 hands. One thumb required reoperation for instability; the implant was removed and a metacarpal-phalangeal arthrodesis was done. Radiographic progression of disease was noted in only one thumb at the interphalangeal joint and in two other thumbs at the carpometacarpal joint. None of these have required further operations. The maintenance of motion appears to help in activities of daily living as stability and pinch strength are often adequate. | |
| 2902267 | Association between villous atrophy in rheumatoid arthritis and a rheumatoid factor and gl | 1988 Oct 8 | 93 patients with rheumatoid arthritis (RA) were examined for histological or other evidence of gut abnormalities. 44 had raised levels of IgG to gliadin, and of these 38 (86%) were also positive for IgA rheumatoid factor (RF). 24 patients (15 with raised levels of IgA RF and wheat protein IgG [AB+] and 9 with normal levels of both antibodies [AB-]) underwent jejunal biopsy. 6 of the AB+ and 1 of the AB- patients had villous atrophy. The AB+ group had lower villous surface/volume ratio and small intestinal lactase concentrations than did the AB- group or age-matched controls. There was no significant difference between the two groups of RA patients in disease severity or treatment regimen. The findings suggest that the gut may play a more important part in the immunopathogenesis of some cases of RA than in others, and that the former may be identified by raised levels of IgA RF and wheat protein IgG. | |
| 3111490 | Articular indices of joint inflammation in rheumatoid arthritis. Correlation with the acut | 1987 Jun | The joints of 30 rheumatoid arthritis patients were assessed by one observer for signs of inflammation. Computer analysis was then used to calculate 70 different articular indices for each patient. Pearson correlation coefficients were calculated between serum C-reactive protein levels and the articular indices. The results show that: findings in a restricted set of examined joints were equivalent to those in a more complete set; the simultaneous presence of joint tenderness and swelling yielded higher correlation than did either variable alone; and joint "weighting" for size yielded higher correlation than did simple counts. | |
| 3349676 | Proximal tibial osteotomy. Factors that influence the duration of satisfactory function. | 1988 Apr | Survival analysis studies of 40 patients treated with high tibial osteotomy for arthritis with angular deformity were performed to determine the dominant factors that adversely affected long-term knee function. Obesity, advanced age, and postoperative overcorrection or undercorrection resulted in short durations of successful function. On the average, the probabilities for continued useful function of the knee at tested intervals were: one year, 86%; three years, 64%; five years, 50%; and nine years, 28%. | |
| 2711524 | [Structure and function of the "neosynovial membrane." Light and transmission electron mic | 1989 Feb | Regenerating synovium from seven patients was examined by light- and transmission electron microscopy. Superficial layers of the "neosynovium" are composed of histocytes, fibroblasts and intermedium cells, developing out of undifferentiated mesenchymal perivascular connective tissue cells. There is no closed cell-layer, as known from mesothelia, endothelia and epithelia. Our results are similar to those of normal synovium and the so-called "pseudo-synovium" of pseudarthroses. So superficial layers of these tissues are comparable specialized connective tissues. According to experimental results in animals, in patients there will develop a "neosynovium" comparable to the original synovium in structure and function. These results confirm synovectomy as a possible operative treatment in patients. | |
| 2306289 | Reduction of the risk of rheumatoid arthritis among women who take oral contraceptives. | 1990 Feb | Discrepant results among investigations of the association between oral contraceptive use and rheumatoid arthritis (RA) have been ascribed to shortcomings in the study methods. In the present study, we obtained detailed information on oral contraceptive use in 135 young women with confirmed definite or classic RA of recent onset and in 378 controls with soft tissue rheumatism or osteoarthritis. All patients had at least 2 years of followup to confirm the consistency of the diagnosis. Oral contraceptive use at any time before disease onset was reported by 70% of the RA patients and 85% of the controls; the latter figure corresponded to general population data for The Netherlands. This yielded a relative risk for RA of 0.39 among those who had ever used oral contraceptives and 0.58 for those using oral contraceptives at the time of symptom onset. The preventive effect of oral contraceptive use on the risk of RA was found to be independent of the dose, duration of use, or presence of HLA-DR4. The strongest protection was seen in women with a family history of RA and in women ages 31-40 at symptom onset. The conflicting results in the literature are discussed, and a possible biologic mechanism for this phenomenon is suggested. | |
| 1891870 | [Lithonite vacuum phonophoresis in the combined treatment of patients with rheumatoid arth | 1991 Jun | A compound of lithium and nicotinic acid--lithonite was used phonophoretically in complex with non-steroid antiinflammatory drugs in 40 patients with rheumatoid arthritis according to a method developed by the authors. The efficacy of complex treatment was 95%. There were no side-effects. Further perfection of this method is desirable. | |
| 1947894 | 111Indium-labelled leukocytes for measurement of inflammatory activity in arthritis. | 1991 | Mononuclear leukocytes and granulocytes have been separated and labelled with 111In-oxine (111In). We show that granulocytes as well as monocytes can be labelled with 111In without serious adverse effects on the viability of the cells. The separated and 111In-labelled cells from patients with rheumatoid arthritis and psoriatic arthritis were reinfused into the patients and detection was made with a gamma camera over the inflamed joints. The study shows that images and semi-quantitative indices of leukocyte accumulation in the joints could be obtained in these patients. We suggest that the method may be a sensitive indicator of non exsudative synovitis and allow assessment of inflammation in joints not amenable to physical examination. This method also opens new possibilities to measure the migration of different leukocytes over the synovial membrane. | |
| 3314877 | Effects of psychological therapy on pain behavior of rheumatoid arthritis patients. Treatm | 1987 Oct | A randomized clinical trial was performed to evaluate a psychological treatment intervention and a social support program, compared with a control program in which no adjunct treatment was rendered, and their effects upon pain behavior, affect, and disease activity of 53 patients with rheumatoid arthritis. The psychological intervention produced significant reductions in patients' pain behavior and disease activity at posttreatment. Significant reductions were also observed in trait anxiety at posttreatment and 6-month followup. Relaxation training may have been the most important component of the psychological intervention. The social support program produced a significant reduction in trait anxiety only at posttreatment. This is the first well-controlled study to demonstrate reduced pain behavior, disease activity, and trait anxiety following psychological treatment. | |
| 2768318 | Synovectomy of the elbow in rheumatoid arthritis. Long-term results. | 1989 Aug | We reviewed 61 elbow synovectomies in 50 patients with rheumatoid arthritis, with follow-up varying from 4 to 10 years (mean 6.5 years). The results were graded as satisfactory in 70%, with no significant difference in the results between joints which were radiologically good before operation and those which had been destroyed. Longer term results were analysed of 27 elbow synovectomies in 22 patients followed up for over six years. The results were satisfactory in 67% of the patients in both 1981 and in 1987, with no deterioration over this period. | |
| 3409744 | HLA-DQw alloantigens and pulmonary dysfunction in rheumatoid arthritis. | 1988 Sep | HLA-DR4 and keratoconjunctivitis sicca (secondary Sjögren's syndrome) are associated with abnormal pulmonary function in patients with rheumatoid arthritis. Since recent investigations have found that much of the genomic polymorphism of the HLA-DR4 haplotype comes from the closely linked DQw allele, we reanalyzed this set of data to evaluate the relationship between the DQw allotypes and pulmonary function in rheumatoid arthritis. Using a step-wise regression analysis, we found that the presence of DQw1 was a stronger predictor of an abnormal forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and carbon monoxide diffusing capacity (D) than the presence of DR4, keratoconjunctivitis sicca, smoking status, or any other clinical parameter. DQw1-positive patients had a mean (+/- SD) percent of predicted FEV1, FVC, and D of 84.2 (+/- 19.8), 88.0 (+/- 17.9) and 85.6 (+/- 20.9) percent, respectively, all significantly lower than DQw-1 negative patients (p = 0.02, 0.02, and 0.03). Smokers with the heterozygous phenotype, DQw1/DQw3, tended to have obstructive disease of the airways, with a mean (+/- SD) FEV1 of 80.1 +/- 24.4 percent of predicted, compared to 95.7 +/- 12.1 percent of predicted in DQw1/DQw3-negative individuals (p = 0.03). Patients who had a DQw2 allele were more likely to have normal pulmonary function. We conclude that the HLA-DQw1 allotype is a strong predictor of abnormal pulmonary function and that it may identify smoking subjects with rheumatoid arthritis subjects who are prone to develop obstruction of airflow. | |
| 3179630 | Patient understanding of the causes and medical treatment of rheumatoid arthritis. | 1988 Oct | One hundred patients with a diagnosis of rheumatoid arthritis (RA) of more than 6 months' duration were interviewed to assess their knowledge of the disease and its treatment. Only 46 patients said they had received information about their RA from health-care professionals. The most popular source of information used by the patients was television (82%). Patients' beliefs of factors which cause RA and cause flare-ups of disease were numerous. These included stress, exercise, infections and climatic factors. Patients' knowledge of disease symptoms was incomplete. Fifty-eight patients had tried non-prescribed remedies for RA but 70% found these ineffective. Patients wanted more information about their disease and its management. Specifically considering drug treatment, 72 patients said information should be provided in leaflets. | |
| 3355258 | The arthropathy of cystic fibrosis. | 1988 Mar | Musculoskeletal symptoms are frequent in cystic fibrosis (CF). Here the clinical features of 29 patients with CF who had significant arthropathy are described. Twelve had episodic arthritis (EA) characterised by repeated short attacks of severe, incapacitating polyarthritis, which in seven was associated with fever and erythema nodosum. Ten patients had hypertrophic pulmonary osteoarthropathy (HPOA). The onset of symptoms in the group with HPOA was usually later (mean age 20 years v 16 years for EA) and was associated with significantly worse lung function than in patients with CF, either without arthropathy or with EA. Seven patients had arthropathies which could not be classified as EA or HPOA. |