Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3313661 | Dendritic cells in the pathogenesis of rheumatoid arthritis. | 1987 | The cause of rheumatoid arthritis is unknown. It appears that abnormal or overstimulated cell-mediated immune mechanisms are operating. Dendritic cells, with their potent antigen presenting and immunostimulatory properties, have been found in increased numbers of rheumatoid synovial fluids and membranes. It is postulated that these cells play a key role in inducing and perpetuating the immune response with subsequent synovial proliferation and joint destruction. | |
| 3133993 | Contact allergy to gold after systemic administration of gold for rheumatoid arthritis. | 1988 May | A patient with seropositive, nodular rheumatoid arthritis (RA) developed contact allergy to gold jewellery following a severe skin rash which occurred after 13 weeks of treatment with sodium aurothiomalate. Patch testing confirmed that the contact allergy was due to gold. This is the first proved case of contact allergy to gold or any other compound initiated by systemic administration of the allergen. | |
| 3293252 | [Piroxicam in the treatment of rheumatoid arthritis]. | 1988 | Open and double blind trials in 80 patients with proved and definite rheumatoid arthritis have shown that piroxicam possesses marked analgesic and antiinflammatory action, is well tolerated producing a therapeutic effect only at high doses exceeding the mean ones recommended in the literature. | |
| 3069061 | [Rheumatoid arthritis: surgery of the metacarpophalangeal joints of the long fingers]. | 1988 | The author reviews the pathophysiological mechanisms of rheumatoid deformations of the long fingers' MP joint. He considers the different possibilities of surgical treatments; then focusing on arthroplasty, he compares and comments on technical points (incision, resection of the MP head, section of intrinsic muscles, size of the implant, joint capsule and ligament reconstruction, dressing, postoperative care) and results (mobility, implant fracture, ulnar deviation and palmar dislocation) achieved by various authors. He concludes that the Swanson implant remains at present the best therapeutic treatment of rheumatoid arthritis of the long fingers' MP joint. However, in order to improve the results obtained, and to avoid long term complications, research should be pushed until we can avail ourselves of a true prosthetic arthroplasty based on other principles and new materials. | |
| 3502560 | HLA-DQ molecular heterogeneity in HLA-DR4-Dw4 consanguineous cell lines. | 1986 Jun | Two-dimensional gel analysis (NEPHGE) of the molecules precipitated by the HLA-DR monomorphic antibody L243 showed a single and identical alpha chain spot from two consanguineous cell lines, BM14 and MCF. The latter was derived from a rheumatoid arthritis patient. No apparent structural polymorphism of the HLA-DR beta chains was detected. The data suggests that the HLA-DR4 haplotype expresses one alpha chain and up to four beta chains. The electrophoretic pattern of the HLA-DQ molecules precipitated with the monomorphic antibody TU22 revealed clear differences between BM14 and MCF. These differences were mainly in the beta chain profiles. Four acidic beta chains were found with the MCF cell line wheras only three beta chains at different isoelectric points were found with the BM14 cell line. The data obtained in this study argue for a considerable heterogeneity of the HLA-DQ antigens detected at the molecular level. | |
| 3390902 | Serum total, HDL, LDL cholesterol, and triglyceride levels in patients with rheumatoid art | 1988 Apr | Patients with rheumatoid arthritis are at risk of increased prevalence of coronary heart disease. In general, the plasma level of high density lipoprotein cholesterol (HDL) correlates with the risk of incidence of ischemic heart disease. The levels of total, HDL, low density (LDL) cholesterol, and triglycerides were measured in sera of patients with rheumatoid arthritis and in healthy controls. In patients with rheumatoid arthritis (26 men and 103 women), the serum total and LDL cholesterol were higher, whereas the HDL cholesterol and triglycerides were lower (p less than 0.001) compared to the values observed in controls (625 men and 749 women). Similar patterns were seen when results of age and sex matched controls were compared to the results of patients suffering from rheumatoid arthritis. The lipid parameters of patients with rheumatoid arthritis were not different when the patients were treated with steroidal or nonsteroidal anti-inflammatory drugs. | |
| 3716510 | [Diagnosis of cardiac involvement in rheumatoid arthritis and some selected collagenoses]. | 1986 Mar 15 | The systemic character of the rheumatoid arthritis and the collagenoses includes an extraarticular organ manifestation. Since the symptomatology of an organ participation is often covered over with dominating joint troubles its diagnostics is difficult. In 34 patients (22 with rheumatoid arthritis, 12 with collagenoses) with the help of non-invasive methods (computed tomography and sonography) is tried to recognize a participation of the heart--particularly of the pericardium. Our examinations show that by means of the computed tomography in 13.6% of the cases an effusion in the pericardium (9.1% of them clinically not conspicuous) could be proved in rheumatoid arthritis, however, the frequency of 30% of the echocardiographically diagnosed pericardial effusions described in the literature could up to now not be confirmed. The classification of the changes of the pericardium as a complication of a rheumatoid arthritis or a collagenosis may be performed only in connection with the adequate clinical and biochemical immunological findings excluding other cardiac diseases. | |
| 3075071 | T cell clones in rheumatoid arthritis (RA). | 1988 | The development of T cell clones has greatly enhanced our knowledge of pathogenetic mechanisms in autoimmune diseases. Thus, it has been possible to induce experimental arthritis in susceptible animals by solely injecting arthritogenic T cell lines or clones. In contrast to many animal models, in rheumatoid arthritis the inciting antigen(s) have still not been identified. However, it has been possible to raise T cell clones from the inflammatory membrane by the addition of Interleukin-2 and/or mitogens. These clones are primarilig of the CD4+ (helper/inducer) phenotype. Molecular analyses on T cell receptor genes have not clearly shown a predominant rearrangement pattern in most studies indicating a polyclonal origin of RA synovial T cells. The availability of T cell clones will clearly help in the near future to probe for the inducing antigen(s) in inflammatory rheumatic diseases thus rendering a basis for new immunotherapeutic approaches. | |
| 3704527 | [Estimate of the prevalence of rheumatoid arthritis based on a rheumatology study in the d | 1986 Feb | The prevalence of rheumatoid arthritis is generally estimated to be 1 per cent, despite the marked differences between the various results published according to the survey techniques and the epidemiological criteria employed. The present survey consisted of patients from the target population (the 248,009 inhabitants of Angers over the age of 15 years), who had been examined by one of the hospital or private rheumatologists working in Angers between 1960 and 1984 and who were considered to be suffering from inflammatory rheumatism. The cases of rheumatoid arthritis included in this survey were still alive and were living in Angers between January 1 and June 30 1984 and corresponded to at least two of the New York criteria. The prevalence determined according to this technique was 0.17 per cent for two criteria and 0.11 per cent for three criteria. After discussing the bias and the particular conditions of the study, it appears that these particularly low levels are essentially related to: a recruitment bias due to the limitation of the survey to patients seen by rheumatologists, to the choice of New York criteria and more especially of 3 criteria which increases the specificity of the survey at the expense of the sensitivity, to the long observation (mean of 10.4 years) which contributed to a reduction in the number of false positives. The validity of this study is supported by the comparison with the study by O'Sullivan et al. also based 2 New York criteria with a follow-up of 3 to 5 years, which concluded on a prevalence of 0.24 per cent compared with 0.17 per cent in Angers.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1681954 | Involvement of macrophages and dendritic cells in synovial inflammation of collagen induce | 1991 | Type II collagen induced arthritis (C1A) is an antigen-specific and T-cell dependent autoimmune disease in which the time course of disease is known. Arthritis is induced with type II collagen (CII) immunization, but can also be induced with passive transfer of anti-CII antibody containing syngenic serum and with local administration of gamma interferon. In the present study we analysed the spectrum of inflammatory cells appearing in the arthritic joints. Three phases of the disease process could be defined: 1) Early infiltration of T cells and appearance of class II expressing macrophages in the synovial lining layer 2) Profound infiltration of granulocytes and oedema formation and 3) Pannus formation containing activated macrophages, granulocytes, T cells and dendritic cells. At this severe destruction of cartilage and bone beginning from the marginal zone was seen. In contrast, joints from spontaneously arising arthritis in MRL lpr/lpr mice showed no granulocytes or T cells, sparse expression of class II but relatively uniform appearance of C3bi-receptor+, Fc-receptor+ and MOMA2+ synovial cells. | |
| 2390121 | Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid ar | 1990 Aug | Suppression of rheumatoid factor (RF) production in rheumatoid arthritis (RA) has been variably attributed to the use of remittive agents per se or to clinical improvement associated with their use. There have been conflicting reports with regard to the influence of methotrexate (MTX) on serum RF levels in RA. We determined IgM-RF and IgA-RF levels in paired serum samples (obtained at study entry and completion) from RA patients enrolled in multicenter trials with the Cooperative Systematic Studies of Rheumatic Diseases program. After exclusion of the 14 IgM-RF-negative sera, there were samples from 30 MTX-treated patients and 52 placebo-treated patients. Changes in IgM-RF and IgA-RF levels were weakly associated with each other. Significant decreases in IgM-RF levels were observed in the MTX-treated patients, but not in the placebo group. These changes were most significant in the MTX-treated patients who improved clinically. There were significant decreases in IgA-RF levels at study completion among MTX-treated patients who had improved clinically and those who had not improved clinically, but not in the placebo group. The contributions of clinical improvement and MTX treatment to changes in serum IgM-RF and IgA-RF levels were examined using a logistic regression model. Changes in IgM-RF were strongly related to MTX treatment and, to a lesser extent, to clinical improvement; changes in IgA-RF were related only to MTX treatment. These results indicate that MTX treatment per se decreases both IgM-RF and IgA-RF levels, whereas clinical improvement correlates with decreased IgM-RF levels only.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2379295 | [Comparative clinical study of rheumatoid arthritis treated by triptolide and an ethyl ace | 1990 Mar | It was satisfactory using the ethyl acetate extract of Tripterygium wilfordii (TW) to treat rheumatoid arthritis (RA). The results showed that the ethyl acetate extract of TW was the effective component part of TW. Although the therapeutic effect of 15 cases with RA cured by triptolide was as effective as the ethyl acetate extract of TW, triptolide could impair some patients' hearts. This suggested that triptolide was one of the main effective elements of TW, but it was also one of the main toxic elements. Clinical research indicated that: (1) the effect of TW in treating RA was the synergistic action of elements with triptolide as the main; (2) triptolide may act as a major standard of controlling the quality of the preparation of TW and assure clinical use safely. | |
| 3092499 | [Use of recombinant human gamma interferon in patients with rheumatoid arthritis]. | 1986 May | In a clinical phase II trial the efficacy and side effects of recombinant human interferon gamma in 13 patients with rheumatoid arthritis (RA) are reported. 2 patients (15.3%) showed a marked improvement of rest- and motion pains and of their general motility after a 6 and 8 month treatment. Only a temporary improvement within 2-3 months was observed in 4 patients (30.7%). In 2 cases a reduction of the erythrocyte sedimentation rate and in 4 cases a reduction of the alpha-1 acid glycoprotein and of the number of thrombocytes was documented parallel to the clinical improvement. 3 patients developed new antinuclear antibodies (ANA) or showed an increased titer of ANA. Fever was the most common side effect followed by lymphopenia and increased liver values. All side effects were reversible after dosage reduction. Our results confirm the relatively good short term efficacy of human recombinant interferon gamma in RA. In contrast, the clinical long term benefit remains doubtful. | |
| 3568358 | Immunoassay of rheumatoid factor by latex particle counting. | 1987 May | We assayed rheumatoid factor by instrumental latex particle counting. The calibration curve ranged from 12.5 to 500 int. units/mL. Maximal within- and between-assay CVs were 5 and 11%, respectively. Analytical recoveries ranged from 92.4 to 108%, and the relation between results and dilutions was linear in the range of 15 to 400 int. units/mL. Correlation with an enzyme-linked immunoassay (ELISA, Cordia kit) was r = 0.934 (n = 58), with turbidimetry r = 0.825 (n = 100), and with the Waaler-Rose test r = 0.834 (n = 73). Of 260 blood donors, 95% gave a value less than 10 kilo-int. units/L, which was taken as the upper normal limit. In a population of patients with rheumatoid arthritis (n = 47), 87.2% had rheumatoid factor greater than 10 kilo-int. units/L. | |
| 3763221 | [The wrist joint]. | 1986 Aug | The wrist joint is involved in a great majority of cases of rheumatoid arthritis. Tenosynovitis and synovitis can lead to severe destruction of the joint and to spontaneous ruptures of the tendons. Therefore, early tenosynovectomy and wrist-joint synovectomy are required. At the advanced stage of the disease, arthroplasty is necessary. Arthrodesis is rarely indicated in the treatment of severe wrist destruction in rheumatoid arthritis. | |
| 2691160 | Collagen induced arthritis: an experimental model for rheumatoid arthritis with involvemen | 1989 Sep | The type II collagen induced arthritis animal model (CIA) provides opportunities to study the nature of autoimmune reactions leading to arthritis and is also a useful model for rheumatoid arthritis (RA). Thus, in similarity with RA, the CIA when induced with autologous type II collagen, shows a chronic and progressive disease course. The susceptibility to both RA and CIA are correlated to the expression of certain MHC class II allotype genes. In both diseases autoantibodies to type II collagen and rheumatoid factors are produced. Immunohistopathology of affected joints show in both diseases a dominance of activated macrophages/fibroblasts with a significant infiltration of activated T cells. We suggest here that both RA and CIA are dependent on a synergy between delayed type hypersensitivity and immune complex mediated inflammatory mechanisms and that CIA could provide a tool for studies of immunospecific reactions leading to arthritis. | |
| 3568422 | Microheterogeneity forms of alpha 1-acid glycoprotein as indicators of rheumatoid arthriti | 1987 Mar 16 | The microheterogeneity of alpha 1-acid glycoprotein (AGP) has been studied in the sera of 48 patients with rheumatoid arthritis and of 12 healthy individuals. For each rheumatoid patient the disease activity has been assessed and each patient has been assigned to one of four activity grades: I, inactive; II, mildly active; III, moderately active; and IV, severe. Concanavalin A-affinity electrophoresis revealed three microheterogeneity variants of AGP: non-reactive with Con A, weakly reactive with Con A and strongly reactive with Con A. The relative amounts of AGP-variants observed in the healthy donors were similar to those observed in the patients with activity grade I, but differed significantly from patients with grades II, III and IV. The differences between the AGP-patterns of patients with activity grades II, III and IV were also statistically significant. | |
| 3219298 | Transient reduction in erythrocyte membrane sialoglycoprotein beta associated with the pre | 1988 Dec | Erythrocyte membranes from an anaemic patient receiving gold therapy for rheumatoid arthritis had reduced beta-sialoglycoprotein (beta-SGP) content but normal expression of sialoglycoproteins alpha, delta and gamma. Elliptocytes were present in the peripheral blood. The serum of the patient contained anti-beta-SGP which did not appear to bind to her own cells. It reacted with all erythrocytes apart from beta-SGP deficient Leach phenotype cells. The antibody was inhibited by purified beta-SGP from normal red cells, bound to beta-SGP on immunoblots and also reacted with the abnormal beta-related-SGP in erythrocyte membranes of both the Gerbich type and Yus type of Gerbich negative. Two years later the patient was no longer anaemic, no elliptocytes were seen in her peripheral blood film and her erythrocyte membranes had normal beta-SGP content. Antibody was no longer present in her serum and antibody from the earlier sample now reacted with the patient's erythrocytes. Erythrocyte membrane beta-SGP is known to be important in the maintenance of normal cell shape. It is likely that the transient occurrence of elliptocytes in the patient resulted from the concurrent temporary reduction in beta-SGP content of her erythrocyte membranes. | |
| 2204865 | [Pathophysiological relations and clinical significance of serine protease inhibitors (ser | 1990 Aug 26 | Serine proteases, like all other proteases, are biologically active substances. Their effects are inhibited by serine proteases inhibitors. The disturbance of balance between protease and antiprotease leads to several diseases and to their progression. The authors give an overview on some important data on serpins (biochemical parameters, structural composition), and on the clinical considerations of some diseases that are arisen from the changes in inhibitor levels. The paper includes some own examinations, too. Finally the possibilities of prevention and therapy are discussed. | |
| 3321755 | [Chlorambucil pulse therapy in progressive chronic polyarthritis. Initial results of an op | 1987 Sep | The first preliminary clinical results with chlorambucil pulse-therapy in patients with refractory rheumatoid arthritis are reported, with a dose of chlorambucil below that which might risk inducing leukaemia. The clinical response was good in 15 out of 19 patients; symptoms and objective findings of rheumatoid arthritis had significantly improved. However, multiple toxic reactions have been identified in our patients. |