Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3731716 | Some aspects of knee joint kinematics in rheumatoid arthritis as studied with roentgen ste | 1986 Jun | Kinematic studies of the rheumatoid knee joint with the aid of roentgen stereophotogrammetry were performed in 4 patients (6 knees). Three kinds of experiments were carried out. The screw axis of rotation between various flexion angles was determined. The displacement of the screw axis indicated pathological function in all cases. Using different treatment techniques the effect of traction was studied. A separation between the femur and the tibia of 1.3-3.8 mm was found in 3 knees which were slightly flexed during the traction. The compression effect of isometric knee extension was determined in 4 knees. Compression of 0.5 mm at a medial point and of 0.3 mm at a lateral point of the femoral condyle were found in one knee. The present study indicates that roentgen stereophotogrammetric analysis may give additional information on the development of internal derangement of the rheumatoid knee joint. | |
| 2913717 | Methotrexate therapy in rheumatoid arthritis. | 1989 Feb | Rheumatoid arthritis (RA) is a common disease with a significant economic and social impact on Americans. Many patients with RA are unresponsive to or intolerant of conventional therapy or the limited therapeutic options available. For many of those patients, immunosuppressive drugs have been the mainstay of therapy. Our experience with methotrexate for these patients indicates that this drug provides symptomatic relief and improvement in objective parameters. Significant toxicity was uncommon. Methotrexate should be considered for selected patients with severe rheumatoid arthritis when conventional measures have been exhausted. | |
| 2291865 | D-penicillamine and D-penicillamine-protein disulphide in plasma and synovial fluid of pat | 1990 Oct | 1. The plasma pharmacokinetics of D-penicillamine (D-pen) and D-penicillamine-albumin disulphide (D-pen-alb) were examined over a dosage interval in six patients with rheumatoid arthritis. In two of these, 24 h synovial fluid profiles of D-pen and D-pen-alb were also obtained. 2. D-pen was undetectable in plasma at the beginning of the study. The peak concentration (5.4 +/- 1.2 microM) occurred at between 45 min and 2 h and the mean elimination half-life was 0.6 h. D-pen-alb, however, was present at a mean plasma concentration of 19.1 microM prior to dosage, peaked at 26.2 microM and was eliminated with a half-life of 40 h. 3. D-pen concentrations in synovial fluid rose more slowly and peaked lower than in plasma. D-pen-alb was present in synovial fluid of the patients at 50.1% and 83.6%, respectively, of the simultaneous plasma concentration prior to dosage. Concentrations varied during the study interval, corresponding to changes in plasma concentrations. 4. These results demonstrate that D-pen forms stable conjugates with protein in treated patients. The presence of D-pen-alb in relatively high concentrations throughout the dosage interval contrasts with the low concentrations and rapid elimination of D-pen. Both D-pen and D-pen-alb were also shown to be present at the putative site of drug action (the inflamed synovial joint) in concentrations lower than those in plasma. | |
| 3466334 | HLA antigens and gold toxicity in American blacks with rheumatoid arthritis. | 1986 | An increase in the frequency of DR3 in rheumatoid arthritis (RA) patients exhibiting toxic reactions to gold salt (GS) therapy has been observed in several studies of Caucasoid patients. Likewise, the association of B35 with gold-induced mucocutaneous reactions has also been reported in Caucasoid RA patients. Similar studies in other ethnic groups have not been previously documented. The present study was performed in American black RA patients receiving GS to determine if there were similar HLA associations with toxic reactions as those reported in Caucasoids. Eight-two seropositive and 18 seronegative American black RA patients were studied. Forty-one of the seropositive (50.0%) and six of the seronegative (33.3%) developed a toxic manifestation. No significant differences in the frequency distribution of HLA-B8, HLA-B35, DR, or DQw antigens were observed between the patients who had a toxic reaction and those who did not in either the seropositive or the seronegative RA patients. In particular, DR3 was not increased in patients with renal toxicity and B35 was not increased in patients with mucocutaneous reaction. Our study demonstrates that American black RA patients exhibiting GS toxicity do not have the same HLA associations as Caucasoids. The possibility that other genetic factor(s) may account for the occurrence of gold salt toxicity in American blacks requires further investigation. | |
| 2269487 | Involvement of interleukin-1-like factor(s) in type II collagen-induced arthritis in mice. | 1990 Nov | To explore the role of interleukins in development of arthritis, we induced collagen-induced arthritis in mice and examined interleukin activities in the inflamed joints. Arthritis developed in 90% of mice 4-5 weeks after primary immunization with type II collagen. Joint extracts from mice with collagen-induced arthritis contained high levels of interleukin 1 (IL-1)-like activity but not interleukin 2 (IL-2) or interleukin 4 (IL-4) activity. IL-1-like activities in the lesions were correlated with development of arthritis assessed by joint swelling and erythema. These results suggest that IL-1-like factor(s) may participate in the etiopathogenesis of collagen-induced arthritis in mice. | |
| 2897527 | Rheumatic disease, heavy-metal pigments, and the Great Masters. | 1988 Jun 4 | The painters Rubens, Renoir, and Dufy suffered from rheumatoid arthritis and Klee from scleroderma. Analysis of the areas of various colours in randomly selected paintings by these four artists and by eight "controls" (contemporary painters without rheumatic disease) suggests that Rubens, Renoir, Dufy, and Klee used significantly more bright and clear colours based on toxic heavy metals and fewer earth colours containing harmless iron and carbon compounds. These four painters may have been heavily exposed to mercury sulphide, cadmium sulphide, arsenic sulphide, lead, antimony, tin, cobalt, manganese, and chromium, the metals of the bright and clear colours, and exposure to these metals may be of importance in the development of inflammatory rheumatic diseases. Artists today are not so exposed, but heavy metal contamination in food and drinking water exists and experience from the occupational exposure of old masters is still relevant. | |
| 2874377 | Ranking of laboratory tests by consensus analysis. | 1986 Aug 16 | A new analytical technique (consensus analysis) was devised to assess the performance of laboratory tests that are commonly used to monitor the acute and chronic phases of inflammatory disease. On thirty-one tests carried out monthly for 7 months in seventeen patients with rheumatoid arthritis, the consensus analysis procedure ranked plasma viscosity and erythrocyte sedimentation rate in a tie for first place. Measurement of the acute-phase serum protein orosomucoid ranked third. Consensus analysis has the potential to reduce laboratory costs by identifying the most useful tests; it also promises to be helpful in the design of new laboratory tests that are more sensitive and specific. | |
| 2116162 | Use of sodium aurothiomalate during lactation. | 1990 Jun | The report concerns a mother who breast fed her infant whilst receiving sodium aurothiomalate for the treatment of rheumatoid arthritis. The milk:serum concentration ratio was not constant, reflecting the non-concurrence of the concentration-time profiles of gold in milk and maternal serum after i.m. injection. Gold was detected in the infant's serum. Calculations indicate that the weight-adjusted dose to the infant exceeded that received by the mother. | |
| 3798044 | The effect of biometeorological factors on Ritchie articular index and pain in rheumatoid | 1986 | The effect of relative humidity, atmospheric pressure, cloudcover, outside temperature, wind velocity and an overall weather index on Ritchie articular index (RAI) and pain registered on visual analogue scale (VAS) have been studied in active rheumatoid arthritis cases. Nineteen such cases were studied prospectively during the hospitalization for an exacerbation of the disease in the winter of 1981-82. Sixty-nine per cent of the patients were found to be sensitive, according to the RAI and VAS scores, to a weather indicator and 16% were not sensitive at all. To be weather sensitive, patients had to have at least one significantly positive correlation. The weather indicators most often positively associated with rheumatic symptoms were relative humidity, outdoor temperature, cloudiness and the overall weather index. There was no absolute correlation between the subjective claim to be weather sensitive and the objective correlations with weather parameters and joint pain. | |
| 3063002 | [D-penicillamine--a current review of areas of use and dosage guidelines]. | 1988 | The present paper reviews the different therapeutic uses of D-penicillamine and outlines the dosage regimen of D-penicillamine for treatment of rheumatoid arthritis. While many open clinical trials are published, only a few controlled, double-blind studies investigate the "optimal" dosing of D-penicillamine. From these findings, a uniform regimen cannot be named but the heterogenous appearance of chronic polyarthritis requires an individual therapy. In order to minimize the risk of side effects, however, it is necessary to follow the guideline "go low--go slow" as postulated by Jaffe. | |
| 1704149 | A spinal transcommissural connection for symmetrical sympathetic reflex response. Intra-ax | 1990 | Wheatgerm agglutinin conjugated horseradish peroxidase was injected into the ganglion cervicale superior of the sympathetic trunk of seven adult rats. Labelled neurons were found in the ipsilateral anterior commissural nucleus of the spinal cord at the C1 level. Transcommissural crossing of labelled fibres and symmetrical labelling of neurons in the contralateral nucleus were also found. Labelled fibres could then be followed contralaterally into the superior cervical ganglion where labelled neurons were also found. | |
| 1903031 | Pure red cell aplasia caused by D-penicillamine treatment of rheumatoid arthritis. | 1991 Apr | A 40 year old woman with rheumatoid arthritis developed pure red cell aplasia after treatment with D-penicillamine 500 mg/day. D-Penicillamine was stopped and short term treatment with steroids resulted in complete recovery of bone marrow. | |
| 2290089 | Total shoulder arthroplasty versus hemiarthroplasty. Indications for glenoid resurfacing. | 1990 Dec | The results of total shoulder arthroplasty and hemiarthroplasty in a similar patient population were compared in an effort to define more clearly the indications for resurfacing the glenoid. The results of 64 Neer hemiarthroplasties in 59 patients were compared with 146 Neer total shoulder arthroplasties in 134 patients in a retrospective review of the period between 1974 and 1986. The average follow-up period was 44 months (range, 24-124 months). Hemiarthroplasty and total shoulder arthroplasty produced similar results in terms of functional improvement. Pain relief, range of motion, and patient satisfaction were better with total shoulder arthroplasty than hemiarthroplasty in the rheumatoid population. Progressive glenoid loosening was found in 12% of total should arthroplasties but no correlation with pain relief or range of motion was noted. Total shoulder arthroplasty is recommended for patients with inflammatory arthropathies, and hemiarthroplasty is recommended for patients with osteoarthritis, avascular necrosis, and four-part fractures with preservation of glenoid congruity and absent synovitis. | |
| 3017859 | Effects of gold compounds on function of phagocytic cells. Comparative inhibition of activ | 1986 Sep | The effect of sodium aurothiomalate and auranofin on the generation of superoxide anions (O2-) by polymorphonuclear leukocytes (PMNLs) and adherent mononuclear phagocytic cells (AMNCs) has been investigated. Sodium aurothiomalate at final concentrations of 1, 10, and 100 micrograms Au/ml and auranofin ranging from 0.1 to 2.0 micrograms Au/ml were used in the reactions involving all cell types. Results have been compared between cells drawn from normal controls and patients with active rheumatoid disease. The effect of gold compounds on both cell types was assessed following activation by phorbol myristate acetate (1 X 10(-8) M) and N-formyl-methionyl-leucyl-phenylalanine (1 X 10(-4) M) using a cytochrome c reduction method. Sodium aurothiomalate at the maximum concentration modestly inhibited O2- generation by PMNLs but not AMNCs. Auranofin inhibits O2- generation by both cell types. Inhibition of cells from patients with rheumatoid arthritis was greater than that seen with cells from normal controls. | |
| 3591020 | [Pharmacologic characteristics as the basis for differential therapy using non-steroidal a | 1987 Jan | An attempt is made to compile the pharmacological data on the leading non-steroidal anti-inflammatory drugs. They concern the pharmacodynamics, the pharmacokinetics and the unwanted effects of these compounds. From these data a few suggestions for rational use are made: Ibuprofen and diclofenac present as drugs with short and reliable elimination-halflife. The compound with the lower potency namely ibuprofen appears particularly suitable for use in patients suffering from mild inflammatory pain of probably short duration (hours, days). Diclofenac being more potent should be used in more serious painful conditions, the variable bioavailability and the sometimes delayed absorption of diclofenac should be kept in mind if success is not achieved. Ketoprofen may have similar characteristics as diclofenac. The quality of the available data is however limited. Indomethacin and piroxicam are highly potent and reliable in onset; the bioavailability amounts to 100%. Both compounds may owe their effectiveness and reliability to substantial enterohepatic recirculation which may also be responsible for the reported somewhat higher incidence of GI-tract problems in connection with their use. They should hence be used in serious conditions going along with intensive, long-lasting inflammatory pain. Naproxen being less potent than the later two may fall into the same category. | |
| 3110956 | Gold induced thrombocytopenia: 12 cases and a review of the literature. | 1987 May | Gold induced thrombocytopenia is immune mediated, with the production of platelet associated IgG leading to peripheral platelet destruction. An association with HLA-DR3 has been demonstrated. Corticosteroid therapy is effective in treatment, although other modes of therapy may be as efficacious. | |
| 2204222 | [Rheumatologic emergencies]. | 1990 Jun 30 | Contrary to the widely assumed opinion there exist rheumatological emergency situations that affect patients hazardously. These cover complications of the antirheumatic therapy as well as complications of the disease itself. The paper gives an overview of rheumatological emergency situations and tries a systemic approach to a rheumatological emergency medicine. | |
| 3828631 | The significance of hyperplastic lymphadenopathy. | 1987 Feb | The finding of reactive hyperplasia in a lymph node removed for diagnostic purposes often induces a feeling of disappointment in the clinician. However, this review indicates that reactive hyperplasia is frequently associated with a number of well-defined clinical conditions. | |
| 3701193 | 19S IgM rheumatoid factor-7S IgG rheumatoid factor immune complexes isolated in patients w | 1986 May | Sera of 12 patients with rheumatoid arthritis (RA) who had positive IgM-rheumatoid factor (RF) tests were separated by use of immunoabsorbent columns (goat anti-human C3 [alpha HC3] and rabbit anti-human C1q [alpha HC1q]) and polyethylene glycol (PEG) precipitation-protein A affinity chromatography to isolate their immune complexes (IC). The isolated fractions were assayed for 19S IgM RF and 7S IgG RF by enzyme-linked immunosorbent assay (ELISA). The sera were further analyzed by preparative isoelectric focusing (IEF). The alpha HC1q and alpha HC3 columns were sequentially eluted with barbital buffer, 0.02 mol/L EDTA, 0.5 mol/L NaCl, and 1 mol/L propionic acid. All 12 patients had IgM RF and IgG RF in the EDTA fractions from both immunoabsorbent columns, but only IgM RF in the NaCl fractions. The PEG precipitation-protein A preparations were eluted with 0.5 mol/L glycine HCl and 3.5 mol/L MgCl2. All 12 patients had significant titers of 19S IgM RF (greater than or equal to 1:192) and 7S IgG RF (greater than or equal to 1:96) in the acid-eluted fraction. Analysis of the sera by preparative IEF revealed IgM RF with a polyclonal spectrotype pattern with pH of 3.0 to 10.0, but predominantly acidic proteins with isoelectric points of 4.0 to 5.5 IgG RF were found in the same restricted spectrotypic pattern. These studies demonstrated that IC can be detected in the sera of patients with RA by isolation with alpha HC1q and alpha HC3 immunoabsorbent columns and PEG precipitation-protein A affinity chromatography.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2584250 | Survivorship of cemented knee replacements. | 1989 Nov | The survivorship method of analysis has been used to compare the failure rate and overall success of 1,430 cemented primary total knee arthroplasties performed at The Hospital for Special Surgery over a 15-year period. There were 224 total condylar prostheses with a polyethylene tibia, 289 of the posterior stabilised type with an all polyethylene tibia, and 917 posterior stabilised with a metal-backed tibial component. There were 12 failures in the total condylar series, giving an average annual failure rate of 0.65% and a 15-year success rate of 90.56%. The posterior stabilised prosthesis with a polyethylene tibia showed an average annual failure rate of 0.27% and a 10-year success rate of 97.34%, and this prosthesis with a metal-backed tibial component gave an annual failure rate of 0.19% and a seven-year success rate of 98.75%. The overall survival rate was not influenced by sex or age, diagnosis or the percentage of ideal body weight. No metal-backed tibial components have yet needed revision for loosening. It seems that infection will be the major cause of failure. |