Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3675092 | Serum lipoprotein in active rheumatoid arthritis and other chronic inflammatory arthritide | 1987 Nov | Serum lipids and lipoprotein patterns were prospectively analyzed in 33 previously untreated patients with active chronic inflammatory arthritides during different anti-inflammatory and disease-modifying drug regimens. Before treatment the lipoprotein pattern was characterized by low cholesterol concentrations in all lipoprotein fractions and low triglyceride concentrations in the very-low-density lipoprotein fraction as well as in the high-density lipoprotein fraction. During treatment with prednisolone combined with azathioprine or cyclophosphamide (n = 10), a reduction of the disease activity was achieved and the lipoprotein pattern was normalized; similar results were noted in a small group of patients (n = 4) treated with prednisolone alone while nonsteroidal anti-inflammatory drug therapy (n = 9) neither significantly affected the lipoprotein pattern nor the inflammatory activity measured by the acute-phase reactants. The long-term treatment with penicillamine (n = 4) and chloroquine (n = 6) induced both a clinical remission of the disease and a reduction of the inflammatory activity. The lipoprotein concentrations started to reverse to the normal values during penicillamine treatment. In contrast, in the chloroquine-treated group the alterations in lipoprotein lipid concentrations were further pronounced, ie, the cholesterol and triglyceride concentrations in serum and the very-low-density lipoprotein fraction decreased. | |
| 1948449 | [D-penicillamine induced myasthenia gravis in a patient with rheumatoid arthritis]. | 1991 Jun | We have encountered a 53 year-old female with myasthenia gravis (MG) possibly induced by the treatment with D-penicillamine (D-pc). She has had a long-standing history of rheumatoid arthritis (RA) prior to the onset of MG. The diagnosis for MG was made based on the clinical findings and tests including antiacetylcholine receptor antibody and EMG. Although the drug had been efficacious for RA, it was discontinued after the development of MG. The symptoms and signs for MG were immediately disappeared, whereas clinical manifestations for RA was relapsed shortly after. Since D-Pc has been frequently used for the treatment of RA, an awareness of this side effect appears to be of particular importance for physicians in clinical practice who deal with RA. Furthermore, it may also provide some important immunological insights into the study of pathogenesis of MG. | |
| 2472638 | Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR b | 1989 Jul | Rheumatoid arthritis is associated with the HLA antigen HLA-DR4. Disease susceptibility maps to the amino acid sequence QKRAA located in the third hypervariable region of the DR beta-1 chain. This region is thought to be a site of recognition for the T-cell antigen receptor. We searched for an antigen in the human environment that could induce T-cell recognition of this sequence. An analysis of protein and DNA databases revealed that the Epstein-Barr virus glycoprotein gp110, which is encoded by the BALF4 open reading frame, contains the sequence QKRAAQRAA, which is highly homologous to the rheumatoid arthritis susceptibility determinant. Experiments using antibodies to synthetic peptides showed that the QKRAA determinant is expressed on the gp110 protein. Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant. | |
| 2565608 | HLA-DR4 associated Dw types in rheumatoid arthritis. | 1989 Jan | Frequencies of HLA-DR4 and its related Dw types were compared between randomly selected normal controls and the index cases of multiplex rheumatoid arthritis (RA) families. A DR4 frequency of 68.3% was observed in index cases (n = 57) compared to 31.2% in normal controls (n = 96). Cellular typing with homozygous typing cells (HTCs) revealed significant increases of Dw4 (49.1% vs 22.9% RR = 3.2 p less than 0.001) and Dw14 (22.8% vs 2.1% RR = 13.9 p less than 0.001) in the index cases. A non-significant increase was seen for Dw13 (8.8% vs 4.1%). When DR4 positive patients and controls were compared, a significant increase was seen only for Dw14 (34.2% vs 6.6% RR = 7.3 p less than 0.01). Data from HLA genotyped RA and normal families allowed an examination of haplotype combinations of HLA-B antigens and DR4/Dw types to be made. HLA-Dw4 was predominantly found with B44 and Bw62 with nearly all DR4/Bw62 haplotypes being Dw4 positive. HLA-Dw13 was associated with B44 and Dw14 with Bw60, B44 and B27. Based on HTC and normal family data. Dw10 was found to be strongly associated with B38 containing haplotypes. Analysis of 69 C4A, C4B complement typed DR4 haplotypes failed to show any statistically significant association between Dw type and "complotype". However, there was a suggestion of C4A3. BQO being associated with Dw4 (34.2% vs 16.1% X2 = 2.9 p = ns) and C4A3, B1 with Dw14 (45.5% vs 27.6% X2 = 2.1 p = ns).(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 3382271 | Pancytopenia related to azathioprine in rheumatoid arthritis. | 1988 Jun | Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily. In one patient this side effect occurred after three weeks, in the other after eight weeks of treatment. Rapid fall of platelets in one patient necessitated platelet transfusion. In the other patient additional treatment with allopurinol was probably responsible for the toxic effect. Haematological side effects of azathioprine are discussed. | |
| 3676485 | [Study of articular cartilage and the synovial membrane using IR spectroscopy]. | 1987 Nov | The infrared spectra of normal knee joint cartilage, normal and rheumatoid arthritis-affected human synovial membrane and the same normal bovine tissues were obtained over the region of 400--4000 cm-1. A comparative analysis of the spectra of these tissues and those containing hyaluronate, protein-chondroitin-keratan sulfate aggregates of cartilage proteoglycans and heparin made it possible to identify greater absorption bands of these biopolymers in the tissue spectra. The interpretation of the results obtained is presented. | |
| 3488088 | Increased levels of osteocalcin (serum bone Gla-protein) in rheumatoid arthritis. | 1986 Aug | Serum osteocalcin was measured by radio-immunoassay in 56 patients with rheumatoid arthritis (RA), and in 50 controls. Mean serum osteocalcin levels were significantly higher in patients with RA. There was a positive correlation between osteocalcin and fasting mucopolysaccharide/creatinine ratio in both sexes, and between osteocalcin and fasting hydroxyproline/creatinine ratio in women. Serum alkaline phosphatase activity, a less specific marker for bone formation, was also increased in RA, and there was a positive correlation with osteocalcin in both sexes. These data suggest that overall bone turnover is increased in RA and that serum osteocalcin may provide additional information for the evaluation of bone metabolism in this disease. | |
| 3497427 | [Class II HLA antigens and rheumatoid factors in rheumatoid polyarthritis. Inverse influen | 1986 Nov | A linkage disequilibrium was searched for between HLA-DR antigens and rheumatoid factor level both measured using latex agglutination and a solid phase immuno-enzymic assay (FR-PAP) among 251 sera from patients suffering from classical rheumatoid arthritis for at least 5 years, recorded in the Cooperative Swiss Study on Rheumatoid Arthritis. An association between the presence of HLA-DR7 and low levels of rheumatoid factor was found. This association was stronger when the DR4, 7 heterozygous subjects were excluded. The comparison of the DR7, not equal to 4 and DR not equal to 4, not equal to 7 subjects demonstrated that the DR7 effect was independent of DR4. Although the association between DR4 and high levels of rheumatoid factor was not statistically significant in this study, these data suggested an opposite influence of DR4 and DR7 on rheumatoid factor level among rheumatoid arthritis suffering patients. The influence of DR4 appeared to be dominant among heterozygous DR4, 7 patients. | |
| 2670022 | New therapies for the rheumatic diseases. | 1989 | The investigational therapies of the rheumatic diseases reviewed in this issue are at various stages of clinical development. Methotrexate and sulfasalazine represent examples of chemotherapies in which the short-term efficacy and toxicities, at least in rheumatoid arthritis, have been carefully documented by controlled trials. The limited information available on cyclosporin A, combination chemotherapy, and radiotherapy is encouraging and appears to warrant additional, more extensive studies. In particular, randomized trials to determine the effects of these interventions on relevant long-term outcomes such as functional disability, organ failure, and life expectancy are necessary. Careful attention to the adverse consequences associated with these interventions, a limiting factor in many currently available therapies, will be mandatory. Disease modification by biologic agents holds the promise of ushering in an entirely new, more selective approach to therapy. A number of these biologic agents are currently at the threshold of clinical evaluation. In all likelihood, the scientific knowledge of pathogenic mechanisms operative in the rheumatic diseases gained through the use of these agents will be of equal importance to the therapeutic benefits. | |
| 3054094 | Two double blind trials of diclofenac sodium with aspirin and with naproxen in the treatme | 1988 Aug | In 2 multicenter, double blind studies, the efficacy and safety of diclofenac, 150 mg/day, were compared with those of aspirin, 3.6 g/day, in 194 patients with rheumatoid arthritis (RA) in Study 1 and with those of naproxen, 1000 mg/day, in 223 patients with RA in Study 2. After single blind, placebo washout periods of 2 days to 2 weeks, patients entered 12-week treatment periods in each study. In both studies, diclofenac, aspirin, and naproxen produced statistically significant improvement (p less than or equal to 0.01) from baseline in all primary efficacy variables at each assessment visit. There were no significant differences between treatments. In both studies, significantly fewer (p less than or equal to 0.05) patients receiving diclofenac experienced adverse effects compared to the aspirin and naproxen groups. Significantly fewer (p less than 0.05) patients in the diclofenac group compared to the aspirin group discontinued the trial due to side effects (primarily tinnitus and deafness). In Study 2, fewer patients in the diclofenac group discontinued the trial due to adverse effects than in the naproxen group. In conclusion, diclofenac, aspirin, and naproxen demonstrated similar efficacy; however, diclofenac was significantly better tolerated than either aspirin or naproxen. | |
| 3764742 | [Individual aspects of pathogenesis and diagnosis of cardiorespiratory disorders in rheuma | 1986 | The authors presented the results of a combined instrumental study of the cardiorespiratory system in 100 patients with rheumatoid arthritis (RA) and 26 patients with systemic scleroderma (SSD). Disturbances of the pulmonary circulation and central hemodynamics in the absence of roentgenomorphological and ventilation disorders in the bronchopulmonary apparatus were revealed. The dependence of hemocirculatory parameters on a degree of the expression and genesis of pulmonary changes was shown. Some reasons for a rare development of the pulmonary heart in rheumatic diseases were described. In the detection of bronchoobstruction in RA and SSD patients the use of drugs controlling it was recommended. | |
| 2203946 | A pyroelectric thermal imaging system for use in medical diagnosis. | 1990 Jul | The value of infra-red thermography in a number of pathologies, notably rheumatology and vascular diseases, is becoming well established. However, the high cost of thermal scanners and the associated image processing computers has been a limitation to the widespread availability of this technique to the clinical community. This paper describes a relatively inexpensive thermographic system based on a pyroelectric vidicon scanner and a microcomputer. Software has been written with particular reference to the use of thermography in rheumatoid arthritis and vasospastic conditions such as Raynaud's phenomenon. | |
| 3619533 | [The rheumatic thumb]. | 1987 | The thumb is one of the most frequent sites of rheumatoid arthritis (62% of patients). Two major deformities predominate: adductus thumb due to a predominant lesion of the trapezo-metacarpal joint (5% of cases) and, more importantly, Z deformity of the thumb due to a predominant lesion of the metacarpo-phalangeal joint (60% of cases). The surgical indications should be discussed in a loco-regional context, but also in a global context of polyarticular lesions and depend on the severity of the deformities. The results, globally useful and greatly appreciated by the patients, were studied in a series of 92 operated thumbs. Involvement of the thumb leads to deformities which, in the majority of cases, are responsible for major functional disorders. The functional adaptation associated with the absence of a parallel anatomo-clinical adaptation must obviously be noted, but the restoration of the function of the thumb, the most important digit of the hand, would appear to be essential in the loco-regional and global context of rheumatoid arthritis. | |
| 2424461 | Reactivity of monoclonal anti-type II collagen antibodies with cartilage and synovial tiss | 1986 Jun | Monoclonal antibodies to 3 different epitopes on native type II collagen were used for immunohistochemical analysis of antigenic determinants that are exposed in the cartilage and synovial tissue obtained from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Two of the monoclonal antibodies reacted with cartilage from both OA and RA joints, but not with that from normal joints. The third monoclonal did not stain any of the cartilage sections. The 2 positive antibodies also reacted with cartilage fragments in the synovial tissue of both RA and OA joints, and in RA pannus tissue, the antibodies showed intracellular staining in many class II transplantation antigen-expressing synovial cells lying close to the damaged cartilage. | |
| 3662650 | Viscosity of plasma in patients with rheumatoid arthritis. | 1987 Aug | The viscosity of plasma (PV) was investigated in 27 outpatients with classical or definite rheumatoid arthritis (RA) according to the American Rheumatism Association (ARA) criteria. The measurements showed a significantly raised PV in patients with RA (p less than 10(-5)) compared with a control group. There was a positive correlation between the PV and the blood erythrocyte sedimentation rate (B-ESR), and the increase in the PV is largely explained by increased concentrations of the plasma proteins, fibrinogen, and IgG. | |
| 2041983 | C1q-bearing immune complexes detected by a monoclonal antibody to human C1q in rheumatoid | 1991 | Using a monoclonal antibody directed against the C-chain of human C1q, we detected C1q-bearing immune complexes (IC) in sera and synovial fluids of rheumatoid arthritis (RA) patients. In a sandwich-ELISA, C1q-bearing IC were captured by the solid-phase monoclonal antibody and then detected with peroxidase-labeled F(ab')2-antibodies to either human IgG or IgM. The results of this assay were compared to an ELISA-modification of the C1q-solid-phase binding assay (C1q-SPBA). C1q-bearing IC were detected in 81.1% of RA-sera and the 65.2% of RA-synovial fluids. IgG as well as IgM was present in 72.6% of the sera and 70% of the synovial fluids which were positive in both assays. Most RA sera that were only positive for C1q-bearing IC, contained IgG alone (81.5%). The corresponding synovial fluids showed IgG alone (53%) or both IgG and IgM (41.1%). IgM alone (25%) could be detected in sera, e.g. in juvenile forms of RA. The levels of IC were higher in synovial fluid than in paired serum. In comparison to normal human serum (NHS) and patients with osteoarthritis, complement activity (CH50 titers) and C1q-values in patients with RA were frequently elevated. Since the formation of C1q-bearing IC is an indicator for the classical complement pathway activation, an assay with monoclonal anti-C1q antibody may be a useful tool in the diagnosis of rheumatoid diseases. | |
| 2613908 | The relationship of process to outcome in brief experiential psychotherapy for chronic pai | 1989 Nov | Six adult females with active rheumatoid arthritis were treated with a 10-session course of focused Gestalt Psychotherapy with the intent of assessing the relationship between key psychotherapy processes and both session and final outcome. Results suggested that high levels of patient participation were related to reduced patient distress, while high ratings of both session depth and session smoothness were related to increased positive feelings at the end of sessions. However, these session results did not generalize to final treatment outcome. | |
| 2963911 | Synovial lymphocyte subsets in rheumatoid arthritis and degenerative joint disease. | 1987 Dec | There is considerable evidence to indicate that the synovitis of rheumatoid arthritis (RA) is immunologically mediated. Recently, it has been postulated that a suppressor-type cell deficiency may play an important role in the pathogenesis of the synovitis. In addition, an immune component may contribute to the synovial alterations in certain examples of degenerative joint disease (osteoarthritis, OA). Using monoclonal antibodies, we evaluated synovial tissue lymphocytes in 12 patients with RA, 2 with juvenile RA, one with adult Still's disease, and 2 patients with OA synovitis in order to delineate the T cell subset patterns. Helper-type cells predominated in 3 patients with RA, while suppressor-type cells were present in equal or greater numbers in 9. The patients with OA showed helper-type cell predominance. Helper-type to suppressor-type cell ratios vary widely in RA synovia which militates against the primacy of the role of a suppressor-type cell deficiency in this disorder. Patients with OA synovitis may display T cell infiltrates comprised mainly of helper-type cells. | |
| 2945684 | Serum IgA levels and ANA behaviour in rheumatoid patients with and without toxicity to rem | 1986 Jul | IgA levels and ANA behaviour were studied in twenty-five patients suffering from toxicity to remission-inducing drugs (Tiopronin or Gold thiosulphate) and in thirty-two without any evidence of toxicity. A comparable number of patients with low IgA levels were found in the two groups. ANA test positivity correlated better with the appearance of toxicity, but the low specificity and predictivity hinder its application as a screening parameter. | |
| 1927039 | [Laboratory diagnosis of human Mycoplasma infection]. | 1991 | The paper shows that aggregate hemagglutination reaction, enzyme immunoassays, and passive hemagglutination may be used in the laboratory diagnosis of Mycoplasma-induced infections. In patients with respiratory diseases of unknown origin, the M. pneumoniae antigen is easiest detected in the first days of the disease, then a long-term persistence of antigens as part of circulating immune complexes is frequently seen. An examination of patients with chronic rheumatoid arthritis has indicated that 26.7% exhibit M. arthritidis or M. fermentans antigens, 16.3% display associations of these two types of mycoplasma. The disease in immunocomplex: the mycoplasma antigens circulate as part of immune complexes long in 80%. In females with urogenital abnormality, serum tests have shown U. urealyticum and M. hominis in 83.6%, the patients having inflammatory diseases of unknown etiology. |