Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3544595 | [Value of arthrosonography in the evaluation of exudative and proliferative synovitis]. | 1986 Sep | The characterization of synovial tissue in rheumatoid arthritis (proliferative or exsudative synovitis), which is important in deciding between local therapies of arthritis, was examined by arthrosonography, computerized axial tomography and arthroscopy. The arthroscopic examination yields the highest significance in characterizing rheumatoid synovial tissue. Compared to arthroscopy, arthrosonographic diagnosis was correct in 70% of our cases. The arthrosonographic results were much influenced by the different concentrations of fibrin in the synovial effusions. | |
| 3564648 | [Differential diagnosis of epicondylitis humeri radialis]. | 1986 Nov | Intensive amateur sport will lead especially in the untrained to frequent traumatisation. Exact discussion of the symptomatics of the epicondylitis seems to be necessary. Sufficient therapy of various pain symptoms, which are usually described as epicondylitis is only possible after exact differentiation. Paraarticular pain can be caused by the ligamentum-anulare-syndrome as well as by the classic insertion tendinosis. A hypertrophy of the radio-humeral disc can also be the reason of pain after posttraumatic synovitis. Osteoarthritis and rheumatoid arthritis can easily be differentiated from posttraumatic changes by anamnesis and clinical examination. In a large group of patients pain in the elbow region is caused by cervical spine disturbancies, which are frequently overlooked. Similar symptoms can be seen in cases with peripheral irritation of the radial nerve, which can be entrapped as in the supinator syndrome. Juvenile patients can also suffer from osteonecrosis (M. Panner, M. Hegemann) or from epiphysiolysis. In the years from 1975 to 1980 1,096 patients with pain symptoms at the radial epicondyle of the humerus were treated at the Orthopedic Clinic of the University of Vienna under exclusion of those cases with cervical spine disturbancies. Out of the 1,096 patients seen 60 were treated surgically (5,47%) because of insertion tendinosis. 35 cases of osteochondrosis dissecans (3,19%) and three of osteonecrosis (0,27%) were seen in the same period. 60 synovectomies with 33 resections of the radial head were operated because of rheumatoid arthritis with massive destruction of the humeroradial joint.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1809995 | [Socioeconomic aspects of rheumatoid arthritis]. | 1991 | This study investigated the financial parameters of the hospital treatment and of the rehabilitation in the Centers for Rehabilitation for the patients with rheumatoid arthritis (RA). The control group consisted of patients who were ill or had been ill from some other diseases which were controlled at the physician of the primary health service. The average duration of the treatment of the patients with RA in hospital was 28 days (ranging from 21 to 35 days), while the average duration of the treatment of the patients from the control group was 18 days (ranging 7 to 45 days). 45 patients with RA were hospitalized and 22 from 65 patients from the control group (P greater than 0.05). The duration of the hospital treatment of 45 patients with RA was 2548 days and it was 1818 days for the patients from the control group (P = 0.039). The cost of one stay of 28 days in the hospital amounted 56.000 din per one patient with RA and it was 36.000 din per one patient from the control group (according to the price-list from 31. 7. 1991.). 49 patients with RA went for several times to the rehabilitation into the Centers for Rehabilitation and 11 from 65 patients from the control group (P less than 0.0001). The average duration of rehabilitation for the patients with RA was 23 days while it was 26 days for the patients from the control group (P greater than 0.06). The rehabilitation for the patients with RA lasted 4278 days and 832 days for the patients from the control group (P less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1882064 | Technique for detecting early rheumatoid arthritis. | 1991 Jul | The authors are of the opinion that the controversy surrounding the value of radiography in the early diagnosis of RA and subsequent assessment of drug therapy is due to the poor resolution of the radiographs used in many of these studies. Given that radiographic findings correlate with the pathological changes occurring in the hands and wrists of the RA patient, the ARA 1987 revised criteria for the classification of RA requires a PA projection of the hands and wrists. With this in mind, it is obvious that a standard radiographic technique offering high-resolution be developed and implemented. Direct magnification procedures as previously described offer high-resolution, however, they are either too cumbersome to use, require specialized, limitedly available equipment, produce partial images, have prolonged exposure times leading to part motion and are too expensive. In addition, radiation dosages to the skin are higher. These problems also preclude their use in the establishment of screening procedures for early RA. By comparison, the authors' optical magnification technique eliminates the major problems encountered in direct magnification. More importantly, the described optical magnification technique provides high-resolution radiographs utilizing readily available equipment and offers a practical means for the effective screening and diagnosis of early RA. | |
| 1947895 | Concentration of substance P, neurokinin A, calcitonin gene-related peptide, neuropeptide | 1991 | We have studied the presence of five neuropeptides in knee joint synovial fluid from either patients suffering from rheumatoid arthritis and pain (n = 18) or being subjected to arthroscopy due to meniscal/cruciate ligament injuries (n = 13). Radioimmunoassay technique was used for peptide analysis using antisera SP2 against substance P (SP), K12 against neurokinin A (NKA), CGRPR8 against calcitonin gene-related peptide (CGRP), NPY1 against neuropeptide Y (NPY) and VIP2 against vasoactive intestinal polypeptide (VIP). No SP could be detected, and lower levels of NKA was found in arthritic joints vs controls. CGRP and NPY was found in higher concentrations in arthritic patients vs controls. VIP was found sporadically in both arthritis and control patients. Our data show some quantitative differences between patients suffering rheumatoid arthritis and pain, and patients with non-inflamed joints without pain; indicating an involvement of peptidergic fibers in arthritis in humans. | |
| 1691032 | Monocyte activation in rheumatoid arthritis: evidence for in situ activation and different | 1990 Apr | Monocytes, defined by staining with the Mo-2 and Leu-M3 monoclonal antibodies which both detect the CD14 antigen, were studied in peripheral blood of control subjects and patients with rheumatoid arthritis as well as in rheumatoid synovial fluid of the latter for expression of activation/differentiation markers. The monocytes in the rheumatoid synovial fluids showed increased expression of class II major histocompatibility antigens (HLA-DR and -DQ) and decreased positivity for the peanut agglutinin receptor as compared with those from patient and control peripheral blood. There were no differences in phenotype between the control and patient peripheral blood monocytes. These findings are consistent with the hypothesis that monocytes are activated and differentiate into more mature macrophage-like cells after entry into the rheumatoid joint. | |
| 2943600 | Interrelationship between the immunological and steroid hormone parameters in rheumatoid a | 1986 Jun | In the present work the correlation between the immunological parameters and plasma androgen hormone levels in rheumatoid arthritis (RA) was examined. Female patients were divided in groups according to their age and immunologic state. Plasma dehydroepiandrosterone (D), D sulphate (DS), and testosterone (T) levels were determined by radioimmunological methods. The values were related first to those of normal controls. The T and DS levels were significantly decreased in all patient groups examined, the D level was low only in "Rf+ active" state aged 18 to 45 years. Furthermore, it was examined whether the decreased hormone levels were in relationship either with the autoantibody (Rf) formation or with the activity of the disease. According to the observations the T levels were influenced neither by the autoantibody formation nor by the activity of the disease. The DS and D levels appeared to correlate both with the autoantibody formation and the activity of the disease, particularly in young patients, being significantly low in the "Rf+ active" state. From these we concluded that the condition of the immune system has an influence on the sex hormone and/or adrenal androgen function. | |
| 1948458 | [A case of rheumatoid arthritis complicated with idiopathic thrombocytopenic purpura and H | 1991 Aug | A 37 year old nurse with the rare combination of idiopathic thrombocytopenic purpura (ITP), Hashimoto's thyroiditis and rheumatoid arthritis (RA) was reported. In 1983, six years before her final diagnosis was made, she presented with purpura over her extremities and swelling of the cervical lymph nodes. Laboratory findings showed the following: platelet count 15 x 10(3)/microliters, the number of megakaryocyte without platelet production in bone marrow was increased, platelet life span (T1/2) 11 min. A diagnosis of ITP was made. In 1984 goiter was noticed. Laboratory data were as follows: T3 502ng/ml, T4 27.0 micrograms/dl, thyroid test x 1,600, microsome test x 409,600. She was diagnosed as having ITP and Hashimotoxicosis. She had been uneventful except temporary hyperthyroidism until 1989 when she developed morning stiffness, polyarthralgia, swelling of PIP joints, contracture of elbow joints and hallux valgus. Laboratory investigation were reported as follows. ESR 111mm/h, platelet count 31 x 10(3)/microliters, platelet associated IgG 800ng/10(7) pl, antinuclear antibody x 2,560, rheumatoid factor 1+, microsome test x 1,600, anti-DNA antibody 3U/ml. Anti-Sm antibody and anti-RNP antibody were not detected. The LE cell test was negative. Schirmer test and sialography were interpreted as normal. These findings confirmed the diagnosis of RA in addition to ITP and Hashimoto's thyroiditis. The combination of RA, ITP and Hashimoto's thyroiditis is extremely rare although these three disorders are classified as autoimmune disease. | |
| 1690301 | HLA-DR, DQ and DP antigen expression in synovial fluid T lymphocytes in rheumatoid arthrit | 1990 Jan | Cell surface expression of HLA-DR, DQ and DP antigens on synovial fluid (SF) T cells was analyzed in 43 patients with rheumatoid arthritis. Marked increase in the positive expression of all 3 Ia antigens was observed in the SF T cells compared to the counterpart, peripheral blood T cells. Both the DNA and RNA content of HLA-DP+ T cells were analyzed using acridine orange stain. RNA content in the HLA-DP+ SF T cells increased in comparison to that in the HLA-DP- SF T cells or normal peripheral blood T cells. Our findings suggest that majority of the SF T cells are activated and express HLA-DP antigen, while not proliferating. | |
| 3278695 | Synovial fluid neutrophils of patients with rheumatoid arthritis have membrane antigen cha | 1988 Jan | The level of expression of surface antigens was studied on neutrophils from paired samples of blood and synovial fluid of patients with rheumatoid arthritis (RA). By measuring the immunofluorescence of labelled monoclonal antibodies it was shown that on joint neutrophils there was an increase in expression of complement receptor 3 (CR3) and granulocyte functional antigens 1 and 2 compared with blood neutrophils, whereas the expression of GpIIb-IIIa was reduced. The pattern of expression was the same as that seen with in vitro activation and strongly suggest that activation is occurring within the joint. | |
| 2243997 | Cystic rheumatoid arthritis: description of a nonerosive form. | 1990 Dec | In a study of patients with rheumatoid arthritis (RA), 9% (n = 70) were found to have a cystic form. At radiologic examination of these patients with cystic RA, the first abnormality seen consisted of periarticular intraosseous cysts without erosions. The cysts were distributed symmetrically, most often located at the proximal side of the joints and predominantly around the proximal interphalangeal, metacarpophalangeal, and wrist joints of the hands and the first interphalangeal and metatarsophalangeal joints of the feet. Computed tomographic scans showed the peripheral intraosseous location of the cysts. Magnetic resonance images showed that the cysts may contain fluid, inflamed synovia, or both. Cysts can be an important feature in the diagnosis of RA and a supplement to the criteria of the American Rheumatism Association. Osteoporosis, joint-space narrowing, and joint destruction occurred less frequently in patients with cystic RA than in patients with classic RA. Of the patients with cystic RA, 54% were male, and 50% were seronegative. This study is a supplement to and an enlargement on earlier descriptions of cyst predominance in RA. | |
| 3426299 | Incidence of antibodies to native and denatured cartilage collagens (types II, IX, and XI) | 1987 Dec | The frequencies of antibodies to the cartilage type IX and XI collagens and to type I collagen were determined in 188 patients with rheumatoid arthritis, of whom 76 were positive for antibodies to native type II collagen. A higher proportion of patients with antibodies to native type II collagen had antibodies to these other collagens, but about one third of patients without antibodies to native type II collagen had antibodies to one or more denatured collagens. The patterns of antibodies present in individual sera suggested that there was a selective response to the collagens in an individual patient. The incidence of patients having antibodies to these native and denatured collagens in a random group of patients with rheumatoid arthritis was calculated. | |
| 2681899 | Clinical studies of polymyalgia rheumatica. A proposal of diagnostic criteria. | 1989 Jul | A differential diagnosis of polymyalgia rheumatica (PMR) and rheumatoid arthritis (RA) can be difficult in elderly patients, especially at the prodromal phase of RA. Furthermore, it was felt that there might be a diagnostic criteria for PMR specific to the Japanese. Accordingly, we have retrospectively studied the PMR patients who had come to our hospital, for making a diagnostic criteria. We especially stressed the distinguishing of PMR from RA in elderly patients. The criteria proposed are as follows: 1. Bilateral muscular pain persisting for 2 weeks at least in more than two of the following areas; neck, shoulders or shoulder girdle, upper arms, hips or pelvic girdle and thighs. 2. Normal serum myogenic enzymes. 3. ESR of more than 40 mm/h. 4. No swelling in the hand joints. PMR is defined by the presence of all of the 4 items. The criteria demonstrated a 93.1% sensitivity and 98.3% specificity for PMR. | |
| 3643734 | A synovial amidase acting on tissue kallikrein-selective substrate in clinical and experim | 1986 | Increased levels of amidase acting on a tissue-kallikrein selective substrate, Val.Leu.Arg.pNA, with an activity optimum at pH9, were detected in blood-free inflamed tissues from adjuvant arthritic rats (p less than 0.01). The component of this activity resistant to inhibition by soybean trypsin inhibitor (SBTI) also greatly increased (p less than 0.05). Both the SBTI-sensitive and SBTI-resistant components were inhibited by aprotinin (93% and 72% respectively). Kallikrein-like amidase also increased in inflamed synovia from seropositive rheumatoid, and osteoarthritic dogs when compared with healthy canine synovia. This increase was parallelled by an increase in kinin-forming enzyme which was also measured in rheumatoid and healthy animals and this activity was inhibited 72% by aprotinin. Total kallikrein-like amidase also increased 989% (p less than 0.05) in synovia from seropositive rheumatoid human patients, compared with healthy synovial tissue. Evidence is presented indicating that the origin of this enzymic activity may be plasma kallikrein. | |
| 3796198 | Evaluation of neutrophil acetyltransferase activity in patients with inflammatory disorder | 1986 Dec 15 | The acetyltransferase activity of neutrophils from patients with inflammatory disorders was assayed using the homogenate preparation of neutrophils. The enzyme activity was evaluated on both non-stimulated and stimulated neutrophils. The enzyme activity of neutrophils from 21 patients with rheumatoid arthritis and 10 patients with Behcet's disease was not significantly different from that of the control group. In contrast, it was significantly elevated in patients with bacterial infection, especially that of non-stimulated cells. The increase in the enzyme activity best correlated with the degree of fever. The elevated enzyme activity tended to normalize during convalescence. | |
| 3338257 | Nucleosides and bases in synovial fluid from patients with rheumatoid arthritis and osteoa | 1988 Jan | 1. Nucleosides and bases in physiological fluids result from metabolism of nucleic acids and nucleotides and from dietary sources. As nucleotide catabolism increases during tissue injury, nucleosides and bases could serve as useful biochemical markers in arthritis. 2. We have quantified nucleosides and bases in synovial fluid and plasma by high-performance liquid chromatography in order to examine whether nucleotide metabolism is increased in patients with rheumatoid arthritis and osteoarthritis. 3. At least ten u.v.-absorbing compounds were detected in plasma and synovial fluid; only urate, creatinine, hypoxanthine and uridine were present in identifiable and quantifiable amounts. 4. In synovial fluid from patients with rheumatoid arthritis the concentration of hypoxanthine was increased and that of urate decreased compared with osteoarthritis. 5. These data suggest that there is an increase in purine metabolism in the rheumatoid arthritis joint and that hypoxanthine is a potential marker of synovitis. | |
| 1690803 | Phenotypic characterization of lymphocytes infiltrating synovial tissue from patients with | 1990 Feb | The phenotypic markers of mononuclear cells in synovial tissue from 19 patients with active rheumatoid arthritis (RA) were identified by a dual immunofluorescent method. The mononuclear cells were isolated from synovial tissue by mechanical disaggregation and an enzymatic digestion technique. The results revealed a marked reduction in CD4+2H4+ cells (suppressor inducer T cells) and an increment in CD4+4B4+ cells (helper T cells) among CD4+ cells in synovial tissue. The percentage of CD8+CD11b+ cells (suppressor effector T cells) was significantly lower in synovial tissue than in peripheral blood from patients with RA, resulting in an increased percentage of CD8+CD11b-- cells (cytotoxic T cells). The synovial tissue had higher percentages of pan B cells (B1+ cells), differentiated B cells (B1+B2-- cells) and plasma cells (PCA-1+ cells). These findings suggest that a combination of the increment in helper T cells, the reduction in suppressor T cells, and the increment in differentiated B cells may lead to excessive production of autoantibodies. | |
| 2134444 | Posterior stabilization of the cervical spine in rheumatoid arthritis: clinical results an | 1990 Dec | Thirteen patients with atlantoaxial dislocation(s) had posterior stabilization and were evaluated clinically with magnetic resonance (MR) imaging and conventional radiography both pre- and postoperatively. Cases with anterior instability had large periodontoid granulomatous pannus formation, but this was lacking in cases with fixed cranial settling. The pannus caused cord compression in four cases and occupied the entire anterior subarachnoid space in four other cases. After stabilization, the granuloma decreased in size in all patients and in four cases it vanished completely. Major signs of myelopathy corresponded to cord compression at MR imaging. Minor possible signs of neural deficit were found in seven cases and their importance was not clearly understood before surgery, but because all preoperative symptoms disappeared, it was necessary to check for even obscure signs as early warnings of a threatening myelopathy. | |
| 2576902 | [The effect of parenteral gold preparations on heart function in rheumatoid arthritis pati | 1989 Oct | A total of 30 patients were treated by chrisanolum and myocrisin. The course of treatment lasted more than 2 years. The authors observed clear positive effect of parenteral preparations of gold on the contractile and pumping function of the heart in RA patients; clinical and laboratory manifestations of the disease were decreased. | |
| 2504919 | Felty's syndrome: response to low dose oral methotrexate. | 1989 Jul | We describe a case of Felty's syndrome with persistent severe neutropenia below 200 granulocytes/mm3, splenomegaly and repeated infections. The patient did not respond to treatment with intramuscular gold salts and lithium carbonate. After 2 months of oral methotrexate administration, 7.5 mg weekly, clinical improvement was notable: she remained afebrile, neutropenia disappeared and splenomegaly regressed. This clinical and laboratory improvement persisted 5 months later. Moreover, accidental discontinuance of the drug and later readministration supported the evidence that the improvement was due to methotrexate. |