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PMID	Title	PublicationDate	abstract
3816094	The relationship between the leg muscle strength and physical capacity in patients with rh	1986 Dec	It has been shown that patients with rheumatoid arthritis have weak muscles, especially when they are treated with corticosteroids. Forty-six female patients suffering from rheumatoid arthritis were evaluated with regard to the physical capacity in the lower legs by measuring the walking speed and the climbing performance as correlated to the isokinetic muscle strength of the knee extensors and the plantar flexors. Twenty-six of the patients (average age 60 years, range 34-76) had been treated with corticosteroids. Twenty patients (average age 58 years, range 31-72) had never received corticosteroids. The mean maximal isokinetic muscle strength of the knee extensors in corticosteroid treated patients was 62 +/- 28 Nm (SD) at the angular velocity 30 degrees/s, and the mean maximal isokinetic muscle strength of the plantar flexors in the same group of patients was 33 +/- 21 Nm (SD) at the same angular velocity. Compared to patients with rheumatoid arthritis who had never been treated with corticosteroids the reduction in muscle strength was 37% and 28%, respectively (p less than 0.001 and p less than 0.01). The mean walking speed in patients with corticosteroid treatment was 0.9 m/s, which was a 36% reduction as compared with that found in patients who had not received corticosteroids (p less than 0.01). Half of the patients who had not received corticosteroids were able to climb a 50 cm step, while this was possible in only 16% of the group of corticosteroid-treated patients.(ABSTRACT TRUNCATED AT 250 WORDS)
1715616	Correlations between IL-2 enhancing activity and clinical parameters in patients with rheu	1991 Apr	In a previous paper (Tomura, K. et al. Tohoku J. Exp. Med., 1989, 159, 171-183), we discovered IL-2 enhancing factor(s) designated B cell derived-growth enhancing factor-2 (BGEF-2), which enhanced IL-2 dependent cell proliferation, and reported that BGEF-2 was produced by B cells of the patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) only when they were in the active stage of the disease. In this paper, we studied relationship between each IL-2 enhancing activity from B cell supernatant of the patients with these diseases and clinical parameters. IL-2 enhancing activities did not correlate with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), but correlated with plasma concentrations of gamma-globulin from the patients with RA and SLE in the active stages. IL-2 enhancing activities correlated with hypocomplementemia and leukocytopenia in the patients with SLE, and also correlated with RAHA titer in the patients with RA. Moreover, on several patients with RA or SLE in the active stages, diminution of IL-2 enhancing activity was found when they were in the remission stage after treatments. These findings suggested that IL-2 enhancing activity (i.e., BGEF-2 activity) correlated with activity of these diseases and supported the hypothesis that BGEF-2 played an important role in the polyclonal B cell activation and autoantibody production in patients with these diseases.
1950068	[Training in coping with illness for patients with chronic polyarthritis: trends and initi	1991	Ten patients with rheumatoid arthritis participated in a controlled study of a cognitive-behavioral group therapy for enhancing the ability to cope with their illness. Results showed a strong tendency in decreasing pain intensity estimates and in depression, and an increase in mood and activation of the participants. Significant changes were found in scales measuring well-being, self-concept and coping with stress. The results encourage a continuation of the group approach and further investigation of its effects in objective outcome measures.
2397828	[TMJ lesions. Dysfunction and occlusion. Radiographic study].	1990 Jun 15	A tomographic investigation was performed on 51 randomly selected patients with Rheumatoid Arthritis in order to identify the prevalence of the temporo-mandibular joint involvement and the relationship with the clinical dysfunction and occlusal state. The relation between the condyle and the fossa in intercuspal position and during opening were measured: protrusive condylar path often got reduced. Articular shape and structural changes were also evaluated: only 4% of total joints resulted uninjured. The survey showed a significant incidence of structural as well as functional involvement of the tmj. Instead subjective symptoms and dental support seemed to be relatively independent, to confirm the heterogeneity of factors in masticatory dysfunction.
2113700	[Yellow nail syndrome: description of a case and review of the associated pathology].	1990 Mar	The AA. report a case of yellow nail syndrome associated with rheumatoid arthritis and monoclonal gammopathy (IgG-lambda). Because of the great variety of the diseases associated with this syndrome, the AA. suggest to control patients periodically to verify the probable appearance of other clinical manifestations.
2080618	[The sensitivity and specificity of the ARA diagnostic criteria for osteoarthrosis of the	1990	The sensitivity and specificity of the ARA criteria for osteoarthrosis of the knee joint (1986) were studied in 61 clinically ill patients. It was established that the diagnostic sensitivity and specificity for the group of clinical and laboratory criteria is 89.2% and 75% respectively, for the clinical and roentgenologic--91.9% and 83.3% and for the classical criteria--94.6% and 70.8%.
3103349	[Results of long-term D-penicillamine therapy in chronic polyarthritis].	1986 Nov	In 34 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for five years. Patients were included in the study only if the duration of their disease exceeded 6 months (upper limit 12 months), and there was involvement of 6 or more joints and an elevated erythrocyte sedimentation rate (1 Hour values greater than or equal to 25 mm). In 9 patients (26%) a decline in the activity index could be observed, but 7 of these subjects had a deterioration of findings as assessed by x-ray. The increase of the activity index indicated no therapeutic benefit in 25 patients (74%), which could be confirmed in all subjects by x-ray.
2653243	Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure	1989 Apr	A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.
3547608	[Mononuclear phagocytic cells in human rheumatoid synovial membrane. Histochemical and imm	1986 Dec	Non specific immunity in human rheumatoid synovium: histochemical and immunohistological analysis. Enzymatic activities and monocyte-specific membrane antigens were looked for on frozen sections from 25 synovial membrane samples from patients with rheumatoid arthritis. Classical histochemical reactions were used to identify non specific esterases, alkaline and acid phosphatases, ATPase and peroxidase. Indirect immunofluorescence was performed with a series of monoclonal antibodies to monocyte membrane antigens and HLA class II molecules. Technical pitfalls were successfully overcome, and specific labelings demonstrated the variety and heterogeneity of these markers among synovial cells and vascular endothelia. Reported data indicated that such a panel of investigations is useful to better define the non-specific immunological phenomenons which take place in this active pathological tissue. They suggest that numerous metabolic activities concur to sustain chronic inflammation.
2889327	[Implant changes in sliding endoprostheses].	1987 Aug	Analysis of 6 failures of resurfacing gliding prostheses of the knee with necessary exchange operations. By this procedure of exchange of the loosened parts of the alloplasty, a good functional result could be achieved with the exception of one case. Importance of careful preoperative indication of gliding prostheses of the knee, where axis deviations of the leg as well as instability of the collateral ligaments should be particularly observed.
3589735	The potential of computed tomography in visualising structures inside the metal cup in sur	1987	Computed tomography (CT) was employed to evaluate the femoral component of the prosthesis in surface-replacement total hip arthroplasty in seven patients suffering from rheumatoid arthritis. Image reconstruction using the high frequency filter resulted in an image of the cement-bone interface inside the cup which allowed the detection of bone resorption. This new application of CT could prove to be a valuable complement to conventional methods in the radiological assessment of metal cup arthroplasties.
2383076	A seasonal pattern in the onset of polymyalgia rheumatica.	1990 Jul	The seasonal distribution in the onset of polymyalgia rheumatica (PMR) was determined in 58 patients with the disease and compared with that in 44 patients affected by rheumatoid arthritis of elderly onset (EORA). Thirty six (62%) cases of PMR developed during May to August; by contrast, only 14 (31%) cases of EORA developed in the same months, this latter disease failing to show any seasonal clustering. The monthly distribution of PMR correlated with outside temperature and hours of sunshine. These data suggest that PMR might be triggered by such factors as actinic damage of superficial vessels or infective agents with a seasonal cycle. Finally, the summer clustering of PMR may be helpful in the differential diagnosis from EORA.
2501453	Functional significance of heterotopic bone formation after total hip arthroplasty.	1989	The effects of heterotopic bone formation on hip function after arthroplasty was studied in 145 cases of total hip arthroplasty. Hip muscle strength was determined 1.8-2.9 years after the operation, using a Cybex II dynamometer. Heterotopic bone formation was seen after 75% of the operations, and in 21% significant amounts developed (Brooker's classes III and IV). The gain in range of motion after surgery was significantly less in the groups with class III or IV heterotopic bone than in those without heterotopic bone formation. Heterotopic bone did not cause pain or Trendelenburg's limp after surgery; in fact, patients with trochanteric pain had less heterotopic bone than those without this pain. Hip flexion strength was greater in men with heterotopic bone than in those without heterotopic bone. Also, men with heterotopic bone formation had a higher mean maximum strength in extension but lower mean strength in abduction than did men without heterotopic bone (NS). When only patients with unilateral hip disease were considered, the same differences were found around the healthy hip; men with heterotopic bone formation had greater strength in flexion and extension than men without heterotopic bone formation and the same tendencies were seen in women. Accordingly, heterotopic bone had no serious impact on hip muscle strength in this study.
2348006	A causal analysis of chronic pain and depression.	1990 May	There is considerable controversy in the literature regarding the extent to which chronic pain and depression are associated and the possible causal relationship of such an association. The present study examines these issues with a sample of 243 patients diagnosed with rheumatoid arthritis (RA) who were mailed questionnaires for six waves of data collection. The results indicated that RA patients experience higher levels of depressive symptomatology than community samples. Using a two-latent-variable, cross-lagged design, covariance structural modeling was conducted on self-report measures of pain and depression over 6-month intervals. Results most strongly supported a causal model in which pain predicts depression during the last 12 months of the study.
2285755	Elastic wrist orthoses. Reduction of pain and increase in grip force for women with rheuma	1990 Sep	The aim of this study was to investigate effects of elastic wrist orthoses on pain, grip strength, and function. Twenty-two women with seropositive rheumatoid arthritis (mean age, 53 years) registered their pain on a visual analogue scale both with and without orthosis on the wrist of the dominant hand in three standardized activities of daily living (ADL) situations. Grip force at onset of pain was measured on an electronic instrument (Grippit) with three different grips. Pain was decreased by 39%, 42%, and 52% when using an orthosis in the three ADL situations. Anecdotally, the women noted that the splints provided support and decreased pain both in home, at work, and during leisure activities. Orthoses improved grip force at onset of pain by 26%, 22%, and 29%. All subjects showed reduced strength (20%-25%) when compared to grip strength in a group of women without rheumatoid arthritis.
2257803	[Pain as an indication for functional TMJ surgery].	1990 Jan	In 113 patients presenting with painful impediment of jaw function, which did not respond to non-surgical treatment, several kinds of functional surgery of the temporomandibular joint were applied. Comparison of the pre- and postoperative pain profiles of these patients show that good results from the surgery methods used could generally be expected when the patient, preoperatively, had pain restricted to the TMJ area with function. More unfavorable results were shown in patients with pain already present for years, muscular or bilateral pain as well as pain not related to function or pain at night. Continuous pain should only be seen as an indication for surgery with rheumatoid arthritis of the TMJ.
2351572	Clonal dominance among synovial tissue-infiltrating lymphocytes in arthritis.	1990 Jun	T-cell receptor gene rearrangement using a C beta probe was evaluated in 12 patients with rheumatoid arthritis, 2 with juvenile rheumatoid arthritis, and 1 with systemic lupus erythematosus, and in all the samples a dominant T-cell receptor gene rearrangement was noted. In rheumatoid arthritis identical T-cell receptor gene rearrangement was noted in freshly isolated synovial tissue-infiltrating lymphocytes (TIL) and the corresponding interleukin 2-propagated culture. TIL from five different joints obtained from one rheumatoid arthritis patient shared one dominant band, and TIL from three joints had an identical rearrangement. Limiting dilution experiments showed that 10% of T-cell clones had rearrangements matching the corresponding bulk in one rheumatoid arthritis patient. These findings lend further support to the suggestion that the clonal dominance noted among synovial tumor-infiltrating lymphocytes is the result of an in vivo process reflecting a selective T-cell receptor gene usage.
2183149	[Rheumatic diseases and alternative medicine].	1990 Feb 18	Besides the scientific- rational medicine alternative medicine keeps spreading in our days. The authors give a review of the possibilities of the alternative therapy of locomotor diseases. Patients suffering from locomotor diseases ask increasingly often for these therapeutical procedures. Literary review is given on acupuncture, manual therapy, homeopathy and certain physiotherapeutical techniques as well as on other less often applied alternative therapeutical procedures. It is stressed that alternative treatment may also involve potential danger. It is stated finally that as shown by the review of the literature well controllable clinical examinations required indispensably for the estimation of the efficacy of a therapeutical procedure are only in limited number at disposal.
2023211	Stimulatory response towards the 65 kDa heat shock protein and other mycobacterial antigen	1991 Feb	Molecular mimicry between mycobacterial antigens and components of human articular cartilage has been suggested to initiate the onset of rheumatoid arthritis (RA). Therefore, the proliferative response of peripheral blood (PB) and synovial fluid (SF) mononuclear cells (MNC) towards a variety of mycobacterial antigen preparations was tested in patients with RA and various non-RA inflammatory joint diseases. The antigen panel included a recombinant 65 kDa heat shock protein of mycobacterial origin which has recently been shown to stimulate arthritogenic rat T cell clones. In our study, no significant response towards the 65 kDa protein was observed with PBMNC of patients with or without RA. When compared to normal donors, the reactivity towards heat killed BCG M. tuberculosis and purified protein derivative was reduced in the blood of patients with RA while enhanced in the non-RA group, however these differences did not reach statistical significance. The data obtained with PBMNC were in striking contrast to the proliferative response of SFMNC. In the majority of cases both with RA and non-RA joint diseases the latter compartment was far better stimulated by mycobacterial antigens including the 65 kDa protein compared to corresponding PBMNC. However, in some cases an enhanced stimulation of SFMNC was also obtained with tetanus toxoid. Our data suggest that the enhanced reactivity of SFMNC may be a common feature of several inflammatory joint diseases and is not restricted to RA. These findings may indicate a preferential homing of antigen reactive (memory) T cells to the inflamed joints while the circulating pool of lymphocytes is depleted of this population.
1768169	Coexistent Felty's syndrome and palindromic rheumatism.	1991 Dec	Palindromic rheumatism is a syndrome of intermittent abrupt onset monoarthritis with asymptomatic intercritical periods of variable duration, which commonly evolves into rheumatoid arthritis. Felty's syndrome consists of leucopenia (selective neutropenia) and splenomegaly, usually occurring in longstanding classic rheumatoid arthritis. Felty's syndrome can be confused with the more recently recognised rheumatoid arthritis associated large granular lymphocyte proliferative disease. This paper describes a patient with palindromic rheumatism presenting with Felty's syndrome in whom large granular lymphocyte proliferative disease was ruled out by lymphocyte phenotyping.