Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1369851 | [Longterm results of McIntosh hemiarthroplasty of the knee in patients with rheumatoid art | 1990 | A series of 35 knees operated on between 1967 and 1977 was reviewed. The follow up of 5 years or longer revealed over 40% of excellent and good results. The analysis of over 50% of poor results is suggestive of inadequate indications for hemiarthroplasty of the knee. In authors opinion Mc Intosh procedure should be still performed providing the indications are very accurate. | |
| 3494848 | Interleukin-1 secretion by peripheral blood monocytes and synovial macrophages from patien | 1987 Feb | Blood monocytes and synovial fluid and tissue macrophages were examined for their ability to produce interleukin-1 (IL-1) measured in a mouse thymocyte proliferation assay. Spontaneous production of IL-1 by monocytes from patients with rheumatoid arthritis (RA) or ankylosing spondylitis was higher than that by cells from normal subjects, patients with osteoarthritis or patients with RA treated with gold. IL-1 production in response to LPS stimulation was similar in all groups. Spontaneous IL-1 production by synovial fluid macrophages from patients with RA was similar to that of their monocytes, but the response to LPS was smaller. Synovial tissue macrophages produced little IL-1. Similar results were obtained in assays of fibroblast proliferation. | |
| 2595022 | [Involvement of the temporomandibular joint in rheumatoid arthritis]. | 1989 Oct | A tomographic investigation was performed on 51 randomly-selected rheumatic patients, according to American Rheumatism Association criteria. Fourteen males and 37 females, aged 26 to 73 (mean age 50.9) were examined in order to identify the prevalence of temporo-mandibular joint involvement. By means of a special examination form, a contemporary clinical survey of both signs and symptoms of mandibular dysfunction was also conducted: the data were used for calculating the Helkimo anamnestic and clinical dysfunction indices. As for X-ray diagnosis, and original linear and angular analysis was proposed to measure the relationship between condyle and fossa in intercuspal position and during opening: the anterior joint space often increased and protrusive condylar path was reduced in more than 41% of patients. Structural changes were also evaluated by classifying the shape of both the condyle and the glenoid fossa (rounded, wedge-shaped and flattened). A special score was used to quantify these morphological features: only 4% of the whole of joints resulted uninjured. The most involved joint portions were the articular tubercle and the anterior condylar pole. Many cases were demonstrated of marked resorption and remodelling of the condyle, of increased joint space and erosion of the fossa; in other instances, reduced joint spaces and sclerosis were observed, depending on associated degenerative arthritis (usually more painful). Sex and age differences were not significant. Severity of clinical dysfunction and seriousness of the lesions coincided, whereas subjective symptoms were relatively independent. At any rate, the survey demonstrated a clear prevalence of structural, as well as functional, involvement of the temporo-mandibular joint in rheumatoid arthritis and suggested a more careful and multimodal therapeutic approach. | |
| 3091675 | Gold-induced ileitis. | 1986 Apr | We describe a patient with rheumatoid arthritis who developed severe ileitis after being treated with gold salts; the patient responded to elimination of the gold therapy and to BAL. | |
| 3111762 | Mononuclear phagocyte system Fc-receptor function in patients with seropositive rheumatoid | 1987 Mar | Mononuclear phagocyte system (MPS) Fc-receptor function in 20 patients with seropositive rheumatoid arthritis (RA) was investigated using radiolabelled autologous erythrocytes coated with an average of 5,800 molecules of anti-rhesus IgG (E. IgG). Although clearance times (T1/2) of E. IgG tended to be longer in RA patients than those in healthy controls (46 +/- 6 min vs 38 +/- 5 min, mean +/- s.e.m., P = 0.38), this did not reach statistical significance. Liver spleen uptake ratios (LS ratios) were increased in patients with RA (13/100 +/- 1/100 vs 7/100 +/- 1/100, P less than 0.05). There was no correlation of T1/2 or LS ratios with articular disease activity, vasculitis, ESR, IgM containing immune complex levels or Clq-binding immune complex levels. Although Clq-binding immune complex levels were significantly higher in patients with vasculitis than in those without (P less than 0.01), T1/2 and LS ratios did not differ in these two groups of patients. The T1/2 and LS ratios of E.IgG did not reveal a defect in MPS Fc-receptor function and did not correlate with one of the above-mentioned clinical and immunological parameters. We suggest that in order to establish a possible defect in Fc-receptor function correlating with disease activity and immune complex levels in RA patients, soluble immune complexes or immune complex-like material should be used as probes. | |
| 2087585 | Resistance exercise training for persons with arthritis. | 1990 Nov | This article reviews the benefits of resistance exercise training in the rehabilitation of persons with arthritis. Without question, the person with arthritis has a need to develop muscular strength and endurance in order to maintain functional movement. Deficits in muscular strength, muscular endurance, range of motion, and other physical fitness indices have been identified clearly in the literature. Research studies have indicated that the effect of training persons with arthritis is promising; however, deficits exist in the literature on the types of specific exercise protocol that are most effective in training persons with arthritis. Guidelines for program development are provided with suggestions for alternative types of resistance exercise programs. It is hoped that the reader will look closely at resistance exercise programs as an important component in the rehabilitation of a person with arthritis. | |
| 1914238 | Occurrence of lymphocytotoxins in multi-case rheumatoid arthritis families: relation to HL | 1991 Oct | The presence of lymphocytotoxic antibodies (LCA) and their association with HLA haplotypes has been studied in 27 multi-case rheumatoid arthritis (RA) families (13 multiplex and 14 simplex) in Northern India. Of the total 59 RA patients, 69.4% had cytotoxins in their sera as compared with 2.5% of healthy controls. No differences were observed in the frequency of LCA in relation to sex and rheumatoid factor. LCA against B cells were significantly more predominant than those against T cells. Twenty families studied for correlation of HLA with LCA showed greater intensity of reaction with DR4+ haplotypes, particularly in simplex families. Similarly, the frequency of LCA among patients and unaffected parents was greater in simplex compared with multiplex families. Haplotype sharing with the patient was increased in the relatives positive for cytotoxins in these families. An immunogenetic contribution made by the affected parent and a common environmental stimulus may be responsible for the increased production of LCA in multi-case families with RA. | |
| 2590800 | Anti-type II collagen antibody in naturally occurring canine joint diseases. | 1989 Dec | Autoimmunity to collagen was investigated in several naturally occurring arthropathies of the dog. Increased levels of serum anti-native collagen type II antibody, as assessed by ELISA, were shown in 72.4% of dogs with rheumatoid arthritis (RA), 88% of dogs with infective arthritis (IA) and 52% of dogs with osteoarthritis (OA) (p less than 0.001). The mean levels of antibody in cruciate disease patients (CR) were also significantly increased compared to control dogs (p less than 0.01). Serum anti-collagen antibody in OA dogs correlated with that in precipitated serum immune complexes. There was also a correlation between anti-collagen antibody level in synovial fluid and in synovial fluid complexes in dogs with rupture of the cranial cruciate ligament. In all patient groups, collagenase digestion of polyethylene glycol (PEG) precipitates from sera and synovial fluids caused a significant rise in specific antibody levels to collagen, indicating the presence of collagen-anti-collagen complexes in all arthropathies. In dogs with RA, the levels of collagen-specific antibody in synovial fluid complexes correlated with the total IgG in these complexes. These findings implicate collagen-anti-collagen complexes in the pathogenesis of naturally occurring joint diseases in the dog, but they are unlikely to be the primary aetiological mechanism. | |
| 2519011 | The distinct subgroup of patients with rheumatoid arthritis shown by Ig G3-reactive rheuma | 1989 | The reactivity of rheumatoid factor (RF) with immunoglobulins of the IgG3 subclass was examined in 49 patients with rheumatoid arthritis (RA) using two types of IgG3 myeloma (routine and IgG3m-15 allotype). Among 49 patients, serum from eight cases showed positive reactivity with both types of IgG3 myeloma by radio-immunoassay (RIA). The isotype of IgG3-reactive RF was not specific; it belonged to the IgM class as well as the IgG subclasses IgG1, IgG2 and IgG4. The patients with IgG3-reactive RF belonged to the clinically-severe classification of RA, having a high erythrocyte sedimentation rate (ESR), high titre in the RA hemagglutination (RAHA) test, and above all they had low levels of complement. Generally, it is concluded that patients with IgG3-reactive RF have serious arthritis and that IgG3-reactive RF might play an important role in the inflammatory process. Furthermore, it was also shown that the RF-reactive site was not associated with the protein-A binding site of IgG3, since RF reacting with IgG3m-15 reacted similarly with routine IgG3, regardless of the difference of the protein-A binding activity. This was confirmed by adding protein-A to the reaction of RF and IgG3m-15 which binds with protein-A. This suggests that the actual reactive site of RF is different to the site that binds protein-A. | |
| 3818588 | Fibronectin gene expression in polymorphonuclear leukocytes. Accumulation of mRNA in infla | 1987 Feb 15 | Using a fibronectin cDNA probe, we have studied the accumulation of fibronectin mRNA in polymorphonuclear leukocytes (PMN) in response to inflammation. Nonactivated PMN from human peripheral blood were used as a source of noninflammatory cells and PMN from inflamed knee joints of patients with chronic inflammatory joint disorders (rheumatoid and psoriatic arthritis) were used as a source of inflammatory cells. By dot blot and Northern hybridization analysis, we have found the presence of fibronectin mRNA in these cells. Its size was estimated at approximately equal to 8.7-8.8 kilobases. When noninflammatory PMN were compared to inflammatory PMN in terms of fibronectin mRNA accumulation, a marked increase was found in inflammatory cells (2- to 12.7-fold stimulation). It was also observed that the increased mRNA levels in inflammatory PMN lead to increased synthesis of the protein. These findings establish that PMN are part of the fibronectin-producing cells and that the level of mRNA in these cells is influenced by the inflammatory process. | |
| 2711919 | Effect of naproxen on renal haemodynamics in elderly patients with arthritis. | 1989 Jan | The effects of naproxen on renal haemodynamics were observed in ten elderly arthritic patients who were otherwise healthy and without clinical evidence of renal disease. Glomerular filtration rate (GFR,51Cr-EDTA clearance) and effective renal plasma flow (ERPF, 125I-iodohippurate clearance) were measured after 2 weeks' treatment with naproxen 500 mg twice daily and again after 2 weeks off the drug, in random order. Baseline values for GFR and ERPF were within normal limits (mean 72 ml/min/1.73 m2, 110% predicted and 326 ml/min/1.73 m2, 111% predicted, respectively). On naproxen, ERPF and renal blood flow decreased by 10% and 9%, respectively (-32 ml/min/1.73 m2; p = 0.05 and -49 ml/min/1.73 m2; p less than 0.01). These events produced no untoward clinical effects. Nevertheless, this response might impair the kidney's ability to preserve GFR if a further stress were to supervene. Consequently, temporary withdrawal of non-steroidal anti-inflammatory drugs from elderly patients should be considered in response to intercurrent illness or drug therapy likely to compromise renal blood flow. | |
| 2084864 | [Two cases of rheumatoid arthritis complicated with vasculitis-induced ischemic enterocoli | 1990 Oct | Episodes of catastrophic entero-colitis associated with mesenteric vascular insufficiency in patients with rheumatoid arthritis(RA) have rarely been recorded thus far. We herein report two cases of RA complicated with severe attacks of entero-colitis presumably due to mesenteric vasculitis. Surgical intervention was necessary in the first case, while the second patient recovered well only through conservative therapy. Case 1: A 74-year-old man with history of RA since 1985 started to complain of abdominal discomfort and nausea early in February, 1989. On February 12, Episodes of tarry stool developed. Rapid down-hill clinical course prompted laparotomy under the clinical diagnosis of peritonitis. Ischemic changes were observed at the ileum end, the entire length of which was 120 cm orally from the cecum. The site was resected. Multiple linear and aphthoid ulcer lesions were discovered throughout the entire lumen. Histopathologically, evidence of necrotizing vasculitis such as fibrinoid necrosis and mural thrombi was demonstrated in small arteries of the submucosal layer underlying the ulcer lesion. Case 2: A 63-year-old woman who had been suffering from RA since 1980 noticed the onset of nausea, abdominal pain and bloody diarrhea in July, 1989. Colonoscopy examination revealed multiple linear and aphthoid ulcers in the sigmoid colon which was presumed to be due to ischemia. Laboratory evaluation at that time demonstrated hypocomplementemia, positive circulating immune complex and high titer of anti-DNA antibody. Corticosteroid therapy with moderate dose was successful in alleviation of all the abnormal findings and the patient fully recovered three months after her initial GI episode. | |
| 2540099 | Phospholipid metabolism in polymorphonuclear leukocytes from rheumatoid arthritis patients | 1989 | Arachidonic acid (AA) metabolism and phospholipase A2 (PLA2) activity were measured in the peripheral blood polymorphonuclear leukocytes (PMNL) from ten patients with rheumatoid arthritis (RA) on treatment with various non-steroidal anti-inflammatory agents (NSAIA). AA metabolism and PLA2 activity were measured both initially and after treatment with either placebo or Clotrimazole, a broad spectrum anti-mycotic agent, as a possible anti-rheumatic drug. AA metabolism was also measured in PMNL from ten patients with active RA untreated with any NSAIA and ten normal volunteers. Using 3H-AA prelabeled cells, we show that there was a significantly higher (P less than 0.025) production of 3H-LTB4 in response to stimulation with the calcium ionophore A23187 in untreated RA patients than in normal volunteers (mean +/- S.D.:4.8 +/- 1.6% and 3.1 +/- 1.0%, respectively). The production of 3H-LTB4 by PMNL from patients on NSAIAs was less elevated (mean +/- S.D.:4.1 +/- 1.5%) and was not significantly different from normal controls. Concurrently we examined PLA2 activity in PMNL-sonicates from ten of our study patients using autoclaved [14C]oleate-labeled E. coli biomembranes as an exogenous substrate. Using linear regression analysis, we demonstrate a significant correlation between in vitro PLA2 activity and the release of 3H-AA from the cellular phospholipids (deacylation) in response to A23187 stimulation (r = -0.526, P less than 0.025). We also demonstrate significant correlations between the overall clinical state of the RA patient, as evaluated by a modified rheumatoid activity index (MRAI), and both the release of 3H-AA from the cellular phospholipids and its production of total [3H]eicosanoids (r = -0.557, P less than 0.025 and r = 0.644, P less than 0.005, respectively). This data suggests that: PLA2 activity may, in part, account for the higher generation of LTB4 by RA PMNL; NSAIAs may be capable of modulating this abnormality; and Clotrimazole may affect the clinical or laboratory data of RA patients already on treatment with NSAIA. | |
| 3059797 | Genetic susceptibility to rheumatoid arthritis and human leukocyte antigen class II polymo | 1988 Dec 23 | Genetic susceptibility for rheumatoid arthritis has been associated with both human leukocyte antigen (HLA)-DR4 and HLA-DR1, depending on the ethnic origin of the population under study. Furthermore, various subtypes of DR4 exist, only some of which appear to be associated with rheumatoid arthritis. DNA sequence analysis of the DR-beta chain genes encoding the DR4 subtypes as well as DR1 has led to the observation that similar third hypervariable region sequences are found on rheumatoid arthritis-associated DR-beta chain alleles. The data indicate that third hypervariable region sequence polymorphisms strongly influence T cell recognition as well as risk for rheumatoid arthritis. This has led to the hypothesis that genetic susceptibility for rheumatoid arthritis is due to a group of similar third hypervariable region sequences that may share conformational determinants important in antigen presentation and/or immune regulation. | |
| 3801070 | Elevated MMPI scores for hypochondriasis, depression, and hysteria in patients with rheuma | 1986 Dec | The Minnesota Multiphasic Personality Inventory (MMPI) scales for Hypochondriasis, Depression, and Hysteria were studied in patients with rheumatoid arthritis (RA). The RA patients showed elevated scores on these scales, and these results are similar to those reported in each of 6 published studies. The elevated MMPI scale scores can be explained largely by 5 "disease-related" MMPI statements which met 2 criteria: they were among 11 of the 117 MMPI statements that two-thirds of rheumatologists predicted would be RA-associated; and RA patients and normal subjects differed significantly in their responses to these statements. The responses of RA patients and normal subjects to most other statements in the MMPI Hypochondriasis, Depression, and Hysteria scales were quite similar. In RA patients, responses to "disease-related" statements were correlated with results of measures of disease activity, which indicates that responses to these MMPI items reflect the severity, as well as the presence, of RA. These findings suggest that new criteria are needed for validation of the MMPI as a clinical tool for the recognition of hypochondriasis, depression, and hysteria in a patient who has RA. | |
| 1784887 | MRI of knee arthritis in rheumatoid arthritis and spondylarthropathies. | 1991 | The knees of fifty-two patients suffering from rheumatoid arthritis (RA), 22 patients with seronegative spondylarthopathies (SA) as well as of 20 healthy volunteers were examined by magnetic resonance imaging (MRI). Osseous erosions (RA 52%-SA 18%; P less than 0.005), Baker cysts (RA 56%-SA 12%; P less than 0.005), pannus formation (RA 67%-SA 36%; P less than 0.05), and cartilage thinning with narrowing of the joint space (RA 46%-SA 18%; P less than 0.05) proved to be more frequent MRI findings in patients with RA. Additionally, in patients with RA erosions were more extensive. Follow-up MRI examinations of 19 patients revealed an improvement in MRI changes in SA within an average interval of 6 months. No substantial changes were noted in 7 of 13 RA patients. Quantitative and qualitative MRI findings of knee arthritis differ in patients with RA and SA and this was statistically significant. However, as there is considerable overlap of the MRI and radiographic changes in both groups the discriminating diagnostic value in the individual case was limited. | |
| 2396201 | [The use of a modified Health Assessment Questionnaire for evaluating the effectiveness of | 1990 | A study was made of a possibility of estimating the efficacy of hospital therapy of patients suffering from rheumatoid arthritis (RA) using the modified Stanford health assessment questionnaire. The general functional index (GFI) derived on the basis of the questionnaire was found to be in good agreement with a number of the commonly accepted indicators in rheumatology: Richi's articular index, the swelling index, the power of pain in accordance with the visual analog scale, hand force as well as with the psychological and social characteristics. The GFI was shown to decrease significantly after the treatment carried out under hospital conditions together with a decrease of pain and the articular index (p less than 0.001) both in grave RA patients with an unfavorable functional and work fitness prognosis and in patients with milder RA, having a favourable prognosis. It is recommended that the GFI may be used for estimating the efficacy of the treatment in addition to other indicators and measurements. | |
| 2425605 | The effects of some polysulphated polysaccharides on hyaluronate (HA) synthesis by human s | 1986 | The in vitro synthesis of HA in synovial fibroblasts derived from normal and rheumatoid joints was investigated. Incubation of these cells with ArteparonR and a variety of sulphated dextrans showed that macromolecular HA synthesis could be modified by these drugs. ArteparonR and a dextran sulphate (DS1) of molecular weight 20,600 and 0.8 sulphate substitution stimulated HA synthesis in rheumatoid cells by approximately 150%. In contrast the dextrans with higher sulphate substitution but similar molecular weight were less effective. Gel filtration chromatography of media from drug-treated cells showed an increase in HA hydrodynamic size. | |
| 2794708 | Rehabilitation of atrophied muscle in the rheumatoid arthritic hand: a comparison of two m | 1989 Aug | This study compares the effectiveness of two therapeutic electrotherapies which result in plastic adaptation in the atrophied muscle of rheumatoid arthritic hands. The natural discharge pattern of a fatigue-resistant motor unit (eutrophic electrotherapy) was more effective than a uniform 10 Hz electrotherapy. It was concluded that uniform 10 Hz electrotherapy ignored the information carried in the motor unit action potential spike train, which was the signal inducing rapid and behaviourally effective plastic adaptation. | |
| 2446384 | Antikeratin antibodies in rheumatoid arthritis. Methods and clinical significance. | 1987 | A method to determine antikeratin antibodies (AKA) is described. AKA were detected by indirect immunofluorescence technique on rat esophagus as antigen in sera of patients with definite rheumatoid arthritis (RA). The frequency of AKA in rheumatoid factor (SCAT/Waaler-Rose) positive RA was 64% and in SCAT-negative RA, 28%. Of 61 control patients with non-RA rheumatic diseases, none was AKA-positive. Of healthy controls, 2.5% were AKA-positive. In serum from 88 definite RA patients, AKA were compared with precoded clinical features. A highly significant correlation to AKA was found with the presence of rheumatoid hand deformity. Some correlation to positive SCAT titre and s-Haptoglobin was observed. Our study suggests that determination of AKA will be of value in the diagnosis of RA, especially in rheumatoid factor negative cases and that the presence of AKA indicates a more aggressive form--or results of an aggressive course--of the disease. |