Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2181657 | [Ultrasound of the knee joint: normal values and changes in rheumatoid arthritis]. | 1990 Feb | The bursa suprapatellaris, infrapatellaris, the patella tendon, condylar cartilage, menisci and fossa poplitea were examined sonographically in 56 healthy persons in defined sections. References for normal findings are given. The examination of 22 patients with rheumatoid arthritis revealed joint effusions, Baker cysts, synovial hypertrophy, intraarticular septae and changes in the echogenicity of the synovial fluid. | |
| 3437208 | Metacarpo-phalangeal joint replacement with a new prosthesis: description and preliminary | 1987 Oct | A new prosthesis for the metcarpo-phalangeal joint is presented. Its advantageous design features and the early results following its use suggest that it is of value in treating the painful, stiff and ulnar deviated metacarpo-phalangeal joint in the rheumatoid hand. | |
| 2175453 | Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rhe | 1990 | Circulating human neutrophil granulocytes (PMNs) from patients with rheumatoid arthritis (RA) have earlier been described to possess an enhanced capacity for production of certain 5-lipoxygenase-derived metabolites of arachidonic acid (AA), 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). In the present investigation the endogenous AA metabolism of synovial fluid PMNs of RA patients was studied and compared with that of the corresponding circulating PMNs. Synovial fluid PMNs prelabelled with 14C-AA released significantly less radioactivity than circulating PMNs when stimulated with calcium ionophore. Furthermore, synovial fluid PMNs produced significantly smaller amounts of both 5-HETE and LTB4 than circulating PMNs from the same patients, whereas no such difference was observed in the LTB4 catabolites or the cyclo-oxygenase products. More information dealing with the complex way in which arachidonic acid is metabolized in diseased RA joints may provide future rational approaches in the treatment of this chronic inflammatory disease. | |
| 2657048 | Does the acetyl group of aspirin contribute to the antiinflammatory efficacy of salicylic | 1989 Mar | In a multicenter, double blind, parallel group study, 233 patients with classical or definite rheumatoid arthritis (RA) were randomized to 12 weeks of either salsalate (salicylsalicylic acid, nonacetylated salicylate) or aspirin following disease flare. One hundred-fifty patients completed, 83 taking salsalate and 67 taking aspirin. Patients received initial doses of 3 g/day of salsalate or 3.6 g/day of aspirin. Doses were adjusted during the first 5 weeks for efficacy and tolerance. Both treatments were equally effective as measured by all the usual variables, but there was a higher incidence of severe gastrointestinal problems among patients taking aspirin. Thus, this study demonstrated that the acetyl group of aspirin does not enhance the antiinflammatory efficacy of salicylic acid in RA. | |
| 2355999 | Septic monarthritis due to Pasteurella multocida after a cat scratch in a patient with rhe | 1990 Apr | A 60-yr-old woman with a history of seropositive rheumatoid arthritis and using a low dose of corticosteroids presented with a very painful, swollen, red coloured knee with limited range of motion. Physical examination revealed a scratch on her left lower leg without discolouration or induration. Synovial fluid cultures yielded Pasteurella multocida. The pathogenetic significance of this commensal of cats and dogs in man is discussed. | |
| 1817565 | Alloimmunization to human immunoglobulin genetic markers is frequent in early rheumatoid a | 1991 | HLA and Gm allotypes of 99 consecutive Swedish patients with rheumatoid arthritis were determined. Ninety-two of the 198 haplotypes contained DR4, a significant increase. The patients' sera from 3 different occasions were studied for anti-immunoglobulin profile as judged by 6 selected anti-Rh coats, 4 of them being monoclonal anti-Ds restricted as to allotype. Ninety-two of the patients were reactive with a polyclonal anti-Rh Ri as against 10 with the monoclonal carrying the G1m(f) allotype. Antibodies to Ig coats carrying defined allotypes were more frequently observed in patients not carrying the allotype in question than in those individuals possessing it. The difference was significant or highly significant as regards presence/absence of G1m(a), G3m(b) and G3m(g), respectively. Anti-G1m(a) and anti-G3m(g) cooccurred in 17 of the patients. Results consistent with presence/absence of particular anti-immunoglobulins at the 3 examinations were observed in 74 of the patients. Gm allotypes or antiallotypes were not statistically related with DR4 status. In conclusion, alloimmunization to Gm markers frequently occurs in early rheumatoid arthritis. | |
| 2757408 | Acute febrile neutrophilic dermatosis (Sweet's syndrome). Association with rheumatoid vasc | 1989 Aug | A 58-year-old woman suffering from rheumatoid arthritis complicated by a leukocytoclastic vasculitis had an acute febrile neutrophilic dermatosis (Sweet's syndrome) develop immediately after worsening of her arthritic condition. This association supports the hypothesis that immunologic abnormality is involved in the pathogenesis of Sweet's syndrome and raises the question of a possible common pathogenic pathway between neutrophilic dermatoses and leukocytoclastic vasculitis. | |
| 3345220 | A new autoantibody in patients with rheumatoid arthritis: characterization of the anti-HaT | 1988 Jan | A unique, new autoantibody, anti-HaT-1, has been identified in the serum of patients with rheumatoid arthritis (RA). Anti-HaT-1 antibody is predominantly IgM, and reacts by double immunodiffusion with HaT-1 antigen, an acidic protein in human and rat liver supernatant (MW approximately 150,000). It was detected in 9 of 38 patients with RA, 2 of 15 patients with RA and Sjögren's syndrome, and none of 92 patients with other connective tissue diseases, indicating that this autoantibody is highly specific for RA. | |
| 3500961 | The Leu-1 B-cell subpopulation in patients with rheumatoid arthritis. | 1987 Nov | Ly-1-B cells have been shown to be elevated in autoimmune mice, especially NZB, and to secrete IgM autoantibody, suggesting that Ly-1 B cells may participate in autoimmune diseases. In this study, B-cell populations carrying Leu-1, a human T-cell surface molecule homologous to mouse Ly-1 (Leu-1 B), were examined by dual fluorescence flow cytometry, in peripheral blood lymphocytes taken from patients suffering from various autoimmune disease. These B cells were shown to be present at a significantly high percentage in rheumatoid arthritis (RA) patients. There was no significant correlation among the incidence of Leu-1 B cells, rheumatoid factor (RF) titers, and the amount of IgM production in vitro. There was, however, a significantly high incidence of Leu-1 B cells in RA patients with a high RF titer (greater than 5 X 2(13), suggesting that these B cells in RA may play an important role in IgM RF production in vivo. | |
| 2672295 | Ultrasonographic evidence of hip synovitis in patients with rheumatoid arthritis. | 1989 | One hundred non-operated hip joints in 50 adult patients with active rheumatoid polyarthritis were examined by ultrasonography as well as by clinical methods and X-ray. In 15 hip joints in 11 patients, ultrasonography indicated intra-articular effusion (a distance between the joint capsule and bone of more than 7 mm in 14 and a difference between the two sides of more than 1.5 mm for one hip). There were no subjective symptoms associated with five of these hip joints, the X-ray findings were normal for 11 hips, and careful clinical examination showed normal findings for one hip joint. The routine clinical examination used in the hospital had revealed pathological findings in only two of these hip joints. It is concluded that ultrasonography may reveal intra-articular effusion or synovitis in clinically and radiologically apparently normal hip joints of patients with active rheumatoid arthritis. The increase in pain and restricted motion was statistically significant in the hips for which ultrasonography indicated intra-articular effusion. Hips that appear pathological in ultrasonography are thus synovitis, and do not fall within the range of normal variation for healthy hip joints. | |
| 2197995 | In situ hybridisation. | 1990 Jun | In situ hybridisation of mRNA in tissues or cell preparations is a powerful technique for studying gene expression. When combined with cell phenotyping with monoclonal antibodies it gives insights into the cellular basis of disease in vivo. The technique has also been used widely to identify foreign nucleic acids--for example, bacterial or viral, in host cells. The major disadvantages of this approach in the past have been that it was technically demanding, time consuming, and provided qualitative rather than quantitative results. Now, with the use of non-radioactive probes and improved imaging systems, the full potential of this form of molecular analysis is increasingly accessible and should generate rapid advances in many fields. | |
| 3794486 | A review of total elbow arthroplasty and an early assessment of the Liverpool elbow prosth | 1986 Oct | The elbow joint is frequently affected by rheumatoid arthritis causing pain and disability which limits the use of the upper limb. Excisional or interpositional arthroplasties of the elbow have failed to provide satisfactory results. The design of a total elbow prosthesis in early 1970's followed the principles and evolution of joint replacement in the lower limb. In this study twenty-two Liverpool elbow prostheses (non-constrained) in nineteen patients were reviewed with an average follow-up of 26.5 months. Postoperatively the arc of flexion-extension improved with no change in pronation-supination range. Pain was significantly improved postoperatively. Rheumatoid patients were very pleased, but patients with secondary osteoarthritis were less satisfied. Two prostheses became loose and three had deep infection and were removed. Five patients had postoperative symptoms of ulnar neuritis and in three the symptoms gradually resolved. Early results of total elbow arthroplasty are promising in carefully selected patients. | |
| 2479387 | Differences in responses of normal and rheumatoid arthritis peripheral blood T cells to sy | 1989 Nov | We examined the response of normal T cells to dendritic cells isolated from the synovial fluid (SF) of patients with either rheumatoid arthritis (RA) or seronegative spondylarthropathies (rheumatoid variants) and to dendritic cells from normal and RA peripheral blood (PB) in the allogeneic mixed leukocyte reaction. Despite the differences in the response kinetics, the stimulatory capacity of SF dendritic cells was similar to that of PB dendritic cells in a 7-day mixed leukocyte reaction. We also tested the responsiveness of normal and RA PB T cells to various allogeneic dendritic cells and found that RA PB T cells responded poorly to both rheumatoid variant SF dendritic cells and normal PB dendritic cells. However, when dendritic cells from RA SF were used as stimulators, the response of RA PB T cells was significantly greater than that of normal PB T cells (P less than 0.02). This difference in response was explained in part by a proliferation of the CD8 T cell subset. There was also a shift of low-intensity CD4+, CDw29+ cells to high-intensity CD4+, CDw29+ cells seen in RA PB T cells but not in normal PB T cells, by fluorescence-activated cell sorter analysis. | |
| 3130212 | Aurothioglucose overdosage in five patients with rheumatoid arthritis. | 1987 Dec | Five patients with active seronegative, rheumatoid arthritis, HLA-DR3 negative, received inadvertently 250 to 500 mg of aurothioglucose instead of their usual weekly dose, during standard remission-inducing chrysotherapy. Subsequently a rapid and sustained clinical remission appeared in all five patients. | |
| 2222128 | [Hemangioblastoma associated with syringomyelia and syringobulbia in a patient with rheuma | 1990 Mar | A 80-year-old woman with a 25-year history of seropositive, erosive rheumatoid arthritis (RA) presented with a neurological clinical picture consistent with cervical cord compression, secondary to a hemangioblastoma with medulla, cerebellum and spinal cord involvement, with associated syringomyelia and syringobulbia. We present a review of the literature remarking the low frequency of this tumor (1%-2% of all intracranial tumors) and its exceptional presentation over the age of 70. We have not been able to find no cases of hemangioblastoma associated with rheumatoid arthritis, thus, we think, this association may be casual. Nevertheless, it emphasizes the need for careful evaluation of patients with rheumatoid arthritis and neurological symptoms before ascribing them to complications due to the rheumatoid disease itself. | |
| 2167685 | Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthri | 1990 Aug | We studied the effects of a single, oral dose of methotrexate (MTX) on arachidonic acid metabolism in neutrophils from 6 patients with rheumatoid arthritis, which were obtained 1 day before and 1 day after their usual weekly MTX dose. The 6 patients had received a mean weekly MTX dose of 9.6 mg (range 5-15) for a mean of 61.7 months (range 58-64), and none received concomitant corticosteroids. Total generation of leukotriene B4 (LTB4) in neutrophils stimulated ex vivo with 10 microM calcium ionophore A23187 for 20 minutes was significantly suppressed, by a mean of 53%, after the MTX dose compared with the predose levels (mean +/- SEM 13.0 +/- 1.4 ng/10(6) cells versus 6.0 +/- 0.9 ng/10(6) cells; P = 0.0019), reflecting a comparable suppression of both released and cell-retained LTB4. A 49% decrease in omega-oxidation products of LTB4 demonstrates that decreased LTB4 synthesis, rather than increased degradation, is responsible for the decrease in LTB4 generation. The absence of a significant change in either 3H-labeled arachidonic acid release or platelet-activating factor generation indicates that the observed decrease in LTB4 synthesis was apparently not caused by diminished phospholipase A2 activity. A 28% decrease in the total formation of the 5-lipoxygenase products 5-hydroxyeicosatetraenoic acid and the 6-trans-LTB4 diastereoisomers, and a 48% suppression of production of LTB4 plus its omega-oxidation metabolites after the MTX dose suggest inhibition of 5-lipoxygenase activity and possible suppression of leukotriene A4 epoxide hydrolase activity. | |
| 3767462 | Bone metabolism during methylprednisolone pulse therapy in rheumatoid arthritis. | 1986 Sep | The deleterious effects of corticosteroids (CS) on bone are well known, but probably differ depending on duration and dosage of CS therapy. Presently huge amounts of CS are given over a short period of time in different rheumatic conditions. Not much is known about the effect of this kind of CS treatment on bone metabolism. Twenty patients with persistently active rheumatoid arthritis were treated with 1 g methylprednisolone (MP) three times on alternate days over a five day period. Twenty four hours after the first MP pulse serum calcium was increased and the values of parathyroid hormone and 1,25-dihydroxyvitamin D tended to increase. After the second MP pulse, however, these values had returned to the starting values. The urinary calcium excretion increased during MP pulse therapy and returned to the initial value immediately after the pulse therapy. The hydroxyproline excretion tended to decrease during therapy and stayed decreased immediately afterwards, indicating a decrease in bone resorption. It is concluded that bone metabolism is not seriously affected during MP pulse therapy. | |
| 2472001 | Thymic hormones and interferons in the treatment of rheumatoid arthritis. | 1988 | Interferon gamma (IFN-gamma) is known to increase the rate of biosynthesis and membrane density of Ia in cells that have normal basal expression of Ia such as Ia+-monocytes and thymic epithelium. IFN-gamma also induces de novo expression of Ia in other cell types such as Ia- macrophages, vascular endothelium, fibroblasts, a.o. Consequently, IFN-gamma enhances the activation of specific T-helper cells and the immunity that is dependent on T-helper cells. If the antigen is a viral product expressed on the membrane of an infected cell, IFN-gamma inducing an aberrant Ia expression, will produce a T-helper cell activation from which the host will benefit. If the antigen presented by the newly Ia+ cell is an autologous cell membrane molecule, one that is unique to a particular tissue and of which the host T-helper cells are not tolerant, IFN-gamma can trigger an autoimmune attack. Several recent reports have described a decreased level and activity of IFN-gamma in the rheumatoid joint environment, in vitro as well as in vivo. It is still unknown whether these findings are due to a defective production or to a physiological down regulation of IFN-gamma in rheumatoid arthritis (RA). Consequently it is not clear whether the pharmacologic administration of IFN-gamma to RA patients would reduce the disease activity or induce a disease exacerbation. Initially, short term assays were performed with daily subcutaneous injections of IFN-gamma (50 micrograms or 100 micrograms). As some encouraging results were obtained, two double-blind long-term studies were started.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2204218 | [Concept and criteria of spondylarthritis]. | 1990 Jun 30 | Since several rheumatic disease share common features, they led to the concept of the spondarthritides: ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritides, juvenile oligoarthritis (type II), and questionable pustolotic arthro-osteitis and Behçet's disease. Furthermore undifferentiated spondarthritides have to be considered. They occur more frequently than ankylosing spondylitis. Definite ankylosing spondylitis is classified according to the New York-criteria, which, however, do not identify the early stage of the disease. In these cases early diagnostic criteria proved to be useful. In a multicenter study the so-called ESSG-criteria were recently introduced for the classification of the whole group of spondarthritides. They are also helpful for the nosological classification of undifferentiated spondarthritides. | |
| 3787321 | Posterior fusion for atlanto-axial subluxation in rheumatoid arthritis. | 1986 Jul | Posterior cervical fusion was performed in 34 patients with advanced rheumatoid atlanto-axial subluxation. Atraumatic surgical technique was used with local anesthesia and without skull traction. Intractable occipital rhizopathy and long-tract signs were the main indications. Anterior atlanto-axial subluxation in 28 patients was operated on with posterior fusion of C1-C2. Superior migration of the odontoid process into the foramen magnum in six patients was treated with posterior fusion of occiput C1-C2. Immediate mobilization in a plastic brace followed surgery. Average follow-up was 3 years. All patients became symptom-free, except for three who had remaining long-tract signs. Bony fusion was achieved in 17 patients; stable fibrous fusion, in 8 patients; and pseudoarthrosis, in 4 patients. There were no major postoperative complications. Five deaths occurred after 1-2 years from unrelated causes. |