Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2575024 | Mechanisms of action of slow-acting drugs in rheumatoid arthritis. | 1989 Sep | Slow-acting anti-rheumatic drugs exhibit a number of similar properties in treated patients that suggest that they may have a common mode of action in rheumatoid arthritis. In vitro evaluation of drug action suggests that each of the slow-acting agents possesses immunosuppressive activity that may explain its therapeutic efficacy in rheumatoid arthritis. Even though these agents appear to be able to suppress immune responses, the site of action of these agents differs. Thus, gold compounds and the antimalarials suppress the activity of mononuclear phagocytes, whereas D-penicillamine and other thiol-containing slow-acting agents inhibit the activity of helper T cells. These agents may therefore be effective by interfering with various specific aspects of the immunologic reactivity that drives the chronic inflammation of rheumatoid arthritis. | |
| 2733246 | An empty sella associated with hypopituitarism in a woman with rheumatoid arthritis. | 1989 Mar | A 66-year-old woman with rheumatoid arthritis experienced severe hyponatremia and hypoglycemia of repeated occurrence. Endocrinologic examinations revealed hypopituitarism and the metrizamide computerized tomographic scan showed a primary empty sella. No evidence of a pituitary or suprasellar tumor was obtained. During the 5-year follow-up, she remains well under replacement therapy and there are no signs of an intracranial tumor. The possibility of an autoimmune mechanism linked to the development of hypopituitarism is discussed. | |
| 2734058 | [Morphofunctional characteristics of thrombocytes in children with rheumatoid arthritis]. | 1989 | Altogether 205 children suffering from rheumatoid arthritis were examined for the morphofunctional status of platelets. Appreciable changes in the functional properties of platelets were revealed together with ultrastructural disorders. The correlation was noted between the characteristics under study as was their relationship with the disease activity and pattern. | |
| 3107230 | [Studies of protein clearance in patients treated with and without gold preparations in rh | 1987 Jan 15 | It is reported on investigations of protein clearance in rheumatics treated with Tauredon in comparison to non-treated patients suffering from rheumatoid arthritis. In that way no significant differences concerning the secretion of selective and unselective proteins could be found between the observed groups of patients. Secondary effects of the gold therapy in the form of a relevant proteinuria as elaborated by some authors cannot be confirmed in our patients. On the other hand investigations of protein clearance allow the premature recognition of renal failure and thus they can contribute to the increasing of the patients' security in the application of this therapy. | |
| 3588908 | Carpal predominance in rheumatoid arthritis. | 1987 Jul | Radiographic and clinical evaluation of the relative severity of wrist versus hand involvement in 101 patients with rheumatoid arthritis revealed more severe changes in the wrists in 60%, equal involvement in wrists and hands in 37%, and more severe changes in the hands in 3%. There were severe changes in the wrists but little or no bone or joint change in the metacarpophalangeal and proximal interphalangeal joints in 43 (21%) of the 202 extremities studied. Serial examinations showed that, in time, the hand changes tended to overtake those in the wrist. Appreciation of this progression of wrist and hand changes can help the physician avoid diagnostic difficulties in a significant percentage of patients. | |
| 3264935 | Immunoregulatory lymphokines in rheumatoid joints. III. B cell growth promoting activity o | 1988 | Synovial fluid (SF) from rheumatoid arthritis patients (RA) and culture-supernatants of synovial tissue (ST) cells from RA patients and juvenile rheumatoid arthritis (JRA) patients were examined for their ability to promote B cell growth. SF was not suitable for studying B cell growth promotion because with the anti-mu driven assay system employed, all 15 samples strongly inhibited B cell proliferation. Supernatants of in vitro unstimulated ST cells from RA and JRA patients affected B cell growth in different ways, ranging from strong inhibition to moderate stimulation. Supernatants of unstimulated peripheral blood mononuclear cells (MNC) from healthy donors did not influence B cell proliferation. After phytohaemagglutinin (PHA) stimulation of the ST cells and normal MNC, culture supernatants of RA ST cells and normal MNC all stimulated B-cell growth, while culture supernatants of PHA-stimulated JRA ST cells displayed a variable picture. The differences between PHA-supernatants from RA, JRA and normal MNC were not statistically significant. These results indicate that the inflamed synovia of JRA and RA patients contain cells that can produce soluble factors with B cell growth promoting activity. Some of the data in the study suggest that these factors are produced in vivo and thus might be responsible for the observed B-cell activation in joints of these patients. | |
| 3291099 | Timegadine: more than a non-steroidal for the treatment of rheumatoid arthritis. A control | 1988 | Timegadine is a tri-substituted guanidine derivative which inhibits both arachidonate cyclo-oxygenase and lipoxygenase activity. In a 24-week randomized double-blind controlled trial, timegadine 500 mg/day was compared with naproxen 750 mg/day in two groups of 20 patients with active rheumatoid arthritis. In the timegadine group, significant improvements were seen in both biochemical and clinical markers of disease activity, i.e. ESR, serum IgG and IgM, leukocyte and platelet counts, duration of morning stiffness, Ritchie index, number of swollen joints, pain, and general condition. In the naproxen group, only the Ritchie index improved. Differences between treatments, when present, were always in favour of timegadine. Serum alkaline phosphatase rose during the first 8 weeks of treatment in the timegadine group. A transient rise was also seen in the naproxen group. The side effects reported were mainly gastrointestinal and allergic, the latter being more frequently found in the timegadine group. Timegadine is superior to naproxen in controlling disease activity in rheumatoid arthritis, and appears to possess disease-modifying properties. | |
| 3425665 | Using technology to control the environment. | 1987 Nov | Over the last 5 years, technological advances have resulted in specialized technical aids, such as electronic communication devices, computer input devices, and environmental control systems, which have made it possible for many persons who are severely physically disabled to enjoy greater functional independence within the home, school, workplace, and the community. This paper focuses on environmental control systems and discusses how occupational therapists match environmental control systems with clients' needs. | |
| 1704698 | C reactive protein and immunoglobulin G in synovial fluid and serum in joint disease. | 1991 Jan | C reactive protein (CRP) and immunoglobulin G (IgG) were measured in synovial fluid and serum of 72 patients (29 with rheumatoid arthritis (RA), 17 with osteoarthritis, 11 with crystal synovitis, seven with undifferentiated arthritis, and eight with seronegative arthritis). The synovial fluid:serum (SF:S) ratios were compared with those calculated from the SF:S ratios of transferrin, caeruloplasmin, and alpha 2 macroglobulin, using the binomial test within groups and the Mann-Whitney test between groups. In RA synovial fluid CRP concentrations were lower than expected and IgG concentrations higher than expected. In osteoarthritis CRP concentrations were higher than expected. In seronegative arthritis IgG concentrations were raised. The ratio of CRP:IgG was depressed in RA. These findings are consistent with a role for CRP in the inflammatory process of RA, while the CRP:IgG ratio may be of value in the differential diagnosis of joint disease. | |
| 3559603 | Long-term results of total ankle replacement. | 1986 | The results are reported of 19 total ankle replacements in 18 patients with rheumatoid or other inflammatory arthritis. After a mean follow-up period of 54.4 months (minimum, 24 months), three arthroplasties had failed, all because of loosening. Although all of the remaining patients were improved in terms of pain and function, there was radiographic evidence of loosening in a further eight patients. Indications for the operation are discussed. | |
| 1830993 | [Fibronectin and immune complexes in rheumatic diseases]. | 1991 | The review presents literature data on studies into fibronectin in rheumatic diseases of immunocomplex genesis, its contribution to the development of abnormalities in the immune system and to hemostatic processes in the diseases. The role of fibronectin in the clearance of immune complexes, disturbed metabolism products of connective tissue, fibrin, and its monomers, cell membrane receptor proteins is emphasized. Extracorporeal heparin precipitation by using fibronectin is ascertained to be promising in removing plasma proteins in rheumatic immunocomplex diseases. A possible involvement of fibronectin in the fixation of immune complexes and DNA on the basal membranes, followed by immunocomplex inflammation, in the fibrin-induced R protein retention in the body, suppression of local immunity reactions, and development of joint ankylosis in rheumatic arthritis. | |
| 1882115 | Rheumatoid arthritis and cryptogenic organising pneumonitis. | 1991 May | We describe three patients with rheumatoid arthritis who presented with non-specific pulmonary symptoms, a restrictive defect in lung function and bilateral changes on chest radiograph. Lung histology showed characteristic features of cryptogenic organising pneumonitis and treatment with steroids produced significant improvement. The clinical and laboratory features of cryptogenic organising pneumonitis (otherwise known as bronchiolitis obliterans organising pneumonia, 'BOOP') are discussed and compared with those of bronchiolitis obliterans with which the condition should not be confused. Cryptogenic organising pneumonitis should be considered as one of the pulmonary manifestations of rheumatoid arthritis, but lung biopsy is essential to make the diagnosis. | |
| 2964318 | Sebum production is increased in Behçet's syndrome and even more so in rheumatoid arthrit | 1987 Oct | Sebum production is under hormonal control. We had shown that male sex is associated with more severe disease in Behçet's syndrome and the acneiform skin lesion of this disorder is not different from ordinary acne, an androgen-dependent lesion. Sebum excretion rate was higher in patients with Behçet's syndrome than in healthy controls, children and patients with ankylosing spondylitis. On the other hand, patients with rheumatoid arthritis had high levels of sebum excretion rate comparable to those found in patients with acne vulgaris. These suggest the presence of a sebotrophic hormone and/or other hormonal effects in Behçet's syndrome and rheumatoid arthritis. | |
| 1948448 | [A case of malignant rheumatoid arthritis associated with obstructive sleep apnea due to m | 1991 Jun | A 55 year old man with malignant rheumatoid arthritis (MRA) was admitted because of severe snoring during sleep and hypersomnolence in the day time. The patient developed an episode of respiratory distress and cardiac arrest, which responded rapidly to tracheal intubation and mechanical ventilation. He could be easily weaned from ventilator after 3 days. Polysomnography showed that the patient had an obstructive sleep apnea syndrome. Lateral view of cranial radiography revealed acquired micrognathia and destruction of the temporomandibular joints caused by RA, which induced obstructive sleep apnea. It is important to consider that obstructive sleep apnea can occur in RA patients showing snoring, hypersomnolence and disordered sleep behavior. | |
| 2011836 | [Diagnosis of arthritis with the aid of imaging methods]. | 1991 Jan | Among imaging techniques plain radiographs still play an outstanding role in the assessment of osteoarthrosis. Main diagnostic features comprise joint space narrowing (often segmental in the initial phase), subchondral sclerosis and cyst formation (both predominantly in the stressed area of the joint), and osteophytes at areas of low stress, often at joint margins. Anatomy and stress characteristics of the joint involved decide upon pattern and extent of the degenerative changes. The most common sites of osteoarthrosis include the interphalangeal joints, often in combination with the first carpometacarpal and trapezio-scaphoid joints, hip, knee, and first metatarsophalangeal joint of the foot. For assessment of these easily accessible joints, conventional radiographic techniques usually provide sufficient information. In special situations where differential diagnostics are important, methods such as computerized tomography or scintigraphy may prove very helpful. In the hands of experienced users ultrasonography is able to depict accompanying soft tissue changes such as rotator cuff ruptures or cysts. Magnetic resonance imaging represents a promising tool for detection of very early osteoarthrosis; small areas of cartilage damage can be assessed adequately. Although this method will certainly give new insight into aspects of early degenerative disease, its use is still confined to research-oriented applications with respect to osteoarthrosis. | |
| 1862247 | Clinical studies of omega-3 fatty acid supplementation in patients who have rheumatoid art | 1991 May | Several studies have now demonstrated reproducible clinical benefits of rheumatoid arthritis disease activity after ingestion of n-3 fatty acids. Biologic changes induced by fish oils include decreases in the production of leukotriene B4, platelet activating factor and interleukin-1. Investigations now focus on the proper dose and duration of fish-oil dietary intervention in order to obtain optimum clinical effects. Their ultimate therapeutic role has not yet been determined. | |
| 3442968 | The coexistence of rheumatoid arthritis and systemic lupus erythematosus. | 1987 Sep | A 29-year-old white female with longstanding classical rheumatoid arthritis (RA) developed clinical and serological manifestations of systemic lupus erythematosus (SLE) with prominent signs of diffuse proliferative lupus nephritis. She fulfilled the ARA criteria for the classification of SLE as well as the ARA criteria for classical RA. The concomitant presence of these two affections in the same patient is rare and the discriminating features suggest that this coexistence may be coincidental. With respect to treatment, our patient had good relief of symptoms by a combined administration of methylprednisolone pulses and cyclophosphamide. | |
| 2545174 | Diffuse large-cell lymphoma of B-cell origin and deficient T-cell function in a patient wi | 1989 Jul | An increased incidence of non-Hodgkin's lymphoma has been described in patients with rheumatoid arthritis. Mechanisms related to abnormal immune regulation have been postulated, but no patients with rheumatoid arthritis and lymphoma have been previously well characterized immunologically. We describe here a patient with long-standing rheumatoid arthritis in whom a B-cell diffuse large-cell lymphoma developed. He was found to have a severe T-cell immunodeficiency and evidence of persistent Epstein-Barr virus infection. Epstein-Barr nuclear antigen was not found to be present within lymphoma cells. The combination of defective T-cell function and persistent Epstein-Barr virus infection may have predisposed this patient with rheumatoid arthritis to the development of a malignant clone of B lymphocytes. | |
| 3803932 | Neck pain in the elderly: a management review. Part II. | 1987 Feb | Rheumatoid arthritis and metastatic cancer occur commonly in the elderly, and may cause neck pain. Rheumatoid arthritis may produce cervical radiculopathy and myelopathy resulting from vertebral body subluxation, although radiological manifestations of subluxation are much more common than neurological dysfunction. Cervical spinal cord compression is a neurological emergency and may produce cervical radiculopathy as well as myelopathy. Careful neurological and radiological assessments are required to minimize pain and preserve neurological function in elderly patients suffering from neck pain complicating rheumatoid arthritis or cervical spinal metastasis. | |
| 2093477 | A new sandwich-ELISA method for the determination of keratan sulphate peptides in biologic | 1990 Dec 31 | A new sandwich-ELISA for the determination of keratan sulphate peptides in biological fluids is described. The technique involves binding a commercially available monoclonal antibody against keratan sulphate to microtitre plates, adding the unknown keratan sulphate antigen then interacting the keratan sulphate-antibody complex with a biotin-monoclonal antibody conjugate which was also specific for keratan sulphate peptides. Alkaline phosphatase conjugated streptravidin was then added and the amount which bound to the biotin was determined by measuring the release of chromogen from an added chromogenic substrate. Using this assay, keratan sulphate peptides in biological fluids within the range 10-1000 ng/ml could be quantitated. This method was found to be more sensitive than presently used techniques. The intra- and inter-assay coefficients of variation were 11% and 13%, respectively. |