Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3757778 | Drug utilization research in clinical practice. | 1986 Sep | This report describes the use of drug utilization studies in clinical practice, with special emphasis on future developments. It has been shown that pharmacy services affect prescribing patterns, have great potential for reducing health care costs, and are in a position to produce financial savings in drug therapy and drug use. However, it is essential to balance the drug utilization figures against the resulting outcome, and attention should be focused on the assessment of therapeutic results. To make therapeutic result assessment possible, end points need to be defined. Several examples of such end points are given and include incidence of nosocomial infections and postoperative wound infections. New parameters have been established to assess the severity of the illness and to follow the effect of drugs on the disease process in the form of an Index of Disease Activity (IDA). IDAs have been prepared for Crohn's disease, rheumatoid arthritis, and ankylosing spondylitis. It then becomes possible to link drug utilization data with a drug's influence on a disease, making drug utilization research a recognized discipline within the medical field. | |
| 3547269 | Lymphocytes, polymorphonuclear leukocytes, macrophages and platelets in synovium involved | 1986 Oct | The inflammatory cell infiltrate involving synovial tissues from joints affected by rheumatoid arthritis (RA)++ has been contrasted with that present in synovium removed from joints involved by previous trauma (T) or osteoarthritis (OA). Cell deployment has been mapped by immunohistochemistry using monoclonal antibodies which recognise epitopes characterising T and B cells, polymorphonuclear leukocytes, mononuclear phagocytes and platelets. Mononuclear phagocytes were the most consistent feature of the rheumatoid inflammatory cell exudate and were present, particularly in the synovial layer, in all OA/T samples. The synovial cells lacked the C3b complement receptor, CR1, but expressed CR3, the receptor for C3bi. In rheumatoid synovium, interdigitating cells were difficult to identify but cells of dendritic morphology bore at least one macrophage epitope. T cells far out-numbered B cells and generally lacked the IL-2 receptor which is an indicator of T cell activation. Care is required in the estimation of the T helper/inducer (TH) T suppressor/cytotoxic (Ts) ratio. Polymorphonuclear leukocytes were demonstrated around vessels and near the synovial intimal cell layer suggesting rapid tissue transit. Extravascular platelets were sparse. Follicular dendritic cells were defined by their central location in lymphoid follicles and strong expression of CR1 receptors. HLA-DR expression was widespread except on endothelial cells. | |
| 2084855 | [Frequency and prognostic features of rheumatoid patients with remission-inducing agents-- | 1990 Oct | Recently, the disease activity has been believed to be effectively controlled by remission inducing agents such as gold salt and D-penicillamine in rheumatoid arthritis. However, there remain some doubts whether the prognosis of RA has been improved by these drugs or not. The frequency of complete remission in RA patients and their special features were studied to know the real state of the remission of RA under the present treatments. The subjects under investigation were 466 RA patients who were treated with remission-inducing agents for one to eight years. There were 90 male and 376 female patients diagnosed as definite or classical RA. Complete remission according to ARA criteria (Pinals R.S. et al. 1981) was noted in 33 (7.1%) of the 466 patients. However, relapse of the disease activity was observed in five patients during an observation period of two years on average. The followings were noted as the clinical and laboratory features of 26 cases with complete remission which could be observed for more than six months. A breakdown on sex revealed that the remission rate was 13.3% in male patients, compared to 5.6% in female patients. Duration of the disease for these complete remission cases was shorter for males than for females. Clinical examination of the cases with complete remission revealed that the most of them had no family history of RA, as well as no rheumatoid nodule or hip contracture.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 3264781 | Serum interleukin-2 receptor in systemic lupus erythematosus and rheumatoid arthritis. | 1988 Feb | Interleukin-2 receptor (IL-2R) is expressed on activated lymphocyte after stimulation with antigen or interleukin-2 (IL-2), meanwhile soluble form of the receptor is released. Using enzyme-linked immunosorbent assay, serum IL-2R levels were determined in 34 healthy controls, 61 patients with systemic lupus erythematosus (SLE) and 32 patients with rheumatoid arthritis (RA), yielding mean +/- SD values of 355 +/- 89, 807 +/- 453 and 567 +/- 210 U/ml respectively. In both SLE and RA patients, the active disease group had more markedly elevated serum IL-2R levels compared with those of the inactive group. In patients with SLE, elevated serum IL-2R is associated with lymphopenia, renal disorders, decreased C3 level and increased anti-DNA, thus make it a good parameter to monitor disease activity in SLE. | |
| 3144408 | Prolonged hypogonadism in male patients with rheumatoid arthritis during flares in disease | 1988 Dec | The pituitary-gonadal axis was assessed in 10 male patients during hospital admissions lasting 3-6 weeks (median 3 weeks) for flares for rheumatoid arthritis. Despite significant improvements in the Ritchie indices from median 16 (range 9-23) to 8.5 (range 5-20) (p less than 0.01) and ESR from median 67 mm/h (range 46-115 mm/h) to 58 mm/h (range 15-116 mm/h) (p less than 0.05) there were no significant changes in serum testosterone, LH, FSH, prolactin (PRL), cortisol or androstenedione during the admission periods. At follow-up (median 14 months, range 5-18 months after admission) there were further improvements in articular indices (median 7, range 3-13; p = NS) and ESR (median 20 mm/h, range 4-62 mm/h; p less than 0.05) and rheumatoid factor titres had fallen from median 1/1025 (range 1/126 to 1/1024) to median 1/512 (range 1/64 - 1/512). One patient showed biochemical features of progressive testicular failure. In the remaining patients, serum and derived free testosterone levels were significantly increased (p less than 0.01 respectively) and serum LH reduced (p less than 0.01). There were no changes, at this time, in prolactin, cortisol or androstenedione. Rheumatoid flares appear to be associated with prolonged suppression of testicular function. | |
| 3522084 | Surgical treatment of arthritis in the elderly. | 1986 Apr | Arthritis in the elderly can be very effectively treated by a combination of careful orthopaedic and rheumatological assessment. The overall functional assessment, and definition of the aims and likely results of surgical treatment by the team approach, involving occupational therapists, physiotherapists and social workers, are important for success. There are many worthwhile surgical procedures available to relieve pain, and restore mobility and independence to those affected by osteoarthritis and rheumatoid arthritis. | |
| 3764744 | [Regional blood circulation in the area of the hip joint in patients with various inflamma | 1986 | An analysis of the results of a study of the regional blood circulation in 36 patients with marked pathology of the hip joints of inflammatory nature (rheumatoid arthritis, Bechterew's disease, Reiter's disease) showed a statistically significant increase in transcutaneous oxygen pressure in the projection of the affected joints in unilateral as well as in bilateral pathology. In unilateral pathology there was a significant increase in transcutaneous oxygen pressure, on the surface of the contralateral joint, where pathology was undetectable by routine clinical methods. In the authors' opinion, it could be indicative either of an early stage of the joint involvement or the general reaction of a region under study to an inflammatory process. | |
| 2651232 | [Corium-plasty of the wrist joint]. | 1989 Mar | This report of thirty-five resection/interposition arthroplasties of the wrist emphasizes the value of the human dermis in comparison to other materials as a mechanically reliable and simultaneously vital interposition. In up to 75% of cases of rheumatoid arthritis this technique is indicated when the flexion contracture of the wrist disturbs the balance of the tendons and when the compensation offered by neighbouring joints is insufficient. Out of 297 joints treated by corium interposition arthroplasty, thirty-five were performed on the wrist. Review after up to sixteen years shows eighteen good, fourteen satisfactory, and three unsatisfactory results. | |
| 3238363 | Rheumatoid factors and physiology of synovial joints. | 1988 | Analysis of rheumatoid factor (RF) effects according to physiological principles suggests that RF activity may decrease joint swelling by (i) decreasing synovial fluid (SF) colloid osmotic pressure, by increasing plasma viscosity and thereby decreasing (ii) fluid escape from the plasma and (iii) convective flux of proteins into joints, and by decreasing (iv) diffusion of proteins from capillaries (et cetera?). RF complexes raising whole blood viscosity might (v) decrease blood flow. A more significant cause of SF hypoxia and lactic acidosis may be tamponade of synovial circulation created by swelling-induced high SF hydrostatic pressures. Increase of non-RF IgG or monomeric IgM and possibly agammaglobulinaemia could contribute to swelling more strongly than RF's. | |
| 3367778 | Spin-echo 1H NMR detected response of ergothioneine to oxidative stress in the intact huma | 1988 Feb | Human erythrocytes were subjected to oxidative stress using arsenicals. The study is a model for thiol-related redox processes observed in the etiology of diseases such as rheumatoid arthritis. Spin-echo NMR spectroscopy of the living cell was used to monitor the cellular biochemistry. Oxidation of glutathione and the first demonstrated response of ergothioneine to a chemical stimulus in a cell were observed. The reversible nature of the ergothioneine response is interpreted as an environmental rather than a chemical change. | |
| 3132833 | MR imaging of the cervical spine in rheumatoid arthritis. | 1988 May | The cervical spine was examined with MR imaging and conventional radiography in 23 patients with severe rheumatoid arthritis. All patients had neck pain and 17 also had neurologic symptoms. MR provided detailed information about soft-tissue lesions, vertebral dislocation, and narrowing of the spinal canal. Pannus surrounding the odontoid process was revealed in 14 patients, all with horizontal atlantoaxial subluxation. Compression of the medulla and/or spinal cord, caused by dislocated vertebrae and/or the soft-tissue mass around the odontoid process, was seen in 15 patients. When there was more than one dislocation the most important level could be determined. Posterior occipitocervical fusion had been performed in six of the patients, and in only two of these was adequate analysis of the upper cervical spine impossible because of artifacts from metal (stainless steel wires and pins). Sagittal MR in the neutral position combined with conventional radiography, including lateral views in flexion and extension, provided all the information necessary for further clinical management of rheumatoid arthritis of the cervical spine. | |
| 3217746 | Distribution of selenium and glutathione peroxidase in plasma compared in healthy subjects | 1988 Feb | The distribution of selenium and glutathione peroxidase activity in plasma was compared in samples from healthy adult controls and patients with rheumatoid arthritis. Plasma was separated by gel filtration, and selenium was measured in the eluted fractions by means of graphite furnace atomic absorption spectrometry with Zeeman background correction. Most of the selenium in plasma of healthy controls was seen in proteins that migrated close to immunoglobulin G, and that had an apparent molecular weight at the peak of 174 kDa. One major peak of glutathione peroxidase activity with an apparent molecular weight of 99 kDa was unmatched by any significant peak in selenium content. Thus, there was only limited correspondence between the elution patterns of selenium and glutathione peroxidase activity. Also, in patients with active rheumatoid arthritis, selenium was distributed amongst plasma proteins with a wide range of molecular weights. The major selenium peak was less pronounced in patients, but the amount of selenium in other parts of the chromatogram was not different from that in controls. Further work is necessary to define the occurrence of different selenoproteins in plasma in patients and in healthy subjects. | |
| 2380515 | Results of extensor carpi ulnaris tenodesis in the rheumatoid wrist undergoing a distal ul | 1990 Jul | Distal ulna resections that are done in patients with rheumatoid arthritis to alleviate pain, correct alignment, and prevent tendon rupture may contribute to distal ulnar instability. A distally based slip of the extensor carpi ulnaris tendon has been used to both stabilize the distal ulnar remnant and to prevent recurrent deformity in 26 rheumatoid wrists, with an average follow-up of 3.5 years. In all postoperative cases, the distal ulna was no longer prominent and the wrist was well aligned. The distal ulna was stabilized in 96% of the patients. Subjectively, pain was relieved in 85% and grip strength improved in 77%. | |
| 1858176 | [Naproxen versus indomethacin as night-time medication for patients with rheumatoid arthri | 1991 Jul 1 | The investigation consisted of a double-blind cross-over study of the effect of 75 mg indometacin, 500 mg naproxen or a placebo in 63 patients with rheumatoid arthritis accompanied by night pain and morning stiffness. All the patients received day treatment with 250 mg naproxen b.i.d. Only a few patients benefitted from the treatment at night and no differences in the effect of indometacin and naproxen were observed. Naproxen was better tolerated than indometacin. Day treatment with naproxen, which has a relatively long half life time decrease the need for supplementary treatment at night. | |
| 1934023 | Rheumatoid arthritis modifies basal and insulin-mediated glucose uptake by human synoviocy | 1991 | Basal and insulin-mediated glucose uptake were studied in human synovial cells. Cell cultures were established from samples of synovium obtained at synovectomy from patients with osteoarthritis (non-rheumatoid synovial cells, NRSC) or rheumatoid arthritis (rheumatoid synovial cells, RSC). Basal glucose uptake was significantly higher in RSC than in NRSC. NRSC were sensitive to insulin at near-physiological concentrations (10(-8)M), with maximal transport occurring after a 30-min. association time (27.2 +/- 2.0%, mean +/- SEM). Insulin did not stimulate significantly 2-déoxy-D-glucose uptake in RSC, regardless of the association time (up to 120 min.) or the insulin concentration (10(-10) to 10(-6) M). Treatment of NRSC with human recombinant interleukin-1 beta (IL-1 beta) enhanced glucose uptake to a level similar to basal uptake by RSC. These results suggest that autocrine production of IL-1 beta by RSC could be responsible for the higher basal glucose uptake by these cells. | |
| 1833021 | Provision of medical and community services to people with severe arthritis; an audit. | 1991 Oct | We have identified severely disabled arthritics who live in the community through social service records. All had either rheumatoid arthritis (RA) or osteoarthritis (OA). The diagnosis influenced referral to hospital, those with RA being referred while only half of those with OA had been referred. Referral was important for both surgical and environmental intervention. Provision of social services and community occupational therapy services was greater if the patients had been seen in hospital departments irrespective of the diagnosis. Recipients of joint surgery had all gained temporary benefit although progression of arthritis or other disabling disease compromised this after several years. There was a substantial minority of people with severe OA living in the community who had not been considered for joint replacement and did not have optimal provision of aids, appliances and environmental adaptation. | |
| 2654267 | Proposed treatment of cystic lesions in the first metatarsal in polyarthritic patients. | 1989 Jan | Inflammatory arthritis frequently produces severe deformities of the forefoot. Erosions and cystic changes in the metatarsal bones are not uncommon in patients with inflammatory arthritis. This report presents two patients who were treated with a bone graft and bone transposition with a good result. | |
| 2739514 | Clinical experience with ketoprofen in the management of osteoarthritis and rheumatoid art | 1989 Jun | Over 100 forms of musculoskeletal disorders affect approximately 50 million persons in this country. While the etiology and cure of many arthritis disease processes remain elusive, the number of drugs available to ease the pain and reduce the inflammation associated with arthritic diseases has increased, improving the outlook for patients. | |
| 3489974 | Rheumatoid factors in Ro (SSA) positive and Ro (SSA) negative rheumatoid arthritis patient | 1986 | In this report increased IgA and IgM rheumatoid factors were detected in the saliva of Ro (SSA) rheumatoid arthritis patients by an isotype-specific radioimmunoassay. | |
| 1668382 | Endogenous opiate response to pain in rheumatoid arthritis and cortical and subcortical re | 1991 | Identification of the main areas in the brain that respond specifically to the "suffering" components of pain has been achieved by using serial dynamic measurements of blood flow as an index of synaptic activity. Specific response to a repeated painful thermal stimulus as compared to a non-painful thermal stimulus in normal male volunteers identified the anterior cingulate cortex and the thalamus contralateral to the side of stimulation as the main sites of significant response. It was concluded that it was these areas where pain was likely to be experienced. Changes in opioid receptor binding in the brain was measured using 11C-diprenorphine and positron emission tomography in three patients with rheumatoid arthritis. In the two patients with active rheumatoid arthritis substantial changes in opioid receptor binding in the brain are described. The significance of these findings are discussed. |