Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2724614 | [A comparative study of CT and plain X-ray film in the diagnosis of interstitial pulmonary | 1989 Jan | In order to detect the interstitial pulmonary disease of rheumatoid arthritis (RA), we studied 91 patients with RA and compared the appearances of high resolution CT with those of plain chest X-ray film. We found 43 cases of interstitial pneumonitis on CT. We classified the CT and X-ray appearances as 4 groups (0-3) based on the degrees of pulmonary lesions. The both classifications accorded only in 46 cases (51%). In 46 cases who were not detected any changes by plain X-ray film, 17 were detected interstitial changes by CT. As to the early interstitial changes, the detectability of CT was superior to that of plain X-ray film. | |
| 1654147 | Isolation of human herpesvirus-6 (HHV-6) from patients with collagen vascular diseases. | 1991 May | The prevalence and activity of human herpesvirus-6 in patients with collagen vascular diseases (CVD) was determined. One hundred and fifty patients with CVD (56 with systemic lupus erythematosus-SLE, 92 with rheumatoid arthritis-RA, 1 with Sharp's syndrome and 1 with atypical polyclonal lymphoproliferation-APL and rheumatoid features) were screened serologically (IFA and ELISA) for antibodies against human herpesvirus-6 (HHV-6), Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Virus isolation was attempted from peripheral blood lymphocytes (PBL) of 25 persons with various disorders. PBL were grown in tissue culture and tested with standard HHV-6-positive antisera for viral antigen expression. Supernatants of the patient's lymphocyte cultures were used to infect HSB2 cells, and virus infection in these cells was proven by IFA, in situ hybridization and by electron microscopy. Fifty-five percent of the SLE patients, 6.5% of the RA patients and both patients with Sharp's syndrome or with APL had antibody titers indicative of active HHV-6 infection. Virus cultures were positive in 9 of the 25 attempts with establishment of stable virus lines. These patients were 5 with SLE or UCVD, and one each with RA, CFS, APL as well as one healthy control. Reactivated and chronic active HHV-6 infections are frequent in SLE like EBV in RA. The role of these viruses in the pathogenesis of the diseases or in their reactivation still needs further investigation. | |
| 2706647 | Cardiovascular mortality in patients with rheumatoid arthritis. | 1989 | Patients with rheumatoid arthritis (RA), 500 men and 500 women, aged 40 years and over, together with a control population matched by age and sex were followed up with respect to cause-specific mortality over a 10-year period. The overall mortality was significantly higher in both men and women with RA than in the controls. A statistically significant increase in mortality from all cardiovascular diseases (p less than 0.001) and cardiac diseases (p = 0.004) was observed in men with RA but not in women with RA compared to corresponding controls. No difference in mortality from cerebrovascular diseases was observed between RA patients and controls. | |
| 3325643 | Methotrexate pneumonitis in rheumatoid arthritis: potential risk factors. Four case report | 1987 Dec | Methotrexate pneumonitis is emerging as one of the most unpredictable and potentially serious adverse effects associated with the use of low dose, pulse methotrexate in treating rheumatoid arthritis (RA). We report 4 new cases of methotrexate pneumonitis in patients with RA and review 6 published cases. A greater than expected proportion of patients had a smoking history, preexisting pulmonary disease and were male. Prognosis was better in those patients treated with corticosteroids. | |
| 3941918 | Pseudarthrosis following proximal humeral fractures: a possible mechanism. | 1986 | A small series of four patients with pseudarthrosis of the proximal humeral shaft is reported. These patients all had restricted movement of the shoulder joint prior to the trauma, three as a result of rheumatoid arthritis and one due a surgical fusion of the glenohumeral joint. It is suggested that pseudarthrosis is more likely under these circumstances and that pursuit of union of the fracture in such patients may not always be necessary. | |
| 2715996 | Visual analogue scales as a measure of pain in arthritis: a study of overall pain and pain | 1989 Jan | Visual analogue scales (VAS) for overall and individual joint pain at rest and on movement were completed by 105 patients with polyarthritis as part of a study of the relationship between overall pain and pain in individual joints. Not all subjects recorded pain on a conventional VAS although all had at least 2 painful joints on movement. At best only 25% of the variance in overall pain was explained by pain in individual joints. Our findings suggest that conventional overall measures of pain in arthritis may neglect aspects of pain experience which relate to individual joints and to pain on movement. | |
| 2822630 | Palladium-109 and holmium-166 potential radionuclides for synoviotherapy--radiation absorb | 1987 | Palladium-109 and holmium-166 are radionuclides with nuclear, physical and chemical characteristics appropriate for therapeutic purposes. Radiation absorbed doses are calculated and compared with currently used radionuclides in synoviotherapy. | |
| 2141249 | [Opioid peptides in RA: modulation of immunologic mechanisms and mental states]. | 1990 Feb | Rheumatoid arthritis (RA) patients were investigated for relationships between the concentrations of various plasma opioid peptides (beta-endorphin (beta-end), methionine-enkephalin (Met-enk), leucine-enkephalin (Leu-enk) and the lymphocyte subsets, serum immunoglobulins, the patient's mood or emotion, and the RA activity. A mental state and patient mood were assessed by the Cornell Medical Index (CMI) and the Face Scale. RA activity was expressed by Lansbury's index. The plasma Met-enk concentration was correlated significantly with the %Leu11+ and %Leu11+Leu7+ cells. The plasma Leu-enk concentration also correlated significantly with the %Leu2a+Leu15- cells. The plasma Leu-enk concentration and pain score were higher while the %Leu11+Leu7- cells was lower in proportion of the degree of neurosis of the RA patient as indicated by the CMI. The plasma Met-enk concentration, the %Leu2a+Leu15-, IgG, pain score and Lansbury's index were significantly higher in the group of RA patients whose facial expression was more severe. These findings suggest that enkephalins have some relationship with the patient's mood and immunologic functions, and that enkephalins have a possibility of exerting indirect effects on RA. | |
| 2161306 | The in vivo effect of nonsteroidal anti-inflammatory drugs, gold sodium thiomalate and met | 1990 Jan | The generation of superoxide radicals by activated peripheral blood polymorphonuclear leukocytes from patients with rheumatoid arthritis (RA) has been measured and the in vivo effect of nonsteroidal anti-inflammatory drugs (NSAIDs) and disease remittive agents studied. Generation of superoxide radicals from RA patients was significantly decreased when compared to a control population. This was principally due to the disease rather than medications in that patients with osteoarthritis receiving NSAID generated superoxide radicals similar to that seen in the control group. RA patients receiving NSAIDs and injectable gold or methotrexate therapy showed a significant trend to normalization of superoxide radical generation when compared to those with RA receiving NSAIDs alone. We conclude that the reduced generation of superoxide radicals on activated polymorphonuclear leukocytes from patients with RA is principally a feature of the disease and that this abnormality can be partially reversed by the use of a disease remittive agent in vivo. | |
| 2357496 | Increased apotranscobalamin II levels in rheumatoid arthritis. | 1990 Jun | The distribution of endogenous cobalamin among serum cobalamin-binding proteins was studied in 30 patients with active rheumatoid arthritis (RA) and 27 in clinical remission. The mean total serum cobalamin concentration (holo-transcobalamin I and II) was similar in both groups of patients, whereas mean apotranscobalamin II was significantly increased in patients with active RA. The clinical significance of this finding is not yet established but it might be a useful parameter for the evaluation of disease activity in RA. | |
| 1856804 | Low dose prednisone does not affect calcium homeostasis or bone density in postmenopausal | 1991 Mar | To assess whether low doses of prednisone produce generalized alterations in skeletal homeostasis in rheumatoid arthritis (RA), indices of calcium metabolism and bone mineral density (BMD) were measured in 22 women with RA treated without or with prednisone (6.6 mg daily). Ionized and total calcium concentrations, intact parathyroid hormone (PTH) and osteocalcin levels were comparable in the 2 groups. BMD measurements in the lumbar spine, and proximal femur sites including the femoral neck, Ward's triangle, and trochanteric region were not significantly different in patients with RA treated without or with prednisone. In our experience low dose prednisone did not adversely affect indices of mineral metabolism, or bone density in RA. | |
| 2051112 | [Castleman's disease associated rheumatoid arthritis recurring 20 years after removal]. | 1991 Apr | A 40-year-old female associated with Rheumatoid Arthritis was treated by extirpation of the mediastinal tumor. Histological examination of the tumor revealed Castleman's disease of Hyaline-Vascular type and histology of the dissected mediastinal lymphnodes was the same appearance as tumor. The present case is unusual in that the tumor recurred in the same site 20 years after removal. The complete removal of tumor with dissection of lymphnodes surrounding tumor is important for the treatment of surgery. The present case is the 1st to be reported in Japan. | |
| 3071008 | [Binding studies with Ulex europaeus agglutinin I (UEA-I) of the vascular endothelium of t | 1988 Sep | The lectin binding sites of the synovium of patients with rheumatoid arthritis and osteoarthritis were investigated. It was shown that Ulex europaeus agglutinin is a constant marker of the vascular endothelium and is not induced during the course of inflammatory process in rheumatoid arthritis. | |
| 3485561 | [B-cell subpopulation, rosetting with mouse erythrocytes, in patients with rheumatoid arth | 1986 Feb | Inactive peripheral B-cells rosetting with mouse erythrocytes (BMR+), as well as the stimulation with anti-mu sepharose beads of peripheral mononuclear cells, are diminished in patients with active rheumatoid arthritis (RA). These data provide further evidence for a B-cell activation in active RA. | |
| 2640551 | The syndrome of seronegative symmetrical synovitis with pitting edema (RS3 PE syndrome): a | 1989 Sep | We describe 4 elderly patients who presented with peripheral seronegative inflammatory polyarthritis with pitting edema. All of these patients had a spontaneous benign evolution of their disease within 9 to 18 months. None developed erosions or relapse after prolonged followup. This particular pattern of arthritis in elderly patients might represent a separate benign clinical entity among inflammatory arthritis in aging patients. | |
| 1981958 | [Pharmachem's salazopyrine in rheumatoid arthritis]. | 1990 | 35 patients with classical form of rheumatoid arthritis were treated with Salazopyrin N "Pharmachim" prepared with the basic substance of the firm "AB-Uppsala"--Sweden. Side effects were seen in 9 patients and in 3 of them the treatment had to be discontinued. After a six months course of treatment remission was found in 18 patients (51%), in 8 patients (22.8%) the result was considered "good" with reduction of the inflammatory activity and in the remaining 5 patients there was little or no effect. The results coincide with those of other authors and support the data for the beneficial action of Salazopyrin N as a basic means in the treatment of rheumatoid arthritis. They also prove that the Bulgarian drug Salazopyrin N is of good quality and can be successfully used in the treatment of rheumatoid arthritis. | |
| 3798028 | The distribution of class-specific rheumatoid factors is similar in rheumatoid and pre-ill | 1986 Dec | The occurrence of IgM, IgG, and IgA class rheumatoid factors (RF) was compared by means of ELISA in 21 sera from patients with established rheumatoid arthritis (RA) and in 22 pre-illness sera from subjects who 4 months to 5 years later developed seropositive rheumatoid arthritis. The positive cases were virtually confined to three groups of about equal size: positive for all three RF classes, positive for IgM-RF and IgG-RF, and positive for IgM-RF only. Thus, the distribution of the RF isotypes was similar in rheumatoid and pre-rheumatoid sera. | |
| 3261674 | Serum aminoterminal type III procollagen peptide in inflammatory and degenerative rheumati | 1988 Mar | Measurement of the aminoterminal type III procollagen peptide in serum has been suggested as a marker of the biosynthesis of collagen type III, a major connective tissue component in repair processes. In the present study the propeptide level correlated with the inflammatory synovial mass in rheumatoid arthritis and osteoarthritis. This implies that the propeptide level reflects the collagen type III synthesis occurring in the synovial repair processes, whether they were caused by inflammatory or degenerative rheumatic disorders. Physical activity did not enhance the transition of the propeptide from the synovial fluid or the inflamed synovial membrane to the blood. Normal serum propeptide values were observed in most patients with ankylosing spondylitis and degenerative diseases of the spine. This may reflect the lower amount of inflammatory tissue in these diseases and hence the sensitivity of the assays. | |
| 2845078 | Functional heterogeneity of human rheumatoid synovial tissue macrophages. | 1988 Jul | Neovascularization plays an important role in the formation of the rheumatoid (RA) synovial pannus. A subpopulation of RA macrophages (F3) (density 1.042-1.062 g/ml) has been shown to induce neovascularization in an in vivo rat corneal model of angiogenesis. We have found that conditioned medium from F3 macrophages induced significantly more endothelial migration (p less than 0.001) and mononuclear cell factor activity (p less than 0.001) than did conditioned medium from F2 macrophages (density 0.998-1.042 g/ml). Exposure of these macrophages to lipopolysaccharide did not increase production of these activities. RA synovial tissue macrophages appear to be heterogeneous in their production, and maximally activated for expression of these activities in vivo. F3 macrophages may be important in mediating both the fibroproliferative and destructive phases of RA. | |
| 3330297 | Infection and arthritis. | 1987 | The categorization in four classes of association between infection and arthritis (namely infective, post-infective, reactive and idiopathic) seems nowadays to be inadequate to cover the extensive field of interactions between infectious agents and host response resulting in arthritis. This paper is a synthetic review of the subject with particular reference to pathogenetic mechanisms in children. An effort has been accomplished, on the basis of the most recent literature, to define the respective roles of the microbial aggression and the host response in a number of conditions: septic arthritis, viral arthritides, Lyme arthritis, rheumatic fever, Reiter's syndrome, ankylosing spondylitis and rheumatoid arthritis. |