Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1832810 | Immune imbalance in the synovial fluid of rheumatoid arthritis patients: effects of intra- | 1991 Apr | T cell subsets in the synovial fluid (SF) and peripheral blood (PB) of RA patients and controls suffering from different forms of chronic synovitis have been investigated. The immunological evaluation showed a reduction of CD4 subsets in RA-SF compared to RA-PB (p less than 0.001), and an almost complete absence of the suppressor-inducer/naive T cells in RA-SF compared to RA-PB and SF from patients with other forms of chronic synovitis. The CD8 subpopulation showed an increased proportion of cytotoxic cells only in RA-SF. On the basis of these results, an intra-articular immunomodulating treatment with thymopentin has been performed: its effects were characterized by an increase of CD8+CD11b+ T cells in the CD8 subset parallel to the enhancement of the suppressor-inducer/naive T cells in the CD4 subset with a statistically significant correlation. The enhanced levels of soluble CD8 decreased after treatment in RA-SF, whereas the soluble IL-2R levels were not significantly modified. Clinical evaluation showed a significative amelioration in all considered parameters. | |
| 3671351 | Neutrophil responsiveness to chemoattractant tripeptide in rheumatoid arthritis. | 1987 Nov | Neutrophils isolated from medication-free rheumatoid arthritis (RA) patients were assayed for responsiveness to the bacterial chemoattractant tripeptide formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe). Rheumatoid arthritis neutrophil preparations contained significantly lower percentages of rapidly migrating cells. This relative hyporesponsiveness of RA neutrophils was related to impaired sensing of chemotactic gradients. Rheumatoid neutrophil abnormalities in sensing of and responding to chemotactic gradients were not associated with resting or f-Met-Leu-Phe-induced changes in arachidonic acid metabolism. | |
| 3393844 | [Therapeutic management of rheumatoid polyarthritis (1988)]. | 1988 Apr 30 | The authors briefly remind of the broad outline of their therapeutic approach regarding rheumatoid polyarthritis, specifying their attitude towards the main medications currently available. They mainly stress the mistakes too often mad in the long-term treatment of the disease. | |
| 2673079 | Hydroxychloroquine sulphate in the treatment of rheumatoid arthritis: a double blind compa | 1989 Jul | A controlled, double blind, parallel group, long term study of hydroxychloroquine sulphate in the treatment of rheumatoid arthritis, comparing daily doses of 200 mg and 400 mg, is described. The trial involved 54 patients with moderate disease activity who had not previously received antimalarial drugs. Forty three patients completed the one year treatment. The groups receiving different doses were homogeneous and did not differ in any of the 25 monitored indicators. Both dose regimens were effective, and a significant reduction of disease activity was observed after one year's treatment. Of the nine laboratory and 11 clinical indices of efficacy monitored, no statistically significant differences were reported, but in the group of patients treated with the 400 mg daily dose the number of side effects was three times greater. As there have been no reports of retinopathy with hydroxychloroquine at daily doses of 200 mg the effectiveness of this dose is of practical importance. | |
| 3340900 | Platelet parameters. Part II. Platelet volume-number relationships in various normal and d | 1988 Jan 9 | The relationship between mean platelet volume (MPV) and platelet count was evaluated in 259 patients with rheumatoid arthritis and 311 patients with various haematological disorders. Platelet volume-number relationships determined in a previous study on normal subjects were used as a reference range. There was a significant inverse relationship between MPV and platelet count in patients with rheumatoid arthritis (r = -0.49; P less than 0.0001), which by interval analysis was shown to be non-linear. In the patients with haematological disorders, the platelets were found to be disproportionately small for number in patients with aplastic anaemia, chemotherapy-induced marrow suppression and some cases of acute idiopathic thrombocytopenic purpura (ITP). In subjects with chronic ITP followed longitudinally, the inverse platelet volume-number relationship was retained. MPV was appropriate for platelet number in myelodysplastic syndromes, variable in iron deficiency anaemia and disproportionately large in myeloproliferative syndromes, most notably in agnogenic myeloid metaplasia. The observation that the MPV was disproportionately large in comparison with the platelet count was used in establishing the diagnosis of an hereditary giant platelet syndrome in a family of British origin. | |
| 3668976 | Disability in rheumatoid arthritis: comparison of prognostic factors across three populati | 1987 Aug | We previously identified variables that predict functional disability in rheumatoid arthritis (RA). Because of potential instabilities in the statistical model, we sought to determine whether these predictors were consistent across populations: 2,448 consecutive patients with (RA) were followed prospectively at ARAMIS centers in Phoenix, AZ, Wichita, KS, and Saskatoon, SK. Average followup was 1.7 years in Phoenix, 3.4 years in Wichita, and 12 years in Saskatoon. Twenty-four potentially predictive variables were analyzed by stepwise linear regression. Common predictors were age, sex, and duration of illness, suggesting that these variables are important predictors of disease regardless of the population being studied. In addition, the initial level of disability and radiographic variables are good predictors of disability. Elevated erythrocyte sedimentation rate and latex titers also were associated with future functional disability but do not have a linear relationship and predict less well. | |
| 2707624 | Lipoprotein oxidation and induction of ferroxidase activity in stored human extracellular | 1989 | It was observed that during the storage of human extracellular fluids at -20 degrees C the azide-inhibitable ferroxidase activity of caeruloplasmin declined, whilst a new azide-resistant ferroxidase activity (ARFA) developed. The literature suggested that storage-induced ARFA might be due to either a poorly defined enzymatic activity of a low density lipoprotein (LDL) or to lipid peroxides formed within the different lipoprotein fractions. To study this further, the major lipoprotein classes were separated from human serum by density gradient centrifugation. After storage of the lipoprotein fractions, it was found that the LDL fraction had the highest specific activity of ARFA and the highest content of lipid peroxidation products, as assessed by diene conjugates. The ARFA of LDL correlated with its content of diene conjugates and TBA reactive material, which initially suggested that the Fe(II) oxidising activity of peroxidase LDL arose from the reduction of peroxides by Fe(II) in the classical reaction between the metal ion and free radical reduction of lipid peroxides. However, steady state kinetic analysis indicated an enzymic role of LDL in Fe(II) oxidation, with lipid peroxides acting as a substrate for the enzyme. These results indicate that LDL may contain a peroxidase activity, catalysing the oxidation of Fe(II) by lipid peroxides, as well as a ferrous oxidase activity where O2 is the oxidising substrate. | |
| 3401053 | Australian mortality statistics for rheumatoid arthritis 1950-81: analysis of death certif | 1988 Jul | An analysis of mortality related to rheumatoid arthritis (RA) in Australia for the period 1950 to 1981 was undertaken based on information recorded in death certificates. These data include every death over a 32 year period where RA was considered to be the underlying cause. Death from RA was commonly reported (0.17% of all deaths). The mean age at death from RA in both sexes exceeded that of the general population for most of the period. There was little difference between patients dying of RA and the general population for age at death in the over 50 years' age group. There was a significant decrease in mortality for women dying of RA over the age of 75. RA accounted for more deaths in women than in men (in a ratio of 2.2:1). Men tended to die at a younger age from RA than did women. The impact of RA remained relatively constant in relation both to the total causes of death and to deaths due to other musculoskeletal diseases. There was a significant decline, however, in female RA deaths as a percentage of deaths due to all musculoskeletal diseases. Cohort analysis does not indicate any marked effect from extrinsic factors on mortality due to RA. | |
| 2591109 | Prevention of postmenopausal bone loss in rheumatoid arthritis patients. A two-year prospe | 1989 Jul | The effect of three different therapeutic regimens on bone mineral content at the radius and lumbar spine was studied in a group of 60 postmenopausal rheumatoid arthritis patients. Results were compared to those in a group of controls matched for sex, age, disease duration and menopausal state. Serum and urinary parameters of calcium metabolism were also evaluated in the three treatment groups. The three treatment regimens were: 1 alpha hydroxyvitamin D + calcium + placebo; 1 alpha hydroxyvitamin D + calcium + lynestrenol; and 1 alpha hydroxyvitamin D + calcium + sodium fluoride. In all treatment groups there was a positive effect of therapy compared to controls, though this was only significant in the 1 alpha hydroxyvitamin D + calcium + lynestrenol group at the axial skeleton after 1 and 2 years of treatment. Serum calcium rose significantly in the 1 alpha hydroxyvitamin D + calcium + placebo group and serum creatinin was raised in all the treatment groups during therapy. In the 1 alpha hydroxyvitamin D + calcium + lynestrenol group, serum alkaline phosphatase activity and urinary hydroxyproline excretion decreased significantly. | |
| 3359569 | Mononuclear cells from rheumatoid arthritis patients exhibit a depressed IgM response to s | 1988 | Human peripheral blood mononuclear cells when cultured for the short term (11 days) produce an optimal IgM plaque-forming cell (PFC) response to sheep erythrocytes, which is dependent on macrophages and T suppressor and helper lymphocytes. With this system we have investigated the PFC response of individuals with rheumatoid arthritis and compared this to the response of normal sex- and age-matched controls and of patients with osteoarthritis. The response of rheumatoid arthritis patients was significantly lower than that of subjects in the other two categories. | |
| 2605821 | Surgical treatment of the rheumatoid hand. | 1989 Sep | Multiple involvement of joints and tendons of the hand by rheumatoid disease is frequent and may result in severe deformities. Surgery plays a major role in an integrated treatment program that considers the patient's possibilities for improvement. Extensor and flexor tenosynovitis requires an early synovectomy to prevent tendon ruptures, to restore tendon gliding and to decompress the median nerve at the wrist level. Ruptured tendons are usually widely degenerated and restoration of function is provided by end-to-side repair, tendon grafts or tendon transfers. Joint synovectomies must be preformed at an early stage to be effective. Restoration of function in eroded, dislocated or unstable joints can be attained by arthroplasty or arthrodesis. A resection arthroplasty, usually completed by a silicone implant, corrects the deformity while preserving or restoring a functional range of motion. Flexible implant arthroplasty is very often performed in the metacarpophalangeal joints, and less frequently in the wrist and interphalangeal joints. Arthrodesis is a satisfactory procedure for those joints where stability is more important than motion. | |
| 3100315 | Excretion of gold into human breast milk. | 1986 | After the administration of 70 mg and 50 mg aurothiomalate, respectively, to 2 patients with rheumatoid arthritis, significant amounts of gold appeared in breast milk. | |
| 3761356 | A rapid enzyme immunoassay for the detection of IgM rheumatoid factor--a comparison of "se | 1986 Aug | The ELISA technique for measuring RF is a reliable, low cost, quick method which has adequate specificity and improved sensitivity over other methods. This last property plus its flexible potential for measuring RF in classes other than IgM should make it a particularly useful tool in assessing "sero-negative" patients, while in the long run its routine use should supersede that of the other tests. | |
| 2477604 | [Level of the C3-component of complement in the blood serum of sick children]. | 1989 | The levels of the complement C3 component have been measured in children with various diseases (immunodeficiency states, food allergy, rheumatoid arthritis, severe and medium-severe forms of acute respiratory viral infections), and the complement consumption in the course of alternative activation has been examined. The findings evidence a relationship between the complement C3 component consumption and the blood serum IgA level, as well as between the C3 level and the neutrophilic phagocytic and metabolic activities. | |
| 2959423 | Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in | 1987 Nov | T lymphocytes can be divided into two main phenotypic populations, CD4 and CD8. These can be further subdivided into 2H4, 4B4, or UCHL1 subsets by appropriate monoclonal antibodies. We have investigated these subsets in the synovial fluid of patients with rheumatoid arthritis and have found (i) a virtual absence of CD4+ 2H4+ and the marked reduction of CD8+ 2H4+ T cells; (ii) a marked increase of CD4+ 4B4+ and CD8+ 4B4+ T cells; and (iii) a marked increase of CD4+ UCHL1+ and CD8+ UCHL1+ T cells compared with peripheral blood. Although the functions of the CD8 subsets are not known, the virtual absence of CD4+ 2H4+ suppressor-inducer T cells and the marked increase of CD4+ 4B4+ helper-inducer T cells and of CD4+ UCHL1+ memory T cells may help to explain the many known functional immunological properties of synovial T cells. | |
| 2480754 | Serological abnormalities, including common idiotype PR4, in families with rheumatoid arth | 1989 Nov | A broad range of autoreactivity among a group of 12 French patients with rheumatoid arthritis (RA) and 58 of their healthy first degree relatives has been identified. Over 15% of the patients were found to have antibodies to ssDNA, histone H1, H2A, and H2bB. Among the relatives, IgG and IgM rheumatoid factor and antibodies to ssDNA, H2A, and H4 were present in more than 10%. Even more remarkable, a common anti-DNA antibody idiotype designated PR4, known to be present in 70% of patients with systemic lupus erythematosus (SLE), was found in approximately 30% of both patients with RA and their healthy relatives. This is quite different from its lack of increased expression in relatives of patients with SLE and suggests that in the family members of those with RA a particular combination of environmental influence on germline gene expression is responsible. | |
| 1667711 | [Prevalence of antibodies against hepatitis C virus in rheumatoid arthritis. Study using s | 1991 Dec | In order to evaluate the seroprevalence of anti-hepatitis C virus (HCV) antibody in rheumatoid arthritis (RA), where a high prevalence of false-positive anti-HCV reactions is reported, we studied 79 patients affected with RA. In these subjects we recorded some clinical and anamnestic data (history of blood transfusion, risk factors of liver disease, therapy) and determined, besides a few routine laboratory parameters including rheumatoid factor (RF), AST and ALT, the anti-HCV serology using the 1st (EIA, Ortho and Abbott; Neutralization test, Abbott; RIBA, Chiron-Ortho) and the 2nd generation tests (EIA, Ortho; RIBA, Chiron-Ortho). Four patients (of whom three were RF seronegative) were anti-HCV reactive by the 1st generation EIA tests (5.1%). According to the results of the confirmatory tests, and particularly of the 2nd generation, two patients resulted infected by HCV. These results do not confirm the previously reported high prevalence of false-positive anti-HCV reactions in RA, and demonstrated the usefulness of the 2nd generation tests in diagnosing the HCV infection. | |
| 2555926 | Natural history of atlanto-axial subluxation in rheumatoid arthritis. | 1989 Oct | In 1969 the authors started their prospective study to determine the natural history of atlanto-axial subluxation in patients suffering from rheumatoid arthritis. Between January 1969 and July 1971 they accumulated 41 cases of atlanto-axial subluxation. These patients were studied clinically and radiologically, and the initial findings were published in the Journal of Bone and Joint Surgery, Volume 55B, August 1973. All of these patients were followed clinically and radiologically until 1981 or until their demise. Roentgenographically, 61% have remained unchanged, 27% have shown progression of the atlanto-axial subluxation, and 12% showed decrease in the amount of atlanto-axial subluxation, including one following surgery. During this 10-year period, 12 patients with atlanto-axial subluxation have died, two with historical evidence of neurologic damage. The remaining 10 patients have died from unrelated causes. Only 3 patients underwent surgical stabilization. This study concluded that the atlanto-axial subluxation is compatible with life, but some patients require surgical intervention. | |
| 2737039 | [Methotrexate (MTX) in the treatment of rheumatoid arthritis]. | 1989 Feb | The efficacy of MTX in the treatment of 35 cases of rheumatoid arthritis (RA) was evaluated. MTX was administered orally (8 cases) or intramuscularly (27 cases) in doses of 15-20 mg per week over a 3 months period. At the completion of three months courses, all clinical parameters measured except for 15 meters walking time, including joint pain count, joint tenderness/swelling counts and scores, morning stiffness, grip strength, joint functional state and rheumatoid nodule were significantly improved (P less than 0.01 or P less than 0.05). The erythrocyte sedimentation rate and rheumatoid factor were also improved significantly after therapy. Four patients were in complete remission, 20 patients had important improvement, 10 patients had clinical improvement, and one unchanged. The drug adverse effect was mild and transient. Gastrointestinal upset was most frequently seen (45.7%), mild leukopenia occurred in 4 patients, skin rash in 2, herpes simplex in 1. No patient were withdrawn drug owing to the untoward effect. We consider that MTX is a useful and safe mode of treatment for RA. | |
| 2695152 | A large multicentre, parallel group, double-blind study comparing tenoxicam and piroxicam | 1989 Sep | A total of 1,328 patients with osteoarthritis or rheumatoid arthritis were entered into this double-blind, parallel group study of tenoxicam and piroxicam. The patient populations were well matched. An improvement was seen in pain on moving and at night in both groups and in both indications. Stiffness was also improved by both drugs, being most marked in the rheumatoid arthritis group. The primary efficacy variable was global assessment, and this showed tenoxicam to have slightly greater effect in osteoarthritis and the reverse in rheumatoid arthritis. There were no statistically significant differences in any of these findings. There were no significant differences in tolerance ratings, although the more serious gastrointestinal events occurred in the piroxicam group. |