Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3518656 | Treatment of secondary osteoarthritis and rheumatoid arthritis by Bateman hip prosthesis. | 1986 | The Bateman hip prosthesis was applied in reconstruction of secondary osteoarthritis and rheumatoid arthritis. Forty-five joints that could be followed up for 45-18 months (mean 26 months) were clinically and roentgenographically re-examined. Forty joints (90.0%) were painless. The clinical score improved from the preoperative mean of 44.8 to the postoperative mean of 87. In 34 patients with secondary osteoarthritis, postoperative protrusion of the outer head into the acetabulum reconstructed by excavation of the previous shallow, steep architecture was only 0.8 mm (mean). Postoperative protrusion of the outer head into the acetabulum reconstructed by bone grafting was only 2.0 mm (mean) in 11 patients with rheumatoid arthritis. Roentgenograms revealed the appearance of sclerosis supermedially in the excavated acetabulum 4-6 months after the operation. This sclerotic change expanded in the entire area of contact with the outer head in 36 of 45 joints within about 1 year. Once the sclerosis had spread completely, the outer head stopped protruding into the acetabulum. A computerized simulation experiment with a rigid spring model demonstrated that central displacement of the outer head can be avoided if the continuity between the sclerosis in the articular surface of the reconstructed acetabulum and the lateral wall is restored for transmission and dispersion of the resultant head force toward the lateral wall as in normal hip joints; this verified the clinical findings. | |
| 3136089 | Effects of long-term aurothiomalate and D-penicillamine treatments on renal function and u | 1988 | The effects of long-term aurothiomalate and D-penicillamine treatments on renal function and the urinary excretion of prostanoids were studied in 20 patients with classic or definite rheumatoid arthritis. Twelve-hour urine was collected overnight, on the following day blood samples were taken in the morning and 12-hour urine was collected during the following day. Albumin excretion into the urine was determined by a sensitive quantitative method. Beta-2-microglobulin (B2MIGLO) and N-acetyl-beta-glucosaminidase (NAG) serum concentrations and excretions into the urine were measured to detect possible tubular or glomerular damage, respectively. The excretions of prostaglandin E2 (PGE2), thromboxane B2 and 6-keto-PGF1 alpha into urine were determined. In the aurothiomalate group, albumin excretion ranged 1-16 mg/12 h, and in the penicillamine group 0.8-31 mg/12 h. In the penicillamine group, but not in the aurothiomalate group, total protein, B2MIGLO and PGE2 excretions were higher (p less than 0.05) during the daytime than during the night. The daytime excretion of PGE2 was higher (p less than 0.01) in the penicillamine than in the aurothiomalate group. In the penicillamine group B2MIGLO excretion into urine correlated (p less than 0.01) with PGE2 excretion in the daytime. According to the results, not even long-term aurothiomalate treatment affects renal prostanoid excretion, while penicillamine increases urinary PGE2 excretion. This could be related either to the cofactor-like activity of penicillamine in the prostanoid synthesis or to damage in tubular cells. The role of prostanoids in maintaining blood flow and filtration may be more important in patients with renal damage than in normal conditions. | |
| 2002078 | Survivorship analysis of total knee arthroplasty. Cumulative rates of survival of 9200 tot | 1991 Mar | From 1971 through 1987, 9200 total knee arthroplasties were performed at the Mayo Clinic. Actuarial analysis was used to estimate cumulative rates of survival. Use of a proportional-hazard, general linear model led to the identification of four independent variables that were associated with a significantly lower risk of failure: primary total knee arthroplasty, a diagnosis of rheumatoid arthritis, an age of sixty years or more, and use of a condylar prosthesis with a metal-backed tibial component. When all four of these favorable variables were present (without regard for radiographic changes and non-disabling symptoms), the probability of an implant being in situ was 97 per cent at both five and ten years. | |
| 2790893 | [Immunologic examination of the synovial fluid in the differential diagnosis of knee joint | 1989 Jul 21 | In the synovial fluid of the knee joint 15 immunological indicators were assessed in 275 patients divided into three groups according to the following diagnoses: rheumatoid arthritis, gonarthritis and synovitis after a blunt injury. The assembled data were evaluated by a stepwise discrimination analysis. This made it possible to select eventually in the compared groups eight characteristics with a differentiating value: IgE, immunocomplexes, beta-2 microglobulin, C3, CRP, alpha-2 macroglobulin, LF-test--reciprocal titre, LF-test--square of reciprocal titre. The classification functions of these characteristics make the correct classification of a random patient with a probability of 78.8-92% possible. | |
| 2267735 | [Levels of tetra-, triiodothyronine and thyroid stimulating hormone in patients with rheum | 1990 Nov | The authors made in patients with confirmed or classical rheumatoid arthritis, using RIA, functional tests of the thyroid gland, i.e. tetra-, triiodothyronine and thyroid stimulating hormone. While deviations of tetraiodothyronine levels from normal very rare, a reduction of triiodothyronine was recorded in 50% and of TSH in 27.2%. Clinically manifest thyropathy, i.e. hyperthyroidism was found only in one female patient. The authors investigated changes in the values of the above tests in the course of rheumatoid arthritis and a dysbalance in the regulation of thyroid functions. The investigation comprises also a group of 18 subjects with rheumatoid arthritis where antibodies against the thyroid gland were assessed. The latter were elevated in two patients. | |
| 3718566 | Binding of normal human mononuclear cells to blood vessels in rheumatoid arthritis synovia | 1986 Jun | We examined the binding of mononuclear cells to blood vessels in the rheumatoid arthritis synovial membrane. Two of 4 synovia that had lymphocyte-rich areas contained blood vessels adhesive for mononuclear cells. These reactive vessels showed striking similarities to high endothelial venules of the paracortical region of lymph node, where normal lymphocyte-endothelial cell adhesion and lymphocyte emigration into tissue occurs. | |
| 3530533 | Evaluation of a quantitative immunoturbidimetric assay for rheumatoid factors. | 1986 Oct | A quantitative immunoturbidimetric assay for rheumatoid factors (RF) is described, based on the immunoprecipitation between aggregated human IgG and rheumatoid factors in serum. The resulting turbidity is measured photometrically at 340 nm. The method is standardized against the WHO international reference preparation and the results are expressed in international units per milliliter (int. units/mL). Results correlate well with those by different latex-agglutination techniques (r = 0.80-0.96). The correlation with Waaler-Rose test modifications were 0.75 and 0.92. The within-run and between-run coefficients of variations were respectively from 1.2 to 2.6% and 1.3 to 1.9% for high and low RF concentrations. Quantitative and reproducible results, together with high throughput of samples and compatibility with most clinical chemistry analyzers and photometers, make this new assay well suited for routine screening and monitoring of rheumatoid factors. | |
| 2694112 | Clinical features and treatment of Lyme disease. | 1989 | Lyme disease is caused by the spirochete Borrelia burgdorferi, which is carried by infected ticks. This disorder has a variable clinical course with multisystem manifestations, including dermatologic, neurologic, cardiac, and rheumatologic abnormalities. Although Lyme disease has been commonly associated with stages, the utility of staging may be limited due to the inconsistency of clinical manifestations among patients. Furthermore, stages may overlap as a result of the acute and chronic phases of the disease. The laboratory characteristics of Lyme disease are highly variable. The use of microbiologic cultures in establishing the diagnosis requires several weeks and has a low yield of positivity. Serologic assays using indirect immunofluorescence and enzyme-linked immunosorbence are preferred. Because of the highly variable features of Lyme disease, clinical and laboratory features must be correlated and interpreted in the context of the disease. Treatment should be initiated as early as possible after the onset of illness. Prompt therapeutic intervention may result in early resolution of the dermatologic hallmark, erythema chronicum migrans, as well as prevention and attenuation of subsequent complications. | |
| 2869466 | Head and neck manifestations of collagen vascular diseases. | 1986 Feb | Collagen vascular disease is among the least understood entities in medicine. What appears to be a localized process may be a manifestation of a systemic disease with serious sequelae. The otolaryngologist must be aware of the manifestations of these disorders in the head and neck. | |
| 3118590 | [Ulcerative colitis caused by oral gold therapy in rheumatoid arthritis]. | 1987 Jul | We report on a 39-year-old male patient suffering from seropositive rheumatoid arthritis who developed severe colitis during oral gold (Auranofin) therapy. So far, two further cases of colitis during oral, and 28 cases of enterocolitis during parenteral chrysotherapy have been described. The pathomechanism has not been identified. Symptomatic therapy was applied, under which our patient recovered from intestinal discomfort in a few weeks. In differential diagnosis gold induced colitis has to be distinguished both from loose stools occurring during oral gold therapy, most probably caused by an inhibition of NA+K+ ATPase, and from colitis induced by concomitant application of nonsteroidal anti-inflammatory drugs. | |
| 3372099 | Semiarthroscopic synovectomy of the hip. | 1988 | A new surgical procedure, semiarthroscopic synovectomy of the hip is described. The operation enables a radical synovectomy to be performed without the risk of necrosis of the femoral head from temporary luxation. The early results have been encouraging and the method appears to offer a low-risk alternative to conventional radical synovectomy. | |
| 1872046 | Complement C3 cleavage product in synovial fluids detected by immunofixation. | 1991 Mar | 54 synovial fluids (SFs), 46 of them derived from various inflammatory diseases (30 rheumatoid arthritis (RA) SFs, 8 undefined arthritis (UA) SFs, 8 psoriatic arthritis (PSA) SFs) and 8 SFs from degenerative joint diseases (OA) were tested for C3c split product, using the immunofixation method. There were significant differences in the C3c product between the four groups investigated. In the OA group in the mean the percentage of C3c was low in comparison to the native C3 (C3c = 2.95%). RA SFs and UA SFs showed considerably higher values (20.1% for RA and 23.2% for UA) which were statistically significant in comparison to the OA SFs. With the exception of one SF the PSA SFs exhibited a relatively low percentage of the cleavage product. Despite the one high value the average C3c content of the PSA SFs was not statistically different from the OA SFs. In contrast to this low percentage of the C3c split product the PSA SFs showed the highest C3 concentration of all groups (87.0 +/- 36.5 mg/100 ml). Immunofixation is a simple and effective tool to determine the C3c split product in SFs. It might also be helpful for establishing the differential diagnosis of PSA vs RA on the basis of the C3 level of the SF in those patients where an elevated level of C3 is present. | |
| 3397742 | An analysis of factors affecting the long-term results of total shoulder arthroplasty in i | 1988 | The authors studied 36 patients undergoing 50 total shoulder arthroplasties for inflammatory arthritis with an average follow-up period of 5 years (range, 2-9 years). There were 7 men and 29 women. Twenty-nine patients (38 shoulders) had rheumatoid arthritis, 6 patients (11 shoulders) had systemic lupus erythematosus, and 1 patient (1 shoulder) had psoriatic arthritis. Twenty-four of the procedures were performed on the dominant hand. Twenty-one patients (32 shoulders) were receiving steroids, chemotherapeutic agents, or Gold therapy at the time of arthroplasty. Using the Hospital for Special Surgery scoring system, 22 shoulders had excellent, 18 good, 1 fair, and 9 poor results. Forty-eight of 50 shoulders had satisfactory pain relief. The average shoulder score was 85 points (range, 50-100 points). There were no reoperations, infections, or persistent nerve palsies and no symptomatically loose prostheses, although there were three cases of glenoid component shift. Eighteen glenoid components and 4 humeral components had radiolucent lines and in two cases metaphyseal bone atrophy was noted about the proximal humerus with firm cement fixation and bone hypertrophy about the stem tip. Total shoulder arthroplasty provides a predictable reconstructive alternative for patients with inflammatory arthritis. Overall functional results are related to the biologic condition and motivation of the patient, the status of the rotator cuff, and prosthesis alignment. | |
| 2083769 | Serum keratan sulphate levels rise in rheumatoid arthritis patients, but fall in ankylosin | 1990 Oct | Serum levels of keratan sulphate (KS) were found to be significantly elevated in patients with destructive and predominantly seronegative rheumatoid arthritis (RA) compared with a control population. Levels in RA did not correlate with clinical or laboratory indices of joint activity or damage. Conversely levels were depressed in ankylosing spondylitis (AS) compared with controls. | |
| 2302272 | Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections | 1990 Jan | The serum concentrations and the pharmacokinetics of low-dose methotrexate (MTX) were compared after both intramuscular (IM) and subcutaneous (SQ) injections in 5 patients with rheumatoid arthritis. Values for the observed peak concentration, the time to the observed peak concentration, and the area under the time versus concentration curve for IM injections were not significantly different from these values for SQ injections. These results suggest that IM and SQ are interchangeable routes of administration. SQ administration may be a more convenient and less painful way of administering low-dose MTX. | |
| 3423618 | Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic ar | 1987 | Peroxidase-anti-peroxidase (PAP) staining and specific antibodies against cathepsin G and elastase from polymorphonuclear leukocytes (PMN) were applied to pannus-free and microscopically intact superficial articular cartilage. Restricted local deposits containing cathepsin G and elastase were found in three of ten patients with seropositive rheumatoid arthritis (RA), in one of three patients with seronegative RA and in one patient with juvenile chronic arthritis (JCA). Similarly, localized deposits of IgG and C3 were found in the patients with seropositive RA and JCA, but not in the patient with seronegative RA. Adjacent sections exhibited esterase activity in and around the PMN. In proteinase-positive areas from patients with seropositive RA the inhibitors alpha 1-proteinase inhibitor (alpha 1-PI) and alpha 2-macroglobulin (alpha 2-MG) were present in two of three and one of three patients, respectively. In JCA only alpha 1-proteinase inhibitor was present, and in seronegative RA no inhibitors were found. No staining of articular cartilage was observed in a patient with psoriatic arthritis. One of three cases with osteoarthritis exhibited patchy superficial staining for IgG only. In articular cartilage covered by pannus, in three patients with seropositive RA, in one with seronegative RA and in the patient with JCA a few regions with variably dense PMN infiltrates were observed. Cathepsin G, elastase and esterase activity were found in and around the PMN. In one of the three patients with seropositive RA the adjacent cartilage-pannus junction exhibited distinct staining for cathepsin G and elastase, but not for IgG/C3 and proteinase inhibitors.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 3964626 | Delayed-onset chloroquine retinopathy. | 1986 Apr | Delayed-onset chloroquine retinopathy was diagnosed in a patient seven years after cessation of treatment by a total dose of 730 g of chloroquine for rheumatoid arthritis. Visual functions continued to deteriorate after the diagnosis. Periodic examinations by ophthalmoscopy and by functional tests such as EOG and visual fields should be continued in patients at risk of delayed-onset chloroquine retinopathy after discontinuance of the drug. | |
| 2787996 | [Expression of the interleukin-2 receptor in T lymphocytes of the rheumatoid synovial memb | 1989 Jan | Indirect immunofluorescence was used to stain DR antigen and interleukin-2 receptor (Tac) of T-lymphocytes (Leu 4+). Tissue samples of synovial membrane were cut from arthroscopic biopsies of inflamed knees in four patients with active rheumatoid arthritis (RA). Consecutive cryostatic sections of rheumatoid sinovium were analysed using monoclonal antibodies. It was found that a high percentage of T-lymphocytes express DR antigen. In contrast the proportion of T cells expressing Tac was small. We conclude that T cell activation in synovial membrane is incomplete, and this disfunction may contribute to the chronic inflammation of RA. | |
| 3539433 | Cytokines and fibrosis. | 1986 Oct | Inflammation is frequently associated with changes in the surrounding connective tissue. Inflammatory mononuclear cells (MNC) produce biologically active molecules, cytokines (CK), which may regulate the growth and function of connective tissue fibroblasts. In this article, we review the characteristics of lymphocyte and monocyte CK which appear to be involved in regulating fibroblast recruitment, proliferation, and matrix synthesis. Whereas these MNC products are important in normal physiologic wound healing, an imbalance of these CK may lead to pathophysiologic fibrosis and/or destruction of connective tissue components. Clinical states associated with MNC-mediated connective tissue pathology include scleroderma, rheumatoid arthritis, diffuse pulmonary idiopathic fibrosis, sarcoidosis and atherosclerosis. Characterization of the molecular pathways linking inflammatory mononuclear cells and fibrosis may provide avenues for therapeutic intervention. | |
| 2664168 | A clinical and biochemical assessment of prinomide in patients with rheumatoid arthritis. | 1989 Apr | Prinomide (CGS-10787B), a potential disease modifying drug, was evaluated clinically and biochemically in 15 patients with active rheumatoid arthritis. The single group study design included monthly assessments of 7 clinical measures and 22 laboratory measures. Twelve patients completed 24 weeks' therapy with prinomide 1.2 g/day. All clinical variables showed improvement which consistently reached statistical significance for articular index from Week 8 (p less than 0.01), for summated change score from Week 12 (p less than 0.01) and for pain score from Week 16 (p less than 0.05). Sustained significant improvement in laboratory variables was seen by Week 2 for erythrocyte sedimentation rate and platelet count (both p less than 0.05), and by Week 4 for plasma viscosity (p less than 0.01), IgG, IgA, IgM (all p less than 0.05). |