Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3690137 | Decreased bioactivity of circulating prolactin in patients with rheumatoid arthritis. | 1987 Dec | Growth hormone and prolactin (PRL) were measured by radio-immunoassay in sera of 36 patients with rheumatoid arthritis (24 females and 12 males) and of 50 normal blood donors (25 males and 25 females). The bioactivity of PRL was also determined for both groups, using the Nb2 rat lymphoma proliferation assay. Although no significant difference was found between serum PRL values of patients and controls when determined by radio-immunoassay, the bioactivity of PRL was significantly decreased in patients' sera, when compared to values obtained in age and sex-matched controls. This decreased PRL bioactivity could not be attributed to drug treatments administered to the patients examined. | |
| 2830890 | A DR4-associated DR-DQ haplotype is significantly associated with rheumatoid arthritis. | 1988 Jan | Forty-three patients with seropositive, erosive rheumatoid arthritis (RA) and 24 members of 5 RA multicase families were studied for HLA class II gene polymorphism, using restriction fragment analysis with complementary DNA probes for DR beta and DQ beta chains. This method generates HLA-DR-DQ haplotypes that are highly correlated with HLA-DR serology. Thirty-five of the 43 RA patients (81%) were positive for one or for both of the DR4-associated DR-DQ haplotypes, 4.1 and 4.2. Among these patients, the 4.1 haplotype was found significantly more often than in DR4+ controls (P less than 0.01). The haplotype segment C3;B15;DR4 was present in all RA patients in 4 of the 5 families, and included the DR-DQ4.1 haplotype. | |
| 3107052 | Immunophotometric analysis of immunoglobulin synthesis and deposition in synovial membrane | 1987 | Immunophotometrical measurements of the Ig synthesis of plasma cells in joint capsules of patients with rheumatoid arthritis and osteoarthritis were compared. Patients with rheumatoid arthritis showed higher mean values in the single plasma cell than patients with osteoarthritis for all Ig isotypes except IgG. These results are indicative for a B cell activation with increased synthesis of Ig in RA. | |
| 3033628 | [What is the role of Epstein-Barr virus in the pathogenesis of connective tissue diseases? | 1987 Apr 25 | In rheumatoid arthritis (RA) abnormalities of T suppressive/cytotoxic responses to Epstein-Barr virus (EBV) have been reported: lack of inhibition of spontaneous proliferation of autologous B lymphocytes infected by EBV, lack of late suppression of immunoglobulin secretion induced in vitro by EBV. Moreover, a cross-reaction between EBNA antigen (Epstein Barr Nuclear Antigen) and a cytoplasmic protein of 62 KD present in the rheumatoid synovitis has been described. In primary Sjögren's syndrome, EBV genome has been observed in the parotid of some patients. The abnormalities of T suppressive/cytotoxic responses observed in rheumatoid arthritis are inconstant and non specific; they are noted in some cases of systemic scleroderma and lupus; they remain for a given patient and could be the marker of a particular subset of connective tissue diseases. The pathophysiological role of EBV infection, especially in rheumatoid arthritis and Sjögren's syndrome, remains to be determined. | |
| 3482986 | Extended haplotypes in rheumatoid arthritis and preliminary evidence for an interaction wi | 1986 Jun | The incidence of extended haplotypes of the Major Histocompatibility Complex was compared between 20 probands with RA, their unaffected family members, and 42 controls. One haplotype only, HLA-Bw62 BfS C4A*3 C4B*3 DR4 GLO2, was significantly increased in the patient group, whereas HLA-B7 BfS C4A*3 C4B*1 DR2 GLO1, which was the most common haplotype in the control groups, was absent. The immunoglobulin allotype Glm(2) was significantly increased in frequency in the RA patients, and analysis showed that of the seven patients carrying Bw62-DR4, five were G1m(2) positive. Further, the increase in frequency of the phenotype Gm(1,2,17,21,3,5,23) was also significant and was carried by two of four probands with the extended haplotype HLA-Bw62 BfS C4A*3 C4B*3 DR4 GLO2 and by one proband also bearing this haplotype but with a null allele at the C4A locus. The striking association of G1m(2) and Bw62 with DR4 in our patients suggests that in interaction of immunoglobulin genes with DR4 is stronger when DR4 is associated with particular haplotypes rather than with DR4 in general. | |
| 3224902 | Keller arthroplasty in combination with resection arthroplasty of the lesser metatarsophal | 1988 Oct | We reviewed the results of the Keller arthroplasty in combination with resection arthroplasty of the forefoot in patients with rheumatoid arthritis. Of the 29 patients (49 feet) in the series, 20 had involvement of both feet and nine had involvement of a single foot. The average age of the patients was 55.4 years, and the average follow-up period was 4.9 years. All feet had resection of the lesser metatarsal heads, resection of the base of the proximal phalanges of the lesser toe, and a Keller arthroplasty of the first metatarsophalangeal joint. The results were satisfactory in 16 feet, satisfactory with some reservations in 21 feet, satisfactory with major reservations in seven feet, and unsatisfactory in five feet. For 40 of the 49 feet (82%), the patients stated that they would repeat the procedure, knowing the results achieved. The major causes of patient reservations and lack of satisfaction were return of the hallux valgus deformity and pain (53%), forefoot instability (27%), and continuing metatarsalgia (20%). Resection arthroplasty of the lesser metatarsophalangeal joints of the forefoot in rheumatoid disease is a satisfactory procedure. When used in combination with Keller resection arthroplasty of the first metatarsophalangeal joint, however, an increased number of unsatisfactory results occur, attributable to returning pain and deformity of that joint. | |
| 3321754 | [Urticaria vasculitis]. | 1987 Sep | Urticarial vasculitis is a syndrome characterized by a chronic intermittent urticaria and the histological features of necrotizing vasculitis. The skin lesions are often accompanied by arthritis or arthralgia and other systemic diseases. Depressed serum complement can be found in half of the patients. | |
| 3623825 | Electron microscopic study of rheumatoid synovial vasculature: intimate relationship betwe | 1987 | A relationship has been demonstrated between the tallness of the endothelial cells (EC) of the postcapillary venules (PCV) of rheumatoid (RA) synovial membrane and the cellular composition of adjacent perivascular mononuclear cell infiltrates. A strong positive correlation between EC tallness and the number and percent of perivascular lymphocytes was observed. In contrast, EC tallness showed negative correlations with percent perivascular plasma cells, macrophages and fibroblasts. None of the preceding correlations were observed in the case of pericapillary infiltrates. The findings obtained indicate that the PCVs of the RA synovial membrane, from which lymphocytes emigrate to form perivascular lymphoid aggregates, resemble the tall endothelial PCVs of normal lymphoid tissue. They suggest that chronic inflammatory tissue and normal lymphoid tissue share common mechanisms of lymphoid emigration. | |
| 1955014 | Bronchiolitis obliterans organizing pneumonia and rheumatoid arthritis. | 1991 Jul | Bronchiolitis obliterans, with or without organizing pneumonia, can be a serious and life-threatening complication of rheumatoid arthritis. We describe a case of bronchiolitis obliterans organizing pneumonia in a patient who recently developed rheumatoid arthritis, presenting as a severe respiratory insufficiency. Diagnosis was made by means of open lung biopsy. Treatment with corticosteroids induced a quick response and substantial improvement of the respiratory symptoms. A simultaneous strong rise in titres of serological tests suggests a relationship between the bronchiolitis obliterans organizing pneumonia and the rheumatoid arthritis. | |
| 3524843 | Double-blind randomized trial of diclofenac sodium versus placebo in patients with rheumat | 1986 | In a six-week, double-blind, randomized, multicenter clinical trial, the efficacy and safety of 150 mg/day of diclofenac sodium and a placebo were compared in 182 patients with active definite or classical rheumatoid arthritis. Safety and tolerability were evaluated in all patients and efficacy was determined in a subset of 158 patients who met all criteria for eligibility. A significantly greater improvement in six of eight treatment variables was seen in the diclofenac-treated patients than in the placebo group after one week of therapy. Fewer diclofenac-treated patients than placebo-treated patients discontinued the study because of lack of therapeutic response. Adverse experiences were reported by 28% of the diclofenac group and 21% of the placebo group, not a statistically significant difference. Gastrointestinal complaints were the most frequently reported side effects in both treatment groups, but there was no significant difference between the treatment groups. Diclofenac was found to be effective, safe, and well tolerated for the treatment of patients with active rheumatoid arthritis. | |
| 3024529 | [Collagenases in rheumatology]. | 1986 | An important role is supposed to be played by the collagenases in the physiological or pathological degradation of collagen. However, their exact effects in rheumatic diseases, especially in rheumatoid arthritis is still controversial. The aim of the authors is to give facts and datas up to date, about this important question of the pathogenic role of collagenases in rheumatoid arthritis, osteoarthritis and in several other rheumatic diseases. | |
| 2405863 | Time for changes in the design, analysis, and reporting of rheumatoid arthritis clinical t | 1990 Jan | We have proposed a set of changes in the design, analysis, and reporting of RA clinical trials which emphasizes the standardization of trials. We have suggested limiting the number of outcome measures used to those most sensitive to change and using uniform measurements of the same outcome measures in all clinical trials. We have also suggested that investigators focus on enumerating which patients improve in a trial, rather than on the mean level of improvement in treated patients versus the control patients. Finally, we have suggested the reporting of confidence intervals rather than simply stating P values. With the inauguration of these changes and more attention to other issues relevant to the quality of clinical trials, we hope that drug treatments of rheumatoid arthritis can be more easily compared with respect to effectiveness. | |
| 1966993 | anti-DR antibodies inhibit in vitro production of human rheumatoid factor. | 1990 Mar | Anti-MHC class II antibodies have been shown to have a profound effect on the immune system and have been used successfully in the therapy of human and animal autoimmune diseases. In addition, naturally-occurring anti-DR antibodies have been observed in the sera of rheumatoid arthritis (RA) and systemic lupus erythematosus patients. Now, we demonstrate that several monoclonal anti-DR, but not anti-DQ antibodies specifically inhibit the production of rheumatoid factor (RF) in pokeweed-stimulated cultures of peripheral blood mononuclear cells from RA patients. Moreover, partially-purified anti-DR antibodies from RA sera have similar inhibitory effects on in vitro RF synthesis. These results indicate the inhibition of autoantibody production as a possible mechanism operative in immunotherapy using anti-class II antibodies. Furthermore, this data also suggests a protective, beneficial role for the endogenous anti-DR autoantibodies in RA. | |
| 3378489 | Cytology of pleural effusions in rheumatoid arthritis. | 1988 Mar | Rheumatoid pleural effusions are relatively uncommon. The cytologic examination of such effusions can be diagnostic of the underlying disease; this is of great clinical significance when the rheumatoid condition has not been diagnosed prior to the pleural involvement. The diagnostic cytologic abnormalities include large elongated and multinucleated giant cells and macrophages in a background of granular and necrotic debris. The cytologic characteristics parallel the histologic features of pleural rheumatoid nodules. | |
| 1911055 | Bacterial arthritis. | 1991 Aug | In this review of the 1990 septic arthritis literature, we revisit synovial fluid leukocytosis, examine the utility of synovial fluid glucose and protein measurements, and look at the levels of two cytokines, tumor necrosis factor and interleukin-1, in infected joint fluids. We see the many faces of gonococcal arthritis and the ravages of septic arthritis when the host has rheumatoid arthritis. Should we recommend antibiotic prophylaxis for the rheumatoid patient with a prosthetic joint who is undergoing a procedure that leads to transient bacteremia? What are some of the salient features of septic arthritis when it involves the sternoclavicular or sacroiliac joints? We also look at some unusual microorganisms, eg, group C Streptococcus, Streptococcus viridans, Listeria monocytogenes, Pseudomonas cepacia, Pseudomonas maltophilia, and Neisseria sicca. In patients with acquired immunodeficiency syndrome, we encounter reports of septic arthritis, osteomyelitis, and spinal epidural abscess caused by opportunistic microorganisms. Two unusual sites of infection include the C1-2 lateral facet joint and subacromial bursa without involvement of the glenohumeral joint. Finally, we examine how to drain a septic knee: the orthopedic point of view. | |
| 2506869 | [Interferon gamma in the treatment of chronic polyarthritis. Long-term therapy in clinical | 1989 Jul | Efficacy and practicability of a defined dosage scheme for interferon gamma was proved during one year's treatment in patients with rheumatoid arthritis. Interferon gamma was well tolerated. It was effective in improving blood sedimentation rate, anemia, leucocytosis and thrombocytosis as well as clinical parameters such as pain, mobility, swollen joints and morning stiffness. Concomitant medication with corticosteroids could be reduced. | |
| 3051091 | The differential diagnosis of geodes. | 1988 Nov | Lytic lesions close to or at the articular margins are secondary to a wide range of etiologies, including osteoarthritis, rheumatoid arthritis, hemophilic arthropathy, and crystal deposition disease as well as tumor and tumor-like conditions. In many cases the features of these "cysts" are distinctive, and the purpose of this article is to outline the characteristic hallmarks in some of the more frequently encountered arthropathies. | |
| 3195601 | Methotrexate-associated hepatotoxicity: retrospective analysis of 210 patients with rheuma | 1988 Dec | PURPOSE: Beginning in the 1980s, methotrexate has been used successfully to treat rheumatoid arthritis. The magnitude and severity of short- and long-term methotrexate toxicity, however, have not been adequately investigated. Our study was performed to determine the prevalence of hepatotoxicity in patients with rheumatoid arthritis receiving long-term methotrexate therapy. PATIENTS AND METHODS: We conducted a retrospective, computer-assisted review of all Duke University Medical Center patients undergoing liver biopsy for methotrexate monitoring from January 1979 to January 1988. A total of 538 biopsies were performed in 399 patients, 259 of whom had inflammatory arthritis (210 with rheumatoid arthritis, 47 with psoriatic arthritis, and two with seronegative spondyloarthropathy). RESULTS: No evidence of cirrhosis was defined in the cohort with rheumatoid arthritis; however, six patients with rheumatoid arthritis had histologic changes of fibrotic liver disease (prevalence of 2.9 percent in the group with rheumatoid arthritis) while taking methotrexate. Five of the six patients were obese and three had glucose intolerance or overt diabetes mellitus, and one person admitted to alcohol usage. Only one patient with fibrotic liver disease had elevated liver function test results, and no person showed a declining serum albumin level at the time of biopsy. Sixty-one patients with rheumatoid arthritis underwent multiple samplings (44 with two, 13 with three, and four with four biopsies). Fourteen of these patients showed progressive hepatic disease, whereas four patients improved. CONCLUSION: Although the prevalence of methotrexate hepatotoxicity in this large cohort of patients with rheumatoid arthritis was low, a small but definite risk of hepatic fibrosis, not predictable by laboratory screening, still exists. | |
| 2969046 | The immunohistology of synovial lining cells in normal and inflamed synovium. | 1988 Jun | The immunohistology of synovial lining cells (SLCs) in normal and inflamed hyperplastic synovium was investigated using monoclonal antibodies directed against leucocyte common antigen (LCA) HLA-DR and other macrophage components. We found that some SLCs in normal synovium express LCA, HLA-DR, and monocyte/macrophage-associated antigens. The number of SLCs expressing these antigens is increased in hyperplastic osteoarthritic (OA) and rheumatoid (RA) synovium. Some SLCs which did not react for LCA or other macrophage markers but were positive for HLA-DR were also noted in normal synovium and some segments of hyperplastic OA synovium. SLCs which are positive for LCA, HLA-DR, and macrophage markers contribute to the intimal hyperplasia in RA where they account for the majority of SLCs in the synovial intima. In OA synovium, the distribution of SLCs showing this pattern of reactivity was less uniform with numerous SLCs which were positive for HLA-DR but negative for LCA and other macrophage markers also present in the synovial intima. These findings indicate that there are some SLCs of bone marrow origin in normal and hyperplastic synovium. They also suggest that recruitment of SLCs of marrow origin is important in the production of intimal hyperplasia in both RA and OA and that there is also a significant local proliferation of non-marrow derived SLCs in OA. | |
| 2570580 | Combination methotrexate and sulfasalazine in the management of rheumatoid arthritis: case | 1989 Sep | Four patients with rheumatoid arthritis received a combination of methotrexate and sulfasalazine for a mean of 24 months (range 20-28 months). All 4 patients experienced clinical improvement, with a reduction in the number of involved joints and in morning stiffness. In all 3 patients who had previously taken methotrexate, we were able to reduce the dosage, and the prednisone dosage was reduced in 2 of 3 patients who had previously taken that drug. No serious toxicity was observed in any patient. |