Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3335140 | Poor prognosis in patients with rheumatoid arthritis hospitalized for interstitial lung fi | 1988 Jan | Fifty-seven patients with rheumatoid arthritis (RA) were treated in hospital for diffuse interstitial lung fibrosis. Although interstitial fibrosis (either on the basis of lung function tests or chest roentgenograms or both) is fairly common among patients with RA, according to this study interstitial fibrosis of sufficient extent or severity to warrant hospitalization was rare: incidence of hospitalization due to the lung disease in RA patients was one case per 3,500 patient-years. Eight patients had a largely reversible lung disease associated with drug treatment (gold, D-penicillamine or nitrofurantoin.) The remaining 49 had interstitial fibrosis of unknown cause. Causes for hospitalization were respiratory and general symptoms in 38, but infiltrations on routine chest roentgenographic examinations alone in eleven patients. Forty-five out of the 49 patients had crackles on auscultation. The most typical findings in lung function tests were restriction and a decreased diffusion capacity. These 49 patients showed a poor prognosis, with a median survival of 3.5 years and a five-year survival rate of 39 percent. | |
| 3336640 | Rheumatoid arthritis and Dupuytren's contracture. | 1988 Jan | Of four patients with rheumatoid arthritis and Dupuytren's contracture, two were not aware of the presence of Dupuytren's contracture. When both diseases coexist, the presence of rheumatoid hand deformities, especially flexion and ulnar deviation of the metacarpophalangeal joints, may mask the flexion deformity caused by Dupuytren's contracture. Careful clinical examination should rule out the presence of a pathologic fascial cord. When reconstructive surgery is indicated for the rheumatoid hand in the presence of advanced Dupuytren's contracture, staged surgery would be appropriate and reconstruction of Dupuytren's contracture should precede other surgery. | |
| 3814970 | Gold-induced hypogammaglobulinaemia. | 1987 Feb | Panhypogammaglobulinaemia has recently been recognized as a rare complication of gold toxicity. We report two further cases of gold-induced hypogammaglobulinaemia which also demonstrated that monitoring of immunoglobulin levels is necessary for the early detection of this condition. | |
| 2491646 | Rheumatoid arthritis and its association with HLA-DR antigens. II. Antibodies to native co | 1989 | The distribution of frequencies of HLA-DR alloantigens in HLA-DR4 negative subjects was determined in patients with Rheumatoid arthritis (RA) and normal individuals. An increased incidence of HLA-DR1 alloantigen in DR4 negative RA patients (45.9%) compared with DR4 negative healthy controls (23.6%) was found. The difference became significant when the incidence of DR1 was compared between patients with severe disease stages (III-IV) (75%) in contrast to 32% of incidence in patients of the milder stages (I-II) (p less than 0.05). Using Enzyme Linked Immunosorbent Assay we have determined the incidence of serum antibodies to native bovine type I and type II collagens and proteoglycans in patients with RA. Presence of serum antibodies to native type I collagen was detected in 59% of patients with RA, 60% of sera exhibited reactivity to type II collagen and 12% had antibodies to proteoglycans. There was no correlation between the presence of antibodies to type I and II collagens and disease stages, however, the incidence of serum antibodies to proteoglycans was increased in severe disease stages. On the other hand, the presence of high levels of antibodies to type I collagen was associated to HLA-DR1 antigen, (p less than 0.05). | |
| 2218263 | [Evaluation and prognosis of work capacity in rheumatoid arthritis]. | 1990 Apr | Assessment of the functional state, social and psychological status of 82 patients with RA was made with the aid of a modified health assessment questionnaire (HAQ) and individual arthritis impact measurement scales (AIMS). A group of disabled persons exhibited a greater markedness of articular destruction, high activity of the disease and a high functional index, all of them being old persons. Patients with working ability underwent prophylactic medical examination, more intensive therapy with basic drugs. The use of a computer for prognostication of capacity for work has been shown. | |
| 10149084 | The clinical status of low energy laser therapy in 1989. | 1990 Jan | Low energy laser therapy has gained varying acceptance as a treatment for a broad range of soft tissue, musculoskeletal and neurological conditions. A controversial, but surprisingly large body of research with cell cultures suggests that laser irradiation can nondestructively alter cellular processes. Unfortunately, animal and human studies are often contradictory and difficult to evaluate due to differing study designs. As a result, the clinical effectiveness of low energy laser therapy remains debatable. Nevertheless, the findings are intriguing and deserve further investigation. | |
| 3439365 | [Mechanochemistry of the joint cartilage and arthrosis--a pathophysiologic correlation]. | 1987 Nov | The influence of changes in physicochemical parameters on the biomechanics of articular cartilage is investigated using relaxation tests in healthy rabbit cartilage. A mathematical model is established. An increase in ionic strength and osmolarity, as well as a rise in temperature lead to an increase in the compliance of cartilage. The majority of these phenomena are nonlinear and in most cases so characteristic that they can be associated with particular molecular processes in the cartilage matrix. The experimental results allow an insight into the functioning of articular cartilage and put another pathogenetical factor of arthrosis up for discussion by demonstrating the lability of the ideal mechanical condition. | |
| 3041924 | A double blind multicentre study of OM-8980 and auranofin in rheumatoid arthritis. | 1988 Jul | The therapeutic efficacy of the immunomodulator OM-8980 in rheumatoid arthritis was compared with that of auranofin, an oral gold salt, in a double blind, randomised multicentre study lasting six months. Seventy patients were treated with auranofin and 75 with OM-8980. The patients of both groups improved significantly at three and six months for all the clinical parameters observed: Ritchie index, number of swollen joints, morning stiffness, pain, grip strength, intake of non-steroidal anti-inflammatory drugs, and erythrocyte sedimentation rate. No serious side effects were observed in either group. The patients receiving auranofin had more adverse reactions, mainly affecting the gastrointestinal system. | |
| 2882451 | Slow-acting anti-rheumatic drug therapy for rheumatoid arthritis. | 1987 Mar | Rheumatoid arthritis is a disorder that frequently can be controlled with a program of physical therapy, rest and therapeutic doses of aspirin or another nonsteroidal anti-inflammatory medication. However, some patients' diseases are not controlled on this regimen. These patients are candidates for therapy with slow-acting anti-rheumatic drugs. This article discusses the indications for use of these medications as well as the potential benefits and adverse drug reactions commonly associated with their use. | |
| 3963023 | Review of the dosing regimens for flurbiprofen. A potent analgesic/anti-inflammatory agent | 1986 Mar 24 | Flurbiprofen (Ansaid, Upjohn) is an effective analgesic and anti-inflammatory agent. At dosages of 50 mg administered every four to six hours as needed, flurbiprofen's analgesic efficacy has been confirmed in patients with postoperative pain as well as in those with postpartum pain and dysmenorrhea. Data also suggest that flurbiprofen administered 30 minutes before surgery reduced the severity of postoperative pain. In patients with rheumatoid arthritis, osteoarthritis, and numerous other inflammatory disorders, 100 to 200 mg of flurbiprofen in two to four divided doses has led to significant clinical improvement. Studies indicate that 100 mg of flurbiprofen at bedtime effectively decreased night pain and the duration of morning stiffness in patients with rheumatoid arthritis. | |
| 2614163 | Concentration of interleukin-1 beta in serum and synovial fluid in patients with rheumatoi | 1989 Nov | The concentration of interleukin-1 beta (IL-1 beta) in serum and synovial fluid of the knee of patients with rheumatoid arthritis (RA) and those with osteoarthritis (OA) was examined using a recently developed radioimmunoassay method. The serum concentration of IL-1 beta was below the detection limit of 0.25 ng/ml in all RA and OA patients. The IL-1 beta concentration in the synovial fluid was higher in RA patients than in OA patients. In RA patients, a significant correlation was demonstrated between the synovial fluid IL-1 beta concentration and the erythrocyte sedimentation rate, C-reactive protein level, synovial fluid white blood cell count and Lansbury index. The synovial fluid IL-1 beta concentration decreased with the reduction of the rheumatoid activity by the medication, but tended to increase or remain high when inflammatory activity of RA could not be adequately controlled. The IL-1 beta concentration, easily determined, shows promise as a new quantitative indicator of rheumatoid activity. | |
| 3673140 | [Pathophysiologic aspects of inflammatory and degenerative joint diseases]. | 1987 Aug 1 | Authors describe the physiological particularities of components of articular system (cartilage, synovialis, synovia, subchondral bone, ligamentous and neuromuscular apparatus). The essential resultant pathophysiological pattern in rheumatoid arthritis and osteoarthritis are demonstrated. Differences between temporary attendant synovitis in osteoarthritis and rheumatoid arthritis are pointed out. | |
| 2529083 | [Open clinical study on the efficacy and tolerance of acemetacin in rheumatoid arthritis a | 1989 Jul 31 | The authors report the results of an open clinical study of 60 outpatients of whom 20 were suffering from rheumatoid arthritis and 40 from osteoarthritis. The study was aimed at evaluating the efficacy and tolerability of the new indole derivative acemetacin and at a comparison with etodolac. The drug studied was found to be effective and to be tolerated better than indomethacin, particularly the absence of the most unpleasant side-effect of indole compounds, i.e., headache, was noted. | |
| 3716384 | [Acid lysosomal hydrolase activity in the serum and synovial fluid of rheumatoid arthritis | 1986 | Five acid lysosome hydrolases were studied in 20 patients with rheumatoid arthritis (RA), active stage in serum (S) and synovial fluid (SF) in parallel, obtained from the knee joint. The enzyme activity was fluorimetrically determined, making use of substrates specific for each enzyme, derivatives of 4-methyl-umbelliferone. The serum lysosome activity of the patients with RA, compared with that of a referent group of healthy subjects, showed a significant increase in three of the hydrolases studied. With the juxtaposition of enzyme activity between SF and serum of the patients with RA, the activity of all acid hydrolases in the synovial fluid studied proved to be several times higher and with high statistical significance (p less than 0.01-0.001). Our data support the valuable informative value of the study on acid lysosome hydrolases in the synovial fluid. A sensitive indicator of the activity of the joint process in RA is the coefficient of lysosome enzymatic activity SF/S, substantially surpassing 1.0. | |
| 1787499 | Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotre | 1991 Nov | We describe the occurrence of a lymphoma in a patient with rheumatoid arthritis (RA) taking weekly oral pulse methotrexate (MTX) in low doses for 33 months. This occurrence may be coincidental. There may be an increased incidence of lymphoma in RA not treated with immunosuppressive medications. However, the increasing use of MTX warrants reporting unusual events, especially malignancy. It is possible that even the mild immunosuppression that occurs with MTX therapy places patients with RA at added risk for developing lymphoproliferative diseases. | |
| 2810287 | The association of pulmonary hypertension with rheumatoid arthritis. | 1989 Sep | Pulmonary hypertension due to vasculitis is a rare complication of rheumatoid arthritis (RA). We describe 2 patients with RA and pulmonary hypertension who died with a clinical diagnosis of idiopathic pulmonary hypertension. In each case postmortem examination revealed severe pulmonary vasculitis as the actual cause of the hypertension. Subclinical systemic vasculitis was found in one case and hepatic nodular regenerative hyperplasia in both cases. Pulmonary vasculitis must be included in the differential diagnosis of pulmonary hypertension associated with RA. Open lung biopsy should be considered in this clinical setting in an attempt to identify this potentially treatable cause of pulmonary hypertension. | |
| 3572933 | Articular chondrocalcinosis in seropositive rheumatoid arthritis. Comparison with a contro | 1987 Feb | The prevalence of articular chondrocalcinosis was studied in a group of 100 patients with seropositive rheumatoid arthritis (RA). Articular chondrocalcinosis was observed less frequently (3%) than in a control group (19%) of 221 age and sex matched patients with low back pain or extraarticular rheumatism. This difference is statistically significant (p less than 0.001). Articular chondrocalcinosis occurred in the older patients with RA, and was observed in those with the shortest duration of the disease. | |
| 1899556 | Gold-associated lymphadenopathy in a patient with rheumatoid arthritis. Histologic and sca | 1991 Feb | The histologic features of adenopathy associated with intramuscular injections of gold sodium thiomalate in a woman with rheumatoid arthritis are presented. We believe that the light microscopic features of the above process are sufficiently distinctive that a diagnosis of gold-associated lymphadenopathy could be rendered. A review of the literature revealed no descriptions of the light microscopic appearance of gold in lymph nodes. In this case, the diagnosis of gold-associated lymphadenopathy was confirmed by scanning electron microscopic studies. | |
| 2185909 | The role of erythropoietin in the anaemia of chronic disease in rheumatoid arthritis. | 1990 Mar | We reviewed studies on the role of erythropoietin (Epo) in the anaemia of chronic disease (ACD) in rheumatoid arthritis (RA). A relatively impaired Epo response to the anaemia was found in a number of studies although in others serum Epo level was the same as in other types of anaemia. Some arguments are found in favor of a reduced bone marrow-Epo sensitivity although these reflect results mainly from in vitro experiments. It is not yet established whether bone marrow macrophage Epo production is impaired in ACD. In two cases Epo administration to RA patients resulted in increased erythropoiesis. It was concluded that impaired Epo production or reduced bone marrow Epo sensitivity might be associated with ACD but it is not certain whether these factors are causally linked with ACD or side phenomena of RA disease activity. Future Epo treatment in RA and ACD will possibly solve this question. | |
| 3239172 | [Spontaneous ruptures of the extensor system of the knee following joint replacement in pa | 1988 Sep | Spontaneous ruptures of the quadriceps tendon and the patellar ligament following total knee arthroplasty in two patients with rheumatoid arthritis are reported. Degenerative and steroid-induced changes of tendinous tissue, circulation problems as well as mechanical changes to the patellofemoral joint by resurfacing the patella are discussed being possible causes of these complications of the extensor mechanism of the knee. |