Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2724248 | Direct coronal high resolution computed tomography of the temporomandibular joints in pati | 1989 Mar | Direct coronal high resolution computed tomography (CT) examination of the temporomandibular joints (TMJ) was performed in 40 patients with rheumatoid arthritis (RA). The patients were divided into 3 groups. Group 1 included patients with juvenile rheumatoid arthritis (JRA). Four patients of this group had disability of the TMJ associated with overgrowth of one of the mandibular condyles. This phenomenon has not yet been reported. Group 2 consisted of 10 patients with RA with clinically asymptomatic TMJ, 4 of whom had mild erosions of the condylar head seen on CT, consistent with RA. The majority of patients in Group 3, with clinically symptomatic TMJ showed CT changes of various degrees, which are discussed in this paper. Mild bone changes, not demonstrated by conventional procedures, were clearly seen by CT. Coronal view of the CT examination had advantages over other projections. | |
| 1663849 | Methodologic challenges in the development of utility measures of health-related quality o | 1991 Aug | Utility measures of health-related quality-of-life (HRQL) are unique in that they focus on patient preferences for alternative health conditions and combine benefit and toxicity into one number. This paper addresses the application of utility measurement techniques to assess HRQL in rheumatoid arthritis (RA). More specifically, the measurement issues and empirical evaluation strategies relevant to establishing the usefulness of utility measures in clinical trials and "n of 1" studies in RA are presented. First, utilities are reviewed within the context of RA and the other measures of benefit and toxicity currently in use. Second, the key methodologic challenges relevant to the development of HRQL measures of RA treatment impact are identified. Finally, a new utility instrument suitable for use in both parallel group and "n of 1" drug trials in RA is presented. The work described also addresses the interpretation of utility values and hence their acceptability to clinicians, researchers and policy makers and may aid initiatives to establish HRQL as one of the criteria for approval by federal drug regulatory agencies. Given that patient preferences constitute a central concept within the framework of HRQL, further empirical evaluation of utility measures of preference is fundamental to improving the HRQL measurement tool-kit. | |
| 3668547 | Total hip arthroplasty in rheumatoid arthritis. A long-term follow-up study. | 1987 | This study was undertaken to assess the clinical and radiographic results of total hip arthroplasty in rheumatoid arthritis patients with a minimum of 10 years of follow-up evaluation. Eighty-three hips in 51 of the original 104 patients were available for follow-up study an average of 12.1 years following surgery. The average age of the patients at the time of surgery was 39.9 years (range, 14-72 years). Fourteen hips were revised, 11 for mechanical loosening and 3 for late infection. The overall revision rate is 16.7%; the revision rate for mechanical loosening was 13.3%. According to Merle D'Aubigne-Postel hip rating scores in the 69 hips that did not require revision, 19 hips were excellent (28%), 37 were good (54%), 11 were fair (15%), and 2 were poor (3%). Therefore, 67 of 83 hips (80.7%) were satisfactory on follow-up study. Radiographic evidence of loosening in nonrevised hips was found in 11 acetabular and 2 femoral components. | |
| 3738396 | [Surveys of the epidemiological team of the French Rheumatology Society (RESFR) on the pre | 1986 May | Two surveys carried out by the Epidemiology Team of the French Rheumatology Society (RESFR) were used to assess the treatment of rheumatoid arthritis (RA) by means of D-penicillamine (DP). In the initial survey, which is described in this article, 119 rheumatologists throughout France were asked to give their opinion as to the place of DP: they use this drug in cases of severe RA, usually after gold salts and synthetic antimalarials have proved ineffective. The dosage is generally 600 mg per day, with a maximum dosage of 900 mg per day. The rheumatologists consider DP an effective treatment with good or fair clinical safety. The most frequent adverse reactions are proteinuria and skin eruptions. | |
| 3805634 | Late rupture of the flexor tendons as a complication of replacement arthroplasty. | 1987 Jan | A case of attritional rupture of the flexor tendons secondary to metacarpophalangeal (MP) replacement arthroplasty for treatment of rheumatoid arthritis is reported. This complication is thought to be the result of resection of the palmar plate during the arthroplasty that was performed 5 1/4 years previously. Although not previously reported, it could be an expected late result if the palmar plate is excised during arthroplasty. | |
| 3561209 | [Osteoscintigraphy in the diagnosis of rheumatoid arthritis and Bechterew's diseases]. | 1987 Mar | The paper is concerned with an analysis of the results of clinical and radionuclide examination of 36 patients with ankylosing spondylitis (AS) and 63 patients with rheumatoid arthritis (RA). The period of observation lasted from several week to 5 yrs. Osteoscintigraphy was performed using labeled agents. The data obtained coincided with pain sensations whereas the correspondence of painful zones and x-ray findings was noted in 39% of the patients. In RA hyperfixation of the drug was determined mainly in small and big joints (130-250%) in 92% of the patients coinciding with the pain syndrome and with X-ray findings in 38% of the cases only. Radionuclide signs of therapeutic efficacy were noted in 56% of the patients with AS and in 82% of the patients with RA. Radiation exposure of the bone marrow in osteoscintigraphy and x-ray investigation was defined (4.1 and 14.4 microGy). A radioimmunoassay showed elevated content of PTH in 67% of the patients with AS up to 4.0 +/- 0.5 iu/ml. | |
| 3073542 | [Quantitative assessment of the status of patients with rheumatic diseases]. | 1988 | A system of operative quantitative assessment of the status of patients with rheumatoid arthritis (RA), osteoarthrosis (OA), systemic lupus erythematosus (SLE) and systemic scleroderma (SSD) was developed using a mathematical model of discriminant analysis. Data contained in case histories of 120 patients with RA, 112 with OA, 106 with SLE and 63 with SSD were used to determine discriminant coefficients of linear discriminant equations of some functional systems: locomotor, cardiovascular, respiratory, renal, digestive, nervous, skin and subcutaneous fat, immunological as well as laboratory findings on disease standing. Knowing discriminant coefficients, one can determine an index in any values of functional indicators that characterize the status of one or another system in any phase of the treatment of a patient. The system can be used in practice in a rheumatological hospital using CM-1600 minicomputer. | |
| 1876749 | Enzymatic hydrolysis of indometacin farnesil, a prodrug of indomethacin, by carboxylestera | 1991 May | The hydrolysis of indometacin farnesil (IMF) in the synovial cells of rat and human and the subcellular fractions of rat liver were investigated in relation to the inhibition of prostaglandin E2 (PGE2) production in the synovial cells. The inhibition of PGE2 production in cultured human synovial cells by anti-inflammatory drugs was potent in the order of IND, IMF and acetyl salicylic acid. However, when the cells were pretreated with IMF, the inhibitory activity of IMF was retained even after the compound was washed out from the medium. No duration of the inhibition was seen in the pretreatment of the cells with IND or acetyl salicylic acid. These results suggest that IMF incorporated into the synovial cells was hydrolyzed gradually to IND. In fact, IMF was taken up by rat synovial cells in culture and considerable amount of IND, which increased with culture period, was found out in the cells. Furthermore, the IMF hydrolase activity was found in microsomal and lysosomal fractions of rat liver, and the hydrolase was identified as carboxylesterase by using bis-(p-nitrophenyl) phosphate, a specific inhibitor of carboxylesterase. | |
| 3213262 | [Determination of endotoxin in inflammatory rheumatic diseases--the effect of nonsteroidal | 1988 May | We measured the amount of plasma endotoxin in 95 patients with inflammatory rheumatic diseases (42 with ankylosing spondylitis; 12 with possible ankylosing spondylitis; 41 with rheumatoid arthritis) and in 16 patients with Crohn's disease with a quantitative Limulus assay. Significantly increased mean values were found in inflammatory rheumatic diseases and in Crohn's disease. Between 31% and 50% of the patients had endotoxin values higher than 10 pg/ml--none of the controls had such values. Patients on regular treatment with NSAIDS had higher amounts of endotoxin again. From our results we discuss an intestinal involvement in inflammatory rheumatic diseases. An inflammation of the gut with an increased permeability seems to be responsible for the raised plasma endotoxin levels compared to healthy controls. NSAIDs probably contribute to the increased permeability of the gut. | |
| 3708233 | 111Indium-labelled polymorphonuclear leucocyte scans in rheumatoid arthritis--an important | 1986 May | The presence of rheumatoid arthritis in patients undergoing 111indium-labelled polymorphonuclear leucocyte scanning represents a source of possible diagnostic confusion. In such patients, the labelled cells frequently accumulate over the caecum and ascending colon, despite the absence of obvious pathology of the large bowel. The aetiology of this effect is unknown. | |
| 3282520 | Tibialis posterior tendon rupture: a cause of rheumatoid flat foot. | 1988 Mar | Flat foot, a major cause of foot pain and disability, may result from rupture of the tibialis posterior tendon. We describe 2 patients with rheumatoid arthritis who developed flat feet secondary to surgically confirmed tendon rupture, and we discuss the anatomy and diagnosis of this condition. In the second patient, we also present the results of tendon imaging with both magnetic resonance and ultrasound. | |
| 3472453 | Differences in prostanoid production between healthy and rheumatic synovia in vitro. | 1987 Feb | To evaluate further the complex role of prostanoids in rheumatoid arthritis we compared the immunoreactive prostanoid production of healthy and rheumatic synovial cells in a primary cell culture. During the first days in culture the adherent cells from rheumatic synovia produced higher amounts of prostanoids, especially the proinflammatory and immunosuppressive prostaglandin E2 (PGE2), than cells originating from non-inflamed synovia. This difference disappeared within one week culture and was partly explained by altered substrate availability. | |
| 2558123 | [Leukotriene B4, leukotriene C4 and prostaglandin E2 in the serum, synovial fluid and syno | 1989 Dec | This study investigated the presence of arachidonic acid metabolites, (leukotriene B4, leukotriene C4 and prostaglandin E2) in the serum, synovial fluid and synovium of rheumatoid arthritis patients (RA). We obtained the serum, synovial fluid and synovium from 16 female patients with RA during knee operations. Leukotriene B4 (LTB4), leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) were detected by RIA analysis. In the patients administered steroids, a positive correlation was found between the concentrations of LTB4 and PGE2 in the synovium. In the patients not administered steroids, significant correlations were found between the concentrations of LTB4 in the synovium and serum, and also between the concentrations of LTB4 and LTC4 in the synovium. The levels of immunoglobulins and LTB4 in the serum were determined and a significant correlation was found between the content of IgG and the concentration of LTB4. In the serum, the concentration of LTB4 was elevated in RA patients relative to the control normal subjects, and the difference was statistically significant. In conclusion, these data suggest that LTB4 in the serum reflects the concentration of LTB4 in the synovium. | |
| 3106632 | Hematuria in patients with rheumatoid arthritis receiving gold and D-penicillamine. | 1987 Feb | We reviewed the urinalyses from 2 multicenter controlled randomized trials, one comparing moderate and low dose D-penicillamine to placebo and another comparing gold sodium thiomalate (GSTM), auranofin (AF) and placebo. In the D-penicillamine trial 30% of the 40 patients taking placebo, 34% of the 70 patients receiving 125 mg/day of D-penicillamine and 31% of the 61 patients receiving 500 mg of D-penicillamine had recurrent hematuria. In the GSTM/AF trial, 35% of the 43 placebo treated patients, 35% of the 54 GSTM treated patients and 30% of the 64 AF treated patients had hematuria. No significant difference in the frequency of hematuria between the groups in either trial was apparent. These findings suggest that the traditionally held belief that gold and D-penicillamine cause hematuria should be reconsidered. | |
| 1870583 | Proto-oncogene expression in cultured synovial fibroblasts of patients with rheumatoid art | 1991 Jun | Total RNA was isolated from cultured synovial fibroblasts of nine patients with rheumatoid arthritis and two controls (cruciate ligament ruptures). RNA was dot-blotted and hybridized with nine different, cloned cellular or viral oncogene probes. None of the proto-oncogenes showed a significant difference of expression in cultured fibroblasts from patients with rheumatoid arthritis when compared to the expression of control fibroblasts. | |
| 3492745 | Spontaneous immunoglobulin synthesis by peripheral mononuclear cells in active rheumatoid | 1986 | Spontaneous production of immunoglobulins (Igs) by peripheral blood mononuclear cells (PBMC) in vitro was investigated to assess B cell activity in a group of 24 patients with rheumatoid arthritis (RA) with or without active joint disease and with or without rheumatoid vasculitis (RV) at the time of study. PBMC of patients with active arthritis (Ritchie index above 16) produced significantly more IgG and IgA than those of patients with inactive joint disease or those of 12 healthy controls. Enhanced production of IgG was found mainly among RA patients with concomitant RV, whereas markedly enhanced IgA production could also be found in patients without symptoms of RV. IgM production was only enhanced in two patients who had both active arthritis and RV. High production of IgG and IgA was probably due to increased numbers of Ig-secreting cells among freshly isolated PBMC, since the concentrations of Ig produced in vitro rose steadily, starting on day 0 and persisting throughout the entire culture period. Moreover, IgG and IgA concentrations measured after 7 days of culture showed significant correlations with the numbers of IgG- and IgA-containing plasma cells in PBMC on day 0. Comparison of the spontaneous production of Igs by PBMC with the levels of circulating immune complexes (CIC), showed that CIC levels were also significantly higher in active arthritis and in RV, but that there was no correlation between the CIC levels in individual patients and Ig production by their PBMC in vitro.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2194464 | Autoantibodies to lamins in rheumatoid arthritis. | 1990 Jun | The presence of autoantibodies reacting with lamins A and C was demonstrated in sera from 2 patients with rheumatoid arthritis (RA). One patient developed antilamin antibodies several years after being diagnosed as having RA; she was also found to have chronic active hepatitis. The second patient had severe nodular RA. We describe the other serologic findings in these 2 patients and discuss the relationships between antilamin antibodies and RA. | |
| 2917226 | 1H nuclear magnetic resonance investigation of synovial fluid components in osteoarthritis | 1989 Feb | The levels of a range of components were measured by 1H nuclear magnetic resonance (1H NMR) in samples of synovial fluid taken from three groups of patients: 10 with osteoarthritis (OA), 18 with rheumatoid arthritis (RA), and 11 with traumatic effusions. A large number of low molecular weight species were measured simultaneously in addition to triglycerides and glycoproteins. Large variations were found between individuals in any one disease group, and there was no measurable correlation between disease state and levels of any low molecular weight component. However, patients with traumatic effusions had high levels of saturated triglycerides, while those with OA had low levels. The chain length of the triglycerides found in OA synovial fluid appears to be shorter than that for the other groups. In RA the composition of triglycerides appears normal, while the overall level is slightly above normal. In a separate study, serial samples of synovial fluid drawn from the knees of two arthritic patients were examined, and the concentrations of glycoprotein, triglycerides and creatinine were found to show a reasonable correlation with each other and with systemic measures of disease activity. These data suggest the potential of synovial fluid triglycerides and creatinine as inflammatory markers. | |
| 2356472 | Changes in the incidence and prevalence of rheumatoid arthritis in England and Wales, 1970 | 1990 Apr | Data from the Second and Third National Studies of Morbidity Statistics from General Practice, conducted from 1970 to 1972 and 1981 to 1982, respectively, by the General Practice Research Unit of the Royal College of General Practitioners, were analyzed to estimate morbidity rates of RA and examine changes in these rates over time. The age-adjusted annual incidence of RA in females fell from 3.3 to 2.6 cases per 1,000 person-years from 1970 to 1972 and 1980 to 1981; there was no change observed in males. Over the same time interval, there was a rise in age-adjusted period prevalence of RA in both sexes from 6.4 to 7.5 per 1,000 and 2.8 to 3.5 per 1,000 in females and males, respectively. These data, which should be interpreted with caution, confirm a decline in incidence of RA in females and demonstrate an increase in prevalence of RA in both sexes over the past decade. | |
| 2731835 | Ankle fusion: a new technique of internal fixation using a compression blade plate. | 1989 Apr | A new technique of tibiotalar arthrodesis has been developed offering wide exposure, excellent correction of deformity, good bony apposition, and blade plate fixation. This technique has even been effective in cases of ischemic necrosis of the talus. A modified pediatric blade plate is used to effect compression of the talus to the tibia and to provide stability against flexion/extension and varus/valgus movement. Fixation is augmented by a lateral fibular struct screwed to the tibia and talus. In this series, 17 compression blade plate tibiotalar arthrodeses were performed. Follow-up averaged 48 months (range 13 to 85 months). Preoperative diagnoses included postraumatic degenerative arthritis, rheumatoid arthritis, and ischemic necrosis of the talus. Solid fusion was achieved in 16 of 17 patients (94%) with a painless, stable pseudarthrosis in the remaining one. Time to fusion averaged 4 months (range 2 1/2 to 6 months). Functional clinical results were excellent in 12 and good in 4 patients. Of 14 patients evaluated by the Mazur scale, 10 scored within the range of excellent; 2, good; and 2, fair. |