Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2281292 | [Increase in plasma androgens in menopausal women with rheumatoid polyarthritis]. | 1990 Jul | The concentrations of sex hormones were studied in 45 women with rheumatoid arthritis (RA). The patients were classified into two groups. Group I (premenopausal) consisted of 26 women and group II (postmenopausal) included 19 women. The two groups were compared with 40 control women (20 premenopausal and 20 postmenopausal). Age and weight were comparable in the 2 groups (controls and patients). The average plasma concentrations of oestradiol, progesterone and androgens were comparable in group I (patients with RA) and the control group (premenopausal women). On the other hand, the plasma concentration of androgens was statistically significantly higher in patients in group II by comparison with the postmenopausal controls. It thus seems that a hyperandrogenic situation may occur in menopausal women with RA, and this might have a beneficial clinical effect on the disease. | |
| 3499649 | Organ-specific autoantibodies in non-organ-specific autoimmune diseases with special refer | 1987 | Sera from 367 patients with rheumatoid arthritis (RA) and from 102 patients with other non-organ-specific (NOS) autoimmune diseases were examined for the presence of organ-specific (OS) autoantibodies. The incidence of these OS autoantibodies was not increased in patients with NOS autoimmune diseases with the exception of thyroglobulin antibodies, which were significantly more frequent in RA (P less than 0.001) and in Sjögren's syndrome (P less than 0.05) patients than in normal controls. Investigation of 169 patients with OS autoimmune diseases did not reveal an increased prevalence of NOS autoantibodies. In RA patients, OS autoantibodies correlated with NOS autoantibodies (P less than 0.04) and with HLA-DR3 antigen (P less than 0.01). | |
| 3488165 | IgM antiplatelet antibodies in 7 out of 20 rheumatoid arthritis sera. A new antiplatelet a | 1986 Jun | In a previous work, we had found that anti-B lymphocyte antibodies exist in rheumatoid arthritis. To investigate whether these antibodies were directed against surface immunoglobulins or not we have investigated if RA sera could recognize similar structures on other targets such as platelets (on which immunoglobulins and immune complexes are present) by a new ELISA method. No IgG antiplatelet antibody was found in 20 RA sera. But 7 out of these 20 RA sera had IgM antiplatelet antibodies when tested on platelets from 5 donors. The comparison of the positivities of these sera on B lymphocytes and platelets from the same donors showed a statistically significant reverse (X2 = 20,008, p much less than 0.0001) correlation. The target antigen and the meaning of these IgM antiplatelet antibodies, which seem to be associated with severe RA, is still under investigation. | |
| 2588721 | [Low T3 syndrome and chronic inflammatory rheumatism]. | 1989 Sep 1 | For the clarification of pathogenesis and clinical relevance of decreases of the triiodothyronine (T3) level in patients with chronic inflammatory rheumatism in a group of 63 patients with clinically, paraclinically and roentgenologically diagnosed rheumatoid arthritis (59 times) and with SLE (4 times), respectively, parallel were determined parameters of the thyroid gland function and of the rheumatic activity as well as a subtile drug anamnesis for the medication of antirheumatic drugs was established. In 33 of the 63 patients who were included into the study decreases and low normal values, respectively, for the total T3 (TT3 less than 1.5 nmol/l) were found. In comparison to the remaining 30 patients with normal TT3 a typical constellation of paraclinical parameters of the thyroid gland with distinct reduction of TT3 and free T3 (FT3), low normal total T4 (TT4), slight increase of the reverse T3 (rT3), moderate decrease of the basal and stimulated TSH and an only very small restriction of the binding capacity of the thyroid hormone (TBG) were found. A clinically relevant hypothyroidism is thus to be excluded with certainty. Antirheumatic drugs, in particular steroidal ones (glucocorticoids) may on principle also induce such paraclinical constellations, related to the thyroid gland. In our investigations a therapy with antirheumatic drugs is causally scarcely considered, since both in the group of patients with decrease of T3 and without decrease comparable quantities of antirheumatic drugs including glucocorticoids were administered and the cortisol values in the plasma do not differ. The investigations confirm our already formerly expressed supposition that also in rheumatics a "low-T3-syndrome" is existing as it is otherwise described in consumptive extrathyroidal diseases (NTI).(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 3335092 | Comparative analysis of ankle arthroplasty versus ankle arthrodesis. | 1988 Jan | In a retrospective study of 41 patients with total ankle arthroplasty (25 patients) and ankle arthrodesis (18 patients), the mean follow-up period was 3.8 years for total ankle arthroplasties and 3.3 for ankle arthrodeses. Sixteen of the 23 ankle arthroplasty patients, and 17 of the 18 arthrodesis patients had good or excellent results. Total ankle arthroplasty was successful in patients with rheumatoid arthritis, but not posttraumatic arthrosis. Total ankle arthroplasty is indicated in rheumatoid patients with severe ankle involvement who have not responded to medical management. It also may be used in the elderly or debilitated patients who will place minimal stress on the ankle. The elderly may not tolerate the prolonged immobilization or repeated operations that fusion may require. Total ankle arthroplasty should not be used in young patients with posttraumatic arthrosis. | |
| 3494122 | Polyarticular septic arthritis. | 1986 Dec | Seven adult patients with nongonococcal polyarticular septic arthritis are presented with a literature review of the clinical features of polyarticular bacterial infection. Polyarticular septic arthritis occurred in 19% of reported cases of septic arthritis in adults. Similar to monoarticular disease, the knee was the most commonly affected joint, and Staphylococcus aureus was the most frequently isolated microorganism. Pneumococcus, group G streptococcus, and Hemophilus influenzae had an increased association with polyarticular infection. Five of our 7 patients had underlying rheumatic diseases and the immediate mortality rate was 57%. Review of the literature yielded an overall mortality of 23% for polyarticular septic arthritis compared to the 9% mortality of septic arthritis in general. The subset of patients with polyarticular infection superimposed on rheumatoid arthritis had a mortality rate of 56%. | |
| 2706819 | Microvascular dynamics at the nailfold in rheumatoid arthritis. | 1989 Jan | Conventional and fluorescence videomicroscopy using Na-fluorescein as tracer was performed in 13 patients with rheumatoid arthritis (RA) and Waaler Rose titers less than 1: 112, 10 patients with titers greater than or equal to 1: 112 and 11 patients with osteoarthritis (OA) (control group). At the nailfold different microvascular diameters, capillary flow pattern, red blood cell velocity and transcapillary diffusion of Na-fluorescein were determined. Mean red blood cell velocity was significantly (p less than 0.02) decreased in patients with RA and high titers (0.23 +/- 0.21 0.21 mm/s) when compared to OA patients (0.59 +/- 0.20 mm/s). Abnormal flow patterns, in 2 cases even a reversal of flow direction, were only observed in RA patients and not in controls. Mean transcapillary and interstitial diffusion of Na-fluorescein was not enhanced at the nailfold in RA-patients. These findings do not exclude increased microvascular permeability in synovial membranes or in RA patients with vasculitis. | |
| 3209590 | Gait in rheumatoid arthritis: an electrogoniometric investigation. | 1988 | For the purpose of detecting early aberrations of gait in rheumatoid arthritis 17 women suffering from that disease were examined. They were all under 50 years of age and had an essentially normal range of motility in the hips, knees and ankles. Eleven healthy women walking at voluntary speed and 6 healthy women walking at the same slow speed as the RA patients were included as controls. The recordings were made while the subject walked on a treadmill with a computerized electrogoniometer measuring the angular excursions of the hip, knee and ankle in three planes simultaneously. The patients with RA walked at a slower speed than did the healthy subjects (0.6 vs 1.2 ms-1). The angular excursions, i.e. inward and outward rotation, abduction and adduction, flexion and extension, were significantly less in the RA patients than in the healthy subjects who walked at voluntary speed. As compared to the healthy subjects walking at a slow speed, the differences in range of motility were much smaller. The major aberrations of the gait pattern were found in the ankles and feet, which showed reduced internal rotation (7 vs 10 degrees), adduction (6 vs 12 degrees) and a less pronounced plantar flexion at toe off (1 vs 8 degrees). | |
| 2273521 | Challenging the therapeutic pyramid: a new look at treatment strategies for rheumatoid art | 1990 Nov | Traditional therapy of rheumatoid arthritis (RA) has been dominated by the therapeutic pyramid. This approach is not working. The designation of drugs as either antiinflammatory or disease modifying is not borne out by experience. We possess a number of drugs, each only partially effective against inflammation, that work by poorly understood mechanisms. Until a major breakthrough appears, it is proposed to treat RA with a combination of these medications early in the disease course, to gain control of the inflammation, and then bridge to a simplified program by withdrawing drugs sequentially. | |
| 3229078 | Thrombocytosis in active rheumatoid arthritis. Relation to other parameters of inflammator | 1988 Sep | The magnitude of thrombocytosis and the possible confounding effect of platelet clumping, an in vitro artifact resulting in spuriously low platelet counts, in active rheumatoid arthritis (RA) was evaluated by a prospective survey of 57 consecutive patients, 60% of whom had thrombocytosis. Five cases (9%) of platelet clumping, assessed by H6000 pictures, were found. A low-grade platelet loss in many of the samples anticoagulated by EDTA was suggested by comparison with platelet counts obtained in parallel blood samples anticoagulated by citrate. Thus, the possibility of spuriously low platelet counts due to laboratory artifacts must always be taken into consideration in RA patients. The relation between thrombocytosis and other estimates of disease activity was also studied. The platelet count in citrated blood in active RA was significantly correlated with ESR, acute phase plasma proteins, and neutrophil, basophil and monocyte counts. In a multivariate regression model, however, only the correlation with haptoglobin (p = 0.06) approached significance. | |
| 3515921 | Comparison of two dosing schedules of flurbiprofen for patients with rheumatoid arthritis. | 1986 Mar 24 | A total daily dose of 200 mg of flurbiprofen (Ansaid, Upjohn) was administered either twice daily (100 mg BID) or four times daily (50 mg QID) to 143 patients with rheumatoid arthritis. Results of this 12-week, randomized, double-blind study showed statistically significant reductions in the number of swollen joints, number of affected joints, duration of morning stiffness, and 50-foot walk time in patients receiving either treatment regimen. Using standard statistical tests, no significant differences between regimens were found. Flurbiprofen treatment was rated as "excellent" or "good" by approximately half of the patients and physicians following both BID or QID dosing. | |
| 1663860 | A comparison of health-related quality-of-life measures for rheumatoid arthritis research. | 1991 Aug | Twenty-eight instruments measuring pain, clinical, functional, and global characteristics were administered to 303 patients in a six-month randomized clinical trial of auranofin and placebo in the treatment of patients with rheumatoid arthritis. The instruments were compared with respect to their responsiveness in detecting a treatment effect, the time involved in administering the instrument, the need for the presence of an interviewer, and ease of administration. The instruments' ability to detect a treatment effect was the deciding characteristic in the clinical, pain, and global categories in choosing the preferred instrument. The counts of tender and swollen joints were found to be the most responsive clinical measures, the 10-cm pain line was the most responsive and the fastest to administer of the pain instruments, and the categorical self-assessment of arthritis was the most responsive global measure. In the functional ability category, the Health Assessment Questionnaire (HAQ), the Keitel Functional Assessment, and the Quality of Well-Being (QWB) Questionnaire were equally responsive. The HAQ was the shortest and the only self-administered questionnaire. The QWB has had the most extensive validation work but was a complex instrument requiring intensive interviewer training. The Keitel was the most time-consuming instrument, but had the advantage of high interobserver agreement. The design of future trials can be guided by the information obtained in this study on their relative efficiencies and ease of use. | |
| 2317977 | Internal fixation compression arthrodesis of the ankle. | 1990 Apr | Sixteen patients were treated by internal compression arthrodesis of the ankle using cancellous screw fixation. Thirteen patients had a preoperative diagnosis of traumatic osteoarthritis, and three patients had rheumatoid arthritis. All patients were followed until clinical and roentgenographic evidence of union had been obtained (average, 15.1 months). Union was obtained in 15 of 16 cases (94%) by an average of 9.2 weeks. The average ankle evaluation score was 77 points, with 80% of the patients rated good or excellent. Suboptimal results were attributed to technical errors. Midtarsal motion averaged 18 degrees, and subtalar motion was present in the majority of patients after surgery. This technique provides a high union rate while permitting early mobilization of the adjacent hindfoot and midfoot joints with earlier return to satisfactory function. | |
| 3811490 | [Value of passive postoperative mobilization treatment following knee joint synovectomy in | 1986 Sep | One group of 17 Knee joints was treated postoperatively with continuous passive motion, while the control group received cyclical changes of the Knee's position in flexion and extension. In the postoperative period the CPM-treated patients suffered less pain than the control group. Furthermore the patients of the CPM-group reached free extension and 90 degrees of flexion earlier than the control group. The amount of liquid in the suction drainage was higher in the CPM-group than in the control group. Based on the results of our examination continuous passive motion is considered to be a useful contribution to the postoperative treatment of synovectomy of the knee joint in rheumatoid arthritis. | |
| 3941140 | Thermographic diagnosis in athletes with patellofemoral arthralgia. | 1986 Jan | Pain in front of the knee is common in athletes and is often called patellofemoral arthralgia, but it is difficult to prove that the pain arises in that joint. Thermograms of 30 athletes clinically considered to have patellofemoral arthralgia were compared with those of a similar number of unaffected athletes matched for age and sex. A comparison was also made with thermograms of two older groups of 30 patients with knee involvement from either rheumatoid arthritis or osteoarthritis. Twenty-eight of the athletes with patellofemoral arthralgia had a diagnostic pattern on thermography. The anterior knee view showed a rise in temperature on the medial side of the patella and the medialis knee view showed that this temperature rise radiated from the patellar insertion of the vastus medialis into the muscle itself. The possible aetiological role of quadriceps muscle imbalance in athletes with patellofemoral arthralgia is discussed in relation to these findings. | |
| 2585411 | Acute, reversible hepatic failure associated with methotrexate treatment of rheumatoid art | 1989 Aug | We describe 2 patients who developed reversible decompensated liver disease while taking pulse dosed methotrexate (MTX) for rheumatoid arthritis. One of the patients was available for biopsy and had chronic active hepatitis--a lesion not previously described with MTX. This appears to be a unique and unusual manifestation of MTX hepatotoxicity. | |
| 2465773 | Antikeratin antibodies in synovial fluid in rheumatoid arthritis. | 1989 Feb | Serum and synovial fluid of 20 patients with classical or definite rheumatoid arthritis (RA) were tested for antikeratin antibodies (AKA) by indirect immunofluorescence using rat esophagus as antigen. AKA were found in 80% of the RA patients, in serum as well as in synovial fluid. None of the 54 serum control patients were AKA positive in serum. None of the 17 synovial fluid control patients were AKA positive in synovial fluid. F(ab)'2 fragments prepared from AKA positive RA serum retained antibody activity. AKA belonged to the IgG class of immunoglobulins. Corrected for the lower IgG content in synovial fluid, AKA constituted a higher percentage of the IgG in synovial fluid than in serum. This could imply a possibility of local production of AKA in the joint. | |
| 2261735 | Follow-up with OM-8980 after a double-blind study of OM-8980 and auranofin in rheumatoid a | 1990 Sep | A 6-month double-blind study of OM-8980 and auranofin in 145 patients with rheumatoid arthritis was followed by an open observation period of 6 months for which 100 OM-8980-treated patients could be assessed. At the end of this second phase, the Ritchie index, number of swollen joints, pain scale, morning stiffness, grip strength and ESR had all improved further with respect to the significant improvements already recorded under OM-8980 and auranofin in the double-blind phase. The statistical analysis of the Ritchie index, pain scale and ESR showed significant changes in these 3 parameters during both the 6-month follow-up phase and the entire 12-month period. As regards the tolerance, 2 patients reported gastrointestinal disorders during the follow-up. The investigators' final assessment of efficacy indicated an improvement in 76% of the patients during the follow-up phase and in 95% during the entire 12-month period. | |
| 2313671 | Minocycline treatment for rheumatoid arthritis: an open dose finding study. | 1990 Jan | Ten patients with active definite or classical rheumatoid arthritis (RA) were treated with oral minocycline (maximal daily dose 400 mg) during 16 weeks in an open study. Seven patients reported side effects (in most cases vestibular) leading to premature discontinuation in one. Half of the efficacy variables improved significantly after 4 weeks of therapy. At the end of the study all variables were significantly changed compared with their pretreatment values. We conclude that minocycline may be beneficial in RA. This effect needs to be confirmed in controlled studies. | |
| 3345104 | Kinetic investigations into the possible cause of low serum histidine in rheumatoid arthri | 1988 Jan | To investigate the cause of low serum histidine in rheumatoid arthritis (RA) single oral and intravenous doses of L-histidine were administered to patients with active RA, and to an equal number of age and sex matched control subjects. In the first study 13 patients and their controls received a 100 mg kg-1 dose of L-histidine as an aqueous slurry. Significant differences were seen in body weight, predose baseline serum histidine concentration, Cmax, t1/2, and area under curve, AUC0-infinity. In a second study six patients and six controls each received a 50 mg kg-1 dose of L-histidine both orally and intravenously on two separate occasions. The patients with RA had a lower baseline serum histidine concentration, a lower volume of distribution, and a shorter plasma half life than the controls, but these differences were not statistically significant. No difference was seen in bioavailability or clearance. Low serum histidine in RA is unlikely to be due to malabsorption from the gut, uptake by abnormal gut flora, or increased metabolism. |