Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 448984 | Bronchiolitis and bronchitis in connective tissue disease. A possible relationship to the | 1979 Aug 10 | Rapid onset of severe and irreversbile airflow obstruction developed in two women. One had eosinophilic fasciitis and the other had rheumatoid arthritis. Both were treated with penicillamine. In the first patient, aged 42 years, dyspnea developed after six months of therapy. Her roentgenogram showed hyperinflation. Forced vital capacity expired in one second (FEV1/FVC%) decreased from 75% to 40%, and the residual volume increased by 1 L. In the second patient, aged 54 years, cough and dyspnea developed after ten months of therapy. The FEV1/FVC% was 56%, the FEV1 was 0.9 L, and the roentgenogram was normal. Lung biopsy specimens demonstrated severe and widespread bronchiolitis. An association between obliterative bronchiolitis and rheumatoid arthritis has been reported. Penicillamine may impair healing of bronchiolitis in such patients. | |
| 6391933 | Long-term treatment of rheumatoid arthritis with fenclofenac or gold: a controlled, single | 1983 | A randomized parallel group study to compare the effects of fenclofenac and gold was carried out in 35 patients with active rheumatoid arthritis. Patients were treated with either 1200 mg fenclofenac per day or gold in standard doses in addition to their non-steroidal anti-inflammatory therapy and monitored for up to twelve months. The two treatments produced similar improvements in erythrocyte sedimentation rate, orosomucoid and haptoglobin. In addition, gold produced improvements in haemoglobin, IgG and alpha 1-antitrypsin, but there were no statistically significant differences between the clinical responses. Fenclofenac caused significantly fewer and less serious unwanted effects. | |
| 1083331 | Gastro-intestinal bleeding in patients with rheumatoid arthritis: the effects of azapropaz | 1976 | A comparative study was carried out, using the Cr51 red blood cell labelling method, to assess the amount of gastro-intestinal blood loss in 20 rheumatoid arthritis patients taking either 600 mg. or 1200 mg. azapropazone daily. The results demonstrate that azapropazone does not produce greater than normal gastro-intestinal bleeding, that the volume of faecal blood loss is not dose-related, and there would not appear to be any correlation between blood loss and the occasional mild gastro-intestinal side-effects reported in a few patients. These results compared favourably with those obtained previously by the investigators in a similar group of patients taking 3 g. aspirin per day. | |
| 6395229 | Clinical trials on the efficacy and toxicity of slow acting antirheumatic drugs. | 1984 | Rheumatologists must constantly ensure that the balance between the activity and the toxicity of slow acting antirheumatic drugs is always to the patient's advantage. Trials must be continued long enough to permit evaluation of activity of these drugs. Double-blind testing with placebo provides information about the influence of a new compound on the natural course of the disease. Comparative studies determine the indications of new drugs and their place in the therapeutic arsenal of rheumatoid arthritis. Patients are selected on the basis of inclusion and exclusion criteria, but the choice of the patient also plays a role. It is still impossible to divide a rheumatoid arthritis population into subgroups in which patients respond to this or that drug. The variability of the natural course of the disease makes it necessary to study large numbers of patients, thus making multicentre studies frequently necessary. The evaluation of disease activity is based principally on subjective measurements (morning stiffness, pain scale, joint counts); objective data are limited to grip strength and laboratory tests which often do not entirely correspond with the subjective variables. The occurrence of adverse reactions depends in great part on the way investigators' questions are formulated. Adverse reactions necessitating interruption of drug administration are particularly important. Withdrawals for inefficacy must be avoided as much as possible in double-blind trials with placebo. | |
| 6532641 | The extensor tendon apparatus. | 1984 Dec | The extensor tendon apparatus is less involved with tenosynovial disease than the flexor tendons. It is, however, frequently affected by bony erosions at the wrist and synovial disease of the metacarpophalangeal joints with consequent loss of function due to rupture or dislocation. The causes of rupture have been discussed and the means of treatment described. Details of metacarpophalangeal deformities of the fingers and thumb, and their management are given in Chapters 5, 8 and 9. | |
| 7287402 | Mycoplasmal arthritis in man. | 1981 Jul | Naturally occurring mycoplasmal arthritis in various animals species and the ability to induce mycoplasmal arthritis experimentally have been the main reasons for searching for evidence of mycoplasmal infection in the joints of patients with rheumatoid arthritis. However, reliable reports of the isolation of mycoplasmas from synovial fluids and tissue of such patients do not exist, and measurements of specific antibodies have not proved rewarding. There is some evidence that infection by Mycoplasma pneumoniae occasionally has an arthritic sequela, although the microorganism has not been isolated from the joints of immunocompetent patients. In contrast, this and other mycoplasmas, including ureaplasmas, have been isolated from the arthritic joints of several hypogammaglobulinemic patients, and there is some evidence to indicate that the organisms are responsible for the disease. A relationship between mycoplasmas and sexually acquired Reiter's disease is unproven, but deserves thorough investigation in view of the link between ureaplasmas and nongonococcal urethritis. Furthermore, as new media and techniques become available, the possibility the mycoplasmas may have some role in rheumatoid arthritis should be reappraised. | |
| 343717 | Bullous pemphigoid and other disorders associated with autoimmune phenomena. | 1978 Feb | Although bullous pemphigoid is a disease associated with autoantibodies, it rarely has been associated with other diseases associated with autoimmune phenomena. We report the occurrence of bullous pemphigoid, pernicious anemia, and rheumatoid arthritis in a patient. | |
| 7082397 | An analysis of the American Rheumatism Association criteria for rheumatoid arthritis. | 1982 May | When a community-derived population of 840 rheumatoid arthritis patients was used to test the American Rheumatism Association's 11 diagnostic criteria for rheumatoid arthritis, these criteria divided patients into 3 reasonably distinct classifications (probable, definite, and classic). The severity of disease increased in direct proportion to the number of positive criteria. Three criteria involve invasive procedures that are rarely performed; they are unnecessary for effective use of the other 8 criteria. Although 256 possible combinations of these 8 criteria exist, the criteria function principally to classify patients into only 7 major clinical syndromes, each of which corresponds to a major clinical presentation. By identifying the logical interrelationships between criteria in this report, we have confirmed their applicability and provided insight into the manner by which criteria classify patients. | |
| 3833413 | [Involvement of the occipito-atlanto-axial articulation in rheumatoid arthritis]. | 1985 Dec | The authors, after reviewing the world bibliography, remember the seriousness, quoad vitam, of the atlanto-axial sub-luxation as a frequent complication of rheumatoid arthritis. They, for such reason, emphasize the importance of a precocious diagnosis, with the systematic research, in patients suffering from rheumatoid arthritis, of the clinical and radiographic signs of such a dreadful complication. | |
| 2411240 | The use of high-dose pulse methylprednisolone in rheumatoid arthritis. Unproved therapy. | 1985 Aug | Pulse methylprednisolone therapy has been used for the treatment of rheumatoid arthritis. The recent literature describing pulse therapy for this disorder is reviewed. The effects of pulse steroids on the immune system, potential side effects of therapy, and recommendations for its use are presented. Because of the lack of substantial benefit and the possibility of adverse side effects, pulse methylprednisolone therapy should be considered investigational for short-term use in patients with aggressive rheumatoid arthritis undergoing induction therapy with long-term agents such as gold or penicillamine. More study is indicated before generalized use of this modality can be advocated. | |
| 6221406 | [Cellular immunity in chronic polyarthritis: the effect of basic therapy on T-lymphocyte s | 1983 Mar 19 | Monoclonal antibodies were used to determinee the various T-lymphocyte subpopulations in 51 patients with rheumatoid arthritis (RA). The findings were compared with an age-matched healthy control population. Patients with active rheumatoid arthritis display a significant decrease in suppressor T lymphocyte subsets as compared with RA-patients with inactive disease. The calculated immunological ratio (helper-suppressor ratio) is accordingly higher than in the inactive disease state or in normals. Remission-aimed therapy with slow-acting agents such as gold salts. D-penicillamin, levamisole or azathioprine induces not only a clinical improvement but also normalization of the immunological ratio. These findings support the hypothesis that immunological imbalance may play a crucial role in the development and perpetuation of rheumatoid arthritis. | |
| 6524112 | [Determination of early changes in the rheumatoid hand with an electronic color analyser]. | 1984 Sep | Using soft rays, X-ray pictures were taken of the hands of patients with possible and probable rheumatoid arthritis, and were then subjected to electronic colour analysis. This method represents a contribution to early diagnosis of rheumatoid arthritis, makes the distinction between the joint capsule and rheumatoid pannus possible, and ensures the early discovery of cartilage damage, which has not been possible with any other noninvasive method. | |
| 6842485 | Rheumatoid cervical myelopathy: evaluation by computerized tomography with multiplanar rec | 1983 Feb | Rheumatoid cervical myelopathy was studied in 14 patients, clinically, radiographically and by computerized tomography with multiplanar reconstruction (CT/MPR). CT/MPR demonstrated significant unsuspected areas of compromise in 9 of the 14 patients, and altered the surgical procedure in 7 of these 9 patients. CT/MPR clearly identifies all levels of involvement including rotary subluxation. CT/MPR also allows assessment of the spinal nerve canal/foramen and the alignment of the foramina transversaria. CT/MPR is an essential addition to the evaluation of rheumatoid cervical myelopathy. | |
| 6503211 | Pregnancy and rheumatic disease. A review of recent studies in rheumatoid arthritis and an | 1984 Oct 1 | The present paper reviews the results of recent investigations into the influence of pregnancy and sex hormones on rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Prospective patient studies have shown that pregnancy exerts a beneficial effect on the majority of RA patients, while AS patients generally have unchanged disease activity during gestation. In AS, gestational remission was confined to patients with accompanying diseases. A postpartum disease flare-up occurred commonly in both RA and AS. Blood parameters reflected mainly the biochemical changes of normal pregnancy. A decrease of circulating immune complexes has been found in RA patients remitting during pregnancy. No single serum factor or combination of serum factors responsible for gestational remission could be detected. The possible influence of alpha 2-pregnancy-associated globulin on disease activity in pregnant patients remains contradictory. Hormonal contraceptives have been found to be protective against the manifestation of RA in four of five studies. However, no beneficial effect of sex hormones on the symptoms of established RA and AS could be demonstrated. | |
| 72955 | alpha 1-antitrypsin phenotypes in fibrosing alveolitis and rheumatoid arthritis. | 1977 Nov 19 | alpha 1-antitrypsin (alpha 1-A.T.) phenotypes were determined in 55 patients with rheumatoid arthritis (R.A.), 33 patients with R.A. and either obstructive airways disease or recurrent chest infections, 49 patients with fibrosing alveolitis (F.A.), 22 patients with R.A. and F.A., and 200 healthy controls. A highly significant increase in the frequency of MZ phenotype was found among patients with F.A., both with and without R.A. Patients with R.A. alone had a normal distribution of phenotypes. Inherited modification of immune function may predispose to F.A. Alternatively, lowered levels of alpha 1-A.T. associated with non-M phenotypes may predispose to tissue damage with subsequent fibrosis. | |
| 340137 | A short-term comparative trial of salsalate and indomethacin in rheumatoid arthritis. | 1977 | A short-term, double-blind, placebo-controlled crossover study was completed in 15 patients with classical or definite rheumatoid arthritis to compare the antirheumatic activity of salsalate (3 g/day) with placebo and indomethacin (75 mg/day). Subjective and objective assessments showed that both salsalate and indomethacin were significantly superior to placebo. Grip strength was not improved by either of the drugs. Patient preference was in favour of indomethacin, but the difference between it and salsalate was insignificant. | |
| 282446 | Measurements of humoral immunity during treatment with levamisole in rheumatoid arthritis- | 1978 | Treatment with levamisole in patients with rheumatoid arthritis reduced significantly titers of rheumatoid factor and the amount of circulating immune complexes as determined by the Clq binding activity. It took between three and six months to observe a significant effect. Levamisole treatment had less effect on the amount of immunoglobulins in serum: the values were rarely abnormal before treatment and the changes were small, but reached statistical significance at six months. The effect on complement and complement components could not be evaluated as properly controlled studies were lacking. | |
| 7434840 | [Anemia in rheumatoid arthritis]. | 1980 Jun 1 | The anaemia in rheumatoid arthritis is apparently of complex origin, in which case an increased accumulation of iron in the RES and the decreased utilisation of storage iron play the quantitatively most important role. According to literary data megaloblastic anaemias shall not appear frequently in rheumatoid arthritis. The frequency of the anaemia is rheumatoid arthritis is clearly depending on the composition of the collective of patients. In our patients anaemia and hypoferraemia do not correlate with the actual activity of the disease, however with the extension of the affection of the joints and the progressing of the basic disease. Anaemia and hypoferraemia may, therefore, be valuated as prognostically unfavourable signs. We could prove decreased vitamin B12-levels in 11.6%. There was no statistically significant relation to the course of the disease. An inhibition of the resportion of vitamin B12 by means of a long-term therapy is discussed. | |
| 6944042 | Antibodies against double-stranded RNA in patients with rheumatoid arthritis, osteoarthros | 1981 Apr | Using a liquid phase radioimmunoassay to detect antibodies to 3H-labelled double-stranded RNA the premise that rheumatoid arthritis and Paget's disease of the bone may be associated with a chronic virus disease was examined. About 33% of patients with rheumatoid arthritis had antibody levels above the normal range and 11% had antibody levels below the normal range of controls (blood bank donors). The low binding activities were attributed to the action of a nuclease that degraded the dsRNA. Some patients with Paget's disease of bone had higher binding activities than the normal range and similar binding activity was also found in patients with osteoarthrosis. The increase in antibodies to double-stranded RNA did not correlate with increasing age. | |
| 6607994 | HLA-B27 and involvement of sacroiliac joints in rheumatoid arthritis. | 1984 Feb | The frequency of radiographic signs of sacroiliac joint involvement (greater than or equal to 2 and greater than or equal to 3 according to the New York criteria) was significantly higher in 28 HLA-B27 positive patients with classical seropositive rheumatoid arthritis (RA), than in 28 B27 negative RA controls. The B27 positive RA patients had more subcutaneous nodules (p less than 0.01), worse functional class (p less than 0.05), and higher levels of erythrocyte sedimentation rate (ESR) (p less than 0.05) and haptoglobin (p less than 0.05). Sacroiliitis, independent of HLA-B27, was associated with higher levels of ESR (p less than 0.05), and with a higher frequency of positive ANA test (p less than 0.05). It is neither related to the functional class nor to the duration of the disease. |