Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6242205 | Two cases of acute poststreptococcal glomerulonephritis superimposed on rheumatoid arthrit | 1984 Oct | Recently, the rheumatoid factor (RF) has been postulated to play a role in the development of acute poststreptococcal glomerulonephritis (APSGN). However, there are few reports in which APSGN is superimposed on rheumatoid arthritis (RA). Two patients are reported in this paper who showed atypical renal histopathological findings as APSGN. It was suggested that renal histopathological finding might become different from those of typical APSGN when it is superimposed on RA. | |
| 4093912 | Monocytes in rheumatoid arthritis. Regulatory, effector, and phenotypic properties. | 1985 Dec | We reported that rheumatoid arthritis (RA) blood mononuclear cells (MNC) secreted less Ig and IgM rheumatoid factor (RF) than synovial cells. Since antibody elaboration is partly monocyte dependent, we compared regulatory, effector, and phenotypic properties of monocytes from 31 patients with RA with those of 21 normal subjects. RA IgG and IgM elaboration was less than normal. Monocyte, T or B cell numbers were comparable in RA and normal MNC and monocyte enriched/depleted preparations. RA and normal Ig production were monocyte dependent and this differed for IgG and IgM for RA and normals. IgM RF elaboration by stimulated RA MNC was also monocyte dependent and addition of normal monocytes/monocyte culture supernatants to RA monocyte depleted cultures and vice versa had inconsistent effects. RA MNC (Ficoll-Hypaque) phagocytosis was less than normal; killing (acridine orange fluorescent microscopy) was not. RA synovial monocyte phagocytosis - but not killing was also reduced. MNC from RA patients and normals contained similar numbers of monocytes; RA monocyte enriched populations (Percoll) showed less phagocytosis than normal; with similar killing. RA phagocytosis was reduced at 1,2,3,4 and 5 h and differed from normal at 3 and 5 h. Different sera - FCS, autologous, normal, RA - exhibited inconsistent effects on phagocytosis. RA and normal neutrophil phagocytosis and killing were comparable. Lastly, RA monocyte enriched preparations contained populations of OKM1, OKM3, OKM5, OKM6, Leu M1, Leu M2, Leu M3, and HLA-DR-positive cells (FACS analysis) comparable with normals. Regulatory and effector but not phenotypic properties of RA blood monocytes differed from normal and may contribute to inappropriate autoantibody production and chronic inflammation. | |
| 3833414 | [A case of concurrent subcutaneous injury of the right quadriceps tendon and the left rotu | 1985 Dec | Authors, after briefly remembered the etiopathogenesis, pathological and therapeutic aspects of subcutaneous ruptures of patellar and quadriceps tendons, present one case of bilateral simultaneous lesions in R.A. | |
| 686858 | Precipitating antibodies to cellular antigens in Sjögren's syndrome, rheumatoid arthritis | 1978 Jun | The prevalence of three precipitating antibodies, anti-SS-A anti-SS-B, and rheumatoid arthritis precipitin (RAP), reacting with an extract of the human lymphoid cell line Wil2, was studied in the sicca syndrome, Sjögren's syndrome with rheumatoid arthritis, rheumatoid arthritis, various seronegative spondyloarthritides, and organ and nonorgan-specific autoimmune disease. Anti-SS-A and snti-SS-B occurred most frequently in the sera of patients with the sicca syndrome whereas RAP occurred most frequently in seropositive rheumatoid arthritis sera. However, the data did not support previous studies where patients with sicca syndrome had a high incidence of anti-SS-A and/or -SS-B antibodies but had a low frequency of RAP, and patients with Sjögren's syndrome in association with rheumatoid arthritis had a high incidence of RAP but a low incidence of anti-SS-A and/or -SS-B. Instead the three antibodies were present in both forms of Sjögren's syndrome. This suggested a difference in the diseases in the UK compared to the USA, or that these antibodies do not have the more subtle diagnostic specificity that was originally suggested. | |
| 913872 | Have the anti-inflammatory drugs helped our understanding in rheumatology? | 1977 | The author discusses the part that certain anti-inflammatory drugs have played in increasing our understanding of the pathogenesis of rheumatoid arthritis and in adding to our knowledge of the mediators of the inflammatory response. Increasingly, the therapeutic agents under discussion have directed attention to the role of the macrophage in inflammation. Closer examination of existing anti-inflammatory or anti-rheumatic drugs and their mode of action has more recently directed attention towards immunomodulation. | |
| 101713 | [Muscle blood flow and capillary diffusion capacity in patients with rheumatoid arthritis | 1978 Sep 15 | Capillary blood flow (Xenon-133) and diffusion capacity for Chrom-51-EDTA (PS-Product of Renkin) of striated muscle tissue were examined by double isotope method in patients with rheumatoid arthritis. Xenon-Clearance and PS-Product were studied under normal conditions and following hyperemisation. There existed no significant difference between rheumatoid patients and normal subjects and there was no evidence of increased capillary permeability. Apparently, derangement of muscle capillaries is rare in rheumatoid arthritis. | |
| 143290 | A description of rheumatology practice. The American Rheumatism Association Committee on R | 1977 Jul | Four rheumatologists kept a log of the diagnoses of all patients seen their offices for 2 months. The great majority of patients had rheumatic complaints. Musculoskeletal pain syndromes and back syndromes were encountered most frequently; rheumatoid arthritis and osteoarthritis were also common. Patients with SLE and connective tissue diseases were relatively infrequent. | |
| 6172064 | [Immunological diagnosis of collagen diseases and rheumatoid arthritis (author's transl)]. | 1981 Jul | Most helpful immunological tests for diagnosis of connectivities are revised. Among them, antinuclear antibodies (AAN) are the most important. They are usually detected by immunofluorescence and show different patterns, being the peripheral one the most specific of SLE and it is related with antibodies anti-DNA which can make immunocomplexes DNA-anti-DNA and be the cause of lupic nephropathy. The "nucleolar" and "speckled" patterns are more frequent in scleroderma. The LE cells have less value than AAN. The rheumatoid factor is a IgM antibody anti-IgG, but also can be of IgG or IgA class. It is uncommon in the juvenile rheumatoid arthritis of systemic onset and more frequent in oligoarticular adult type. May became positive during disease evolution. Other factors as immunoglobulin of complement usually are increased, except when the activation of complement take place. Acute phase reactants are helpful just for evaluating the importance of inflammation, they have not diagnosis value and commonly do not exceed the value of erythrocyte sedimentation rate. | |
| 795022 | Controlled trial of D-penicillamine in rheumatoid arthritis. Dose effect and the role of z | 1976 | The findings are reported of a controlled clinical trial comparing in 66 rheumatoid arthritis patients 0 g (placebo), and 0.50 g a day and 1 g a day of penicillamine. Each of these groups has been subdivided into two, one part receiving 5 mg a day of zinc metal supplement, the other a placebo. The trial was planned to be double-blind, and for each patient to take part for 4 months. The results prove the effectiveness of penicillamine in rheumatoid arthritis. 0.50 g a day has the same effect as 1 g a day but gives less side effects. Zinc supplement inhibits the clinical effects of penicillamine but does not prevent the side effects. | |
| 7221495 | Synovial fluid hydroxyproline fractions before and after osmic acid treatment in rheumatoi | 1981 | Synovial fluid total, dialysable and non-dialysable hydroxyproline were determined in patients with Rheumatoid Arthritis before intra-articular osmic acid injection and on days 2 and 4 after this local treatment. On day 2 the increase in dialysable hydroxyproline paralleled the increase in non-dialysable hydroxyproline. Patients with the highest pre-treatment dialysable hydroxyproline levels also had the highest levels of this fraction on day 2 suggesting that articular damage proceeds after osmic acid injection. However, on day 4 dialysable hydroxyproline levels were consistently lower than before the treatment; the same pattern was observed with non-dialysable hydroxyproline, except for all the joints but one, where effusion recurred 6-12 months after osmic acid treatment. This study suggests that the determination of synovial fluid non-dialysable levels 4 days after osmic acid injection may provide a clue to the prediction of recurrent joint effusion and possibly justify a complementary injection either with osmic acid or with a beta-emitting isotope. | |
| 6678199 | Serum lipids and lipoprotein concentrations in women with rheumatoid arthritis. | 1983 Dec | Serum lipid and lipoprotein concentrations were measured in 51 women with rheumatoid arthritis treated with both nonsteroidal and steroidal drugs and compared to a group of women with rheumatoid arthritis not receiving anti-inflammatory drugs and to a healthy control group. Significantly lower concentrations of total cholesterol and low density lipoprotein cholesterol were found in the rheumatoid patients on nonsteroidal or steroidal anti-inflammatory drugs, while no difference was found in high density lipoprotein cholesterol and triglycerides. In the group of rheumatoid patients who received no nonsteroidal or steroidal anti-inflammatory drugs, the triglyceride level was higher than in the control group, and that of HDL-C was lower. Total cholesterol and LDL-C levels were higher in the patients not on anti-inflammatory drugs than in patients receiving anti-inflammatory drugs. The results of this study suggest that hyperlipidemia is not one of the predisposing factors for coronary disease in patients with rheumatoid arthritis receiving anti-inflammatory therapy. Anti-inflammatory drugs may play a role in the regulation of serum lipids in patients with rheumatoid arthritis. | |
| 7173776 | [Distribution of non-steroidal anti-inflammatory agents in human tissues]. | 1982 Oct 7 | Non-steroidal antirheumatic drugs (NSAIDs) have become essential in the treatment of chronic joint disease. The dosage has to be established individually for each patient because the resorption is independent from body size and body weight. After repeated administration NSAIDs are selectively concentrated in the inflamed tissue, which therefore has to be considered an independent compartment for the distribution of the drug. The concentration in this compartment is related to the basic disease and its degree of activity. With increasing activity of the disease the concentrations of NASIDs increase in the involved tissues. | |
| 6353231 | Does drug therapy slow radiographic deterioration in rheumatoid arthritis? | 1983 Oct 27 | Many clinicians believe that slow-acting therapeutic agents, such as fold, penicillamine, the antimalarials, and cytotoxic drugs, can retard joint destruction in rheumatoid arthritis. We reviewed 60 published studies employing these drugs to evaluate critically the evidence that drug therapy can slow the radiographic progression of disease. Seventeen studies were found that included radiographic assessment of both treated and control groups; they were analyzed using methodologic criteria known to be important in affecting the results of drug trials. In addition to numerous qualitative methodologic deficiencies, many studies showed inadequacies in sample size and duration of treatment, and the drug dosage used varied from one study to another. We found evidence suggesting that both gold and cyclophosphamide can retard radiographic progression of joint destruction. At present, there are too few technically adequate studies to permit even provisional conclusions concerning other agents. | |
| 459563 | Total joint arthroplasty. The wrist. | 1979 Aug | Total wrist arthroplasty, which has been performed in 101 patients, has proved to be a satisfactory procedure for the relief of pain and provision of mobility in the deformed wrist involved with rheumatoid arthritis. This procedure should not be performed after traumatic conditions in patients who expect to make heavy use of the wrist. Early cases were associated with technical problems in the development of the concept, but at present the procedure is reliable and is most often preferred to arthrodesis inpatients with rheumatoid arthritis. | |
| 3879527 | [Selective IgA deficiency in patients with systemic lupus erythematosus and rheumatoid art | 1985 Oct | In this study, antinuclear antibody (ANA), rheumatoid factor (RF) studied and IgA was determined with single radial immunodiffusion (RID) technic in the sera of 96 patients with systemic lupus erythematosus, 25 with rheumatoid arthritis and 100 normal individuals. In normal control group, the average level of IgA was found to be 212 mg/dl. In one patient (1: 100), IgA deficiency was detected with a level of 2.1 mg/dl, the average level of IgA in 96 patients with SLE was 320 +/- 16.25 mg/dl. In 3 patients of this group IgA deficiency was observed. According to this finding, the prevalence of IgA deficiency in the group of SLE ise 1: 32. This prevalence is higher than that of the normal population. The average level of IgA in 25 patients with RA 302.66 +/- 36.57 mg/dl. In this group we observed IgA deficiency only in one patient which means a prevalence of 1: 25, that is higher than the normal group. Reports indicate that the incidence of IgA deficiency in general populations may vary from 1: 400 up to 1: 3080. But in patients with SLE and RA, this may be encountered more frequently as we observed in our cases. | |
| 7247476 | Leaking rheumatoid olecranon bursitis as a cause of forearm swelling. | 1981 Jun | A patient with seropositive rheumatoid arthritis and recurrent oedema of the forearm was shown to have a leak from a multilobulated olecranon bursa. | |
| 303801 | Serum lysozyme, antinuclear factors and antibody to native DNA. | 1977 | This work was done in order to investigate the previously reported antinuclear property of lysozyme (LZM). Addition of human or hen egg white lysozyme (hLZM or eLZM) to normal serum and to 11 sera with different types of antinuclear factors (ANF) produced no consistent changes in ANF titre or type. Likewise, absorption of LZM from the sera with bentonite failed to influence ANF titre and, finally, hLZM and eLZM were incapable of binding native DNA (nDNA). Elevated serum lysozyme levels in rheumatic diseases are therefore unlikely to produce false-positive results in tests for antinuclear antibodies. | |
| 961081 | [Morphologic studies on rats with adjuvant disease of long duration]. | 1976 Jul | Morphological studies were performed on Wistar-AF/Han-EMD-SPF-rats with adjuvant disease of 3 tp 14 months duration. Synovitis was observed in the noninjected paw up to the 6th month. While in the central bones resorption and new bone formation had ceased about the 7th month, periostal bone resorption proceeded until the 14the month. Morphological end results of the longlasting disease were pannus formation and fibrous ankylosis of the joints and severe sclerosis of the affected bones. Amyloid deposits were never observed. | |
| 7201022 | Oligoarthropathy with chronic iridocyclitis--a disease only of childhood? | 1982 Jan | The association between chronic iridocyclitis and pauciarticular disease in childhood is well recognized. In view of this important subset of childhood arthritis, a comparable entity was searched for in adults. Twenty-three rheumatologists and 149 ophthalmologists were contacted in the San Francisco Bay area regarding the possible presence of this association in their catchment area of several million adult individuals. Replies were received from 15 and 41, respectively. Following detailed questionnaire and clinical evaluation of potential patients, only 2 such subjects were identified. These probably reflect a chance occurrence of 2 prevalent conditions. The apparent absence of the iridocyclitis/oligoarthritis subset in adults is in stark contrast to the situation in children. | |
| 6651369 | Clinical judgment in rheumatoid arthritis. II. Judging 'current disease activity' in clini | 1983 Dec | Two rheumatologists made judgments about 'current disease activity' in real patients and 'paper patients' with rheumatoid arthritis. Analysis of each set of judgments provides a model of judgment policy which contains only 3 clinical variables but explains over 94% of the variance in judgments. The judgment policy models differ markedly from each other and from the clinicians' own perceptions of their behaviour. Judgment policy modelling offers a means of improving co-ordination between clinical investigators within and between centres. |