Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6592146 | Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs. | 1984 Jun | The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0 micrograms/ml), carprofen (10 micrograms/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis. | |
| 1083217 | Study of lymphoid cells from inflamed synovial membranes. | 1975 Dec | Synovectomy specimens from patients with rheumatoid arthritis were cultured and after 24 hours the nonadherent cells were removed. These were found to include cells with the morphological characteristics of lymphocytes. Using the sheep-cell rosetting test, up to 94% of these cells were found to be T cells, and while T cells could be found in all the supernatant cell populations studied, not all made a mitogen response. None or only a very small number of B cells were found by staining for surface immunoglobulin. The possible roles which T lymphocytes might play in chronic inflammation in the rheumatoid synovium are discussed in relation to experimental work, and factors which attract T cells into areas of nonspecific inflammation are similarly considered in the light of animal experiments. | |
| 6753850 | Comparison of five assays for immune complexes in the rheumatic diseases. An assessment of | 1982 Oct | Clinical assessment (disease activity, severity, and extraarticular manifestations) of 101 rheumatoid arthritis patients was correlated with several laboratory tests, including 5 immune complex assays: the bovine conglutinin, 125I-Clq binding, monoclonal rheumatoid factor inhibition, Raji cell, and staphylococci binding assays. Elevated disease activity indices were most closely associated with the presence of immune complexes detected by the 125I-Clq and staphylococci binding assays. There were significant but weak correlations between the level of disease activity and the level of immune complexes as measured by the bovine conglutinin, 125I-Clq binding, Raji cell, and staphylococci binding assays. Articular disease severity, as measured by anatomic stage, was discriminated by the bovine conglutinin, monoclonal rheumatoid factor inhibition, and staphylococci binding assays. Extraarticular manifestations were best discriminated by the Raji cell and staphylococci binding assays. We concluded that the sensitivity, specificity, predictive value, and overlap of the associations were not sufficient to warrant their wide use for the diagnosis and management of rheumatoid arthritis in individual patients. Conversely, the 125I-Clq and staphylococci binding assays were as good as the erythrocyte sedimentation rate and the IgG rheumatoid factor test (the 2 best of many examined) in assessing disease activity. Further prospective studies with these assays will determine their usefulness in following rheumatoid arthritis for a prolonged period. | |
| 3879101 | Synovial fluid kinetics of non-steroidal anti-inflammatory drugs. | 1985 | Synovial fluid kinetics of NSAIDs are still in a relatively nascent stage. These kinetics are determined by the biochemical characteristics of the drugs, the characteristics of the synovium, and the characteristics of the host. NSAIDs show a delayed peak concentration (relative to serum) in the synovial fluid, and their terminal synovial half-lifes generally parallel the serum half-life. Their intrasynovial concentrations are determined to a large extent by synovial fluid protein concentrations plus diffusional barriers to ingress and egress, although displacing substances (including other drugs), and disease, may complicate kinetics. The synovial pharmacodynamic of NSAIDs are understood very poorly. Hopefully a better understanding of synovial fluid and tissue kinetics will lead to more rational therapy with NSAIDs in the future. | |
| 3863516 | Flexible implant resection arthroplasty for the rheumatoid hand and wrist. | 1985 | Surgery of destroyed joints in the hand and wrist in the arthritic patient can be added to the armamentarium of the reconstructive arthritis surgeon. With proper patient selection, appropriate surgical technique, and postoperative management, rewarding results with freedom of pain and improved function can be expected. | |
| 3918545 | Diagnosis-related group regulations. Implications for the practicing rheumatologist. | 1985 Feb | Data from our university hospital on the 2 most common rheumatologic diseases that require hospitalization indicate that total charges for patients admitted with rheumatoid arthritis or systemic lupus erythematosus break down as follows: room, board, and nursing, 55%; tests/procedures, 30%; drugs, 5%; physical and occupational therapy, 5%; and miscellaneous, 5%. Thus, shortening the length of stay would be the most effective mechanism to reduce total charges. We also found marked heterogeneity in the single diagnosis-related group containing rheumatoid arthritis and systemic lupus erythematosus inpatients under 70 years old who had no comorbid conditions. Planners should be sensitive to this as prospective reimbursement is extended beyond Medicare patients. | |
| 6442057 | [Comparison of oral and parenteral gold therapy--review of the literature]. | 1984 | Numerous open and placebo-controlled trials have shown Auranofin, an oral gold salt, to be effective in the base-line treatment of rheumatoid arthritis. In comparative trials the drug was found to be somewhat less potent than sodium aurothiomalate. Whether it is equal or superior to other base-line antirheumatoids like D-penicillamine or antimalarials, can as yet not be established because of the small patient groups involved in the published trials. While adequately effective clinically, oral gold salts, like their parenteral counterparts, do not halt the radiological progression of rheumatoid lesions. Overall, Auranofin is much better tolerated than the parenteral gold salts, although soft feces are more commonly seen and diarrhea may occur occasionally. Skin rashes as well as proteinuria and thrombocytopenia have been reported in some instances so that, as during parenteral treatment, laboratory studies at regular intervals are mandatory. On account of its oral dosage form and its low side-effect rate Auranofin is a true alternative to conventional parenteral gold salt therapy. | |
| 6182293 | Studies of antinuclear antibodies in rheumatoid arthritis. | 1982 Jul | Antinuclear antibodies (ANA) by the indirect immunofluorescence method and their immunospecificities were investigated in 60 patients with rheumatoid arthritis using HEp-2 cells as substrates. ANA were detected in 35% of the patients. The patterns of nuclear staining observed included: diffuse or patchy homogeneous (20%), speckled (8.3%), centromere (3.3%), nucleolar (1.6%) and in 1 patient a mixed pattern (1.6%). The presence of antihistone antibodies (20%) correlated with the presence of an homogeneous pattern on the HEp-2 cells. | |
| 1058340 | Early experience with total knee replacement. | 1975 Jul 23 | This paper presents a review of two years' experience with the geometric total knee replacement. The results of 23 arthroplasties in 22 patients are discussed. Relief of pain was consistent and dramatic, movement was increased postoperatively in only three patients, but imporvement in overall function occurred in 20 of the 22 patients. There was one failure requiring arthrodesis. In this patient, six months after surgery the medial tibial condyle collapsed and the polyethylene tibial component fractured. This complication has not been reported before. Early results are encouraging. Total knee joint replacement is a useful procedure in advanced arthritis when arthrodesis is the only alternative. | |
| 1228708 | Activity of lysosomal enzymes and glycogen content of phytohemagglutinin-stimulated lympho | 1975 Sep | In patients with rheumatoid arthritis and in healthy controls a continuous rise in acid phosphatase activity was observed in PHA-stimulated lymphocytes and the activity index was higher in patients than in controls. Differences were also observed between these groups in the activity of nonspecific esterase, beta-glucuronidase, and glycogen content at different hours of culture. | |
| 6800312 | Fall in immune complex levels during gold treatment of rheumatoid arthritis. | 1981 Dec | Prior to starting gold treatment 30 patients with rheumatoid arthritis had an elevated mean level of circulating immune complexes measured by Clq binding activity. Gold treatment led to an improvement in disease reflected by significant falls in erythrocyte sedimentation rate (p less than 0.001), C-reactive protein (p less than 0.01), Ritchie articular index (p less than 0.001), and duration of morning stiffness (p less than 0.05). Concurrently immune complex levels fell, and this change first reached significance after 3 months' treatment (p less than 0.05). Serum Clq binding activity was not related to clinical and laboratory measurements of joint inflammation. This suggested to us that there is no direct immunopathological relationship between circulating immune complexes and joint inflammation in rheumatoid arthritis. Serum Clq binding activity was strongly related to IgM-RF levels measured at latex titre (r - 0.7, p less than 0.001). Removal of immune complexes from serum with Sepharose 4B-staph A (staphylococcal protein A) led to a fall in IgM-RF from 2 mg/ml (2 g/l) to 0.4 mg/ml (0.4 g/l). This suggests that the reason for the relationship between Clq BA and IgM-RF is that, on average 80% of serum IgM-RF exists as part of immune complexes containing IgG. | |
| 1058297 | Bilateral enlargement of the mandibular coronoid processes in a patient with rheumatoid ar | 1975 Oct | A case of rheumatoid arthritis of the temporomandibular joint with enlargement of both coronoid processes has been presented. Limited excursions of the mandible were due mainly to the encroachment of the coronoid processes on the posterolateral surfaces of the maxilla. The condition was relieved by unilateral arthroplasty and bilateral coronoidectomies. The etiology of the enlarged coronoid processes is unknown. However, the condition does resemble that which occurs experimentally when condylectomy is performed and the ramus is shortened. In this case, shortening of the ramus could be attributed to condylar destruction by the arthritic condition. | |
| 462126 | Degradation of thymidine to thymine by rheumatoid arthritis synovial tissue eluate. | 1979 | A study was made of the effect of rheumatoid synovial tissue eluate on phytohaemagglutinin (PHA) stimulation of peripheral blood lymphocytes. It was found that rheumatoid synovial tissue eluate caused marked inhibition of 3H-thymidine incorporation by lymphocytes stimulated with PHA. Synovial tissue from traumatic joints had no effect. The inhibitor was a heat-sensitive and nondialysable substance. The inhibitory effect of PHA stimulation was diminished by thymine. In thin-layer chromatography it showed the capacity to convert thymidine to thymine. Because thymine is not incorporated by DNA-synthesizing cells, this report explains why negative results are obtained when lymphocytes are stimulated by rheumatoid synovial tissue using 3H-thymidine incorporation as an indicator of lymphocyte activation. | |
| 343718 | Cicatricial pemphigoid and rheumatoid arthritis. | 1978 Mar | A review of our experience with cicatricial pemphigoid revealed three patients with cicatrical pemphigoid and rheumatoid arthritis and one patient with ankylosing spondylitis who had a high titer of rheumatoid factor. A comparison of these four patients with patients who had bullous pemphigoid and rheumatoid arthritis shows similarities between cicatricial pemphigoid and bullous pemphigoid in relation to the development of rheumatoid arthritis. | |
| 1261301 | Long-term use of azapropazone in rheumatoid conditions. | 1976 | In an open assessment of azapropazone, 51 patients with rheumatoid disorders, mainly rheumatoid arthritis, were treated continuously for periods up to 3 years (range 2 weeks to 38 months). Treatment was interrupted or discontinued in 9 patients for various reasons. Initial dosage was 1200 mg. daily, but this was usually reduced after a few months to a maintenance level of 900 mg. daily. An overall assessment of patient response at the end of the study period indicated that only 4 (7.8%) of the 51 patients failed to obtain satisfactory relief during treatment: 28 (54.6%) showed objective signs of improvement, such as reduced joint swelling and stiffness, as well as subjective evidence of symptom relief, and a further 19 patients (37.3%) reported an equivocal analgesic effect with azapropazone. Few side-effects were reported, mainly mild gastralgia and nausea, and routine laboratory investigations throughout the long-term study revealed no abnormalities in the blood picture, liver or renal function or coagulation factors. There was also no evidence of any interaction between azapropazone and other drugs used concomitantly. | |
| 1020381 | [Longitudinal study on the locomotor function test in patients with rheumatoid arthritis]. | 1976 Oct 15 | With the help of a four-year observation of the course of rheumatoed arthritis in 100 patients the evidence of the locomotor functional test after Keitel is examined for the longitudinal research. The locomotor functional test proved depending on the actual activity and in a high percentage of patients showed considerable variations from year to year which were not parallel to the clinical and radiological progression. It is not sufficiently evident as the only criterion for the establishment of the progression of the disease. The locomotor functional test is well suited for the judgement of the success of therapy in short periods and the objectivation of the actual restriction of the function especially for questionings of experts. It is proposed to include the locomotor functional test into the criteria for the establishment of the degree of function. | |
| 6852660 | Stabilisation of distal ulna after excessive Darrach's procedure. | 1983 Feb | A patient is presented in whom painful instability persisted more than a year after the resection of 1 1/2 inches of the distal ulna, for a painfully subluxed distal radio-ulnar joint. The palmaris longus tendon was detached distally, passed through a drill hole in the distal radius and then wrapped and stitched, as a sling, around the distal ulna stump. Two years later the patient's symptoms were relieved. | |
| 3929421 | HLA associations in aurothioglucose- and D-penicillamine-induced haematotoxic reactions in | 1985 Jul | HLA phenotype frequencies were studied in 21 rheumatoid arthritis (RA) patients with haematotoxic reactions to aurothioglucose (AuTG) or D-penicillamine (DP), 65 matched RA controls and 277 healthy controls. Antigens B8 and DR3 were significantly increased in the toxic RA patient group as compared to both RA controls and healthy controls. These contrasts were strongest in the patients with AuTG-induced thrombocytopenia or leucopenia: all patients developing either reaction to this drug were B8- and/or DR3-positive (p less than 0.001), 7 (78%) being positive for both antigens. In the patient group with DP-induced reactions these antigens were also increased but these differences were not significant. In the latter group the prevalence of antigen DR4 was high, especially in the patient group with DP-induced thrombocytopenia, all 12 patients with this type of reaction being DR4 positive. Our data suggest that haematotoxic reactions to AuTG and DP develop primarily (or even exclusively) in genetically predisposed RA patients. Furthermore, the HLA phenotype contributing to an increased risk seems not to be the same for the two anti-rheumatic drugs studied. | |
| 6282290 | [Drug-induced changes in chemotaxis under normal conditions and in rheumatoid arthritis]. | 1982 Apr 15 | The effects of agents used in RA treatment, various drugs, RF, rheumatoid nodule and synovial fluid was studied on chemotaxis of PMNs. NSAIDS, corticosteroids, theophylline, colchicine, SOD, RF, rheumatoid nodule and synovial fluid were found to inhibit the chemotactic responsiveness while AMPc, GMPc, PGEI and immunodulator drugs enhanced chemotaxis. The results support the hypothesis that drugs tested may modulate chemotactic function by affecting cellular microtubules assembly and/or GMPc accumulation. | |
| 6581119 | Presence of HLA-DR antigen on synovial type A and B cells: an immunoelectron microscopic s | 1983 Dec | The HLA-DR antigen was investigated in synovial epithelia of rheumatoid arthritis, osteoarthritis and normal traumatic joints, using monoclonal anti-human HLA-DR antibody and horseradish peroxidase-conjugated antibody. The HLA-DR staining was observed in an electron microscope. HLA-DR antigen was observed to be present on the surface of both macrophage-like (type A) and fibroblast-like (type B) cells in synovial epithelia in all rheumatoid arthritis, osteoarthritis and normal joints. Since type A and B cells are ultrastructurally considered to be of synovial origin, the findings suggest that the expression of HLA-DR antigen on the surface is one of the common attributes of type A and B cells in synovial epithelia, even before cellular infiltration of chronic inflammation in rheumatoid arthritis. These cells may play an important role in the initiation of rheumatoid inflammation, since HLA-DR antigen is considered equivalent to murine Ia antigen. |